Overview
Ventricular arrhythmias (VAs) are abnormal heart rhythms originating in the ventricles, often leading to serious complications such as syncope, hemodynamic instability, and sudden cardiac death. Treatment strategies include catheter ablation, pharmacological management, and emerging technologies like AI-enabled electrocardiography and novel ablation techniques.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 1056 indexed papers.
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Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2026. link 9 Amin M, De Smet M, Lador A, Patel A, Schurmann PA, Dave A et al.. Venous Ethanol Ablation as the Sole Treatment for Intramural Ventricular Arrhythmias. JACC. Clinical electrophysiology 2026. link 10 Zhu C, Makita T, Lucero EY, Jyothidasan A, Patel R, Wang JJ et al.. Adrenergic Hypersensitivity Drives Ventricular Arrhythmias Following Loss of Plexin-Mediated Cardiac Innervation. JACC. Clinical electrophysiology 2026. link 11 Sawalha K, Kusumoto F, Al-Akchar M, Sadeq A, Goldsweig AM. Catheter Ablation Versus Medical Therapy as First-Line Treatment for Ventricular Electrical Storm: A Systematic Review and Meta-Analysis. Journal of cardiovascular electrophysiology 2026. link 12 Dewland TA, Venkateswaran R, Higuchi S, Lee C, Gerstenfeld EP. Ultra-Low Temperature Cryoablation Combined With Pulsed Field Ablation in a Swine Ventricular Infarct Model. JACC. 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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026. link 17 Feng JY, Frankel DS, Supple G, Garcia FC, Arkles JS, Nazarian S et al.. Ablation of idiopathic ventricular arrhythmias from the right ventricular apex. Heart rhythm 2026. link 18 Ruwald MH, Johannessen A, Worck R, Hansen ML, Haugdal M, Hansen J. Feasibility and midterm effectiveness of focal pulsed field ablation for ventricular arrhythmias. Heart rhythm 2026. link 19 Bussmann BM, George B, Robinson M, Grist J, Sukumar P, Chinherende E et al.. Protocol of the RADIO-STAR trial: a phase 1 safety and dose finding study of hypofractionated radiotherapy to the stellate ganglia for the treatment of ventricular arrhythmia. BMJ open 2026. link 20 Park YM, Yang T, Chung WJ, Shin MS. Key role of intracardiac echocardiography in catheter ablation of anterolateral papillary muscles. The international journal of cardiovascular imaging 2026. link 21 Marcus GM, Tung R, Gerstenfeld EP, Hue TF, Lin F, Cheng J et al.. Left Ventricular Entry to Reduce Brain Lesions During Catheter Ablation: A Randomized Trial. Circulation 2025. link 22 Zeppenfeld K, Rademaker R, Al-Ahmad A, Carbucicchio C, De Chillou C, Cvek J et al.. Patient selection, ventricular tachycardia substrate delineation, and data transfer for stereotactic arrhythmia radioablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025. link 23 Arya A, Di Biase L, Bazán V, Berruezo A, d'Avila A, Della Bella P et al.. Epicardial ventricular arrhythmia ablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society, the Asian Pacific Heart Rhythm Society, the Latin American Heart Rhythm Society, and the Canadian Heart Rhythm Society. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025. link 24 Patel S, Deng J, Zubair A, Heybati K, Heybati S, Chang O et al.. Sedation Versus General Anesthesia for Ablation of Ventricular Arrhythmias: A Systematic Review and Meta-Analysis. Annals of cardiac anaesthesia 2025. link 25 Zhang L, Guo F, Xu S, Deng Q, Xie M, Sun J et al.. AIEgen-Based Covalent Organic Frameworks for Preventing Malignant Ventricular Arrhythmias Via Local Hyperthermia Therapy. Advanced materials (Deerfield Beach, Fla.) 2025. link 26 Chouairi F, Fudim M, Benak A, Piccini JP, Toman J, Kautzner J et al.. Factors associated with stellate ganglion block success in recurrent ventricular arrhythmias. ESC heart failure 2025. link 27 Cheng YJ, Zhu C, Deng H, Wu Y, Wei HQ, Lin WD et al.. Air pollution, genetic susceptibility, and the risk of ventricular arrhythmias: a prospective cohort study in the UK Biobank. European journal of preventive cardiology 2025. link 28 Yang Y, Li M, Jiang C, Tang R, Sang C, Wang W et al.. Idiopathic ventricular arrhythmia originating from the vicinity of lateral tricuspid annulus: The precise origin and anatomic concerns. Heart rhythm 2025. link 29 Zhou ZX, Hu WM, Yu JS, Hong ZC, Yan Y, Shen Y et al.. Catheter Ablation of Idiopathic Left Anterior Fascicular Ventricular Arrhythmias: Predicting Origin Sites via Mapping and Electrocardiography. Journal of cardiovascular electrophysiology 2025. link 30 Tokavanich N, Huntrakul A, Yokokawa M, Kovacs B, Ghannam M, Liang JL et al.. Relationship of Structural Abnormalities of Papillary Muscles to the Site of Origin of Ventricular Arrhythmias. JACC. Clinical electrophysiology 2025. link 31 Zheng L, Maimaitijiang P, Chen A, Lai Z, Yao Y. Feasibility and safety of pulsed field ablation at the ventricular outflow tract using focal point catheter. Heart rhythm 2025. link 32 Baldi E, Rordorf R, Compagnoni S, Dusi V, Sanzo A, Gentile FR et al.. Efficacy of percutaneous stellate ganglion block according to ventricular arrhythmia cycle length: A post hoc subanalysis of the STAR study. Heart rhythm 2025. link 33 Aldrich J, Daniels Z, Eisner M, Kistler I, Bowman J, Hor K et al.. High Burden Ventricular Ectopy > 10% in Children with Structurally Normal Hearts: Investigating the Association of Ventricular Ectopy Frequency, Holter and ECG Findings, and Ventricular Dysfunction. Pediatric cardiology 2025. link 34 Rakza R, Groussin P, Benali K, Behar N, Mabo P, Pavin D et al.. Quinidine for ventricular arrhythmias: A comprehensive review. Trends in cardiovascular medicine 2025. link 35 Ganse FG, Ernst LM, Rodríguez C, Ruiz-Meana M, Inserte J, Martínez-González J et al.. Insights into the causal role of diesel exhaust particles in ventricular arrhythmogenesis: protective effects of antioxidant cerium oxide nanoparticles. Particle and fibre toxicology 2025. link 36 Kumar R, Amadio JM, Luk AC, Bhaskaran A, Ha ACT. Extracorporeal Membrane Oxygenation for Patients With Electrical Storm or Refractory Ventricular Arrhythmias: Management and Outcomes. The Canadian journal of cardiology 2025. link 37 Tateishi R, Shimizu M, Suzuki M, Sakai E, Shimizu A, Shimada H et al.. Machine Learning-Based Clustering Using a 12-Lead Electrocardiogram in Patients With a Implantable Cardioverter Defibrillator to Identify Future Ventricular Arrhythmia. 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Anatomy of the Ventricular Outflow Tracts: An Electrophysiology Perspective. Clinical anatomy (New York, N.Y.) 2024. link 43 Gardziejczyk P, Piotrowski R, Kryński T, Sikorska A, Kułakowski P, Baran J. Bipolar catheter ablation with dedicated radiofrequency system for highly refractory ventricular arrhythmia-Does the rate of success depend on arrhythmia origin?. Journal of cardiovascular electrophysiology 2024. link 44 Załęska-Kocięcka M, Wojdyńska Z, Kalisz M, Litwiniuk A, Mączewski M, Leszek P et al.. Epicardial fat and ventricular arrhythmias. Heart rhythm 2024. link 45 Aguilera J, Cabrera J, Saenz LC, Santangeli P. Catheter Ablation of Idiopathic Epicardial Outflow Tract Premature Ventricular Contractions: A Case Report and Review of the Literature. Cardiac electrophysiology clinics 2024. link 46 Krzowski B, Kutyifa V, Vloka M, Huang DT, Attari M, Aktas M et al.. Sex-Related Differences in Ventricular Tachyarrhythmia Events in Patients With Implantable Cardioverter-Defibrillator and Prior Ventricular Tachyarrhythmias. JACC. Clinical electrophysiology 2024. link 47 Ballı Ş, Kanlıoğlu P, Akgun G. Experience of left ventricular outflow tract arrhythmia ablation in paediatric patients using limited fluoroscopy and three-dimensional mapping technique. Cardiology in the young 2024. link 48 Liu M, He Z, Ying P, Lin D, Yu M, Tan X. Differentiating Origins of Outflow Tract Ventricular Arrhythmias: The Correction of Transitional Zone Index Is Not Superior to the Original One. Cardiology 2024. link 49 Tan JL, Guandalini GS, Hyman MC, Arkles J, Santangeli P, Schaller RD et al.. Substrate and arrhythmia characterization using the multi-electrode Optrell mapping catheter for ventricular arrhythmia ablation-a single-center experience. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2024. link 50 Hasegawa K, Yoneda ZT, Powers EM, Tokutake K, Kurata M, Richardson TD et al.. Stroke and Bleeding Risks of Endocardial Ablation for Ventricular Arrhythmias. JACC. Clinical electrophysiology 2024. link 51 Yoder M, Dils A, Chakrabarti A, Driesenga S, Alaka A, Ghannam M et al.. Gender and race-related disparities in the management of ventricular arrhythmias. Trends in cardiovascular medicine 2024. link 52 Takase S, Mukai Y, Nagaoka K, Ogawa K, Kawai S, Honda N et al.. Mapping of Purkinje-related ventricular arrhythmias by a multispline catheter with small and close-paired electrodes: Comparison with conventional catheters. Pacing and clinical electrophysiology : PACE 2024. link 53 Kautzner J, Hašková J, Stojadinovič P, Peichl P, Wichterle D. Percutaneous mechanical support in catheter ablation of ventricular arrhythmias: hype or hope?. 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Stereotactic body radiation therapy for refractory premature ventricular contractions that originate from the left ventricular summit: A case report. Pacing and clinical electrophysiology : PACE 2023. link 62 Pietrzak R, Łuczak-Woźniak K, Książczyk TM, Werner B. Cardiopulmonary capacity is reduced in children with ventricular arrhythmia. Heart rhythm 2023. link 63 Yamada T. Predictors of Successful Endocardial Ablation of Epicardial Left Ventricular Summit Arrhythmias. Cardiac electrophysiology clinics 2023. link 64 Foo FS, Sy RW, D'Ambrosio P, Quininir L, Irons J, Silberbauer J et al.. Novel Epicardial Access Technique Facilitated by Carbon Dioxide Insufflation of the Pericardium for Ablation of Ventricular Arrhythmias: Lessons From the Early Experience From a Single Centre in Australia. Heart, lung & circulation 2023. link 65 Restrepo AJ, Saenz Morales LC. Preventing Complications During Mapping and Ablation of Left Ventricular Summit Arrhythmias. Cardiac electrophysiology clinics 2023. link 66 Kuniewicz M, Budnicka K, Dusza M, Jakob N, Cholewa N, Defonseka R et al.. Gross anatomic relationship between the human left atrial appendage and the left ventricular summit region: implications for catheter ablation of ventricular arrhythmias originating from the left ventricular summit. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2023. link 67 Yalin K, Aksu T, Ikitimur B, Onder SE, Soysal AU, Ozturk S et al.. Intracardiac electrogram characteristics of intramural outflow tract ventricular arrhythmias. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2023. link 68 Matto F, Venugopal D, Bhave PD, Rhodes TE, Mazur A. Utility of high resolution mapping to guide ablation of ventricular arrhythmias from the aortic sinuses of Valsalva. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2023. link 69 Chen WT, Li CH, Chou YH, Lin WL, Lin YJ, Chang SL et al.. Post-ablation augmentation of skin sympathetic nerve activity predicts a poor outcome of idiopathic ventricular arrhythmias. Journal of cardiology 2023. link 70 Fong KY, Chan YH, Wang Y, Yeo C, Lim ETS, Tan VH. Catheter Ablation of Ventricular Arrhythmia in Patients With an Implantable Cardioverter-Defibrillator: A Systematic Review and Meta-analysis. The Canadian journal of cardiology 2023. link 71 Markman TM, Gugger D, Arkles J, Riley MP, Dixit S, Guandalini GS et al.. Neuromodulation for the Treatment of Refractory Ventricular Arrhythmias. JACC. Clinical electrophysiology 2023. link 72 Liang JJ, Bogun F. Ablation of Focal Intramural Outflow Tract Ventricular Arrhythmias. Cardiac electrophysiology clinics 2023. link 73 Shah R, Sharma A, Assis F, De Vasconcellos HD, Alugubelli N, Pandey P et al.. Quality assessment of cardiac magnetic resonance myocardial scar imaging prior to ventricular arrhythmia ablation. The international journal of cardiovascular imaging 2023. link 74 Engwall MJ, Baublits J, Chandra FA, Jones ZW, Wahlstrom J, Chui RW et al.. Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration-QTc analysis. Clinical and translational science 2023. link 75 Kitamura T, Fukamizu S, Arai T, Kawajiri K, Tanabe S, Tokioka S et al.. Long-term outcome of ventricular tachycardia ablation in patients who did not undergo programmed electrical stimulation after ablation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2023. link 76 Stegemann E, Weidmann M, Miyazawa AA, Shun-Shin MJ, Leyva F, Zegard A et al.. Laser Doppler flow for the hemodynamic differentiation of tachycardia. 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Adjunctive Therapies for Ventricular Arrhythmia Management: Autonomic Neuromodulation-Established and Emerging Therapies. Cardiac electrophysiology clinics 2022. link 82 Nakagawa H, Ikeda A, Yokoyama K, An Y, Hussein AA, Saliba WI et al.. Improvement in Lesion Formation with Radiofrequency Energy and Utilization of Alternate Energy Sources (Cryoablation and Pulsed Field Ablation) for Ventricular Arrhythmia Ablation. Cardiac electrophysiology clinics 2022. link 83 Juhos P, Janik M, Hatala R, Benacka O, Balaz R, Lucenic M et al.. Bilateral thoracoscopic cardiac sympathetic denervation in patients with refractory ventricular tachyarrhythmias non‑responsive to other treatment. Bratislavske lekarske listy 2022. link 84 Yanagihara T, Kobayashi N, Saeki Y, Kikuchi S, Goto Y, Sato Y. Left thoracoscopic sympathectomy for refractory ventricular arrhythmias. General thoracic and cardiovascular surgery 2022. link 85 Yamada T. Techniques for Catheter Ablation of Idiopathic Ventricular Arrhythmias Originating from the Outflow Tract and Left Ventricular Summit. Cardiac electrophysiology clinics 2022. link 86 Farran AE, Lugo DF, Boyer J. Bilateral cardiac sympathetic denervation on an ECMO patient for refractory ventricular arrhythmia: A case report. Journal of cardiac surgery 2022. link 87 Çinier G, Hayıroğlu Mİ, Özcan KS, Pay L, Tekkeşin Aİ, Gürkan K. The use of ivabradine in a patient with idiopathic ventricular arrhythmia originating from the left ventricular summit. Journal of electrocardiology 2022. link 88 Sandhu U, Nguyen AT, Dornblaser J, Gray A, Paladino K, Henrikson CA et al.. Patient-Reported Outcomes in a Multidisciplinary Electrophysiology-Psychology Ventricular Arrhythmia Clinic. Journal of the American Heart Association 2022. link 89 Anderson RD, Rodriguez Padilla J, Joens C, Masse S, Bhaskaran A, Magtibay K et al.. On the Electrophysiology and Mapping of Intramural Arrhythmic Focus. 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Prediction and classification of ventricular arrhythmia based on phase-space reconstruction and fuzzy c-means clustering. Computers in biology and medicine 2022. link 94 Nso N, Nassar M, Lakhdar S, Enoru S, Guzman L, Rizzo V et al.. Comparative Assessment of Transvenous versus Subcutaneous Implantable Cardioverter-defibrillator Therapy Outcomes: An Updated Systematic Review and Meta-analysis. International journal of cardiology 2022. link 95 Mathew S, Fink T, Feickert S, Inaba O, Hashiguchi N, Schlüter M et al.. Complications and mortality after catheter ablation of ventricular arrhythmias: risk in VT ablation (RIVA) score. Clinical research in cardiology : official journal of the German Cardiac Society 2022. link 96 Styczkiewicz K, Ludwik B, Styczkiewicz M, Śledź J, Gorski M, Stec S. Implementation of zero or near-zero fluoroscopy catheter ablation for idiopathic ventricular arrhythmia originating from the aortic sinus cusp. The international journal of cardiovascular imaging 2022. link 97 Miao F, Zhou B, Liu Z, Wen B, Li Y, Tang M. Using noninvasive adjusted pulse transit time for tracking beat-to-beat systolic blood pressure during ventricular arrhythmia. Hypertension research : official journal of the Japanese Society of Hypertension 2022. link 98 Salazar P, Beaser AD, Upadhyay GA, Aziz Z, Besser S, Shatz DY et al.. Empiric ablation of polymorphic ventricular tachycardia/fibrillation in the absence of a mappable trigger: Prospective feasibility and efficacy of pacemap matching to defibrillator electrograms. Heart rhythm 2022. link 99 Raja J, Guice K, Oberoi M, Whitwell S, Asbeutah AA, Russell A et al.. Shock Without Wires: A Look at Subcutaneous Implantable Cardioverter-Defibrillator Compared to Transvenous Implantable Cardioverter-Defibrillator for Ventricular Arrhythmias. Current problems in cardiology 2022. link 100 Hsue W, Huh T, Gelzer AR, Tschabrunn CM. Three-dimensional electroanatomic mapping and radiofrequency catheter ablation of ventricular arrhythmia in a dog without structural heart disease. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 2022. link