Overview
Coronary atherosclerosis involves the buildup of plaque in the coronary arteries, leading to reduced blood flow and increasing the risk of myocardial infarction and ischemic heart disease. This chronic inflammatory process is driven by lipid accumulation, immune cell infiltration, and endothelial dysfunction 121925.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 11785 indexed papers.
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Endocrinology, diabetes & metabolism 2026. link 5 Hon A, Lu M, Demer LL, Tintut Y. Specific serotonin receptor antagonist reduces murine calcific atherosclerosis. Atherosclerosis 2026. link 6 Zulkefli SB, Mohamad F, Nasir NAA, Shuid AN, Azme N. Mechanistic Insights into Therapeutic Strategies for Post- Menopausal Atherosclerosis: Evidence from an Ovariectomized Mouse Model. Journal of cardiovascular translational research 2026. link 7 Griffin F, Fridolfsson J, Arvidsson D, Ekblom-Bak E, Ekblom Ö, Bergström G et al.. Lower cardiorespiratory fitness is associated with coronary artery atherosclerosis in individuals with a zero CAC score - cross-sectional results from SCAPIS. Atherosclerosis 2026. link 8 Khan Y, Fatima R, Ilma B, Kalra JM, Maqbool M, Ramalingam PS et al.. Ubiquitin-specific proteases in Atherosclerosis: Exploring novel therapeutic strategies beyond conventional approaches. European journal of pharmacology 2026. link 9 Gao T, Li X, Zhang W, Yang Y, Liu Y, Liang F et al.. SWAP70 Promotes Atherosclerosis Via Endothelial CAV1 Nuclear Translocation. Circulation research 2026. link 10 Singh A, Yadav PK. Analysis of bio-convective ternary hybrid nanofluid flow in atherosclerotic bifurcated artery: A numerical approach. Computer methods and programs in biomedicine 2026. link 11 Ziadeh H, Badreddine J, Rajan T, Chemali Y, Rhodes S, Beard L et al.. Erectile Dysfunction as a Predictor of Subclinical Atherosclerosis: A Community Health Assessment Using Coronary Calcium Scoring in Underserved Cleveland, Ohio. Urology 2026. link 12 Armani A, Marzolla V, Mammi C, Vitiello L, Bellucci E, Feraco A et al.. Protective effects of ketogenic diet on aldosterone-induced atherosclerosis in ApoE-/- mice. Journal of endocrinological investigation 2026. link 13 Wang X. Serum osteopontin is associated with coronary plaque vulnerability and short-term cardiovascular events: a prospective cohort study. Frontiers in endocrinology 2026. link 14 Zhang P, Bao X, Wu X, Yang Y, Sun Y, Qian Y et al.. A potential explanation of the causal relationship between atherosclerosis and lung cancer from an immunological perspective: A Mendelian randomization and transcriptomics study. Medicine 2026. link 15 Song H, Yu J, Li L, Fan H, Zhang Y, Ma Y et al.. Anti-atherosclerotic effects of Thymus quinquecostatus Celak extracts in vitro: Regulating macrophage foaming and endothelial cell injury. Fitoterapia 2026. link 16 Peng Y, Chen S, Yu Y, Tong W, Sun S. Caveolin-1 regulates cellular cholesterol homeostasis and its potential as an atherosclerosis therapy target. The Journal of steroid biochemistry and molecular biology 2026. link 17 Weng J, Huan L, Zhang S, Cao W, Xu F, Zhang Y. Exploring potential mechanism of Chuanzhi Qingyu recipe for vulnerable atherosclerosis plaques based on UPLC-Q-TOF-MS. Journal of pharmaceutical and biomedical analysis 2026. link 18 Zhou Q, Zhang GL, Sun W, Cai J, Yu LH. Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review). International journal of molecular medicine 2026. link 19 Dmitrieva AA, Mogilenko DA, Larionova EE, Nekrasova EV, Churakov GA, Orlov SV. The LOX-1 scavenger receptor plays a central role in multiple positive feedback loops driving the escalation of oxLDL uptake by macrophages. FEBS letters 2026. link 20 Qiao X, Toma VW, Wang J, Herraiz-Adillo Á, Söderholm S, Berglind D et al.. Genetic predisposition to coffee consumption and the association with the early risk of atherosclerosis. Scientific reports 2026. link 21 Jiang MC, Ding HY, Cheng CK, Cai DQ, Guan HX, Kuang J et al.. Targeting the 5-HT. Acta pharmacologica Sinica 2026. link 22 Liu WC, Lin CS, Luo CL, Yang WY, Yang CH, Cheng ML et al.. Intracellular Galectin-3 as a Crucial Regulator of Foam Cell Formation and Apoptosis Progression Through the Modulation of Membrane Lipid Rafts. Archives of medical research 2026. link 23 He Y, Jiang K, Sun J, Zhao Q, Yue J, Wei W et al.. METTL3-dependent N6-methyladenosine modification on LGMN mRNA promotes macrophage ferroptosis and atherosclerosis. Journal of molecular and cellular cardiology 2026. link 24 Chen X, Jiang X, Hou S, Lai F, Hu K, Li J et al.. Meteorin-like protein inhibits vascular smooth muscle cell-derived foam cell formation and atherosclerosis via KIT- endoplasmic reticulum stress signaling. Metabolism: clinical and experimental 2026. link 25 Schade DS, Blankenship JC, Gonzales K, Adolphe A, Eaton RP. A new paradigm to reduce cardiovascular disease based on the pathogenesis of atherosclerosis. The American journal of medicine 2026. link 26 Tardajos Ayllon B, Diagbouga M, Das A, Tian S, Edsfeldt A, Kalucka J et al.. TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques. Nature communications 2026. link 27 Cao W, Wang B, Wang Y, Li Y, Yang H, Sun Y et al.. Spatio-temporal dynamics of autophagy-associated genes in macrophage-driven atherosclerosis: an integrated omics and experimental study. Frontiers in endocrinology 2026. link 28 Wang J, Cai Y, Sagor MIH, Chu Y, Liu F, Wang T. Irisin protects against atherosclerosis in ApoE. Molecular and cellular biochemistry 2026. link 29 Li Y, He X, Liu Y, Deng Y, Zhang B, Wei D et al.. Engineered nanozymes enhance atherosclerosis therapy via inflammation-lipid homeostasis modulation. Colloids and surfaces. B, Biointerfaces 2026. link 30 Gannon O, Rahtes A, Bonin JL, Salfate Del Rio I, Partridge J, Nickerson C et al.. Cholesterol Lowering Alone Fails to Reverse Atherosclerotic Plaque Necrosis, Granulopoiesis, and Neurovascular Neutrophils in Middle-Aged Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026. link 31 Fujita K, Kinoshita Y, Sagawa H, Bongguk K, Kobayashi Y, Wakabayashi H et al.. Influence of Elevated Serum Lipoprotein(a) on Carotid Artery Plaque Ulceration in Patients Considered for Carotid Revascularization. Journal of atherosclerosis and thrombosis 2026. link 32 Delialis D, Manifava P, Giannakopoulou SP, Konstantaki C, Athanasopoulos S, Zervas G et al.. Country-specific prevalence and clinical relevance of elevated Lp(a) as a risk enhancer in 2 Greek cohorts. Journal of clinical lipidology 2026. link 33 Oršolić N, Toljanić B, Odeh D, Čuljak N, Šešelja K, Baus Lončar M et al.. Anti-Atherogenic Activities of Exopolysaccharides and Their Producing Strain . International journal of molecular sciences 2026. link 34 Yang Y, Shen S, Guan Y, Guo X, Lin M, Dong H et al.. Isolinderalactone attenuates atherosclerosis through inhibiting NF-κB-mediated inflammation in macrophages. International immunopharmacology 2026. link 35 Mostaza JM, Pintó X, Armario P, Guijarro C, Masana L, Real JT et al.. SEA 2026 Standards for Global Control of Vascular Risk. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis 2026. link 36 Yang FK, Chen R, Zhou CH, He WM, Shang JH, Wang K et al.. Real-Time Monitoring of Intraplaque Furin in Atherosclerotic Mice during Pneumonia and Dexamethasone Treatment. Analytical chemistry 2026. link 37 Rehman S, Moses E, Dwyer T, Venn A, Gall S. Sex differences in the longitudinal association between metabolomic biomarkers and carotid artery plaques. Nutrition, metabolism, and cardiovascular diseases : NMCD 2026. link 38 He Y, Xu F, Deng J, Li M, Leng S. Association of Composite Metabolic Indices With Incident Carotid Plaque: A Chinese Cohort Study. Journal of the American Heart Association 2026. link 39 Bajaj R, Huang X, Alves-Kotzev N, Weyers JJ, Levine M, Garg M et al.. Deep learning-based plaque characterization in hybrid IVUS-OCT images is superior to single-modality deep learning analysis and human experts: head-to-head comparison against histology. Cardiovascular research 2026. link 40 Evans NR, Bhakta S, Zeicu C, Tarkin JM, Chowdhury MM, Rudd JHF et al.. Carotid Atherosclerosis Shows Distinct Patterns of Atheroinflammation and Microcalcification Relating to Frailty and Multimorbidity. Cerebrovascular diseases (Basel, Switzerland) 2026. link 41 Patel N, LaMastro V, Giblin J, Avery E, Noor B, Magee G et al.. Genetically engineering cells to produce therapeutically boosted extracellular vesicles for cardiovascular calcification. Biomaterials 2026. link 42 Peng C, Liu GJ, Li J, Chen Y, Zhu XH, Yin H et al.. Evolocumab alleviates atherogenesis by inhibiting inflammation-mediated endothelial cell activation via the PI3K/AKT/NF-κB pathway. European journal of pharmacology 2026. link 43 Li S, Cao S, Li P, Zhang F, Ren G, Wang X et al.. Endothelial BMP6 Drives Hemodynamic-Dependent VSMCs Calcification in Carotid Atherosclerosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026. link 44 Sakaguchi K, Fujioka S, Shishikura D, Michikura M, Kusumoto H, Kanzaki Y et al.. Discordance in Achilles Tendon Assessment between Radiography and Ultrasonography due to Torsion. Journal of atherosclerosis and thrombosis 2026. link 45 Raddatz MA, Allayee H, Lusis AJ. Genetic factors contributing to atherosclerosis. Current opinion in cardiology 2026. link 46 Deng H, Zhang X, Wang Y, Joshi D, Tellides G, Schwartz MA. FOXO1 Integrates Endothelial Hemodynamic, Inflammatory, and Metabolic Pathways in Atherosclerosis. Circulation research 2026. link 47 Wu Y, Ke J, Lv J, Cao C, Zhou C, Wu L et al.. Rosuvastatin protects against oxLDL-induced endothelial cell oxidative stress and attenuates atherosclerotic plaque formation in ApoE-/- mice through the NF-κB pathway. PloS one 2026. link 48 Liu Y, Zhao G, Zhang X, Xiao Y, Zhi H, Zhang D et al.. Si-Miao-Yong-An decoction restores macrophage efferocytosis and modulates vascular inflammation via PPAR-γ/MerTK pathway to treat atherosclerosis. Fitoterapia 2026. link 49 Chen M, Ding N, Wang FM, Obisesan OH, Folsom AR, Howard-Claudio CM et al.. Associations of cigarette smoking with coronary artery and extra-coronary calcification in older adults: The Atherosclerosis Risk in Communities study. Atherosclerosis 2026. link 50 Li X, Tu Y, Jin Y, Liu X, Luo Z, Zhao H et al.. Dingxin Recipe III resolves atherosclerotic inflammation via revitalizing Regulatory T cell lineage fidelity associated with fatty acid oxidation metabolic reprogramming. Phytomedicine : international journal of phytotherapy and phytopharmacology 2026. link 51 Zhang K, Han J, Chen P, Li H, Wu Y, Shi Y et al.. Integrative epidemiology and multi-omics reveal a frailty-associated ACKR1 redox axis linking cadmium exposure to atherosclerosis. Redox biology 2026. link 52 Wang H, Huang X, Mou J, Wang E, Li Y, Pu W et al.. Contribution of Gli1. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026. link 53 Li Q, Zhu S, Chen G, Du Y, Guo H, Zou T et al.. Exosomal miR-10b derived from protocatechuic acid-treated efferocytic macrophages inhibits endothelial inflammation by targeting MAP3K7/β-TrCP/NF-κB signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology 2026. link 54 Serbulea V, Martin JM, Owens GK. Role of Diverse Smooth Muscle Cell Phenotypic Transitions in Atherosclerosis Development and Late-Stage Pathogenesis. Annual review of physiology 2026. link 55 Liu Q, Shi Y, Qin L. Targeting pyroptosis in atherosclerosis: emerging pharmacologic strategies and natural compound-based therapeutics-a narrative review. International journal of clinical pharmacy 2026. link 56 Rangel MVS, Alam MA, Islamuddin M, Chen Z, Qin X, Borges JP. Exercise-induced effects on atherogenesis and tryptophan catabolism via the kynurenine pathway in an HIV-associated atherosclerosis mouse model. Experimental physiology 2026. link 57 T A A, Vallazhath A, Maniyal V, Menon D. Advances in therapeutic strategies for atherosclerosis: from pharmacologics to stents and stent coatings. Journal of materials chemistry. B 2026. link 58 Zhou L, Wang X, Meng C, Li T, Wang Q, Zhang M et al.. Exploring the role of curcumin in anti-atherosclerosis: Mechanisms and pathways of action. Phytomedicine : international journal of phytotherapy and phytopharmacology 2026. link 59 Wang G, Yan Y, Sun Q, Chen L, Qiang L, Liu L. Distinct Roles of PPARs in Atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology 2026. link 60 Kawamura A, Okayama K, Nohara H, Nakano T, Sakata Y. Difference Between Low-Speed and High-Speed Rotational Atherectomy Using Two Types of Guidewires. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2026. link 61 Li T, Kong C, Zuo J, Wu P, Zhao H, Jiang K et al.. A Membrane-Impermeable Near-Infrared Probe Enables High-Fidelity Tracking of Foam Cell Progression. Analytical chemistry 2026. link 62 Yao H, Zhang Y, Lin L, Yang S, Chen D, He L et al.. Puerarin mitigates tumor necrosis factor-nuclear factor-κB axis-driven macrophage inflammation and atherogenesis: Integrative network pharmacology and experimental validation. Phytomedicine : international journal of phytotherapy and phytopharmacology 2026. link 63 Yang Z, Liu M, Shi Y, Lu Z, Lu Z, Lin Y et al.. Upregulation of IL-32γ in endothelial cells promotes macrophage recruitment and inflammatory progression in atherosclerosis. Scientific reports 2026. link 64 Buriman DG, Noveanu L, Furdui-Lința AV, Feier HB, Lazou A, Kiss A et al.. Vasculoprotective Effects of Sodium-Glucose Co-Transporter Inhibitors in Non-Diabetic Experimental Settings: A Narrative Review. International journal of molecular sciences 2026. link 65 Teramoto M, Terry JG, Pletcher MJ, Marcus GM, Hoffmann TJ, Sidney S et al.. Coronary Artery Calcium Progression and Cognitive Function in Midlife-The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Circulation. Population health and outcomes 2026. link 66 Yuan Z, Li H, Ruan BX, Huang H, Li Y, Wang J. Macrophage-derived galectin-3 contributes to pyroptosis, apoptosis and necroptosis through TLR4/MyD88/NF-κB/NLRP3 during atherosclerosis. Clinical and translational medicine 2026. link 67 Zhou Y, Matsumura T, Saito S, Yagi Y, Yoshinaga T, Takeshita M et al.. Hematopoietic dipeptidyl peptidase-4 deficiency promotes M2 macrophage polarization and attenuates atherosclerosis. Biochemical and biophysical research communications 2026. link 68 Kim J, Park D, Yoo J, Kim JE, Kim EH, Bang OY. Multimodal Antiatherosclerotic Effects of Clinical-Grade Mesenchymal Stem Cell-Derived Extracellular Vesicles. Stroke 2026. link 69 Yakimov B, Vishnyakova P, Bagrianskaia U, Gantsova E, Markin A, Fatkhudinov T et al.. Autofluorescence Flow Cytometry for Macrophages Analysis: Polarization, Stress Conditions, and Atherosclerosis Model. Journal of biophotonics 2026. link 70 Sun H, Lv C, Wang L, Xie M, Zeng Z, Liu Y. Flexible ultrasonic transducer array with automatic phase calibration for arteriosclerosis detection. Ultrasonics 2026. link 71 Liu W, Chen R, Jia Z, Han S, Jin Q. Protein lactylation influences atherosclerotic plaque stability by regulating macrophage functions. Frontiers in immunology 2026. link 72 Mallén A, Rotllan N, Griñán R, Varela C, Bertolino E, Paloschi V et al.. In vivo inhibition of miR-125b-5p modulates monocyte trafficking through the CCR7 receptor and reduces atherosclerosis. American journal of physiology. Cell physiology 2026. link 73 Stahr N, Moriarty AK, Ma SD, Keeter WC, Kim WK, Sanford LD et al.. STAT4-dependent regulation of neuroinflammation in atherosclerosis. Physiological reports 2026. link 74 Fan Z, Wang J, Zhang X, Deng X, Yan C. Mesoscopic Insights Into Low-Density Lipoprotein Transport: A Dissipative Particle Dynamics Study. Journal of biomechanical engineering 2026. link 75 Li WH, Zhang YL, Zhang YF, Yu Z, Chen L, Fang HY et al.. Cell type-specific contribution of low-density lipoprotein receptor to atherosclerosis. Science China. Life sciences 2026. link 76 Shu K, Chen J, Song K, Feng Y, Zhang J, Zhao H et al.. An Atherosclerosis Model in Mice Induced by Both Partial Carotid Ligation and Overexpression of PCSK9. Journal of visualized experiments : JoVE 2026. link 77 Tang Y, Peng Y, Zhang Y, Tong W, Sun S. Melatonin ameliorates ox-LDL-induced lipid accumulation and enhances ABCA1 expression in VSMCs via inhibition of the TRPV1-Ca. Biochimica et biophysica acta. Molecular and cell biology of lipids 2026. link 78 Kunimura A, Tsukamoto N, Suzuki W, Kuno S, Naito K, Ando H et al.. Association between the Atherosclerotic Modifiable Risk Factor Burden and Coronary Inflammation. Journal of atherosclerosis and thrombosis 2026. link 79 Ma X, Li Z, Liu H, Wang M, Gao F, Xiao Z et al.. Tartrate-Resistant Acid Phosphatase 5 (TRAP/ACP5) aggravates atherosclerosis by regulating macrophage polarization and promoting ferroptosis. Free radical biology & medicine 2026. link 80 Cai Y. Probiotics in atherosclerosis: mechanisms, efficacy and future directions - a review study. Frontiers in immunology 2026. link 81 Zheng M, Yang X, Tian R, Xia X, Xu Q, Hui Y et al.. A Segatella Copri-centered Gut Microbiota-mediated Metabolic Dysregulation Associated with Transition from Asymptomatic to Symptomatic Intracranial Atherosclerosis. Translational stroke research 2026. link 82 Franze' A, Plana E, Jiménez-Hernández N, Artacho A, Pons J, Moya A et al.. Application of high-throughput sequencing to the study of the main bacterial populations in carotid stenosis. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis 2026. link 83 Cho LD, Parikh SA. Next-Generation Drug Delivery Systems and Drugs for Vascular Intervention. Interventional cardiology clinics 2026. link 84 Yang Y, Zhang T, Dong L, Liu Y, Wu H, Shi X et al.. Paeonol alleviates atherosclerosis by inhibiting CD8. Journal of ethnopharmacology 2026. link 85 Chen J, Miao Q, Xiao X. Targeted nanocarriers effectively remove cholesterol from macrophages. Bio-medical materials and engineering 2026. link 86 Chen L, Zhou SN, Tan RH, Zhang ZS, Wang QW, Wang XR et al.. S-nitrosylation of AMP-activated protein kinase beta 1 drives atherosclerotic calcification in diabetes. European journal of pharmacology 2026. link 87 Ma M, Zhang Y, Gao L, Wang Z, Xin R, Wang M et al.. Atherosclerotic progression at sites of low shear stress is attenuated by myeloid-PlexinD1 deficiency through suppression of classical macrophage polarization. European heart journal 2026. link 88 Tang Y, Cai Y, Peng F, Li M, Mo Z. Midkine Promote Atherosclerosis by Regulating the Expression of ATP-Binding Cassette Transporter A1 via Activator Protein-1. Cardiovascular drugs and therapy 2026. link 89 Su X, Zhou B, Xu Y, Du X, Chen J, Yin M et al.. USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses. EBioMedicine 2026. link 90 Fu X, Liu C, Chen YL, Qin JL, Wang TT, Fu SS. Rosuvastatin Upregulates RCOR1 to Repress C10ORF10 Transcription and Alleviate Oxidative Stress and Plaque Formation in Atherosclerosis. The Kaohsiung journal of medical sciences 2026. link 91 Liu Y, Luo N, Xi X, Hou J, Li X, Xia M et al.. Mitochondrial dysfunction and applications of mitochondrial-targeted delivery systems in atherosclerosis. Drug delivery 2026. link 92 Zhao R, Sun Q, Shan S, Sun H, Baima C, Jin Y. Mechanistic insights into acacetin-mediated atherosclerosis suppression: targeting HDAC4/p53-regulated ferroptosis signaling pathway. Biochemical pharmacology 2026. link 93 Saba L. Progress in the identification of unstable carotid artery plaque. Current opinion in neurology 2026. link 94 Zhu Y, Liu Z, Wan Y, Ding S, Liu J, Wu A et al.. miR-375-3p/STX6 Exacerbates Atherosclerosis by Promoting Endothelial Cell Senescence via Activation of TGF-Beta Signals. Aging cell 2026. link 95 Muñiz-Anquela R, Redondo-Angulo I, Lewis EA, Lolo FN, González-Cintado L, Toledano-Donado M et al.. Progression of Established Atherosclerotic Lesions Is Not Inhibited by Endothelial Knockout of Caveolin-1-Brief Report. Arteriosclerosis, thrombosis, and vascular biology 2026. link 96 Augstein A, Porth S, Mierke J, Friedrich J, Jellinghaus S, Linke A et al.. Ephrin-A1/EphA2 modulates vascular smooth muscle cell proliferation in vitro, while VSMC-specific ephrin-A1 deletion is not sufficient to alter arteriosclerosis in vivo. Biochimica et biophysica acta. Molecular cell research 2026. link 97 Semler EM, Michell DL, Kingsley PJ, Ramirez MA, Massick C, Castleberry M et al.. Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis. Atherosclerosis 2026. link 98 Feng J, Xie Y, Wang S, Feng L. Elucidating the mechanism of plasticizers associated with atherosclerosis through network toxicology, bulk RNA sequencing, and single-cell RNA sequencing analysis. Ecotoxicology and environmental safety 2026. link 99 You L, Chen Y, Zhang Z, Wang Y, Gu Z, Shen L et al.. The FLOW Framework: a panvascular-on-a-chip platform to model systemic disease and guide panvascular interventional device suitcordance. 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