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Oncology51 papers

Infection by human herpesvirus 6

Last edited: 4/10/2026

Overview

Human herpesvirus 6 (HHV-6) is a common virus that can cause infection. HHV-6B is particularly relevant after hematopoietic cell transplantation (HCT) and chimeric antigen receptor-T-cell therapy 1.

Diagnosis

  • Diagnostic considerations for HHV-6B infection after HCT and CAR-T therapy are addressed 1.

    • Management

  • Prophylaxis and treatment approaches for HHV-6B infections after HCT and CAR-T therapy are discussed 1.

    • Special Populations

  • Guidelines address HHV-6B in both adult and pediatric populations undergoing HCT and CAR-T therapy 1.

    • Key Recommendations

  • Guidelines focus on relevant risk factors, diagnostic considerations, prophylaxis, and treatment approaches for HHV-6B infections after HCT and chimeric antigen receptor-T-cell therapy 1. (Evidence: Expert opinion)
  • The guidelines were developed by adult and pediatric infectious disease and HCT content experts, reaching consensus on recommendations 1. (Evidence: Expert opinion)

    • References

    1 Kampouri E, Handley G, Phan TL, Lee YJ, Shaw R, Carpenter PA et al.. American Society for Transplantation and Cellular Therapy Series #9: Management of Human Herpesvirus 6B After Hematopoietic Cell Transplantation and Chimeric Antigen Receptor-T-Cell Therapy. Transplantation and cellular therapy 2025. link 2 Li F, Sun Z, Tao M, Song K, Wang Z, Ren X. Epidemiological characterization of human infection with H5N6 avian influenza. Frontiers in public health 2024. link

    Original source

    1. [1]
      American Society for Transplantation and Cellular Therapy Series #9: Management of Human Herpesvirus 6B After Hematopoietic Cell Transplantation and Chimeric Antigen Receptor-T-Cell Therapy. — Kampouri E, Handley G, Phan TL, Lee YJ, Shaw R, Carpenter PA et al. Transplantation and cellular therapy (2025)
    2. [2]
      Epidemiological characterization of human infection with H5N6 avian influenza. — Li F, Sun Z, Tao M, Song K, Wang Z, Ren X Frontiers in public health (2024)
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