Overview
Acquired thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy (TMA) characterized by thrombocytopenia, microangiopathic hemolytic anemia (MAHA), and microvascular thrombosis 1. It is defined by these three core features 1.Diagnosis
Diagnosis is based on thrombocytopenia, MAHA, and microvascular thrombosis 1.
All TTP cases in England should be managed within designated regional centers 1.Management
Management of TTP and related TMAs, including complement-mediated hemolytic uremic syndrome (CMHUS), is provided 1.Key Recommendations
All TTP cases should be managed within designated regional centers as per NHSE commissioning for highly specialized services 1. (Evidence: Expert opinion)
Healthcare professionals should be provided with clear, up-to-date, and practical guidance on the management of TTP and related TMAs 1. (Evidence: Expert opinion)References
1 Scully M, Rayment R, Clark A, Westwood JP, Cranfield T, Gooding R et al.. A British Society for Haematology Guideline: Diagnosis and management of thrombotic thrombocytopenic purpura and thrombotic microangiopathies. British journal of haematology 2023. link