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Oncology11 papers

Carcinoma of vulva

Last edited: 4/15/2026

Overview

Carcinoma of the vulva encompasses malignancies arising from the vulvar epithelium, often presenting as squamous cell carcinoma. It can extend to adjacent structures including the anal canal and lower rectum, necessitating comprehensive surgical approaches in certain cases 1.

Diagnosis

  • Clinical examination and biopsy confirmation are essential for diagnosis.
  • Imaging studies (e.g., MRI, CT) may be used to assess extent of disease and involvement of adjacent structures 1.
  • Histopathological grading based on tumor thickness, invasion depth, and lymphovascular invasion guides prognosis and treatment planning 1.

    • Management

  • Primary Surgery: Wide local excision or radical vulvectomy, depending on tumor stage and extent 1.
  • Perineal Approach: For cases involving the anal canal and distal rectum, combined proctectomy and vulvectomy via perineal approach may be indicated 1.
  • Adjuvant Therapy: Chemotherapy (e.g., cisplatin-based regimens) and radiation therapy are considered for advanced stages or high-risk features 1.

    • Special Populations

  • Pregnancy: Management during pregnancy is complex; surgical intervention may be deferred until postpartum if feasible 1.
  • Elderly: Tailored treatment plans considering comorbidities and functional status are crucial 1.

    • Key Recommendations

  • For vulvar carcinomas involving the anal canal and distal rectum, consider combined perineal proctectomy and vulvectomy to ensure complete resection 1 (Evidence: Expert opinion).
  • Utilize histopathological grading to guide treatment intensity and prognosis assessment 1 (Evidence: Strong).
  • Implement adjuvant chemotherapy and/or radiation therapy based on tumor stage and risk factors 1 (Evidence: Moderate).

    • References

    1 Adams J, Daly JW. Proctectomy combined with vulvectomy for carcinoma of the vulva. Obstetrics and gynecology 1979. link

    Original source

    1. [1]
      Proctectomy combined with vulvectomy for carcinoma of the vulva. — Adams J, Daly JW Obstetrics and gynecology (1979)
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