Left ventricular cardiac dysfunction

Overview

Diagnosis

Management

Special Populations

Key Recommendations

References

Showing 100 most recent of 436 indexed papers.

1 Yu J, Jiang Z, Ackers-Johnson M, Zou G, Zhang F, Zhu M et al.. Ultrapliable bioelectronic interface for mechanosensitive cardiac electrophysiology. Science advances 2026. link 2 Yang X, Zhang Q, Yang L. Subchronic 2,6-dichloro-1,4-benzoquinone exposure induced dose-dependent cardiac functional failure via cytoskeletal remodeling in zebrafish cardiac tissue. Aquatic toxicology (Amsterdam, Netherlands) 2026. link 3 Chen E, Ramgopal S, Lorenz D, Jone PN, Horowitz R. Use of e-point septal separation to screen for left ventricular function in children. The American journal of emergency medicine 2026. link 4 Yoshida Y, Zu Y, Aguilar D, Ferdinand KC, Fonseca VA. Cumulative effect of hyperglycemia and insulin resistance on cardiac dysfunction: The coronary artery risk development in young adults (CARDIA) study. American heart journal 2026. link 5 Pulath N, Velayutham R, Bhargav A, Barathkrishnan J, Selvaraj RJ. Atrial repolarization in patients with left ventricular dysfunction. Journal of electrocardiology 2026. link 6 Pal S, Ishihara T, Setoyama D, Chen CL, Onoue K, Yonemura S et al.. Non-canonical role of natural quinones in mitochondrial nucleoid organization for maintaining respiration and protecting cardiac function. Journal of biochemistry 2026. link 7 Makihara K, Kongo K, Motomura K, Kimoto D, Yamamoto Y, Tanihata M et al.. Optimal follow-up duration of cardiac function tests in patients treated with trastuzumab: an analysis using the Japanese Adverse Drug Event Report (JADER) database. International journal of clinical oncology 2025. link 8 Han X, Ashraf M, Shi H, Nkembo AT, Tipparaju SM, Xuan W. Combined Endurance and Resistance Exercise Mitigates Age-Associated Cardiac Dysfunction. Advanced biology 2025. link 9 Yaqub A, Bis JC, Frenzel S, Koini M, Mbangdadji D, Peloso GM et al.. Clinical and Imaging Markers of Cardiac Function and Brain Health: A Meta-Analysis of Community-Based Studies. Neurology 2025. link 10 Dowsing B, Dehbi HM, Chung R, Pedra J, Worn O, Artico J et al.. HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related cardiac dysfunction. BMJ open 2025. link 11 Yoshida Y, Nguyen NQ, Moon EH, Rebholz C, Skali H, Arthur V et al.. A Metabolomics Study of Cardiac Dysfunction in Hyperglycemia: Findings From the Atherosclerosis Risk in Communities (ARIC) Study and the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Diabetes care 2025. link 12 Zaman MU, Fatima N. Detection of Hibernating Myocardium: A Gate Keeper in Decision Making in Patients with Left Ventricular Dysfunction. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2024. link 13 Alerhand S, Adrian RJ, Taylor LA. Cardiac Point-Of-Care Ultrasound: An Emergency Medicine Review. Emergency medicine clinics of North America 2024. link 14 Song P, Rooke GA. Fundamental Electrophysiology Principles Related to Perioperative Management of Cardiovascular Implantable Electronic Devices. Journal of cardiothoracic and vascular anesthesia 2024. link 15 Liu WT, Hsieh PH, Lin CS, Fang WH, Wang CH, Tsai CS et al.. Opportunistic Screening for Asymptomatic Left Ventricular Dysfunction With the Use of Electrocardiographic Artificial Intelligence: A Cost-Effectiveness Approach. The Canadian journal of cardiology 2024. link 16 Kintsu M, Odajima S, Takeuchi K, Ichikawa Y, Todo S, Ota E et al.. Effect of increase in heart rate after anthracycline chemotherapy on subsequent left ventricular dysfunction. Journal of cardiology 2024. link 17 Shang R, Lee CS, Wang H, Dyer R, Noll C, Carpentier A et al.. Reduction in Insulin Uncovers a Novel Effect of VEGFB on Cardiac Substrate Utilization. Arteriosclerosis, thrombosis, and vascular biology 2024. link 18 Ayala R, Gewehr DM, Godoi A, Velasquez C, Fernandez M, Carvalho PEP et al.. Preoperative Levosimendan in Patients With Severe Left Ventricular Dysfunction Undergoing Isolated Coronary Artery Bypass Grafting: A Meta-Analysis of Randomized Controlled Trials. Journal of cardiothoracic and vascular anesthesia 2024. link 19 Culler KL, Sinha A, Filipp M, Giro P, Allen NB, Taylor KD et al.. Metabolomic profiling identifies novel metabolites associated with cardiac dysfunction. Scientific reports 2024. link 20 Ryan M, Taylor D, Dodd M, Spertus JA, Kosiborod MN, Shaukat A et al.. Effect of PCI on Health Status in Ischemic Left Ventricular Dysfunction: Insights From REVIVED-BCIS2. JACC. Heart failure 2024. link 21 Tapaskar N, Wayda B, Malinoski D, Luikart H, Groat T, Nguyen J et al.. Donor Electrocardiogram Associations With Cardiac Dysfunction, Heart Transplant Use, and Survival: The Donor Heart Study. JACC. Heart failure 2024. link 22 Ingle K, Pham L, Lee V, Guo L, Isayeva-Waldrop T, Somarathna M et al.. Cardiac changes following arteriovenous fistula creation in a mouse model. The journal of vascular access 2023. link 23 Andreini D, Conte E, Mushtaq S, Melotti E, Gigante C, Mancini ME et al.. Comprehensive Evaluation of Left Ventricle Dysfunction by a New Computed Tomography Scanner: The E-PLURIBUS Study. JACC. Cardiovascular imaging 2023. link 24 Punn R, Falkensammer CB, Blinder JJ, Fifer CG, Thorsson T, Perens G et al.. Hemodynamic and Echocardiographic Predictors of Mortality in Pediatric Patients on Venoarterial Extracorporeal Membrane Oxygenation: A Multicenter Investigation. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2023. link 25 Zhao P, Wang Y, Yang Q, Yu G, Ma F, Dong J. Abamectin causes cardiac dysfunction in carp via inhibiting redox equilibrium and resulting in immune inflammatory response and programmed cell death. Environmental science and pollution research international 2023. link 26 Coletti K, Griffiths M, Nies M, Brandal S, Everett AD, Bembea MM. Cardiac Dysfunction Biomarkers Are Associated With Potential for Successful Separation From Extracorporeal Membrane Oxygenation in Children. ASAIO journal (American Society for Artificial Internal Organs : 1992) 2023. link 27 Ikeda N, Loomba RS, Patel R, Dorsey V, Yousaf F, Nelson-McMillan K. Effect of Carnitine Supplementation in Pediatric Patients with Left Ventricular Dysfunction. Pediatric cardiology 2023. link 28 Chin JF, Aga YS, Abou Kamar S, Kroon D, Snelder SM, van de Poll SWE et al.. Association between epicardial adipose tissue and cardiac dysfunction in subjects with severe obesity. European journal of heart failure 2023. link 29 Saraiya A, Yu J, Huang C, Frisch D, Pavri BB. Evaluating Goldberger's triad as a marker of congestive heart failure: A systematic review and retrospective study. Journal of electrocardiology 2023. link 30 Ramonfaur D, Skali H, Claggett B, Windham BG, Palta P, Kitzman D et al.. Bidirectional Association Between Frailty and Cardiac Structure and Function: The Atherosclerosis Risk in Communities Study. Journal of the American Heart Association 2023. link 31 Gorski PA, Lee A, Lee P, Oh JG, Vangheluwe P, Ishikawa K et al.. Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a. International journal of molecular sciences 2023. link 32 Ito A, Ohnuki Y, Suita K, Matsuo I, Ishikawa M, Mitsubayashi T et al.. Effects of the angiotensin-converting enzyme inhibitor captopril on occlusal-disharmony-induced cardiac dysfunction in mice. Scientific reports 2023. link 33 Cho JM, Ghosh R, Mookherjee S, Boudina S, Symons JD. Reduce, Reuse, Recycle, Run ! : 4 Rs to improve cardiac health in advanced age. Aging 2022. link 34 Jenkins S, Shiha MG, Yones E, Wardley J, Ryding A, Sawh C et al.. Cardiovascular examination using hand-held cardiac ultrasound. Journal of echocardiography 2022. link 35 Saleh Y, Al-Abcha A, Abdelkarim O, Abdelnabi M, Almaghraby A, Kleiman NS. Direct Oral Anticoagulants Versus Vitamin K Antagonists in the Treatment of Left Ventricular Thrombi. American journal of cardiovascular drugs : drugs, devices, and other interventions 2022. link 36 Gee LC, Massimo G, Lau C, Primus C, Fernandes D, Chen J et al.. Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide. British journal of pharmacology 2022. link 37 Akhabue E, Wong M, Mehta R, Isakova T, Wolf M, Yancy C et al.. Fibroblast growth factor-23 and subclinical markers of cardiac dysfunction: The coronary artery risk development in young adults (CARDIA) study. American heart journal 2022. link 38 Kain V, Mat Y, Halade GV. Interaction of aging with lipoxygenase deficiency initiates hypersplenism, cardiac dysfunction, and profound leukocyte directed non-resolving inflammation. GeroScience 2022. link 39 Li A, Zheng N, Ding X. Mitochondrial abnormalities: a hub in metabolic syndrome-related cardiac dysfunction caused by oxidative stress. Heart failure reviews 2022. link 40 Siti HN, Jalil J, Asmadi AY, Kamisah Y. Effects of Quercetin on Cardiac Function in Pressure Overload and Postischemic Cardiac Injury in Rodents: a Systematic Review and Meta-Analysis. Cardiovascular drugs and therapy 2022. link 41 Commander SJ, Gonzalez D, Kumar KR, Spears T, Cohen-Wolkowiez M, Zimmerman KO et al.. The relationship between simulated milrinone exposure and hypotension in children. Cardiology in the young 2022. link 42 Sazonova SI, Varlamova JV, Nikitin NA, Minin SM, Kisteneva IV, Batalov RE et al.. Cardiac . Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2022. link 43 Merkx R, Leerink JM, de Baat EC, Feijen EAM, Kok WEM, Mavinkurve-Groothuis AMC et al.. Asymptomatic systolic dysfunction on contemporary echocardiography in anthracycline-treated long-term childhood cancer survivors: a systematic review. Journal of cancer survivorship : research and practice 2022. link 44 Narkar A, Feaster TK, Casciola M, Blinova K. Human in vitro neurocardiac coculture (ivNCC) assay development for evaluating cardiac contractility modulation. Physiological reports 2022. link 45 Byrne J. Consultation and clinical assessment of the heart and cardiovascular system. British journal of nursing (Mark Allen Publishing) 2021. link 46 McNally LA, Altamimi TR, Fulghum K, Hill BG. Considerations for using isolated cell systems to understand cardiac metabolism and biology. Journal of molecular and cellular cardiology 2021. link 47 Khan MR, Kayani WT, Pelton J, Ansari A, Paniagua D, Khalid U et al.. Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention in Patients with Left Ventricular Systolic Dysfunction. Cardiovascular drugs and therapy 2021. link 48 Rodgers JL, Vanthenapalli S, Panguluri SK. Electrical remodeling and cardiotoxicity precedes structural and functional remodeling of mouse hearts under hyperoxia treatment. Journal of cellular physiology 2021. link 49 Rattka M, Westphal S, Gahr BM, Just S, Rottbauer W. Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish. Journal of molecular and cellular cardiology 2021. link 50 Papa A, Kushner J, Hennessey JA, Katchman AN, Zakharov SI, Chen BX et al.. Adrenergic Ca. Circulation research 2021. link 51 Meessen JMTA, Cesaroni G, Mureddu GF, Boccanelli A, Wienhues-Thelen UH, Kastner P et al.. IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study. BMC cardiovascular disorders 2021. link 52 Pinckard KM, Shettigar VK, Wright KR, Abay E, Baer LA, Vidal P et al.. A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function. Circulation 2021. link 53 Ugata Y, Michihata N, Matsui H, Fushimi K, Yasunaga H. Periprocedural hypotension after conscious sedation versus local anesthesia during defibrillator implantation for left ventricular dysfunction: analysis of a national inpatient database in Japan. Heart and vessels 2020. link 54 Kim H, Kim IC, Choi SW, Chung JW, Kim JY. Clinical significance of early-diastolic tissue velocity imaging of lateral mitral annulus for prognosis of nonischemic left ventricular dysfunction. Journal of clinical ultrasound : JCU 2020. link 55 Pyo WK, Kim WK, Kim JB. A Huge Pericardial Gossypiboma Causing Severe Cardiac Dysfunction. The Annals of thoracic surgery 2020. link 56 Carnevale C, Roberts JC, Syme DA, Gamperl AK. Hypoxic acclimation negatively impacts the contractility of steelhead trout (. American journal of physiology. Regulatory, integrative and comparative physiology 2020. link 57 Kollert S, Döring F, Gergs U, Wischmeyer E. Chloroform is a potent activator of cardiac and neuronal Kir3 channels. Naunyn-Schmiedeberg's archives of pharmacology 2020. link 58 Hu LF, Feng J, Dai X, Sun Y, Xiong M, Lai L et al.. Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction by regulation of multicombined signaling. The Journal of nutritional biochemistry 2020. link 59 Bo-Htay C, Shwe T, Higgins L, Palee S, Shinlapawittayatorn K, Chattipakorn SC et al.. Aging induced by D-galactose aggravates cardiac dysfunction via exacerbating mitochondrial dysfunction in obese insulin-resistant rats. GeroScience 2020. link 60 Felmly LM, Savage AJ, Kavarana MN. Right Ventricular Function is Important for Pulmonary Artery Banding in Left Ventricular Dysfunction. World journal for pediatric & congenital heart surgery 2020. link 61 Rodgers JL, Rodgers LE, Tian Z, Allen-Gipson D, Panguluri SK. Sex differences in murine cardiac pathophysiology with hyperoxia exposure. Journal of cellular physiology 2019. link 62 Ciccarone F, Castelli S, Ioannilli L, Ciriolo MR. High Dietary Fat Intake Affects DNA Methylation/Hydroxymethylation in Mouse Heart: Epigenetic Hints for Obesity-Related Cardiac Dysfunction. Molecular nutrition & food research 2019. link 63 Liu Y, Liu Y, Huang X, Zhang J, Yang L. Protective effects and mechanism of curcumin on myocardial injury induced by coronary microembolization. Journal of cellular biochemistry 2019. link 64 Seilitz J, Hörer TM, Skoog P, Sadeghi M, Jansson K, Axelsson B et al.. Splanchnic Circulation and Intraabdominal Metabolism in Two Porcine Models of Low Cardiac Output. Journal of cardiovascular translational research 2019. link 65 Xue Y, Sun C, Hao Q, Cheng J. Astaxanthin ameliorates cardiomyocyte apoptosis after coronary microembolization by inhibiting oxidative stress via Nrf2/HO-1 pathway in rats. Naunyn-Schmiedeberg's archives of pharmacology 2019. link 66 Hiemstra B, Koster G, Wetterslev J, Gluud C, Jakobsen JC, Scheeren TWL et al.. Dopamine in critically ill patients with cardiac dysfunction: A systematic review with meta-analysis and trial sequential analysis. Acta anaesthesiologica Scandinavica 2019. link 67 Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E et al.. Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction. JCI insight 2019. link 68 Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R et al.. Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload. Circulation research 2019. link 69 Singh A, Voss WB, Lentz RW, Thomas JD, Akhter N. The Diagnostic and Prognostic Value of Echocardiographic Strain. JAMA cardiology 2019. link 70 Cao Z, Jia Y, Zhu B. BNP and NT-proBNP as Diagnostic Biomarkers for Cardiac Dysfunction in Both Clinical and Forensic Medicine. International journal of molecular sciences 2019. link 71 Santulli G. Overlooking cardiac dysfunction triggered by immune checkpoint inhibitors: Caution, trespassers will be ventilated. Science translational medicine 2018. link 72 Kanaan GN, Ichim B, Gharibeh L, Maharsy W, Patten DA, Xuan JY et al.. Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies. Redox biology 2018. link 73 Chakroun-Walha O, Karray R, Jerbi M, Ben Rebeh A, Jammeli C, Bahloul M et al.. Value of troponin levels in the diagnosis of cardiac dysfunction in moderate scorpion envenomation. Human & experimental toxicology 2018. link 74 Tryon D, Hasaniya NW, Jabo B, Razzouk AJ, Bailey LL, Rabkin DG. Effect of left ventricular dysfunction on utilization of donor hearts. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2018. link 75 Vaughan L, Marley R, Miellet S, Hartley PS. The impact of SPARC on age-related cardiac dysfunction and fibrosis in Drosophila. Experimental gerontology 2018. link 76 Cunha DNQ, Del Rio CL, Youngblood BL, Ferris EL, Geist GE, Ueyama Y et al.. Efficacy of a mephentermine-based product as a vasopressor and a cardiac performance enhancer when given intramuscularly to cattle. Journal of veterinary pharmacology and therapeutics 2018. link 77 Yamaguchi Y, Mizumaki K, Nishida K, Sakamoto T, Nakatani Y, Kataoka N et al.. Vasovagal syncope is associated with poor prognosis in patients with left ventricular dysfunction. Heart and vessels 2018. link 78 Blaustein MP. The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na. American journal of physiology. Cell physiology 2018. link 79 Nathania M, Hollingsworth KG, Bates M, Eggett C, Trenell MI, Velicki L et al.. Impact of age on the association between cardiac high-energy phosphate metabolism and cardiac power in women. Heart (British Cardiac Society) 2018. link 80 Niu Y, Kane AD, Lusby CM, Allison BJ, Chua YY, Kaandorp JJ et al.. Maternal Allopurinol Prevents Cardiac Dysfunction in Adult Male Offspring Programmed by Chronic Hypoxia During Pregnancy. Hypertension (Dallas, Tex. : 1979) 2018. link 81 Cunningham TC, Maghrabi K, Sanatani S. Morbidities in the ultra-athlete and marathoner. Cardiology in the young 2017. link 82 Armenian SH, Lacchetti C, Barac A, Carver J, Constine LS, Denduluri N et al.. Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017. link 83 Zhao YC, Xu LW, Ding S, Ji QQ, Lin N, He Q et al.. Nuclear receptor retinoid-related orphan receptor α deficiency exacerbates high-fat diet-induced cardiac dysfunction despite improving metabolic abnormality. Biochimica et biophysica acta. Molecular basis of disease 2017. link 84 Hathaway QA, Nichols CE, Shepherd DL, Stapleton PA, McLaughlin SL, Stricker JC et al.. Maternal-engineered nanomaterial exposure disrupts progeny cardiac function and bioenergetics. American journal of physiology. Heart and circulatory physiology 2017. link 85 Gherghina FL, Tica AA, Deliu E, Abood ME, Brailoiu GC, Brailoiu E. Effects of VPAC1 activation in nucleus ambiguus neurons. Brain research 2017. link 86 Gleeson S, Liao YW, Dugo C, Cave A, Zhou L, Ayar Z et al.. ECG-derived spatial QRS-T angle is associated with ICD implantation, mortality and heart failure admissions in patients with LV systolic dysfunction. PloS one 2017. link 87 Carbone S, Lee PJ, Mauro AG, Mezzaroma E, Buzzetti R, Van Tassell B et al.. Interleukin-18 mediates cardiac dysfunction induced by western diet independent of obesity and hyperglycemia in the mouse. Nutrition & diabetes 2017. link 88 El-Bassossy HM, Awan Z, El-Mas MM. Perinatal ciclosporin A exposure elicits sex-related cardiac dysfunction and inflammation in the rat progeny. Toxicology letters 2017. link 89 Rose-Felker K, Border WL, Hong BJ, Chow EJ. Cardio-oncology Related to Heart Failure: Pediatric Considerations for Cardiac Dysfunction. Heart failure clinics 2017. link 90 Feldmann C, Zayat R, Goetzenich A, Aljalloud A, Woelke E, Maas J et al.. Perioperative onset of acquired von Willebrand syndrome: Comparison between HVAD, HeartMate II and on-pump coronary bypass surgery. PloS one 2017. link 91 Adel W, Roushdy AM, Nabil M. Mitral Annular Plane Systolic Excursion-Derived Ejection Fraction: A Simple and Valid Tool in Adult Males With Left Ventricular Systolic Dysfunction. Echocardiography (Mount Kisco, N.Y.) 2016. link 92 Feng W, Xu X, Zhao G, Zhao J, Dong R, Ma B et al.. Increased Age-Related Cardiac Dysfunction in Bradykinin B2 Receptor-Deficient Mice. The journals of gerontology. Series A, Biological sciences and medical sciences 2016. link 93 Cho EJ, Park SJ, Park KM, On YK, Kim JS. Paced QT interval as a risk factor for new-onset left ventricular systolic dysfunction and cardiac death after permanent pacemaker implantation. International journal of cardiology 2016. link 94 Chen W, Huang Z, Jiang X, Li C, Gao X. Overexpression of myeloid differentiation protein 88 in mice induces mild cardiac dysfunction, but no deficit in heart morphology. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2016. link 95 García M, García-Pedraza JÁ, Villalón CM, Morán A. Pharmacological Evidence that Histamine H3 Receptors Mediate Histamine-Induced Inhibition of the Vagal Bradycardic Out-flow in Pithed Rats. Basic & clinical pharmacology & toxicology 2016. link 96 Saha KK, Goel S, Kumar A, Saha KK. Anaortic off-pump bilateral internal mammary grafting in severe left ventricular dysfunction - Case report. Indian heart journal 2016. link 97 Beer LA, Kossenkov AV, Liu Q, Luning Prak E, Domchek S, Speicher DW et al.. Baseline Immunoglobulin E Levels as a Marker of Doxorubicin- and Trastuzumab-Associated Cardiac Dysfunction. Circulation research 2016. link 98 Niemeijer MN, Leening MJ, van den Berg ME, Hofman A, Franco OH, Deckers JW et al.. Subclinical Abnormalities in Echocardiographic Parameters and Risk of Sudden Cardiac Death in a General Population: The Rotterdam Study. Journal of cardiac failure 2016. link 99 Rimehaug AE, Skogvoll E, Aadahl P, Lyng O, Nordhaug DO, Løvstakken L et al.. Minimally invasive beat-by-beat monitoring of cardiac power in normal hearts and during acute ventricular dysfunction. Physiological reports 2016. link 100 Giudice J, Xia Z, Li W, Cooper TA. Neonatal cardiac dysfunction and transcriptome changes caused by the absence of Celf1. Scientific reports 2016. link