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Psychiatry20 papers

Inflammation of pancreas caused by alcohol

Last edited: 4/10/2026

Overview

Alcohol use disorder (AUD) is associated with elevated levels of certain inflammatory cytokines in the blood 1. While alcohol is linked to inflammatory diseases, the specific role of neuroimmune signaling in AUD development and severity requires further study 1.

Diagnosis

Management

Special Populations

Key Recommendations

  • Individuals with alcohol use disorder (AUD) have significantly higher concentrations of interleukin-6 (IL-6) compared to healthy controls 1. (Evidence: Moderate)
  • Other inflammatory cytokines, including tumor necrosis factor (TNF)-a, IL-1, IL-1RA, IL-2, IL-4, IL-5, IL-7, IL-8, IL-10, IL-13, IL15, interferon (IFN)-g, and sCD14, were not found to be significantly altered in individuals with AUD compared to healthy controls in a meta-analysis 1. (Evidence: Moderate)
  • Methodological heterogeneity, small study numbers, and confounding factors such as active use, abstinence, quantity of alcohol consumed, and co-occurring physical or psychiatric illnesses may explain variations in cytokine findings 1. (Evidence: Expert opinion)

    • References

    1 Moura HF, Hansen F, Galland F, Silvelo D, Rebelatto FP, Ornell F et al.. Inflammatory cytokines and alcohol use disorder: systematic review and meta-analysis. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 2022. link 2 Wei J, Zhu J, Xu H, Zhou D, Elder JT, Tsoi LC et al.. Alcohol consumption and smoking in relation to psoriasis: a Mendelian randomization study. The British journal of dermatology 2022. link

    Original source

    1. [1]
      Inflammatory cytokines and alcohol use disorder: systematic review and meta-analysis. — Moura HF, Hansen F, Galland F, Silvelo D, Rebelatto FP, Ornell F et al. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) (2022)
    2. [2]
      Alcohol consumption and smoking in relation to psoriasis: a Mendelian randomization study. — Wei J, Zhu J, Xu H, Zhou D, Elder JT, Tsoi LC et al. The British journal of dermatology (2022)
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