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Cardiology73 papers

Thrombosis of aortic valve

Last edited: 4/15/2026

Overview

Native aortic valve thrombosis is a rare condition characterized by clot formation on the aortic valve, often presenting with acute cardiovascular symptoms such as myocardial infarction and frequently associated with hypercoagulable states 1.

Diagnosis

  • Clinical Presentation: Commonly presents with myocardial infarction (36%) 1.
  • Diagnostic Imaging: Echocardiography is crucial for visualization of thrombus 1.
  • Additional Tests: Doppler ultrasound and CT angiography can confirm thrombosis and extent 12.
  • Etiology Assessment: Evaluate for hypercoagulable states through laboratory tests (e.g., coagulation profiles) 1.
  • Management

  • Revascularization: Immediate surgical intervention (e.g., thrombo-endoarterectomy) for acute cases 2.
  • Anticoagulation: Initiate anticoagulation therapy post-operatively, considering specific agents based on underlying hypercoagulability 1.
  • Cardiac Support: Manage complications with appropriate cardiac support measures 1.
  • Special Populations

  • Elderly: Higher risk due to increased prevalence of comorbidities and hypercoagulable states 1.
  • Comorbidities: Patients with atrial fibrillation or other hypercoagulable conditions require vigilant monitoring and management 12.
  • Key Recommendations

  • Prompt Imaging and Diagnosis: Utilize echocardiography and imaging modalities to confirm aortic valve thrombosis (Evidence: Moderate) 12.
  • Surgical Intervention for Acute Cases: Consider immediate surgical revascularization for acute thrombosis to prevent fatal outcomes (Evidence: Weak) 2.
  • Anticoagulation Therapy: Initiate appropriate anticoagulation post-surgery based on underlying causes (Evidence: Expert opinion) 1.
  • References

    1 Alajaji W, Hornick JM, Malek E, Klein AL. The Characteristics and Outcomes of Native Aortic Valve Thrombosis: A Systematic Review. Journal of the American College of Cardiology 2021. link 2 Riccioni G, Bucciarelli V, Bisceglia N, Totaro G, Scotti L, Aceto A et al.. Acute abdominal aortic thrombosis caused by paroxysmal atrial fibrillation. Journal of biological regulators and homeostatic agents 2013. link

    Original source

    1. [1]
      The Characteristics and Outcomes of Native Aortic Valve Thrombosis: A Systematic Review.Alajaji W, Hornick JM, Malek E, Klein AL Journal of the American College of Cardiology (2021)
    2. [2]
      Acute abdominal aortic thrombosis caused by paroxysmal atrial fibrillation.Riccioni G, Bucciarelli V, Bisceglia N, Totaro G, Scotti L, Aceto A et al. Journal of biological regulators and homeostatic agents (2013)

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