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Neurology12361 papers

Ischemic stroke

Last edited: 4/23/2026

Overview

Ischemic stroke occurs due to the interruption of blood supply to brain tissue, leading to cell death and neurological deficits. It is a significant cause of disability and mortality worldwide.

Diagnosis

  • Clinical Presentation: Sudden onset of focal neurological deficits 4.
  • Imaging: Non-contrast CT scan often used initially to rule out hemorrhagic stroke; MRI may show early ischemic changes 42.
  • Laboratory Tests: Blood tests to assess coagulation profile, cardiac biomarkers, and inflammatory markers 7.
  • Grading: NIH Stroke Scale (NIHSS) for assessing severity and prognosis 4.

    • Management

  • Acute Phase:
    • - Thrombolysis: IV tissue plasminogen activator (tPA) within 4.5 hours of symptom onset 555. - Mechanical Thrombectomy: For large vessel occlusions, especially if eligible within 24 hours 115.
  • Anticoagulation:
    • - Atrial Fibrillation: Direct oral anticoagulants (DOACs) initiated after acute phase, timing varies based on stroke severity 1. - Antiplatelet Therapy: In patients with atherosclerotic cardiovascular disease (ASCVD) and NVAF, adding antiplatelet to OAC does not improve net clinical benefit 2.
  • Supportive Care: Management of blood pressure, glycemic control, and prevention of complications like aspiration pneumonia 339.

    • Special Populations

  • Pregnancy: Limited data; focus on maternal and fetal outcomes; individualized management 16.
  • Elderly: Endovascular thrombectomy remains beneficial even in patients aged ≥90 years, though outcomes vary 60.
  • Comorbidities:
    • - Atrial Fibrillation and ASCVD: Optimal antithrombotic strategies include DOACs with caution on dual antiplatelet therapy 24. - Frailty: Consideration of frailty risk through predictive models aids in treatment decisions 8.

    Key Recommendations

  • Initiate IV tPA within 4.5 hours of symptom onset for eligible patients (Evidence: Strong 55).
  • Consider mechanical thrombectomy for large vessel occlusions within 24 hours, guided by imaging and clinical criteria (Evidence: Strong 11).
  • Post-stroke anticoagulation with DOACs in atrial fibrillation patients, timing post-stroke depends on stroke severity and clinical context (Evidence: Moderate 1).
  • Avoid dual antiplatelet therapy (APT) plus oral anticoagulants (OAC) in patients with ischemic stroke, NVAF, and ASCVD due to lack of net clinical benefit (Evidence: Moderate 2).
  • Monitor and manage potential complications such as intracranial hemorrhage, especially post-thrombolysis (Evidence: Moderate 15).

    • References

    Showing 100 most recent of 9422 indexed papers.

    1 Spina E, Romoli M, Mosconi MG, Padroni M, Canavero I, Mannino M et al.. Timing of anticoagulation therapy in patients with acute ischemic stroke and atrial fibrillation: a GRADE-based expert opinion recommendation. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2026. link 2 Sharma M, Srivastava A. In patients with ischemic stroke, NVAF, and ASCVD, adding an antiplatelet to OAC therapy did not affect net clinical benefit at 2 y. Annals of internal medicine 2026. link 3 Rosenberg K. Vaginal estradiol tablets not likely to increase risk of recurrent ischemic stroke. The American journal of nursing 2026. link 4 Linares N, Cambron J, Xu T, Danboise B, Richman P. Emergency Physician Versus Telemedicine Neurologist Assessment for Thrombolytic Indication in the Treatment of Acute Ischemic Stroke (AIS). Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2026. link 5 Athiraman U, Roy A, Barreto A, Broderick J, Derdeyn C, Elm J et al.. General Anesthesia Versus Conscious Sedation for Mechanical Thrombectomy in Patients With Acute Ischemic Stroke in the MOST Trial. Journal of the American Heart Association 2026. link 6 Fujii T, Fukui Y, Maruyama K, Takigawa K, Tashiro N, Matsukawa H et al.. Outcomes following thrombectomy for acute ischemic stroke using procedural sedation with midazolam. The neuroradiology journal 2026. link 7 Cao W, Zhu B, Jia X, Gu N, Zhang Q, Wang B et al.. Risk factors for drug-related ischemic stroke: an analysis of the FDA adverse event reporting system (FAERS). Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2026. link 8 Kang YL, Kong JT, Tian H. Prediction model for frailty risk in ischemic stroke patients: Application and validation of support vector machines and nomograms. Medicine 2026. link 9 Nguyen Tung B, Quoc Thai N, Manh Hung P, Ngoc Quang N, Huynh Linh D, Duy Ton M. Timing of extracranial carotid revascularization following ischemic stroke or TIA: Outcomes of early carotid stenting in a cohort study. Medicine 2026. link 10 Wang S, Xiang X, Guo X, Qin M, Chen J, Jiang D et al.. Multi-omics analysis reveals the neuroprotective effects of phosphatidylcholine (18:1/18:2) on ischemic stroke by inhibiting plasma IL-18 levels. European journal of pharmacology 2026. link 11 Yan G, Li W, Guo B, Wen S, Zhang R, Yin L et al.. The timing of arterial thrombectomy on neurological recovery in patients with acute ischemic stroke: A retrospective observational study. Medicine 2026. link 12 Weng Y, Zhou J, Zhang L, He X, Guo H, Zhang Q et al.. miR-15b-5p impairs myelin repair and cognitive recovery after ischemic stroke by targeting the E2F7/CXCL2 axis. Experimental neurology 2026. link 13 Hu Y, Xia M, Cao M, Zhang J, Cao X, Guo J. Combined treatment with tPA and Chinese herbal medicine for ischemic stroke: is it valuable?. Journal of ethnopharmacology 2026. link 14 Zhang K, Liang F, Wu Y, Wang X, Hou X, Zhang Z et al.. Emergency Conversion to General Anesthesia During Endovascular Therapy and Stroke Outcomes: A Retrospective Matched Study. Journal of neurosurgical anesthesiology 2026. link 15 Coşkun Yaş S, Üçöz Kocaşaban D, Güler S, Uludağ Tunçel C, Demirtaş E. Computed Tomography Measurement of Optic Nerve Sheath Diameter in Thrombolysis-Treated Ischemic Stroke: Association with Post-Thrombolytic Intracranial Hemorrhage. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2026. link 16 Richardt A, Verho L, Rantanen KK, Korhonen A, Laivuori H, Tikkanen M et al.. Long-Term Recovery, Morbidity, and Mortality After Maternal Ischemic Stroke. Neurology 2026. link 17 Wang Z, Liu C, Wang M, Cai S, Nie X, Liu L et al.. White matter lesions modifying endovascular therapy outcomes in large ischemic core stroke: A secondary analysis of the ANGEL-ASPECT trial. Chinese medical journal 2026. link 18 Wang N, Guo K, Zhu B, Zhang Y, Jia X, Liu Z et al.. The relationship between controlling nutritional status (CONUT) and cerebrovascular stenosis: a retrospective study with implications for ischemic stroke prevention. PeerJ 2026. link 19 Marqués J, Basurco L, Ainzúa E, Marqués V, Solas M, Santamaría E et al.. NADPH oxidase 5 promotes adhesion and infiltration of immune cells in the brain. Implications in ischemic stroke. Biochimica et biophysica acta. Molecular basis of disease 2026. link 20 Hsu A, El Baba B, Eshraghi S, Giraudo F, Saberian S, Chalhoub R et al.. Concurrent Anterior Cerebral Artery and Middle Cerebral Artery Occlusions Predict Poor Neurological Outcome Despite Successful Thrombectomy in Anterior Circulation Stroke. Neurosurgery 2026. link 21 Ding N, Xiang B, Jiang H, Yu Y, Liu J, Zhao Y et al.. OCT-PAM dual-mode imaging to evaluate early ischemic stroke in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026. link 22 Shen YC, Kim AS, Hsia RY. Does Exposure to Certified Stroke Centers Affect All Communities Equitably? Stroke Patient Outcomes by Community Socioeconomic Status. Annals of emergency medicine 2026. link 23 Sioutas GS, Reavey-Cantwell J, Rivet DJ. The gut-brain axis: a nationwide propensity score-matched analysis of gastrointestinal syndromes preceding ischemic stroke. Brain injury 2026. link 24 Ibrahim A, Balbaa E, Awashra A, Shubietah A, Cavolina G, Villari A et al.. Optimal antithrombotic therapy for post-ischemic stroke patients with atrial fibrillation and atherosclerotic cardiovascular disease: A frequentist network meta-analysis. Journal of the neurological sciences 2026. link 25 Chen M, Li M, Lu Y, Liu Z, Yang D, Guo Y et al.. Mitochondria-targeting urolithin A/borneol nanoparticles: enhanced therapeutic effects for cerebral ischemia-reperfusion injury in rats. International journal of pharmaceutics 2026. link 26 Patil RM, Back DB, Hamanaka G, Desai R, Hayakawa A, Chan SJ et al.. Meningeal lymphatic-associated brain swelling in acute stroke. PloS one 2026. link 27 Wang L, Chen Y, Chang Z, Shen W, Zhao D, Zhang Y et al.. Naoxintong capsules for secondary prevention of ischemic stroke: Meta-Analyses of clinical and preclinical evidence. Journal of ethnopharmacology 2026. link 28 Liu C, Wang Z, Wang M, Cai S, Nie X, Huo X et al.. Effects of Computed Tomography Hyperdense Middle Cerebral Artery Sign on the Efficacy of Endovascular Therapy in Acute Ischemic Stroke With Large Infarcts: A Subgroup Analysis of the ANGEL-ASPECT Trial. Journal of the American Heart Association 2026. link 29 Wang J, Qiao Y, Li S, Li C, Wu C, Hao X et al.. Impact of Prestroke Antiplatelet Therapy on the Efficacy of Intravenous Tirofiban at Preventing Early Neurological Deterioration: A Prespecified Subgroup Analysis of the TREND Trial. American journal of cardiovascular drugs : drugs, devices, and other interventions 2026. link 30 Jiang W, Xia C, Cui Z, Shi L, Feng W, Chen Y et al.. Redox-modulating macrophage biohybrid nanoplatform for targeted RIPK1-PANoptosome suppression in ischemic stroke. Redox biology 2026. link 31 Xu F, Mei S, Yang L, Zhai D, Xu Y, Gui T et al.. Mediating effect of dyadic coping on the relationship between patient empowerment and quality of life in acute ischemic stroke patients and their spouses. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2026. link 32 Chu X, Lan J, Ma Z, Yin Y, Gu H, Baron JC et al.. Effect of IL-6 receptor inhibition on infarct volume after endovascular treatment for ischaemic stroke: a phase 2, randomised, placebo-controlled trial. EBioMedicine 2026. link 33 Karisik A, Moelgg K, Buergi L, Scherer L, Delazer L, Dejakum B et al.. Antidepressant Intake and Recovery of Dysphagia After Acute Ischemic Stroke. Stroke 2026. link 34 Monguillon V, Kelly PJ, O'Donoghue ML, Park JG, Bohula EA, Saver JL et al.. Efficacy and Safety of Very Low Achieved LDL Cholesterol in Patients With Previous Ischemic Stroke. Circulation 2026. link 35 Usuki N, Ueda T, Takeuchi M, Morimoto M, Tsuboi Y, Yamamoto R et al.. Recent outcomes of intravenous tissue plasminogen activator (t-PA) alone in the era of mechanical thrombectomy: A sub-analysis of the Kanagawa Intravenous and Endovascular Treatment (K-NET) registry. Clinical neurology and neurosurgery 2026. link 36 Ji Z, Chen M, Zhou X, Chen X, Wang H, Han L et al.. Taohong Siwu decoction alleviates cerebral ischemia-reperfusion injury by inhibiting the formation of NETs through STAT1/NLRP3/GSDMD pathway. International immunopharmacology 2026. link 37 Hlubek N, Verhoeven J, Koop Y, Wagtendonk A, Vienneau D, Vaartjes I. Air pollution and ischemic stroke across socioeconomic groups in the Netherlands. The Science of the total environment 2026. link 38 Sabben C, Charbonneau F, Obadia M, Strambo D, Ong E, Heldner MR et al.. Clinical outcome following best medical management in acute stroke with a proximal isolated occlusion of the anterior cerebral artery: an international multicentre study. European stroke journal 2026. link 39 Li H, Lu M, Ye X, Guo X, Ma T, Zhang Z et al.. Association of plasma ceramide with stroke-associated pneumonia in acute ischemic stroke. Frontiers in immunology 2026. link 40 Feler J, Porto CM, Chang C, Torabi R, Chuck CC, Shaaya E et al.. Large-volume single-institution experience with transradial versus transfemoral mechanical thrombectomy in acute ischemic stroke: a retrospective cohort study. Journal of neurointerventional surgery 2026. link 41 Gong P, Zou Y. Letter to the Editor. Effect of encephalomyosynangiosis procedure on post stroke recovery in a permanent model of ischemic stroke. Experimental neurology 2026. link 42 Ben Alaya I, Felhi F, Messelmani M, Labidi S. Advancing Stroke Diagnosis: A Comprehensive Review of Artificial Intelligence in Detecting Early Ischemic Changes on Noncontrast CT (NCCT). Academic radiology 2026. link 43 Li G, Liu Z, Li W, Zhang R, Han H, Dong P. Tongqiao huoxue decoction and its components promote angiogenesis and treat ischemic stroke via glycolysis-enhanced VEGF-A/VEGFR2 pathway. Brain research 2026. link 44 Yang S, Zhang H, Xu LL, Zhou LQ, Chu YH, Chen L et al.. Ectopic B lymphocyte follicles exacerbate ischemic brain damage via MIF-CD74/CXCR4 and interferon signaling. The Journal of clinical investigation 2026. link 45 Xu L, Feng Y, Zheng X, Wang M, Fang Y, Li L et al.. Astragaloside IV-preconditioned neural stem cell transplantation promotes neurogenesis and functional recovery via the miR-199a-5p/Caveolin-1 pathway in a rat model of ischemic stroke. International immunopharmacology 2026. link 46 Li X, Shi G, Guo W, Wen K, Liu Y, Cheng J et al.. Oxytocin may promote hippocampal neurogenesis in ischemic stroke rats via a pathway related to DNMT1-mediated Wnt3a/β-catenin. Neuropharmacology 2026. link 47 Wang M, Ahmad SN, Reed P, Sprague S, Sayre NL. Knockout of Low-Density Lipoprotein Receptor-Related Protein 1 From Astrocytes in Adult Mice Accelerates Long-Term Functional Recovery After Ischemic Stroke. Brain and behavior 2026. link 48 Tanada S, Uchida K, Shirakawa M, Shindou K, Baba D, Tsuji S et al.. Impact of First-pass Effect for M2 Segment of Middle Cerebral Artery Occlusion. Neurologia medico-chirurgica 2026. link 49 Xia C, Yu M, Ni Y, Fang S, Feng K, Zhang T et al.. Discovery of Novel Natural Product-Based PDE4 Inhibitors for Ischemic Stroke Treatment without Emetogenicity at Ultra-High Doses. Journal of medicinal chemistry 2026. link 50 Zhou J, Chen L, Li J, Luo L, Shao S. Single-Cell Multiomics Decoding of TCIRG1-Mediated Cuproptosis Circuitry Rewiring Immune-Metabolic Landscape in Ischemic Stroke. Translational stroke research 2026. link 51 Ahmad S, Maeda T, Contreras J, Karamanova N, Morrow KT, Raikwar S et al.. Monosialoganglioside-Containing Nanoliposomes Protect Against Acute and Chronic Ischemic Stroke Injury. Journal of the American Heart Association 2026. link 52 Gao Y, Feng X, Pang M, Guo Q, Xu H, Li Q et al.. Extended treatment in cerebral ischemia score 2c or 3 will be goal of successful endovascular treatment: A systematic review and meta-analysis. European journal of radiology 2026. link 53 Sun G, Dong Y, Wang Y, Su Y, Chen J, Deng J et al.. Hierarchically collapsible nanoactuator modulates mitochondrial ferroptosis-bioenergetic homeostasis cascade to decouple ischemic stroke. Cell reports. Medicine 2026. link 54 Miao M, Ye C, Wang Z, Long J, You S, Sun Y et al.. Traditional Lipid Ratios and Carotid Atherosclerosis in Patients with Ischemic Stroke. Cerebrovascular diseases (Basel, Switzerland) 2026. link 55 Kachnic M, Matysiewicz M, Natorska J, Bembenek JP, Szczygieł-Pilut E, Undas A. FVIIa-AT complexes in patients with acute ischemic stroke: Impact on clinical outcomes. Thrombosis research 2026. link 56 Huang Y, Wu X, Li Y, Wang Y, Zhang Z, Ye C et al.. Serum EphA4 is Associated with both Parenchymal Hematoma and Increased Blood-Brain Barrier Permeability after Ischemic Stroke. Neurocritical care 2026. link 57 Peng W, Feng M, Zhang J, Mofatteh M, Chen Z, Ye F et al.. Early Neurological Deterioration After Recanalization: A Retrospective Study of 1053 Endovascular Treatment Patients. World neurosurgery 2026. link 58 Balian J, Kwon OJ, Tabibian K, Cherif A, Mahrokhi S, Rowe V et al.. Racial disparities in carotid revascularization following stroke in minority-serving hospitals. Journal of vascular surgery 2026. link 59 Zhang H, Feng L, Lai X, Gao Y, Liang N, Que C et al.. Comparative effectiveness of Panax notoginseng saponins-related agents and antiplatelet agents in ischemic stroke: A systematic review and network meta-analysis. Journal of ethnopharmacology 2026. link 60 Guan X, Ma J, Hao C, Bu G. Should Patients ≥90 Years with Acute Ischemic Stroke Still Undergo Endovascular Thrombectomy?. Academic radiology 2026. link 61 Pressman E, Vakharia K, Guerrero WR, Sowlat MM, Schimmel S, Maier I et al.. Hurting More Than Helping? Decompressive Craniectomy in Patients With Symptomatic Intracerebral Hemorrhage After Mechanical Thrombectomy in Acute Ischemic Stroke: Insights From Stroke Thrombectomy and Aneurysm Registry. Neurosurgery 2026. link 62 Li X, Yuan Y, Jing W, Liu C, Wei M, Liu Q et al.. Circulating cfdna: A novel biomarker for preventing early recurrence in ischemic stroke. Journal of thrombosis and thrombolysis 2026. link 63 García-Alix A, Núñez C, Arca G, Arnaez J, Agut T, Cordeiro M et al.. Sex Disparities in Neonatal Arterial Ischemic Stroke: Larger Lesion Volume and More Severe Long-Term Disability in Male Infants. Pediatric neurology 2026. link 64 Powell B, Chopp M, Zhang Z, Liu X. Neurovascular Unit-Derived Extracellular Vesicles as Regulators of Post-Stroke Pathology and Neurorestoration. Biomolecules 2026. link 65 Zhang Y, Li Y, Li X, Liao P, Chen W, Feng Y et al.. Theacrine protects vascular endothelial cells against oxidative damage after ischemic stroke by inhibiting Rac1 and activating Nrf2 pathway. International immunopharmacology 2026. link 66 Zhang H, Hao W, Chang H, Bie Y, Sun X. H3K27ac-Activated lncRNA-DAPK1-IT1 Aggravated Oxidative Stress Damage Induced by Focal Cerebral Ischemia/Reperfusion via the miR-25-3p/HMGB1 Molecular Axis. Molecular neurobiology 2026. link 67 Broderick JP, Mistry EA, Wechsler PM, Elkind MSV, Liebeskind DS, Harston G et al.. Artificial Intelligence and Novel Trial Designs for Acute Ischemic Stroke: Opportunities and Challenges. Stroke 2026. link 68 Alaqel SI, Khan A, Alanazi MN, Nayeem N, Khaled HB, Imran M. Integrative transcriptomic and structural analysis identifies PTGS2 as a key target in ischemic stroke associated with neuroinflammation. Molecular diversity 2026. link 69 Chu H, Pan J, Guo Q, Huang C. Aquaporin-4 suppresses neuronal pyroptosis after ischemic stroke via the IκBα/NF-κB signaling pathway. Frontiers in immunology 2026. link 70 Yamashita H, Kikuchi T, Kodaka Y, Doi D, Ikeda M, Takahashi J. Transplantation of Human iPS Cell-derived Cerebral Cortical Neurons Promotes Fine Motor Recovery in a Female Mouse Model of Ischemic Stroke. Stem cell reviews and reports 2026. link 71 Liu J, Deng Q, Wei S, Cheng L, Shen C, Liu Z et al.. The nitrate-nitrite-nitric oxide pathway of neuroinflammation and cognitive impairment in ischemic stroke. Frontiers in immunology 2026. link 72 Rogers P, Parker E, Marangoni M, MacDonald IR, Kim CN, Hendriks EJ et al.. Discrepancies in Vessel Diameter Measurements Between CTA and DSA in MCA M1 Occlusions: An Interobserver Study. Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes 2026. link 73 Kilci Aİ, Gedik MS, Hakkoymaz H, Doğan K, Kaya E, Alkaya M et al.. Optic Nerve Sheath Diameter Measurement: Preliminary Findings in Ischemic Stroke Patients. Nigerian journal of clinical practice 2026. link 74 Mrestani A, Höfling C, Michalski D. Super-resolution localization microscopy visualizes ischemia-related cytoskeletal and vascular alterations at the nanoscale level in a mouse model of stroke. Neuroscience 2026. link 75 Shi X, Jia X, Bi Y, Wang J, Xie Z, Hu J et al.. Uncovering the pharmacological foundation of NLXT through an ischemic stroke rat model combined with UHPLC-QTOF/MS techniques. Journal of pharmaceutical and biomedical analysis 2026. link 76 Goyal N, Khattar NK, Peterson J, Dashti R, Sims JJ, Baumeister M et al.. The RED 43 catheter for aspiration thrombectomy of distal medium vessel occlusions (DMVOs): a multicenter experience. Journal of neurointerventional surgery 2026. link 77 Liu R, Jiang X, Wang Z, Huang X, Ma Y, Nuermaimaiti B et al.. Anticoagulant peptide LR from Whitmania pigra ameliorates cerebral ischemia-reperfusion injury. Brain research 2026. link 78 Wang Y, Li X, Li W, Wang C, Xu G, Yu S. Microglial P2RY12 mediates migration to and protection of cerebral microvasculature after ischemia-reperfusion via Caveolin-1. Experimental neurology 2026. link 79 Moriyama T, Sato F, Yokomichi N, Yamanaka K, Yoshikawa Y, Tachibana M et al.. Acute-phase Geriatric Nutritional Risk Index is associated with swallowing function after convalescent rehabilitation in older patients with ischemic stroke: A retrospective cohort study. Nutrition (Burbank, Los Angeles County, Calif.) 2026. link 80 Sun X, Niu H, Pei Y, Wang X, Chen M. Development and Validation of a Prediction Model for Acute Ischemic Stroke Based on a Novel Ultrasound-Based Carotid Plaque Scoring System and Clinical Factors. Journal of clinical ultrasound : JCU 2026. link 81 Zhou Y, Zhou Y, Yang H, Huang G. Decision-making delays in endovascular treatment for acute ischemic stroke: A qualitative study of perspectives from family surrogates, physicians, and nurses. Patient education and counseling 2026. link 82 Torrado M, Sinthon C, Silva D, Moreira DA, Magalhães N, Ferreira-da-Silva F et al.. DETOX: An innovative dendritic nanosystem for the delivery of BoNT/A LC domain to ischemic neurons. Biomaterials 2026. link 83 Xu S, Sy LS, Huang X, Hong V, Han B, Bruxvoort KJ et al.. A three-part model for the self-controlled case series design to estimate and characterize adverse event risk in an overlapping risk period after multiple vaccines: application to ischemic stroke following Pfizer-BioNTech bivalent COVID-19 vaccine and influenza vaccine. American journal of epidemiology 2026. link 84 Tao R, Zhang Z, Li X, Zhang R, Ouyang F, Lin Y et al.. Neuroprotective compounds from endophytic fungi metabolites of Rhodiola tibetica attenuate post-stroke deficits via multi-targeted modulation of neuroinflammation. Bioorganic chemistry 2026. link 85 Zhang Y, Bai X, Yin P, Guo Y, Yang L, Li S et al.. BMSC-EVs improve post-stroke cognition by promoting regionally distinct synaptic repair via Sema3G-Nrp2/PlexinA4 Signaling. Experimental neurology 2026. link 86 Waters MJ, Vargas J, Turk A, Chaudry I, Turner RD. Safety and efficacy of eptifibatide in acute ischemic stroke requiring extracranial carotid artery stenting. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences 2026. link 87 Mikulik R, Neto G, Sedani R, Ameriso SF, Mammadova N, Marchenko S et al.. Differences in acute ischemic stroke treatment: A cross-sectional study from international Registry of Stroke Care Quality (RES-Q). International journal of stroke : official journal of the International Stroke Society 2026. link 88 Biatougou NM, Picot A, Abiou-Mourgues M, Bourdin M, Repesse Y, Contant G et al.. Chondroitin Sulfate as a New Profibrinolytic-Like Agent: A Preclinical Proof of Concept in a Model of Thromboembolic Stroke in Mice. Arteriosclerosis, thrombosis, and vascular biology 2026. link 89 Zhao C, Bai X, Ding Y, Zeng A, Wen A, Fu Q et al.. The role of salvianolic acid B and benzoylpaeoniflorin in enhancing angiogenesis through Nrf2/HO-1/VEGFA signaling axis in ischemic stroke recovery. Pharmaceutical biology 2026. link 90 Gu H, Jiang J, Huang H, Min Z, Liu J, Peng M et al.. Leveraging infarct topography for early warning: a robust model for predicting malignant cerebral edema after endovascular treatment in acute ischemic stroke. BMC medical imaging 2026. link 91 Chen Q, Zhang Q, Wang J, Xiong X, Luo B, Chen Y et al.. Diselenide-bridged dual-action nanoscavengers drive fasting-boosted BBB penetration and ROS-responsive resveratrol delivery for synergistic ischemic stroke therapy. Journal of nanobiotechnology 2026. link 92 Lainelehto K, Pienimäki JP, Savilahti S, Huhtala H, Sarkanen T, Numminen H et al.. Cervicocerebral atherosclerosis and atrial fibrillation increase long-term mortality in patients with ischemic stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2026. link 93 De Rubeis G, Fabiano S, Bertaccini L, Mangiardi M, Pezzella FR, Anticoli S et al.. Setting benchmark for ischemic stroke treated endovascularly: A systematic review and meta-analysis. Revue neurologique 2026. link 94 Li D, Huang S, Wang X, Hong Z, Qiu X. Efficacy and safety of tenecteplase versus urokinase in the treatment of acute ischemic stroke. Medicine 2026. link 95 Ter Schiphorst A, Seners P, Dargazanli C, Labreuche J, Marchi N, Yuen N et al.. Hypoperfusion on Early MRI Despite Successful Thrombectomy: A Prospective Imaging and Inflammatory Biomarkers Study. Stroke 2026. link 96 Wang Q, Wei M, Wu R, Ma Y, Hu J, Ding Y et al.. Corilagin reduces ischemic stroke damage by neural stem cell-mediated neurorepair. European journal of pharmacology 2026. link 97 Wu J, Huang Z, Chang S, Peng Z, Fang Z, Ni G et al.. From first responders to outcome modulators: The evolving paradigm of neutrophils in ischemic stroke and thrombolysis. Experimental neurology 2026. link 98 Öztürk D, Özcelik F, Sönmez BM, Altınbilek E, Bekgöz AB, Bulut S et al.. Diagnostic value of sclerostin, RANKL, oxidized LDL, and phoenixin-14 levels in acute ischemic stroke. Biomarkers in medicine 2026. link 99 Cao W, Wang M, Chai W, Luo C, Wang Y, Zhou X et al.. Regulation of angiogenesis in cerebral ischemic rats through ceRNA networks and its impact on cerebral ischemic stroke prognosis. Brain research bulletin 2026. link 100 Zhou Y, Luo B, Shang T, Wei Z, Zou W. Cerebral Ischemia-Reperfusion Injury: Unraveling the Mitophagy-Oxidative Stress Axis for Neuroprotective Strategies. International journal of molecular sciences 2026. link

    Original source

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      Timing of anticoagulation therapy in patients with acute ischemic stroke and atrial fibrillation: a GRADE-based expert opinion recommendation. — Spina E, Romoli M, Mosconi MG, Padroni M, Canavero I, Mannino M et al. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2026)
    2. [2]
      In patients with ischemic stroke, NVAF, and ASCVD, adding an antiplatelet to OAC therapy did not affect net clinical benefit at 2 y. — Sharma M, Srivastava A Annals of internal medicine (2026)
    3. [3]
      Vaginal estradiol tablets not likely to increase risk of recurrent ischemic stroke. — Rosenberg K The American journal of nursing (2026)
    4. [4]
      Emergency Physician Versus Telemedicine Neurologist Assessment for Thrombolytic Indication in the Treatment of Acute Ischemic Stroke (AIS). — Linares N, Cambron J, Xu T, Danboise B, Richman P Academic emergency medicine : official journal of the Society for Academic Emergency Medicine (2026)
    5. [5]
      General Anesthesia Versus Conscious Sedation for Mechanical Thrombectomy in Patients With Acute Ischemic Stroke in the MOST Trial. — Athiraman U, Roy A, Barreto A, Broderick J, Derdeyn C, Elm J et al. Journal of the American Heart Association (2026)
    6. [6]
      Outcomes following thrombectomy for acute ischemic stroke using procedural sedation with midazolam. — Fujii T, Fukui Y, Maruyama K, Takigawa K, Tashiro N, Matsukawa H et al. The neuroradiology journal (2026)
    7. [7]
      Risk factors for drug-related ischemic stroke: an analysis of the FDA adverse event reporting system (FAERS). — Cao W, Zhu B, Jia X, Gu N, Zhang Q, Wang B et al. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (2026)
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      Prediction model for frailty risk in ischemic stroke patients: Application and validation of support vector machines and nomograms. — Kang YL, Kong JT, Tian H Medicine (2026)
    9. [9]
      Timing of extracranial carotid revascularization following ischemic stroke or TIA: Outcomes of early carotid stenting in a cohort study. — Nguyen Tung B, Quoc Thai N, Manh Hung P, Ngoc Quang N, Huynh Linh D, Duy Ton M Medicine (2026)
    10. [10]
      Multi-omics analysis reveals the neuroprotective effects of phosphatidylcholine (18:1/18:2) on ischemic stroke by inhibiting plasma IL-18 levels. — Wang S, Xiang X, Guo X, Qin M, Chen J, Jiang D et al. European journal of pharmacology (2026)
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      The timing of arterial thrombectomy on neurological recovery in patients with acute ischemic stroke: A retrospective observational study. — Yan G, Li W, Guo B, Wen S, Zhang R, Yin L et al. Medicine (2026)
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      miR-15b-5p impairs myelin repair and cognitive recovery after ischemic stroke by targeting the E2F7/CXCL2 axis. — Weng Y, Zhou J, Zhang L, He X, Guo H, Zhang Q et al. Experimental neurology (2026)
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      Combined treatment with tPA and Chinese herbal medicine for ischemic stroke: is it valuable? — Hu Y, Xia M, Cao M, Zhang J, Cao X, Guo J Journal of ethnopharmacology (2026)
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      Emergency Conversion to General Anesthesia During Endovascular Therapy and Stroke Outcomes: A Retrospective Matched Study. — Zhang K, Liang F, Wu Y, Wang X, Hou X, Zhang Z et al. Journal of neurosurgical anesthesiology (2026)
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      Computed Tomography Measurement of Optic Nerve Sheath Diameter in Thrombolysis-Treated Ischemic Stroke: Association with Post-Thrombolytic Intracranial Hemorrhage. — Coşkun Yaş S, Üçöz Kocaşaban D, Güler S, Uludağ Tunçel C, Demirtaş E Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (2026)
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      Long-Term Recovery, Morbidity, and Mortality After Maternal Ischemic Stroke. — Richardt A, Verho L, Rantanen KK, Korhonen A, Laivuori H, Tikkanen M et al. Neurology (2026)
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