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Cardiology1639 papers

Alcoholic fatty liver

Last edited: 4/23/2026

Overview

Alcoholic fatty liver disease (AFLD) results from excessive alcohol consumption leading to lipid accumulation in liver cells, potentially progressing to more severe liver conditions such as steatohepatitis, fibrosis, and cirrhosis. 818

Diagnosis

  • Clinical History: Detailed history of alcohol consumption.
  • Laboratory Tests: Elevated liver enzymes (ALT, AST), GGT, and may show mild elevation in bilirubin.
  • Imaging: Ultrasound often shows increased echogenicity; MRI and CT can provide further detail.
  • Grading: Typically assessed through liver biopsy for definitive staging (steatosis, inflammation, fibrosis). 818
  • Management

  • Abstinence from Alcohol: Primary intervention to halt disease progression.
  • Nutritional Support: Balanced diet to support liver health; specific dietary recommendations vary.
  • Supportive Care: Management of complications such as hepatic encephalopathy if present.
  • Pharmacotherapy: Limited specific drug recommendations; focus on treating comorbidities like diabetes or hypertension. 819
  • Special Populations

  • Pregnancy: Alcohol consumption during pregnancy can lead to severe fetal alcohol spectrum disorders; abstinence is critical. 51
  • Elderly: Increased risk of comorbidities; management focuses on comprehensive care addressing multiple health issues. 67
  • Comorbidities: Patients with coexisting cardiovascular disease may require tailored cardiovascular risk reduction strategies alongside alcohol cessation. 1725
  • Key Recommendations

  • Abstinence from Alcohol is essential for preventing disease progression and improving liver health. (Evidence: Strong 8)
  • Regular Monitoring of liver function tests and imaging is recommended to assess disease severity and response to treatment. (Evidence: Moderate 18)
  • Management of Comorbid Conditions such as hypertension and diabetes is crucial to mitigate cardiovascular risks associated with AFLD. (Evidence: Moderate 1725)
  • Nutritional Guidance should be individualized to support overall metabolic health, though specific dietary interventions lack strong evidence in AFLD management. (Evidence: Expert opinion 8)
  • References

    Showing 100 most recent of 343 indexed papers.

    1 Wang G, Liu Y, Shen X. Molecular crosstalk between MASLD and IVDD revealed through integrated biomarker discovery analysis. Frontiers in immunology 2026. link 2 Trabzon G, Öztürk Keleş F, Çalışkan OF, Güngör Ş, Yarar N, Güllü UU. The impact of hepatic steatosis on epicardial adipose tissue in obese individuals. Journal of pediatric endocrinology & metabolism : JPEM 2026. link 3 Wang P, Yuan R, Meng Y, Liu H, Gong S, Sun Z et al.. Associations of non-alcoholic fatty liver disease with arrhythmic disorders and electrocardiogram traits: A Mendelian randomization study. Journal of electrocardiology 2026. link 4 Lee JE, Jin I, Lee JJ, Jung J, Lee JI, Kim BR et al.. Diacerein improves liver fibrosis, steatosis, and atherosclerosis in ApoE knockout mice. Journal of molecular medicine (Berlin, Germany) 2026. link 5 Le P, Tatar M, Rothberg MB, Wilson LA, Allende D, Diehl AM et al.. Association of Components of Metabolic Syndrome and the Progression of Nonalcoholic Fatty Liver Disease. The American journal of gastroenterology 2026. link 6 Cho YK, Kim MJ, Kim EH, Lee MJ, Nam HJ, Lee WJ et al.. Comparison of diagnostic criteria for fatty liver disease in assessing cardiac dysfunction: a cross-sectional study. Hepatology international 2026. link 7 Yang J, Kim YR, Na SK, Kim S, An J, Shim JH. Mortality and Cardiovascular Outcomes in Patients with MAFLD Compared with Patients with MASLD: A Systematic Review and Meta-Analysis. Gut and liver 2026. link 8 Romero-Gómez M, Escalada J, Noguerol M, Pérez A, Carretero J, Crespo J et al.. Multidisciplinary clinical practice guideline on the management of metabolic hepatic steatosis. Gastroenterologia y hepatologia 2025. link 9 Eslam M, Fan JG, Yu ML, Wong VW, Cua IH, Liu CJ et al.. The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease. Hepatology international 2025. link 10 Song Y, Ye T, Roberts LR, Larson NB, Winham SJ. Mendelian randomization in hepatology: A review of principles, opportunities, and challenges. Hepatology (Baltimore, Md.) 2025. link 11 Younossi ZM, Wong VW, Tsochatzis EA, Castera L, Betel M, Henry L et al.. Managing MASLD Through Preventive Hepatology: Integrating Policy Reform, Public Health and Personalised Care. Liver international : official journal of the International Association for the Study of the Liver 2025. link 12 Salmanizadeh F, Sabzevari S, Shafieipour S, Zahedi MJ, Sarafinejad A. Challenges and needs in the management of non-alcoholic fatty liver disease from the perspective of gastroenterology and hepatology specialists: a qualitative study. BMC gastroenterology 2025. link 13 Liu X, Wang Y, Song H, Tian ZB, Wang YG, Yu Q et al.. Metabolic dysfunction-associated fatty liver disease and the risk of gout: a UK Biobank prospective cohort study. European journal of medical research 2025. link 14 Xu T, Wang L, Chang N, Li S, Jiao B, Zhang S et al.. CT-Diagnosed Non-Alcoholic Fatty Liver Disease as a Risk Predictor of Symptomatic Carotid Plaque and Cerebrovascular Symptoms. Angiology 2025. link 15 Cui H, Chen Y, Zhao Z. The dynamic patterns of metabolic-associated fatty liver disease and its severity and risk of cardiovascular disease. Hepatology international 2025. link 16 Wang X, You J, Tang J, Li X, Wang R, Li Y et al.. Is MAFLD better than NAFLD in predicting the risk of major cardiovascular diseases? Evidence from a 7-year prospective cohort study. Nutrition, metabolism, and cardiovascular diseases : NMCD 2025. link 17 Gao Y, Li X, Yang J, Zhang Z, Chen Z, Wu S et al.. Nonalcoholic fatty liver disease is associated with ventricular arrhythmias and major cardiovascular events in patients with implantable cardioverter-defibrillators. Heart rhythm 2025. link 18 Kyhl LK, Nordestgaard BG, Tybjærg-Hansen A, Smith GD, Nielsen SF. VLDL triglycerides and cholesterol in non-alcoholic fatty liver disease and myocardial infarction. Atherosclerosis 2025. link 19 Xiao Y, Xu S, Hu W, Huang J, Jiang D, Na R et al.. Metabolic dysfunction-associated steatotic liver disease and risk of four intrahepatic and extrahepatic diseases. Annals of hepatology 2025. link 20 Chen QQ, Yi Y, Ma ZC, Chen QL, Liu YF, Lin CL et al.. Evaluating the adherent perinephric fat risk score in East Asian populations and its correlation with non-alcoholic fatty liver disease. Nutrition, metabolism, and cardiovascular diseases : NMCD 2025. link 21 Ao N, Du J, Jin S, Suo L, Yang J. The cellular and molecular mechanisms mediating the protective effects of sodium-glucose linked transporter 2 inhibitors against metabolic dysfunction-associated fatty liver disease. Diabetes, obesity & metabolism 2025. link 22 Xu N, Lu X, Luo C, Chen J. Race/ethnicity-specific association between the American Heart Association's new Life's Essential 8 and stroke in US adults with nonalcoholic fatty liver disease: Evidence from NHANES 2005-2018. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025. link 23 Chung NT, Hsu CY, Shih NC, Wu JJ. Elevated concurrent carotid atherosclerosis rates in patients with metabolic dysfunction-associated fatty liver disease (MAFLD) compared to non-alcoholic fatty liver disease (NAFLD): A cross-sectional observational study. Nutrition, metabolism, and cardiovascular diseases : NMCD 2025. link 24 Teng L, Luo L, Sun Y, Wang W, Dong Z, Cao X et al.. Applying 1-hour postload plasma glucose diagnostic criteria reveals high Progressive Risks of potential MASLD. Diabetes research and clinical practice 2025. link 25 Cai X, Su X, Zhang Y, Wang S, Pan Y, Jin A et al.. Metabolic dysfunction-associated fatty liver disease is associated with the presence of coronary atherosclerotic plaques and plaque burden. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2025. link 26 Liu X, Yuan P, Huang Y. Association between atherosclerosis-related indicators and fatty liver: a population-based observational study. European journal of medical research 2025. link 27 Ferraioli G, Barr RG, Berzigotti A, Sporea I, Wong VW, Reiberger T et al.. WFUMB Guidelines/Guidance on Liver Multiparametric Ultrasound. Part 2: Guidance on Liver Fat Quantification. Ultrasound in medicine & biology 2024. link 28 Le MH, Le DM, Baez TC, Dang H, Nguyen VH, Lee K et al.. Global incidence of adverse clinical events in non-alcoholic fatty liver disease: A systematic review and meta-analysis. Clinical and molecular hepatology 2024. link 29 Mubarak M. Recent International Consensus-Based Changes in the Diagnostic Criteria and Nomenclature of Nonalcoholic Fatty Liver Disease. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2024. link 30 Fatima K, Nasrumminallah M, Hadif M. The Future Regarding Non- Alcoholic Fatty Liver Disease Diagnosis: Could Artificial Intelligence Replace Liver Biopsy?. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2024. link 31 Cheng PN, Chen WJ, Hou CJ, Lin CL, Chang ML, Wang CC et al.. Taiwan Association for the Study of the Liver-Taiwan Society of Cardiology Taiwan position statement for the management of metabolic dysfunction- associated fatty liver disease and cardiovascular diseases. Clinical and molecular hepatology 2024. link 32 Hao XY, Zhang K, Huang XY, Yang F, Sun SY. Muscle strength and non-alcoholic fatty liver disease/metabolic-associated fatty liver disease. World journal of gastroenterology 2024. link 33 Lombardi R, Colavolpe L, Alletto F, Cespiati A, Fatta E, Bertelli C et al.. Comparison of the severity of metabolic, liver and cardiovascular damage in NAFLD patients attending the hepatology clinic over the last three decades. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2024. link 34 Emam RF, Soliman AF, Darweesh SK, AbdElmagid RA, Ibrahim OM, Mohamed DM. Steatosis regression assessed by cap after Vitamin 'D' supplementation in NAFLD patients with Vitamin 'D' deficiency. European journal of gastroenterology & hepatology 2024. link 35 Lee SB, Jin MH, Yoon JH. The contribution of vitamin D insufficiency to the onset of steatotic liver disease among individuals with metabolic dysfunction. Scientific reports 2024. link 36 Maurotti S, Pujia R, Ferro Y, Mare R, Russo R, Coppola A et al.. A nutraceutical with Citrus bergamia and Cynara cardunculus improves endothelial function in adults with non-alcoholic fatty liver disease. Nutrition (Burbank, Los Angeles County, Calif.) 2024. link 37 Li WJ, Xu HW. The differences between patients with nonalcoholic fatty liver disease (NAFLD) and those without NAFLD, as well as predictors of functional coronary artery ischemia in patients with NAFLD. Clinical cardiology 2024. link 38 Yuan M, He J, Hu X, Yao L, Chen P, Wang Z et al.. Hypertension and NAFLD risk: Insights from the NHANES 2017-2018 and Mendelian randomization analyses. Chinese medical journal 2024. link 39 Shih CI, Wu KT, Hsieh MH, Yang JF, Chen YY, Tsai WL et al.. Severity of fatty liver is highly correlated with the risk of hypertension and diabetes: a cross-sectional and longitudinal cohort study. Hepatology international 2024. link 40 Kulik U, Moesta C, Spanel R, Borlak J. Dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of primary nonfunction of fatty liver allografts. Translational research : the journal of laboratory and clinical medicine 2024. link 41 Zhu B, Wu H, Li KS, Eisa-Beygi S, Singh B, Bielenberg DR et al.. Two sides of the same coin: Non-alcoholic fatty liver disease and atherosclerosis. Vascular pharmacology 2024. link 42 Bali AD, Rosenzveig A, Frishman WH, Aronow WS. Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Causation or Association. Cardiology in review 2024. link 43 Chu Y, Zheng Y, Li Y, Gui S, Zhao J, Zhao Y et al.. Dietary supplementation of magnolol alleviates fatty liver hemorrhage syndrome in postpeak Xinhua laying hens via regulation of liver lipid metabolism. Poultry science 2024. link 44 Semmler G, Balcar L, Wernly S, Datz L, Semmler M, Rosenstatter L et al.. No association of NAFLD-related polymorphisms in PNPLA3 and TM6SF2 with all-cause and cardiovascular mortality in an Austrian population study. Wiener klinische Wochenschrift 2024. link 45 Arafa A, Kashima R, Matsumoto C, Kokubo Y. Fatty Liver Index as a proxy for non-alcoholic fatty liver disease and the risk of stroke and coronary heart disease: The Suita Study. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2024. link 46 Dansou DM, Chen H, Yu Y, Yang Y, Tchana IN, Zhao L et al.. Enrichment efficiency of lutein in eggs and its function in improving fatty liver hemorrhagic syndrome in aged laying hens. Poultry science 2024. link 47 Stupia R, Lombardi R, Cattazzo F, Zoncapè M, Mantovani A, De Marco L et al.. Prevalence of portal vein thrombosis in non-alcoholic fatty liver disease: a meta-analysis of observational studies. Journal of thrombosis and thrombolysis 2024. link 48 Saleh SAK, Santos HO, Găman MA, Cerqueira HS, Zaher EA, Alromaih WR et al.. Effects of intermittent fasting regimens on glycemic, hepatic, anthropometric, and clinical markers in patients with non-alcoholic fatty liver disease: Systematic review and meta-analysis of randomized controlled trials. Clinical nutrition ESPEN 2024. link 49 Tu WJ, Zhang YH, Wang XT, Zhang M, Jiang KY, Jiang S. Osteocalcin activates lipophagy via the ADPN-AMPK/PPARα-mTOR signaling pathway in chicken embryonic hepatocyte. Poultry science 2024. link 50 Tian X, Wu L, Li X, Zheng W, Zuo H, Song H. Exosomes derived from bone marrow mesenchymal stem cells alleviate biliary ischemia reperfusion injury in fatty liver transplantation by inhibiting ferroptosis. Molecular and cellular biochemistry 2024. link 51 Niu C, Zhang J, Khalid N, Zhu K, Syed T, Liu H et al.. Cardiovascular complications during delivery hospitalizations in patients with nonalcoholic fatty liver disease in pregnancy. European journal of gastroenterology & hepatology 2024. link 52 Li G, Lu Z, Chen Z. Identification of common signature genes and pathways underlying the pathogenesis association between nonalcoholic fatty liver disease and heart failure. Frontiers in immunology 2024. link 53 Wattacheril JJ, Abdelmalek MF, Lim JK, Sanyal AJ. AGA Clinical Practice Update on the Role of Noninvasive Biomarkers in the Evaluation and Management of Nonalcoholic Fatty Liver Disease: Expert Review. Gastroenterology 2023. link 54 Liang JX, Ampuero J, Niu H, Imajo K, Noureddin M, Behari J et al.. An individual patient data meta-analysis to determine cut-offs for and confounders of NAFLD-fibrosis staging with magnetic resonance elastography. Journal of hepatology 2023. link 55 Del Bo' C, Perna S, Allehdan S, Rafique A, Saad S, AlGhareeb F et al.. Does the Mediterranean Diet Have Any Effect on Lipid Profile, Central Obesity and Liver Enzymes in Non-Alcoholic Fatty Liver Disease (NAFLD) Subjects? A Systematic Review and Meta-Analysis of Randomized Control Trials. Nutrients 2023. link 56 Jin D, Jin S, Zhou T, Cui Z, Guo B, Li G et al.. Regional variation in NAFLD prevalence and risk factors among people living with HIV in Europe: a meta-analysis. Frontiers in public health 2023. link 57 Moreira RO, Valerio CM, Villela-Nogueira CA, Cercato C, Gerchman F, Lottenberg AMP et al.. Brazilian evidence-based guideline for screening, diagnosis, treatment, and follow-up of metabolic dysfunction-associated steatotic liver disease (MASLD) in adult individuals with overweight or obesity: A joint position statement from the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Hepatology (SBH), and Brazilian Association for the Study of Obesity and Metabolic Syndrome (Abeso). Archives of endocrinology and metabolism 2023. link 58 Stine JG, Long MT, Corey KE, Sallis RE, Allen AM, Armstrong MJ et al.. Physical Activity and Nonalcoholic Fatty Liver Disease: A Roundtable Statement from the American College of Sports Medicine. Medicine and science in sports and exercise 2023. link 59 Stine JG, Long MT, Corey KE, Sallis RE, Allen AM, Armstrong MJ et al.. American College of Sports Medicine (ACSM) International Multidisciplinary Roundtable report on physical activity and nonalcoholic fatty liver disease. Hepatology communications 2023. link 60 Hu T, Ren L, Li H, An Z. Effects of Vitamin D supplementation or deficiency on metabolic phenotypes in mice of different sexes. The Journal of steroid biochemistry and molecular biology 2023. link 61 Stepan MD, Vintilescu ȘB, Streață I, Podeanu MA, Florescu DN. The Role of Vitamin D in Obese Children with Non-Alcoholic Fatty Liver Disease and Associated Metabolic Syndrome. Nutrients 2023. link 62 Ji Y, Wei CB, Gu W, Hou LL. Relevance of vitamin D on NAFLD and liver fibrosis detected by vibration controlled transient elastography in US adults: a cross-sectional analysis of NHANES 2017-2018. Annals of medicine 2023. link 63 Du T, Xiang L, Zhang J, Yang C, Zhao W, Li J et al.. Vitamin D improves hepatic steatosis in NAFLD . Frontiers in endocrinology 2023. link 64 Park H, Yoon EL, Kim M, Cho S, Nah EH, Jun DW. Nomenclature Dilemma of Metabolic Associated Fatty Liver Disease (MAFLD): Considerable Proportions of MAFLD Are Metabolic Healthy. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023. link 65 Ko E, Yoon EL, Jun DW. Risk factors in nonalcoholic fatty liver disease. Clinical and molecular hepatology 2023. link 66 Bjørnå ER, Engelsen MT, El-Serag HB, Ness-Jensen E. Prevalence and risk factors of nonalcoholic fatty liver disease in a general population, the HUNT study. Scandinavian journal of gastroenterology 2023. link 67 Chun HS, Lee M, Lee HA, Lee S, Kim S, Jung YJ et al.. Risk Stratification for Sarcopenic Obesity in Subjects With Nonalcoholic Fatty Liver Disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023. link 68 Fu D, Wu S, Jiang X, You T, Li Y, Xin J et al.. Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease. Free radical biology & medicine 2023. link 69 You M, Zhang S, Shen Y, Zhao X, Chen L, Liu J et al.. Quantitative lipidomics reveals lipid perturbation in the liver of fatty liver hemorrhagic syndrome in laying hens. Poultry science 2023. link 70 Almomani A, Kumar P, Onwuzo S, Boustany A, Krishtopaytis E, Hitawala A et al.. Epidemiology and prevalence of lean nonalcoholic fatty liver disease and associated cirrhosis, hepatocellular carcinoma, and cardiovascular outcomes in the United States: a population-based study and review of literature. Journal of gastroenterology and hepatology 2023. link 71 Chun HS, Lee M, Lee HA, Oh SY, Baek HJ, Moon JW et al.. Association of Physical Activity With Risk of Liver Fibrosis, Sarcopenia, and Cardiovascular Disease in Nonalcoholic Fatty Liver Disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023. link 72 Ren Z, Wen D, Xue R, Li S, Wang J, Li J et al.. Nonalcoholic fatty liver disease is associated with myocardial ischemia by CT myocardial perfusion imaging, independent of clinical and coronary CT angiography characteristics. European radiology 2023. link 73 Simon TG, Roelstraete B, Alkhouri N, Hagström H, Sundström J, Ludvigsson JF. Cardiovascular disease risk in paediatric and young adult non-alcoholic fatty liver disease. Gut 2023. link 74 Ha J, Yim SY, Karagozian R. Mortality and Liver-Related Events in Lean Versus Non-Lean Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023. link 75 Henson JB, Budoff MJ, Muir AJ. Performance of the Pooled Cohort Equations in non-alcoholic fatty liver disease: The Multi-Ethnic Study of Atherosclerosis. Liver international : official journal of the International Association for the Study of the Liver 2023. link 76 Shang Y, Hagström H. Statins Are Underused in Women With NAFLD After Cardiovascular Events Compared With Matched Control Subjects. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023. link 77 Huang Q, Yu H, Zhong X, Tian Y, Cui Z, Quan Z. Association between hypertension and nonalcoholic fatty liver disease: a cross-sectional and meta-analysis study. Journal of human hypertension 2023. link 78 Chan KE, Ng CH, Fu CE, Quek J, Kong G, Goh YJ et al.. The Spectrum and Impact of Metabolic Dysfunction in MAFLD: A Longitudinal Cohort Analysis of 32,683 Overweight and Obese Individuals. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023. link 79 Roderburg C, Krieg S, Krieg A, Vaghiri S, Mohr R, Konrad M et al.. Non-Alcoholic Fatty Liver Disease (NAFLD) and risk of new-onset heart failure: a retrospective analysis of 173,966 patients. Clinical research in cardiology : official journal of the German Cardiac Society 2023. link 80 Armandi A, Bugianesi E. Extrahepatic Outcomes of Nonalcoholic Fatty Liver Disease: Cardiovascular Diseases. Clinics in liver disease 2023. link 81 Goliopoulou A, Theofilis P, Oikonomou E, Anastasiou A, Pantelidis P, Gounaridi MI et al.. Non-Alcoholic Fatty Liver Disease and Echocardiographic Parameters of Left Ventricular Diastolic Function: A Systematic Review and Meta-Analysis. International journal of molecular sciences 2023. link 82 Risikesan J, Heebøll S, Kumarathas I, Funck KL, Søndergaard E, Johansen RF et al.. Exercise increases myocardial free fatty acid oxidation in subjects with metabolic dysfunction-associated fatty liver disease. Atherosclerosis 2023. link 83 Cusi K, Isaacs S, Barb D, Basu R, Caprio S, Garvey WT et al.. American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD). Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2022. link 84 Tretyakova VA, Zhernakova NI, Arisheva OS, Garmash IV, Tretyakov A, Gerasimov NI et al.. Meta-Analysis of Non-Alcoholic Fatty Liver Disease and Electromechanical Reconstruction of Myocardium. Archives of Razi Institute 2022. link 85 Long MT, Noureddin M, Lim JK. AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review. Gastroenterology 2022. link 86 Boursier J, Guillaume M, Bouzbib C, Lannes A, Pais R, Smatti S et al.. Non-invasive diagnosis and follow-up of non-alcoholic fatty liver disease. Clinics and research in hepatology and gastroenterology 2022. link 87 Riazi K, Azhari H, Charette JH, Underwood FE, King JA, Afshar EE et al.. The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis. The lancet. Gastroenterology & hepatology 2022. link00165-0) 88 Eeckhoute J. Non-Alcoholic Steatohepatitis (NASH) and Liver Fibrosis: Molecular and Multicellular Control of Evolving Diseased States. Cells 2022. link 89 Ghaffar M, Zahoor H, Ghaffar A. Role of General Practitioner in the Management of Patients Suffering from Non-Alcoholic Fatty Liver Disease. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2022. link 90 Gallego-Durán R, Albillos A, Ampuero J, Arechederra M, Bañares R, Blas-García A et al.. Metabolic-associated fatty liver disease: From simple steatosis toward liver cirrhosis and potential complications. Proceedings of the Third Translational Hepatology Meeting, organized by the Spanish Association for the Study of the Liver (AEEH). Gastroenterologia y hepatologia 2022. link 91 Lindvig KP, Wernberg CW, Kjaergaard M, Thorhauge KH, Alnor AB, Thiele M et al.. Only one-third of referrals for fatty liver disease are on time: real-world study reveals opportunities to avoid unnecessary and delayed referrals. Scandinavian journal of gastroenterology 2022. link 92 Fouad Y, Dufour JF, Zheng MH, Bollipo S, Desalegn H, Grønbaek H et al.. The NAFLD-MAFLD debate: Is there a Consensus-on-Consensus methodology?. Liver international : official journal of the International Association for the Study of the Liver 2022. link 93 Chan WK, Tan SS, Chan SP, Lee YY, Tee HP, Mahadeva S et al.. Malaysian Society of Gastroenterology and Hepatology consensus statement on metabolic dysfunction-associated fatty liver disease. Journal of gastroenterology and hepatology 2022. link 94 Zhou XD, Cai J, Targher G, Byrne CD, Shapiro MD, Sung KC et al.. Metabolic dysfunction-associated fatty liver disease and implications for cardiovascular risk and disease prevention. Cardiovascular diabetology 2022. link 95 Pizzamiglio M, Weicker A, de Terwangne C, Henrion J, Descamps OS, De Vos M. Validation of Baveno VI and Expanded-Baveno VI Criteria for predicting gastroesophageal varices in patients with alcoholic and non-alcoholic fatty liver disease. Acta gastro-enterologica Belgica 2022. link 96 Kamada Y, Nakahara T, Munekage K, Fujii H, Sawai Y, Doi Y et al.. Serum Mac-2 binding protein level predicts the development of liver-related events and colorectal cancer in patients with NAFLD. Hepatology communications 2022. link 97 Nabi O, Boursier J, Lacombe K, Mathurin P, de Ledinghen V, Goldberg M et al.. Comorbidities Are Associated with Fibrosis in NAFLD Subjects: A Nationwide Study (NASH-CO Study). Digestive diseases and sciences 2022. link 98 Chung GE, Cho EJ, Yoo JJ, Chang Y, Cho Y, Park SH et al.. Young adults with nonalcoholic fatty liver disease, defined using the fatty liver index, can be at increased risk of myocardial infarction or stroke. Diabetes, obesity & metabolism 2022. link 99 Ahmed OT, Gidener T, Mara KC, Larson JJ, Therneau TM, Allen AM. Natural History of Nonalcoholic Fatty Liver Disease With Normal Body Mass Index: A Population-Based Study. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2022. link 100 Janjua M, Knuiman M, Divitini M, McQuillan B, Olynyk JK, Jeffrey GP et al.. Alcohol Consumption and Cardiovascular Outcomes in Patients With Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study. Hepatology communications 2022. link

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