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Endocrinology8 papers

Hypothyroidism in pregnancy

Last edited: 4/10/2026

Overview

Hypothyroidism in pregnancy is associated with adverse pregnancy outcomes and concerns regarding fetal development 1. Thyroid medications can cross the placenta and affect the fetal thyroid gland 1.

Diagnosis

  • Diagnosis involves assessing overt and subclinical maternal thyroid disease 1.
  • A clinical algorithm for management of thyroid disease in pregnancy is available 1.

    • Management

  • Management of thyroid disease in pregnant women is reviewed 1.
  • Medications affecting the maternal thyroid gland can cross the placenta and affect the fetal thyroid gland 1.

    • Special Populations

  • Pregnancy: Both thyrotoxicosis and hypothyroidism are associated with adverse pregnancy outcomes 1. Concerns exist about the effect of overt maternal thyroid disease on fetal development 1.

    • Key Recommendations

  • Thyroid disease in pregnancy requires careful diagnosis and management due to associations with adverse pregnancy outcomes 1. (Evidence: Expert opinion)
  • Medications used to treat maternal thyroid disease can cross the placenta and impact fetal thyroid function 1. (Evidence: Expert opinion)
  • A clinical algorithm exists to guide the management of thyroid disease during pregnancy 1. (Evidence: Expert opinion)

    • References

    1 . Thyroid Disease in Pregnancy: ACOG Practice Bulletin, Number 223. Obstetrics and gynecology 2020. link

    Original source

    1. [1]
      Thyroid Disease in Pregnancy: ACOG Practice Bulletin, Number 223. Obstetrics and gynecology (2020)
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