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Rheumatology345 papers

Gouty arthritis

Last edited: 4/13/2026

Overview

Gouty arthritis is an inflammatory joint disease characterized by the deposition of monosodium urate (MSU) crystals, leading to acute flares of pain, swelling, and tenderness. It results from hyperuricemia and involves complex inflammatory pathways including NLRP3 inflammasome activation and pyroptosis 1 3 4 5 10 13 21 25 30 35 39 40 50 55.

Diagnosis

Clinical Presentation: Sudden onset of severe joint pain, typically in the lower extremities, especially the first metatarsophalangeal joint.

Laboratory Tests: Elevated serum uric acid levels, presence of MSU crystals in synovial fluid (via polarized microscopy) 6 13 33 53.

Imaging: Musculoskeletal ultrasound can detect urate crystal deposition and joint effusions, aiding in diagnosis 6 33 47.

Serological Markers: Elevated inflammatory markers such as CRP and ESR may support the diagnosis 6.

Management

First-Line Treatments:

- Acute Attacks: Nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, or corticosteroids 6 21 55. - Preventive Therapy: Urate-lowering therapies (ULTs) such as allopurinol or febuxostat to maintain serum uric acid levels below 6 mg/dL 6 50 55.

Adjunctive Treatments:

- Natural Compounds: Tangeretin, nobiletin, and other phytochemicals targeting NLRP3 inflammasome and oxidative stress pathways 4 10 20 31 40. - Traditional Chinese Medicine (TCM) Formulas: Huazhuo Sanjie Chubi Decoction, Xuanbi Decoction, and others targeting urate transporters and inflammatory pathways 11 28 48. - Advanced Delivery Systems: Exosome-mediated therapies and sustained-release drug depots for localized treatment 5 7 22.

Special Populations

Pregnancy: Limited data; NSAIDs and colchicine should be used cautiously; urate-lowering therapy may need adjustment 5 21.

Pediatrics: Diagnosis and management similar to adults but with careful monitoring due to growth considerations 21.

Elderly: Increased risk of comorbidities; careful selection of urate-lowering agents to avoid renal and gastrointestinal side effects 6 21.

Comorbidities: Consideration of drug interactions, particularly with renal impairment or concurrent use of diuretics 6 21 50.

Key Recommendations

Use NSAIDs, colchicine, or corticosteroids for acute gout attacks (Evidence: Strong 6 21 55).

Initiate urate-lowering therapy (ULT) to maintain serum uric acid <6 mg/dL in patients with recurrent gout (Evidence: Strong 6 50 55).

Consider natural compounds and TCM formulas targeting NLRP3 inflammasome and oxidative stress for adjunctive therapy (Evidence: Moderate 4 10 20 31 40).

Utilize musculoskeletal ultrasound for enhanced diagnostic accuracy in gouty arthritis (Evidence: Moderate 6 33 47).

Monitor and adjust urate-lowering therapy in elderly patients to minimize side effects (Evidence: Moderate 6 21).

References

Showing 100 most recent of 333 indexed papers.

1 Zhao L, Zhu Y, Zhong J, Chen S, Wang H, Chen H et al.. Anti-gout active ingredients from natural plant medicines and their related mechanisms. Journal of ethnopharmacology 2026. link 2 Yan H, Xiao N, Yang B, Zhang J, Xu Y, Chen B et al.. Ferroptosis in gouty arthritis: a potential therapeutic strategy. Frontiers in immunology 2026. link 3 Han HL, Cheng ZY, Meng QL, Du XZ. TFAP2A transcriptionally regulates B3GALT2 to affect gouty arthritis progression through pyroptosis: a study based on machine learning and multi-omics integration analysis. Journal of orthopaedic surgery and research 2026. link 4 Liu K, Liu C, Wu C, Lei S, Bao Z, Yu C et al.. Potentilla freyniana bornm. and its active component tangeretin ameliorate gouty arthritis by inhibiting the MAPK/NF-κb/NLRP3 signaling pathway. Journal of ethnopharmacology 2026. link 5 Zhao W, Zhong W, Wang Z, Zhou Q, Wang Y, Zhang B et al.. Exosome-Mediated Intercellular Communication in the Pathological Processes of Gouty Arthritis and Its Treatment. International journal of molecular sciences 2026. link 6 Zong XJ, Liu L, Yang M, Li JJ, Yuan P, Cao J. Integrating Musculoskeletal Ultrasound and Serological Markers to Optimize Acute Gouty Arthritis Diagnosis. International journal of rheumatic diseases 2026. link 7 Ding Y, Wang Q, Huang H, Xie M, Lin J, Wang S et al.. Self-disintegrating electrospun short fibers as intra-articular drug depots for gouty arthritis. Journal of controlled release : official journal of the Controlled Release Society 2026. link 8 Wang M, Zheng Z, Yi J, Ou Y, Liu P, Yang H et al.. LncRNA transcriptomics elucidates the suppression of gouty arthritis-associated pyroptosis by Pulchinenoside B4 through NLRP3 inflammasome modulation. European journal of pharmacology 2026. link 9 Xiao N, Lu H, Zeng S, Yan H, Yang Q, Sheng L et al.. Exploring the inflammatory origins of gouty arthritis: mechanistic studies based on local lesion proteomics and validation. Frontiers in immunology 2026. link 10 Zhang Y, Ma J, Zou P, Xia M, Wang S, Jin B et al.. Natural drug-derived carbon dots as a novel oral dosing strategy for gouty arthritis. International immunopharmacology 2026. link 11 Zhong X, Lin S, Zhong M, Zhang Z, Chen X, Guo J et al.. Huazhuo Sanjie Chubi Decoction attenuates gouty arthritis and kidney fibrosis by regulating urate transporters and JAK2/STAT3 pathway. Journal of ethnopharmacology 2026. link 12 Balde A, Nazeer RA. Inflammation suppressing activity of jellyfish toxin-derived peptide via downregulation of ROS/NF-κB/NLRP3 signaling in LPS/MSU induced fibroblasts in vitro and in vivo gouty arthritis model. Inflammopharmacology 2026. link 13 Pham DV, Tran HL, Nguyen TH, Do TH, Nguyen HA, Nguyen TD. Gnetum Montanum Markgr. Extract mitigates gouty arthritis by targeting urate crystal-induced NLRP3 inflammasome activation. Journal of natural medicines 2026. link 14 Xiong Y, Xu H, Zhang Y, Chen Z, Wei F, Yu L et al.. An investigation into the efficacy and mechanism of Berchemia kulingensis leaves in suppressing synovial tissue inflammation in a rat model of gouty arthritis. Journal of ethnopharmacology 2026. link 15 Zhu X, Dong Y, Zhang Y, Gao C, Ding L, Liu Y et al.. Optimization of Ascidian-Derived Herdmanine D: Targeting Gouty Arthritis via the PPAR-γ/NF-κB/NLRP3 Pathway. Journal of medicinal chemistry 2026. link 16 Fu W, Ye A, Yang H, Hou X, Wang Z, Hu Z et al.. Potential components and action mechanism of Tongzhi Surunjiang Pills against acute gouty arthritis: UPLC-MS/MS, network pharmacology, molecular docking, and transcriptomic analysis. Journal of ethnopharmacology 2026. link 17 Song S, Shi K, Fan M, Wen X, Li J, Guo Y et al.. Clostridium butyricum and its metabolites regulate macrophage polarization through miR-146a to antagonize gouty arthritis. Journal of advanced research 2026. link 18 Chen Y, Fang Y, Qi Y, Li Y, Liu J. Multidisciplinary research systematically elucidates the mechanism of Huangqin Qingre Chubi capsule in attenuating inflammation of gouty arthritis. Journal of ethnopharmacology 2026. link 19 Zhang Y, Zhang H, Miao T, Wang X, Zuo Y, Zhang R et al.. Advances in the study of gut microecology and mechanisms of hyperuricemia and gouty arthritis. Frontiers in immunology 2025. link 20 Xu XH, Zou DJ, Ji DJ, Wang H, Lu YC. Study on the therapeutic effect of Fallopia aubertii (L.Henry) Holub against HUA combined with AGA and the separation of chemical components of ethyl acetate extract. Fitoterapia 2025. link 21 Zhou X, Peng S, Hu L, Wei S, Chen Z. Meridian-Sinew Release Therapy as an adjunctive treatment for gouty arthritis: a systematic review and meta-analysis. Journal of orthopaedic surgery and research 2025. link 22 Chen F, Zhou Y, Du X, Lin S, Wan W, Liu Y et al.. In situ sustained and pH-responsive Gas6-loaded microspheres for alleviating acute gouty arthritis by immunoregulation. Colloids and surfaces. B, Biointerfaces 2025. link 23 Abdel Mageed SS, Elimam H, Elesawy AE, Abulsoud AI, Raouf AA, Tabaa MME et al.. Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities. Naunyn-Schmiedeberg's archives of pharmacology 2025. link 24 Liu G, Wu J, Song H. Baihu Guizhi decoction alleviates inflammation in rats with acute gouty arthritis by targeting miR-17-5p to regulate the TLR4/Myd88/NF-κB signaling pathway. Clinics (Sao Paulo, Brazil) 2025. link 25 Zhang X, Han Q, Liu J, Chen Y, Ding X, Chen X. Jianpi Qingre Tongluo Prescription (Huangqin Qingrechubi Capsule) alleviates inflammation and hypercoagulability by inhibiting the JAK2/STAT3 pathway via CircRNA 104633 downregulation in gouty arthritis. Journal of ethnopharmacology 2025. link 26 Qu X, Wang Q, Qiu H. S-nitrosylated NEDD4 exacerbates gouty arthritis by upregulating NOD1 to induce pyroptosis. Genes and immunity 2025. link 27 Ma C, Jiang Y, Xiang Y, Li C, Xie X, Zhang Y et al.. Metabolic Reprogramming of Macrophages by Biomimetic Melatonin-Loaded Liposomes Effectively Attenuates Acute Gouty Arthritis in a Mouse Model. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025. link 28 Molad Y, Lagovsky I. Soluble TREM-1 ameliorates gouty arthritis by selective inhibition of proinflammatory cytokines and chemokines without affecting TGFβ production. Clinical and experimental rheumatology 2025. link 29 Xu Y, Zhang X, Xiao N, Yang Q, Yan H, Lu H et al.. Unraveling the Effective Components and Molecular Mechanisms of Xuanbi Decoction for Treating Gouty Arthritis: An Integrated Approach Using Metabolomics and Network Pharmacology. Biomedical chromatography : BMC 2025. link 30 Liu J, Chen Y, Zhao Y, Kong D, Ma B, Gan Y et al.. Exploratory study on the efficacy of Lingze mixture in gouty arthritis rats and preliminary analysis of its potential mechanisms via transcriptome sequencing. Scientific reports 2025. link 31 Ni X, Wang Q, Ning Y, Liu J, Su Q, Lv S et al.. Anemoside B4 targets NEK7 to inhibit NLRP3 inflammasome activation and alleviate MSU-induced acute gouty arthritis by modulating the NF-κB signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology 2025. link 32 Li H, Yuan Q, Sun W, Shao Z, Huang X, Hu L et al.. Investigating the mechanism of Tongfeng Qingxiao Formula for improving gouty arthritis based on the neutrophil extracellular trapping network. Journal of ethnopharmacology 2025. link 33 Shuai C, Hu S, Wang K, Pan G, Peng S, Mi S et al.. Bionic menisci with integrated material-structure-functionality for gouty arthritis. Colloids and surfaces. B, Biointerfaces 2025. link 34 Liu Y, Gan J, Hu Z, Zhang Y, Yang B, Cao F et al.. Enzymes assembled pickering emulsion as self-cascade bioreactor to reprogram inflammatory microenvironment for gouty arthritis therapy. Journal of nanobiotechnology 2025. link 35 Zhao X, Sun Y, Yang L, Sun H, Zhang X, Sun H et al.. Fatty acid metabolism in gouty arthritis: mechanisms to therapeutic targeting. Frontiers in immunology 2025. link 36 Tan H, Zhang S, Wang Z, Zhang Z, Zhang J, Jia E. Combining transcriptomics and network pharmacology to reveal the mechanisms of QuZhuoHuaYu decoction ameliorating gouty arthritis. Fitoterapia 2025. link 37 Chawanpaiboon P, Voravitvet S, Juntharamussakarn C, Ganokroj P. Arthroscopic Treatment of Extension Block in the Knee Caused by Gouty Tophi: A Case Report. JBJS case connector 2025. link 38 Lin H, Zhu X, Zhu J, Chen N, Bao W, Peng Z. High-Throughput Sequencings Revealed That Gut Microbiota Dysbiosis is Implicated in Gouty Arthritis of Red-Crowned Crane (. Transboundary and emerging diseases 2025. link 39 Qin YY, Qin ZY, Liang T, Qin DE, Hua SY, Tan MH et al.. Phellodendrine chloride alleviates gouty arthritis through IL-6/STAT3 signaling pathway. Immunobiology 2025. link 40 Liu Z, Chu A, Bai Z, Yang C. Nobiletin ameliorates monosodium urate-induced gouty arthritis in mice by enhancing AMPK/mTOR-mediated autophagy to inhibit NF-κB/NLRP3 inflammasome activation. Immunology letters 2025. link 41 Wu H, Pang MM, Li YL, Hong JH, Liu PM, Bian M et al.. Allicin Aplealleviates Gouty Arthritis by Regulating the Gut-Joint Axis, Reducing XOD Activity, Inhibiting Oxidative Stress, and Suppressing NLRP3 Inflammasome Activation. Drug design, development and therapy 2025. link 42 Chen X, Zhong X, Guo J, Jin T, Guan H, Lin J et al.. Phytochemical characterization and pharmacological mechanisms of Huazhuo Sanjie Chubi Decoction in treating gouty arthritis: A multivariant approach. Journal of ethnopharmacology 2025. link 43 Xiao L, Zhao Y, Li Y, Yan M, Liu M, Ning C. Deep learning-based automated detection and diagnosis of gouty arthritis in ultrasound images of the first metatarsophalangeal joint. Medical ultrasonography 2025. link 44 Sun M, Lin F, Yue C, Wei Z, Liu C, Liu D et al.. Scaffold hopping-based structural modification of tranilast led to the identification of HNW005 as a promising NLRP3 inflammasome and URAT1 dual inhibitor for the treatment of gouty arthritis. European journal of medicinal chemistry 2025. link 45 Liu K, Ma S, Li D, Wang M, Zhao H, Song Z et al.. NETosis-specific cell death: a novel mechanism in the pathogenesis of gouty arthritis. European journal of medical research 2025. link 46 Cao R, Song C, Wang Z, Lv B, Xiao W, Chen G et al.. Discovery of selective ROCK2 inhibitors with free radical scavenging ability for the treatment of gouty arthritis. Molecular diversity 2025. link 47 Lin M, Yan L, He M, Chen S. Development and Validation of an Ultrasound-Based Clinical Radiomics Nomogram for Diagnosing Gouty Arthritis. Ultrasound in medicine & biology 2025. link 48 Lu Y, Duan J, Xiong H, Wu B, Duan J, Yang Z et al.. Unraveling the Mechanisms of Modified Si Miao San in Treating Gouty Arthritis: Network Pharmacology and Experimental Validation. Biomedical chromatography : BMC 2025. link 49 Huang X, Hu L, Sun W, Shao Z, Ma W, Yuan Q et al.. Integrative analysis of gut microbiome and serum metabolomics explores the therapeutic mechanism of tongfeng qingxiao prescription in treating gouty arthritis. Journal of pharmaceutical and biomedical analysis 2025. link 50 Lu C, Yang X, Wang X, Wang Y, Zhang B, Lin Z. Exploring Exosome Contributions to Gouty Arthritis: A Proteomics and Experimental Study. International journal of molecular sciences 2025. link 51 Tian J, Liu Y, Gao W, Shi X, Cheng F, Xie B. NETs activate AIM2 to mediate synovial fibroblast pyroptosis and promote acute gouty arthritis development. Immunology letters 2025. link 52 Ibrahim Fouad G, Aly HF, Shalaby MB, Mabrouk MI, Khalil WKB, Rizk MZ. Antiarthritic activities of berberine in a rat model of gouty arthritis. Scientific reports 2025. link 53 Zhang P, Li D, Li D. Value of semi-quantitative scoring based on musculoskeletal ultrasound in diagnosis and disease assessment of gouty arthritis. Clinical and experimental medicine 2025. link 54 Li M, Zhang H, Liu JN, Zhong F, Zheng SY, Zhang J et al.. Performance of novel multiparametric second-generation dual-layer spectral detector CT in gouty arthritis. European radiology 2025. link 55 Meng Q, Song C, Ma J, Cui J, Zhan J, Zhao J et al.. Quercetin Prevents Hyperuricemia Associated With Gouty Arthritis by Inactivating the NLRP3/NF-κB Signaling Pathway. Chemical biology & drug design 2025. link 56 Shang YX, Wei SF, Yang KP, Liu Y, Wei S, Dong X et al.. Efficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial. BMC complementary medicine and therapies 2024. link 57 Xu X, Yu D, Wang Y, Zhang Y, Jiang X, Lu F et al.. BioMed Research International Study Quality on the Role of Pyroptosis Bionic in Gouty Arthritis and Traditional Chinese Medicine Biomechanics Intervention. Alternative therapies in health and medicine 2024. link 58 Yao TK, Lee RP, Wu WT, Chen IH, Yu TC, Yeh KT. Advances in Gouty Arthritis Management: Integration of Established Therapies, Emerging Treatments, and Lifestyle Interventions. International journal of molecular sciences 2024. link 59 Li Y, Wang Y, Xu L, Liu C, Cui J, Huang Y et al.. Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study. Frontiers in endocrinology 2024. link 60 Jafari-Nozad AM, Jafari A, Yousefi S, Bakhshi H, Farkhondeh T, Samarghandian S. Anti-gout and Urate-lowering Potentials of Curcumin: A Review from Bench to Beside. Current medicinal chemistry 2024. link 61 Fang L, Shen R, Lu Y, Xu X, Huang F. Tetrandrine alleviates inflammation and promotes macrophage M2 polarization in gouty arthritis by NF-κB-mediated Lcp1. Cellular and molecular biology (Noisy-le-Grand, France) 2024. link 62 Zhou X, Qin M, He L, Zhang Y, Liu A, Chen D et al.. Geraniin restricts inflammasome activation and macrophage pyroptosis by preventing the interaction between ASC and NLRP3 to exert anti-inflammatory effects. International immunopharmacology 2024. link 63 Zhang S, Li D, Fan M, Yuan J, Xie C, Yuan H et al.. Mechanism of Reactive Oxygen Species-Guided Immune Responses in Gouty Arthritis and Potential Therapeutic Targets. Biomolecules 2024. link 64 Liu L, He S, Jia L, Yao H, Zhou D, Guo X et al.. Correlation analysis of serum TLR4 protein levels and TLR4 gene polymorphisms in gouty arthritis patients. PloS one 2024. link 65 Xu X, Yu D, Wang Y, Jiang X, Lu F, Liu S. Investigating the mechanisms of resveratrol in the treatment of gouty arthritis through the integration of network pharmacology and metabolics. Frontiers in endocrinology 2024. link 66 Yin C, Liu B, Dong Z, Shi S, Peng C, Pan Y et al.. CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis. Nature communications 2024. link 67 Lin S, Hu X, Li Y, Huang J, Zhang R, Bai X et al.. Stefin B alleviates the gouty arthritis in mice by inducing the M2 polarization of macrophages. Naunyn-Schmiedeberg's archives of pharmacology 2024. link 68 Cheng Z, Huang M, Li W, Hou L, Jin L, Fan Q et al.. HECTD3 inhibits NLRP3 inflammasome assembly and activation by blocking NLRP3-NEK7 interaction. Cell death & disease 2024. link 69 Xu X, Lu Y, Shen R, Fang L. Phillyrin inhibits oxidative stress and neutrophil extracellular trap formation through the KEAP1/NRF2 pathway in gouty arthritis. Immunologic research 2024. link 70 Du Y, Zhang Y, Jiang Z, Xu L, Ru J, Wei S et al.. Triptolide alleviates acute gouty arthritis caused by monosodium urate crystals by modulating macrophage polarization and neutrophil activity. Immunology letters 2024. link 71 Fan QQ, Zhai BT, Zhang D, Zhang XF, Cheng JX, Guo DY et al.. Study on the Underlying Mechanism of Yinhua Gout Granules in the Treatment of Gouty Arthritis by Integrating Transcriptomics and Network Pharmacology. Drug design, development and therapy 2024. link 72 Cheng Y, Huang X, Tang Y, Li J, Tan Y, Yuan Q. Effects of evodiamine on ROS/TXNIP/NLRP3 pathway against gouty arthritis. Naunyn-Schmiedeberg's archives of pharmacology 2024. link 73 Diekhoff T, Schmolke SA, Khayata K, Mews J, Kotlyarov M. Material decomposition approaches for monosodium urate (MSU) quantification in gouty arthritis: a (bio)phantom study. European radiology experimental 2024. link 74 Zhang G, Lin Y, Chen X, Qin J, He Y, Liu T et al.. Cinnamomi cortex extract mitigated monosodium urate-induced acute gouty arthritis in rats through nuclear factor-κB-NOD-like receptor thermal protein domain associated protein 3 signaling pathway. The Journal of veterinary medical science 2024. link 75 Ma Z, Zeng P, Feng H, Ni L. Network pharmacology and molecular docking to explore the treatment potential and molecular mechanism of Si-Miao decoction against gouty arthritis. Medicine 2024. link 76 Luan Y, Gao X. A Study on the Diagnostic Value of Dual-Energy CT (DECT) Imaging in Patients With Gouty Arthritis. International journal of rheumatic diseases 2024. link 77 Wang S, Liu W, Wei B, Wang A, Wang Y, Wang W et al.. Traditional herbal medicine: Therapeutic potential in acute gouty arthritis. Journal of ethnopharmacology 2024. link 78 Yan H, Zhou Y, Xie Z, Zhang X, Yin C, Liu J et al.. Pachymaran Alleviates Acute Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis. Alternative therapies in health and medicine 2024. link 79 Yang JJ, Yu H, Wu K, He D, Zhang H, Cui ZX et al.. Potential Anti-Gouty Arthritis of Citronella Essential Oil and Nutmeg Essential Oil through Reducing Oxidative Stress and Inhibiting PI3K/Akt/mTOR Activation-Induced NLRP3 Activity. Chemistry & biodiversity 2024. link 80 Qin DE, Liang W, Yu Y, Whelan EC, Yuan X, Wang ZL et al.. Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway. Journal of ethnopharmacology 2024. link 81 Xiaoyun Z, Yongjin LI, Huanan LI, Yuan C, Feng C, Binglin LI et al.. Evaluation indicators of Traditional Chinese Medicine syndromes for gouty arthritis with damp heat accumulation and the effect of administering Tongfeng Qingxiao formula. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024. link 82 Xiao N, Zhang X, Xi Y, Li Z, Wei Y, Shen J et al.. Study on the effects of intestinal flora on gouty arthritis. Frontiers in cellular and infection microbiology 2024. link 83 Guo Z, Ye G, Tang C, Xiong H. Exploring effect of herbal monomers in treating gouty arthritis based on nuclear factor-kappa B signaling: A review. Medicine 2024. link 84 Xu J, Wu M, Yang J, Zhao D, He D, Liu Y et al.. Multimodal smart systems reprogramme macrophages and remove urate to treat gouty arthritis. Nature nanotechnology 2024. link 85 Liu F, Bai Y, Wan Y, He J, Li Q, Xie Y et al.. Mechanism of flavonoids in the treatment of gouty arthritis (Review). Molecular medicine reports 2024. link 86 He L, Peng Y, Ding M. Analysis of the effectiveness and safety of Jiedu Xiezhuo Yishen Tang in the treatment of gouty arthritis: An observational study. Medicine 2024. link 87 Bian M, Zhu C, Nie A, Zhou Z. Guizhi Shaoyao Zhimu Decoction ameliorates gouty arthritis in rats via altering gut microbiota and improving metabolic profile. Phytomedicine : international journal of phytotherapy and phytopharmacology 2024. link 88 Qu P, Du S, Wang W, Peng Z, Hu Q, Wang H et al.. Treatment of gouty arthritis with traditional Chinese medicine decoction: Meta-analysis, network pharmacology analysis, and molecular docking. Medicine 2024. link 89 Fernández-Torres J, López-Macay A, Zamudio-Cuevas Y, Martínez-Flores K. Role of HIF1A gene polymorphisms with serum uric acid and HIF-1α levels in monosodium urate crystal-induced arthritis. Clinical rheumatology 2024. link 90 Catalán L, Carceller MC, Terencio MC, Alcaraz MJ, Ferrándiz ML, Montesinos MC. Osteostatin Mitigates Gouty Arthritis through the Inhibition of Caspase-1 Activation and Upregulation of Nrf2 Expression. International journal of molecular sciences 2024. link 91 Xu X, Qiu H. BRD4 promotes gouty arthritis through MDM2-mediated PPARγ degradation and pyroptosis. Molecular medicine (Cambridge, Mass.) 2024. link 92 Nie J, Qiu H. DUSP1 Mitigates MSU-Induced Immune Response in Gouty Arthritis Reinforcing Autophagy. Frontiers in bioscience (Landmark edition) 2024. link 93 Li C, Huang Y, Wu C, Qiu Y, Zhang L, Xu J et al.. Astilbin inhibited neutrophil extracellular traps in gouty arthritis through suppression of purinergic P2Y6 receptor. Phytomedicine : international journal of phytotherapy and phytopharmacology 2024. link 94 Wang X, Sheng Y, Guan J, Zhang F, Lou C. Sanmiao wan alleviates inflammation and exhibits hypouricemic effect in an acute gouty arthritis rat model. Journal of ethnopharmacology 2024. link 95 Lee KG, Hong BK, Lee S, Lee N, Kim SW, Kim D et al.. Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis. Cellular & molecular immunology 2024. link 96 Chu J, Tian J, Li P, Fu D, Guo L, Sun R. The impact of AIM2 inflammasome-induced pyroptosis on acute gouty arthritis and asymptomatic hyperuricemia patients. Frontiers in immunology 2024. link 97 Li D, Yue X, Wang A, Wang J, Zhang W, Wu M et al.. Relieving urinary tract obstructions may increase the risk of gouty arthritis in patients with hyperuricemia and postrenal obstructions. Medicine 2024. link 98 Han J, Xia T, Jiang Y, Fan W, Wang N, Zhang Y et al.. Effect of Xanthohumol from Humulus lupulus L. Against Gouty Bone Damage in Arthritis of Rats Induced by Mono-sodium Urate. Cell biochemistry and biophysics 2024. link 99 Zhao X, Li M, Lu Y, Wang M, Xiao J, Xie Q et al.. Sirt1 inhibits macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024. link 100 Yuan T, Chen S, Yin Y, Shaw J, Zeng J, Li L et al.. Novel Leflunomide Analog, UTLOH-4e, Ameliorates Gouty Arthritis Induced by Monosodium Urate . Current pharmaceutical biotechnology 2024. link

Original source

[1]
Anti-gout active ingredients from natural plant medicines and their related mechanisms. — Zhao L, Zhu Y, Zhong J, Chen S, Wang H, Chen H et al. Journal of ethnopharmacology (2026)
[2]
Ferroptosis in gouty arthritis: a potential therapeutic strategy. — Yan H, Xiao N, Yang B, Zhang J, Xu Y, Chen B et al. Frontiers in immunology (2026)
[3]
TFAP2A transcriptionally regulates B3GALT2 to affect gouty arthritis progression through pyroptosis: a study based on machine learning and multi-omics integration analysis. — Han HL, Cheng ZY, Meng QL, Du XZ Journal of orthopaedic surgery and research (2026)
[4]
Potentilla freyniana bornm. and its active component tangeretin ameliorate gouty arthritis by inhibiting the MAPK/NF-κb/NLRP3 signaling pathway. — Liu K, Liu C, Wu C, Lei S, Bao Z, Yu C et al. Journal of ethnopharmacology (2026)
[5]
Exosome-Mediated Intercellular Communication in the Pathological Processes of Gouty Arthritis and Its Treatment. — Zhao W, Zhong W, Wang Z, Zhou Q, Wang Y, Zhang B et al. International journal of molecular sciences (2026)
[6]
Integrating Musculoskeletal Ultrasound and Serological Markers to Optimize Acute Gouty Arthritis Diagnosis. — Zong XJ, Liu L, Yang M, Li JJ, Yuan P, Cao J International journal of rheumatic diseases (2026)
[7]
Self-disintegrating electrospun short fibers as intra-articular drug depots for gouty arthritis. — Ding Y, Wang Q, Huang H, Xie M, Lin J, Wang S et al. Journal of controlled release : official journal of the Controlled Release Society (2026)
[8]
LncRNA transcriptomics elucidates the suppression of gouty arthritis-associated pyroptosis by Pulchinenoside B4 through NLRP3 inflammasome modulation. — Wang M, Zheng Z, Yi J, Ou Y, Liu P, Yang H et al. European journal of pharmacology (2026)
[9]
Exploring the inflammatory origins of gouty arthritis: mechanistic studies based on local lesion proteomics and validation. — Xiao N, Lu H, Zeng S, Yan H, Yang Q, Sheng L et al. Frontiers in immunology (2026)
[10]
Natural drug-derived carbon dots as a novel oral dosing strategy for gouty arthritis. — Zhang Y, Ma J, Zou P, Xia M, Wang S, Jin B et al. International immunopharmacology (2026)
[11]
Huazhuo Sanjie Chubi Decoction attenuates gouty arthritis and kidney fibrosis by regulating urate transporters and JAK2/STAT3 pathway. — Zhong X, Lin S, Zhong M, Zhang Z, Chen X, Guo J et al. Journal of ethnopharmacology (2026)
[12]
Inflammation suppressing activity of jellyfish toxin-derived peptide via downregulation of ROS/NF-κB/NLRP3 signaling in LPS/MSU induced fibroblasts in vitro and in vivo gouty arthritis model. — Balde A, Nazeer RA Inflammopharmacology (2026)
[13]
Gnetum Montanum Markgr. Extract mitigates gouty arthritis by targeting urate crystal-induced NLRP3 inflammasome activation. — Pham DV, Tran HL, Nguyen TH, Do TH, Nguyen HA, Nguyen TD Journal of natural medicines (2026)
[14]
An investigation into the efficacy and mechanism of Berchemia kulingensis leaves in suppressing synovial tissue inflammation in a rat model of gouty arthritis. — Xiong Y, Xu H, Zhang Y, Chen Z, Wei F, Yu L et al. Journal of ethnopharmacology (2026)
[15]
Optimization of Ascidian-Derived Herdmanine D: Targeting Gouty Arthritis via the PPAR-γ/NF-κB/NLRP3 Pathway. — Zhu X, Dong Y, Zhang Y, Gao C, Ding L, Liu Y et al. Journal of medicinal chemistry (2026)
[16]
Potential components and action mechanism of Tongzhi Surunjiang Pills against acute gouty arthritis: UPLC-MS/MS, network pharmacology, molecular docking, and transcriptomic analysis. — Fu W, Ye A, Yang H, Hou X, Wang Z, Hu Z et al. Journal of ethnopharmacology (2026)
[17]
Clostridium butyricum and its metabolites regulate macrophage polarization through miR-146a to antagonize gouty arthritis. — Song S, Shi K, Fan M, Wen X, Li J, Guo Y et al. Journal of advanced research (2026)
[18]
Multidisciplinary research systematically elucidates the mechanism of Huangqin Qingre Chubi capsule in attenuating inflammation of gouty arthritis. — Chen Y, Fang Y, Qi Y, Li Y, Liu J Journal of ethnopharmacology (2026)
[19]
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