Clinical Presentation
No adverse effects were noted in the mother despite moderately severe deficiency of methionine adenosyltransferase I/III activity [PMID:14518826].
Diagnosis
Plasma methionine concentrations remained consistently elevated at 300-350 micromol/L throughout the pregnancies in a woman with MAT I/III deficiency [PMID:14518826].
Management
It was suggested that the patient ingest two eggs daily from gestation week 17, which tended to raise plasma choline and phosphatidylcholine levels [PMID:14518826].
References
1 Mudd SH, Tangerman A, Stabler SP, Allen RH, Wagner C, Zeisel SH et al.. Maternal methionine adenosyltransferase I/III deficiency: reproductive outcomes in a woman with four pregnancies. Journal of inherited metabolic disease 2003. link
1 papers cited of 5 indexed.