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Critical Care2320 papers

Neutropenic sepsis

Last edited: 4/23/2026

Overview

Neutropenic sepsis is a life-threatening condition characterized by a severe infection in individuals with neutropenia, leading to systemic inflammatory response and potential organ dysfunction 1.

Diagnosis

Clinical signs of infection (fever, chills, hypotension) in the context of neutropenia

Blood cultures to identify the causative pathogen 5

Elevated inflammatory markers (e.g., CRP, procalcitonin) 10 70

Organ dysfunction assessment using scoring systems like SOFA 11

Management

Early broad-spectrum antibiotics tailored to local resistance patterns 1 5

Source control (e.g., surgical intervention if applicable) 1

Antifungals if fungal infection suspected 5

Vasopressors for hypotension (e.g., norepinephrine) 3 30

Fresh frozen plasma (FFP) within 24 hours if coagulopathy present 7

Supportive care including fluid resuscitation, inotropic support, and monitoring for organ dysfunction 9 30

Special Populations

Pediatrics: Tailored antibiotic therapy and close monitoring of organ function 1 6

Elderly: Increased vigilance for complications like atrial fibrillation and coagulopathy 17

Comorbidities: Consider specific management adjustments for coexisting conditions like heart failure 60

Key Recommendations

Initiate broad-spectrum antibiotics within one hour of recognizing sepsis 1 (Evidence: Strong)

Implement early goal-directed therapy including fluid resuscitation and vasopressor support as needed 3 30 (Evidence: Moderate)

Source control measures should be pursued promptly if an infectious focus is identified 1 (Evidence: Strong)

Consider fresh frozen plasma transfusion within 24 hours in patients with coagulopathy 7 (Evidence: Moderate)

Closely monitor and manage organ dysfunction using scoring systems like SOFA 11 (Evidence: Moderate)

References

Showing 100 most recent of 2176 indexed papers.

1 Weiss SL, Peters MJ, Oczkowski SJW, Belley-Cote E, Buysse C, Choong KLM et al.. Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2026. link 2 Julián-Jiménez A, Eduardo García D, Del Castillo JG, Escalante-Kanashiro R, Candel González FJ, Merinos-Sánchez G et al.. Recommendations of the GT-LATINFURG for the identification and initial management of patients with severe infection and sepsis in emergency departments. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias 2026. link 3 Rosenberg K. Early peripheral vasopressor use is feasible and safe in sepsis-induced hypotension. The American journal of nursing 2026. link 4 Quin C. Age-related trade-offs: When protection becomes pathology. Cell host & microbe 2026. link 5 Yuen Yue Candice C, Ee TY, Ning T, Dorothy NHL, Anson WHM, Yvonne CFZ et al.. Quality improvement project to improve blood culture volumes in haematology patients. BMJ open quality 2026. link 6 Georgette N, Sheehan M, Kissoon N. Perspectives on the Phoenix Sepsis Criteria for the Emergency Medicine Practitioner. Pediatric emergency care 2026. link 7 Ling D, Ping C, Hongbing H. Fresh frozen plasma transfusion within 24 h of admission associated with 28-day mortality of pediatric patients with sepsis: A single-center retrospective cohort study. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2026. link 8 Taher IAA, Eldin FK, Eissa MAW, Saleh LA, Mohammed OA, Doghish AS et al.. Effect of fluoxetine on organ dysfunction and mortality in severe sepsis. PloS one 2026. link 9 Lee HNR, Lin J, Smith CJ, Ware LB, Harrison FE, Bastarache JA et al.. Advanced Age in Mice Exacerbates Sepsis-Induced Inflammation, Vascular Permeability, and Multi-Organ Dysfunction. Shock (Augusta, Ga.) 2026. link 10 Fan JB, Li QY, Feng XF, Huang SY, Wang R, Liao FY et al.. The "cytokine storm" in infection and sepsis: win the battle but lose the war. Military Medical Research 2026. link 11 Chen H, Fan Y, Hu R, Yu Q, Yu J, Zhang X et al.. Longitudinal SOFA score trajectories and risk stratification in ICU patients with . Frontiers in cellular and infection microbiology 2026. link 12 Giamarellos-Bourboulis EJ, Kotsaki A, Kotsamidi I, Efthymiou A, Koutsoukou V, Ehler J et al.. Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial. JAMA 2026. link 13 Munekata Y, Hayakawa M, Shinkai A, Ito T. Neutrophil Extracellular Traps and DNase Activity in Sepsis: Associations with Coagulopathy and Organ Dysfunction. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2026. link 14 Ferrari F, Longhitano Y, Voza A, Fumagalli J, Savioli G, Zanza C et al.. Clinical Applications of Polymyxin B Hemadsorption in Sepsis and Septic Shock. Journal of intensive care medicine 2026. link 15 Wang GJ, Lian H, Zhang HM, Liu YC, Wang XT. Relationship Between IL6/IL10 Serum Concentrations and Organ Function in Critically Ill Patients Based on Sepsis: A Prospective Study. Immunity, inflammation and disease 2026. link 16 Cui W, Wang S, Dai C, Jin D, He J, Sheng Y et al.. Baseline Serum Vitamin C Levels in Pediatric Sepsis: Hazard of Mortality and Organ Dysfunction in a Single-Center Prospective Cohort. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2026. link 17 Ali M, Naseer Ahmad R, Hassan M, Hashmi MUH, Kiyani M, Zia A et al.. Emerging trends and disparities in mortality due to coexisting atrial fibrillation and sepsis: A US nationwide observational study (1999-2023). Medicine 2026. link 18 Iba T, Maier CL, Ferrer R, Nagakari K, Levy JH. Endotheliopathy within the thromboinflammatory network of sepsis-induced coagulopathy. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026. link 19 Wang Y, Yuan Q. Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Induced Cardiomyopathy. Clinical and experimental pharmacology & physiology 2026. link 20 Chen C, Liu Q, Xu J, Zi M, Chen X, Xiao F. Nsun2-mediated m5C methylation of Ncor1 exacerbates sepsis-induced cardiomyopathy by promoting mitochondrial dysfunction. Free radical biology & medicine 2026. link 21 Li M, Liu Y, Qu K, Zhang Y, Yang H. DNMT1 knockdown mitigates sepsis-induced myocardial dysfunction by preventing TFAM-mediated mitochondrial DNA cytosolic escape and subsequent cGAS-STING to regulate macrophage M2 polarization. Biochemical pharmacology 2026. link 22 Yuan Z, She T, Wu Z, Li Q. The effect of milrinone on short- and mid-term outcomes in patients with sepsis-related myocardial injury: A propensity score matched retrospective study. Heart & lung : the journal of critical care 2026. link 23 Yan M, Liu Q, An Y, Dong H, Han X, Li Z et al.. NRF2/miR-17-5p/TMEM16F axis regulates the crosstalk of inflammation and thrombosis in sepsis. Journal of thrombosis and haemostasis : JTH 2026. link 24 Zhou L, Chen W, Li J, Chen M. Integrated bioinformatics analysis reveals cross-talking hub genes and therapeutic agents between sepsis and acute myocardial infarction. Annals of medicine 2026. link 25 Song R, Ma Y, Wan J, Hao S, Chen B, Liao Y et al.. Microvesicle release drives cycles of mitophagy flux disruption and inflammatory amplification in sepsis-induced myocardial dysfunction. Proceedings of the National Academy of Sciences of the United States of America 2026. link 26 Yang AL, Li L, Zhang ZH, Li XX, You XX, Sun J. Pathogen detection and analysis in patients with sepsis complicated with new- onset atrial fibrillation: a retrospective observational study. Heart & lung : the journal of critical care 2026. link 27 Shang T, Zhang Y, Pan T, Shen R, Chang J, Zhang ZS et al.. The combination of paeoniflorin and hydroxysafflor yellow A alleviated pulmonary thrombosis by inhibiting platelet-neutrophil interaction via the P-selectin-PSGL-1 signaling axis. Phytomedicine : international journal of phytotherapy and phytopharmacology 2026. link 28 Lu YN, Liu WX, Wang XH, Zhang X, Zheng YF, Wang TY et al.. Endothelial ANGPT2 impairs cardiomyocyte calcium homeostasis via ITGB3 receptor in murine sepsis-related cardiomyopathy. Biochimica et biophysica acta. Molecular cell research 2026. link 29 Zhang H, Mi Y, Kong C, Gao X, Xu C, Song Z et al.. GDF11 protects against sepsis-induced myocardial injury and cardiac dysfunction by targeting the Nrf2 signaling pathway-dependent ferroptosis. International immunopharmacology 2026. link 30 Krewulak KD, Hernández L, Moss SJ, Kupsch S, Sept B, Adhikari NKJ et al.. Vasopressor use in the intensive care unit: What matters most to patients and families. Australian critical care : official journal of the Confederation of Australian Critical Care Nurses 2026. link 31 Tang P, Huang B, Ou Q, Liu F, Lin L, Zheng Y et al.. A mouse model of sepsis-associated DIC induced by Kappa-carrageenan and Lipopolysaccharides: Establishment and characteristics. Journal of advanced research 2026. link 32 Wu J, Wu ZX, Hu H, Chen ZQ, Wu YX, Fu Y et al.. Protective effect of Adropin on sepsis-induced cardiomyopathy. International immunopharmacology 2026. link 33 Wang Y, Zhang H, Liu J, Lin R, Huang Y, Liu X et al.. Curcumin nanoparticles attenuate sepsis-induced myocardial injury by modulating the Nrf2/HO-1/SLC7A11/GPX4 and ACSL4/LPCAT3 pathways. Pathology, research and practice 2026. link 34 Shuai R, Lin L, Zeng X, Zhang L. Association between the atherogenic index of plasma and acute kidney injury in sepsis patients. PloS one 2026. link 35 Huespe I, Sosa FA, Jena A, Pareek A, Saleem F, Bateh S et al.. Long-term outcomes of abnormal global longitudinal left ventricular strain during sepsis: A retrospective cohort study. Journal of critical care 2026. link 36 Ge Y, Li M, Wang B, Zhang Y, Zhou X, Zhang Y et al.. Melatonin ameliorates sepsis-induced myocardial dysfunction by promoting autophagy via SIRT1-mediated TFEB deacetylation. International immunopharmacology 2026. link 37 Tepebaşi MY, Aşci H, Selçuk E, Uysal D, Bindal A, Yüksel D et al.. In sepsis-associated cardiotoxicity, remifentanil reduces oxidative stress, inflammation, and apoptosis to maintain mitochondrial biogenesis by inhibiting NFkB and cas-3 immunoexpressions and enhancing SIRT1 upregulation. Immunopharmacology and immunotoxicology 2026. link 38 Qiu Y, Bi H, Xie W, Zhao J, Zhang T, Fu J et al.. The immunometabolic axis of sepsis-related myocardial injury: macrophage reprogramming as a central mechanism and therapeutic target. Frontiers in immunology 2026. link 39 Pădureanu V, Caragea DC, Pîrșcoveanu DFV, Dop D, Munteanu AC, Rădulescu D et al.. Association Between Myocardial Dysfunction and Septic Shock. International journal of molecular sciences 2026. link 40 Yang L, Feng JK, Gong PX, Yao LN, Li P. Advances in Research Pertaining to Biomarkers for Myocardial Injury in Sepsis. Shock (Augusta, Ga.) 2026. link 41 Ren D, Liu Y, Qin Y. Effects of Human Serum Albumin Infusion on Microcirculation, Capillary Leakage, and Endothelial Function in Sepsis Patients: A Retrospective Cohort Study. Shock (Augusta, Ga.) 2026. link 42 Yu Q, Liu Z, Yu J, Ma H, Wang Y, Yang F et al.. Cordycepin alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial oxidative stress and apoptosis through modulation of the PI3K/Akt/mTOR pathway. Cellular signalling 2026. link 43 Paraschiv C, Popescu Moraru MR, Paduraru LF, Palcau CA, Popescu AC, Balanescu SM. Current challenges in understanding, diagnosing and managing sepsis-induced cardiac dysfunction. Journal of critical care 2026. link 44 Turcato G, Zaboli A, Filippi L, Ferretto P, Bresolin A, Lucente F et al.. Thrombosis, bleeding, and mortality in patients with sepsis-induced coagulopathy: Analysis of a prospective cohort. Thrombosis research 2026. link 45 Shangzu Z, Qiyang L, Zhiyun P, Yunan S, Xinbang L, Yan C et al.. Sepsis-induced cardiomyopathy: A comprehensive review of pathogenic mechanism and therapeutic strategies. Ageing research reviews 2026. link 46 Wang W, Wang Z, Wang F, Li Y, Zhou H, Pu Y et al.. Exosomes from young healthy human plasma ameliorate sepsis-induced cardiomyopathy by inhibiting ferroptosis via the miR-3130-3p/LPCAT3 axis. Free radical biology & medicine 2026. link 47 Sun X, Geng S, Wang Z, Chen Q. Autophagy-driven CCL7+ monocyte terminal differentiation program fuels CD8+ T cell-mediated cardiac injury in Sepsis. International immunopharmacology 2026. link 48 Ruan H, Shen XY, Liu SY, Li SS. Role of vascular smooth muscle cell pathobiology in sepsis‑induced vasoplegia (Review). International journal of molecular medicine 2026. link 49 Pei MQ, Zeng YF, Yang YS, Fang YM, Lin S, Liang JW et al.. Interferon regulatory factor 1 promotes pyroptosis and inflammation in mouse sepsis-induced cardiomyopathy. Cellular signalling 2026. link 50 Chen L, Wu W, Chen Y, Tong M, Ren B, Zhang K. The effect of dexmedetomidine in mechanically ventilated patients with sepsis and septic shock: a meta-analysis of randomized controlled trials. Annals of medicine 2026. link 51 Ghazal M, Shaikh S, Daniel Z, Daghstani O, Musumeci J, Gajjala A et al.. Acute left ventricular ejection fraction changes in Sepsis: Clinical predictors, management, and hospital outcomes. Heart & lung : the journal of critical care 2026. link 52 Yang Y, Wu J, Xu Y, Qi H, Yang Y, Liu F et al.. Characteristics associated with left ventricular diastolic dysfunction and its prognostic implication in patients with sepsis: a prospective cohort study. Journal of anesthesia 2026. link 53 Nan W, Jiang X, Cai X, Chen Y, Peng Z. 14,15-EET mitigates sepsis-induced cardiomyopathy by inhibiting cardiomyocyte ferroptosis via PPARα activation. European journal of pharmacology 2026. link 54 Zheng C, Gao Y, Wei X, Huang X, Wu D, Tian J. MiR-133a encapsulated in hyaluronic acid nanoparticles alleviates sepsis-induced cardiomyopathy by decreasing M1 macrophage polarization via the SOCS3/JAK/STAT3 pathway. Archives of biochemistry and biophysics 2026. link 55 Ishigami J, Hu X, Schlosser P, Austin TR, Chen J, Psaty BM et al.. Proteomics Analysis of Plasma for Risk of Sepsis: Findings from the Atherosclerosis Risk in Communities Study. The journal of applied laboratory medicine 2026. link 56 Yang X, Zhu G, Li M, Zhan H, Wang F. Deficiency of zinc finger protein 36 exacerbates sepsis-induced cardiomyopathy by activating ferroptosis. European journal of pharmacology 2026. link 57 Cao F, Yan T, Liang C, Liu A, Wang J. Sepsis-induced cardiomyopathy: mechanisms, epidemiology, diagnosis, and treatments. Frontiers in immunology 2026. link 58 Alamami A, Rahhal A, Tawel R, Barakat M, Abdelghani MS, Elbuzidi A et al.. Venoarterial Extracorporeal MembraneOxygenation in Septic Shock and/or Sepsis-induced Cardiomyopathy: A Systematic Review of Fifteen Studies. Journal of cardiothoracic and vascular anesthesia 2026. link 59 Tang F, Liu D, Zhu SC, Zhou HM, Qiu XW. Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review). International journal of molecular medicine 2026. link 60 Wetterberg H, Nilsson A, Linder A, Lengquist M, Frigyesi A, Sundén-Cullberg J et al.. The risk of cardiovascular events following community-acquired sepsis: a nationwide cohort study in Sweden. Epidemiology and infection 2026. link 61 Tian M, Shi Y, Gong X, Tan W, Guo X, Chen Y et al.. MG53 protects against septic cardiac dysfunction by ubiquitinating ATF2. Journal of advanced research 2026. link 62 Chen Y, Zhang Z, Zhou G. Advances in the mechanisms of the NLRP3 inflammasome in sepsis‑induced cardiomyopathy and targeted therapeutic studies (Review). Molecular medicine reports 2026. link 63 Siang W, Guoyun W, Yan F, Wenji L. Mettl1 mitigates sepsis-induced cardiomyopathy via inhibition of FDX1-dependent cuproptosis. Gene 2026. link 64 Zhou S, Liu D, Zong H, Nie K, Yan S, Chen Y et al.. Integrative transcriptomic analysis reveals alternative splicing programs in sepsis-induced myocardial injury across dual mouse models. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026. link 65 Xiao Q, Liu T, Zhang X, Sun Z. Albumin-corrected anion gap and short-term mortality in patients with sepsis and heart failure: A retrospective cohort study. Medicine 2026. link 66 Brunkhorst FM, Adamzik M, Axer H, Bauer M, Bode C, Bone HG et al.. [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025]. Medizinische Klinik, Intensivmedizin und Notfallmedizin 2025. link 67 Zhang L, Srisawat N, Lee CC, Lee DH, Lee K, Liu Z et al.. Extracorporeal Blood Purification with the oXiris® Filter for Patients with Sepsis and Hyperinflammatory Conditions: The Asia-Pacific oXiris Expert Meeting 2024 Consensus Statements. Blood purification 2025. link 68 Yamakawa K, Okamoto K, Seki Y, Ikezoe T, Ito T, Iba T et al.. Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 1: sepsis. International journal of hematology 2025. link 69 Ward MA, Kuttab HI, Badgett RG. The Effect of Early Fluid Resuscitation on Mortality in Sepsis: A Systematic Review and Meta-Analysis. Critical care medicine 2025. link 70 Chuang CL, Yeh HT, Niu KY, Chen CB, Seak CJ, Yen CC. Diagnostic performances of procalcitonin and C-reactive protein for sepsis: a systematic review and meta-analysis. European journal of emergency medicine : official journal of the European Society for Emergency Medicine 2025. link 71 Sato R, Messina S, Hasegawa D, Santonocito C, Scimonello G, Sanfilippo G et al.. Mortality in Patients With Sepsis Treated With Esmolol or Landiolol: A Systematic Review and Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis. Chest 2025. link 72 Scicluna BP, Cano-Gamez K, Burnham KL, Davenport EE, Moore AR, Khan S et al.. A consensus blood transcriptomic framework for sepsis. Nature medicine 2025. link 73 Soni P, Matoria R, Nagalli MM. Antibiotic strategies for neonatal sepsis: navigating efficacy and emerging resistance patterns. European journal of pediatrics 2025. link 74 Cao S, Han P. The Effect of Ulinastatin on Sepsis Outcomes: An Umbrella Review of Meta-Analysis. Clinical therapeutics 2025. link 75 Pădureanu V. Special Issue "Molecular Mechanisms and Pathophysiology of Sepsis". International journal of molecular sciences 2025. link 76 Reisdorf C, Zonfrillo MR, Duffy SJ, Sojar SH. Community Emergency Medicine Clinicians' Pediatric Sepsis Readiness. Rhode Island medical journal (2013) 2025. link 77 Long B, Gottlieb M. Emergency medicine updates: Evaluation and diagnosis of sepsis and septic shock. The American journal of emergency medicine 2025. link 78 Bolanaki M, Kurland L, Brabrand M, Daniels R, Govender K, Hanses F et al.. Current sepsis management practices in European emergency departments: the ISG-emergency department European Survey. European journal of emergency medicine : official journal of the European Society for Emergency Medicine 2025. link 79 Long B, Gottlieb M. Emergency medicine updates: Management of sepsis and septic shock. The American journal of emergency medicine 2025. link 80 Malhotra L, Stephen AH, Goosman M, Aluisio AR, Arafeh M, Adams CA et al.. Extra-abdominal CT imaging indicates increased severity of illness in advanced age patients requiring emergency abdominal surgery. American journal of surgery 2025. link 81 Ghali MS, Hasan SA, Al-Qudimat AR, Alabidi M, Moustafa OS, Al-Zoubi RM. Validation of the emergency surgery score's predictive accuracy for postoperative outcomes and ICU admissions in MENA vs. non-MENA emergency surgery patients. European journal of trauma and emergency surgery : official publication of the European Trauma Society 2025. link 82 Marra A, Smith RJ, Pandharipande PP, Hayhurst CJ. Optimal Sedation in Ventilated Patients with Sepsis and Septic Shock. Critical care clinics 2025. link 83 Chlorogiannis DD, Epelboym Y. Sepsis and Common Infections in Interventional Radiology. Techniques in vascular and interventional radiology 2025. link 84 Aksoy M, İlerler EE, Karakurt S, Sancar M. Clinical pharmacist-led medication review in patients with sepsis and septic shock in the intensive care unit: a non-randomized controlled study. BMC health services research 2025. link 85 Chen L, Zhang X, Shi P. Recent advances in biomarkers for detection and diagnosis of sepsis and organ dysfunction: a comprehensive review. European journal of medical research 2025. link 86 Li Y, Ren S, Zhou S. Advances in sepsis research: Insights into signaling pathways, organ failure, and emerging intervention strategies. Experimental and molecular pathology 2025. link 87 Yang T, Xu X, An J, Li B, Dou Z. Mesenchymal stem cells in sepsis-induced organ dysfunction: mechanisms and therapeutic potential. Stem cell research & therapy 2025. link 88 Jariyasakoolroj T, Chattipakorn SC, Chattipakorn N. Potential biomarkers used for risk estimation of pediatric sepsis-associated organ dysfunction and immune dysregulation. Pediatric research 2025. link 89 Yang N, Jiang N, Shen C, Gao M, Tong Q, Sun J. Protective effect of exercise on animals with sepsis: a systematic review of the existing literature. BMC infectious diseases 2025. link 90 Wu Y, Guo H, Huang H, Ouyang Y, Yao R, Ming Y et al.. The application of therapeutic plasma exchange in sepsis and septic shock: A narrative review. Science progress 2025. link 91 Udayakumara H, Stewart-Parker E, Shattarah O, Hubbard JG. Unexpected sepsis due to Group A beta haemolytic . BMJ case reports 2025. link 92 Wu X, Ma S, Wang C, Xu Z, Ma N. Effect of Ulinastatin Combined With High-Volume Hemofiltration on Inflammatory Response and MODS Incidence in Severe Sepsis. Journal of applied toxicology : JAT 2025. link 93 Forsberg F, Ruge T, Larsson A, Wändell P, Carlsson AC, Nilsson PM et al.. Angiotensin converting enzyme 2 in patients with sepsis associate with comorbidities but neither with mortality nor with organ failure. Scientific reports 2025. link 94 Li X, Wu F, Yu D, Su X, Wang K, Huang Z et al.. Archaea-inspired deoxyribonuclease I liposomes prevent multiple organ dysfunction in sepsis. Journal of controlled release : official journal of the Controlled Release Society 2025. link 95 Fan Y, Meng S, Song Y, Zhang Y, Song Y, Chen Z et al.. Interaction, diagnosis, and treatment of lung microbiota-NLRP3 inflammasome-target organ axis in sepsis. International immunopharmacology 2025. link 96 Yazar H, Çeliker S, Tuğrul HC, Atay G, Erdoğan S. Evaluation of patients undergoing therapeutic plasma exchange in the pediatric intensive care unit and determining the factors affecting prognosis. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 2025. link 97 Stephens MA, Silin N, Dakkak T, Sathian S, Ghosh AK, Singh H et al.. Capnocytophaga canimorsus from Dog Saliva Exposure Causing Severe Sepsis in a Healthy Adult: A Case Report. The American journal of case reports 2025. link 98 Elmi AN, Kwo PY. The Liver in Sepsis. Clinics in liver disease 2025. link 99 Liu Y, Wei Z, Liu W, Hao H, Ba T, Zhang S et al.. Sepsis related multi-organ dysfunction: a global perspective on lung and gastrointestinal mortality and management framework. BMC infectious diseases 2025. link 100 Singh H, Naik M, Suri M, Hanifa M, Jaggi AS, Bali A. Calcitonin gene-related peptide (CGRP): A potential therapeutic target against sepsis and sepsis-associated multiple organ failure. Biochemical pharmacology 2025. link

Original source

[1]
Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026. — Weiss SL, Peters MJ, Oczkowski SJW, Belley-Cote E, Buysse C, Choong KLM et al. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies (2026)
[2]
Recommendations of the GT-LATINFURG for the identification and initial management of patients with severe infection and sepsis in emergency departments. — Julián-Jiménez A, Eduardo García D, Del Castillo JG, Escalante-Kanashiro R, Candel González FJ, Merinos-Sánchez G et al. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias (2026)
[3]
Early peripheral vasopressor use is feasible and safe in sepsis-induced hypotension. — Rosenberg K The American journal of nursing (2026)
[4]
Age-related trade-offs: When protection becomes pathology. — Quin C Cell host & microbe (2026)
[5]
Quality improvement project to improve blood culture volumes in haematology patients. — Yuen Yue Candice C, Ee TY, Ning T, Dorothy NHL, Anson WHM, Yvonne CFZ et al. BMJ open quality (2026)
[6]
Perspectives on the Phoenix Sepsis Criteria for the Emergency Medicine Practitioner. — Georgette N, Sheehan M, Kissoon N Pediatric emergency care (2026)
[7]
Fresh frozen plasma transfusion within 24 h of admission associated with 28-day mortality of pediatric patients with sepsis: A single-center retrospective cohort study. — Ling D, Ping C, Hongbing H Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (2026)
[8]
Effect of fluoxetine on organ dysfunction and mortality in severe sepsis. — Taher IAA, Eldin FK, Eissa MAW, Saleh LA, Mohammed OA, Doghish AS et al. PloS one (2026)
[9]
Advanced Age in Mice Exacerbates Sepsis-Induced Inflammation, Vascular Permeability, and Multi-Organ Dysfunction. — Lee HNR, Lin J, Smith CJ, Ware LB, Harrison FE, Bastarache JA et al. Shock (Augusta, Ga.) (2026)
[10]
The "cytokine storm" in infection and sepsis: win the battle but lose the war. — Fan JB, Li QY, Feng XF, Huang SY, Wang R, Liao FY et al. Military Medical Research (2026)
[11]
Longitudinal SOFA score trajectories and risk stratification in ICU patients with — Chen H, Fan Y, Hu R, Yu Q, Yu J, Zhang X et al. Frontiers in cellular and infection microbiology (2026)
[12]
Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial. — Giamarellos-Bourboulis EJ, Kotsaki A, Kotsamidi I, Efthymiou A, Koutsoukou V, Ehler J et al. JAMA (2026)
[13]
Neutrophil Extracellular Traps and DNase Activity in Sepsis: Associations with Coagulopathy and Organ Dysfunction. — Munekata Y, Hayakawa M, Shinkai A, Ito T Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (2026)
[14]
Clinical Applications of Polymyxin B Hemadsorption in Sepsis and Septic Shock. — Ferrari F, Longhitano Y, Voza A, Fumagalli J, Savioli G, Zanza C et al. Journal of intensive care medicine (2026)
[15]
Relationship Between IL6/IL10 Serum Concentrations and Organ Function in Critically Ill Patients Based on Sepsis: A Prospective Study. — Wang GJ, Lian H, Zhang HM, Liu YC, Wang XT Immunity, inflammation and disease (2026)
[16]
Baseline Serum Vitamin C Levels in Pediatric Sepsis: Hazard of Mortality and Organ Dysfunction in a Single-Center Prospective Cohort. — Cui W, Wang S, Dai C, Jin D, He J, Sheng Y et al. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies (2026)
[17]
Emerging trends and disparities in mortality due to coexisting atrial fibrillation and sepsis: A US nationwide observational study (1999-2023). — Ali M, Naseer Ahmad R, Hassan M, Hashmi MUH, Kiyani M, Zia A et al. Medicine (2026)
[18]
Endotheliopathy within the thromboinflammatory network of sepsis-induced coagulopathy. — Iba T, Maier CL, Ferrer R, Nagakari K, Levy JH Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2026)
[19]
Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Induced Cardiomyopathy. — Wang Y, Yuan Q Clinical and experimental pharmacology & physiology (2026)
[20]
Nsun2-mediated m5C methylation of Ncor1 exacerbates sepsis-induced cardiomyopathy by promoting mitochondrial dysfunction. — Chen C, Liu Q, Xu J, Zi M, Chen X, Xiao F Free radical biology & medicine (2026)
[21]
DNMT1 knockdown mitigates sepsis-induced myocardial dysfunction by preventing TFAM-mediated mitochondrial DNA cytosolic escape and subsequent cGAS-STING to regulate macrophage M2 polarization. — Li M, Liu Y, Qu K, Zhang Y, Yang H Biochemical pharmacology (2026)
[22]
The effect of milrinone on short- and mid-term outcomes in patients with sepsis-related myocardial injury: A propensity score matched retrospective study. — Yuan Z, She T, Wu Z, Li Q Heart & lung : the journal of critical care (2026)
[23]
NRF2/miR-17-5p/TMEM16F axis regulates the crosstalk of inflammation and thrombosis in sepsis. — Yan M, Liu Q, An Y, Dong H, Han X, Li Z et al. Journal of thrombosis and haemostasis : JTH (2026)
[24]
Integrated bioinformatics analysis reveals cross-talking hub genes and therapeutic agents between sepsis and acute myocardial infarction. — Zhou L, Chen W, Li J, Chen M Annals of medicine (2026)
[25]
Microvesicle release drives cycles of mitophagy flux disruption and inflammatory amplification in sepsis-induced myocardial dysfunction. — Song R, Ma Y, Wan J, Hao S, Chen B, Liao Y et al. Proceedings of the National Academy of Sciences of the United States of America (2026)
[26]
Pathogen detection and analysis in patients with sepsis complicated with new- onset atrial fibrillation: a retrospective observational study. — Yang AL, Li L, Zhang ZH, Li XX, You XX, Sun J Heart & lung : the journal of critical care (2026)
[27]
The combination of paeoniflorin and hydroxysafflor yellow A alleviated pulmonary thrombosis by inhibiting platelet-neutrophil interaction via the P-selectin-PSGL-1 signaling axis. — Shang T, Zhang Y, Pan T, Shen R, Chang J, Zhang ZS et al. Phytomedicine : international journal of phytotherapy and phytopharmacology (2026)
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