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Cardiology390 papers

Acute heart failure

Last edited: 4/23/2026

Overview

Acute heart failure (AHF) is a clinical syndrome characterized by the sudden onset of signs and symptoms due to impaired cardiac pumping function, leading to fluid overload and congestion. Early recognition and management are crucial for improving outcomes 12.

Diagnosis

  • Clinical Presentation: Dyspnea, edema, elevated jugular venous pressure, and pulmonary crackles 13.
  • Laboratory Tests: Elevated B-type natriuretic peptide (BNP) or N-terminal pro-BNP (NT-proBNP) levels 16.
  • Electrolytes: Monitor for hypochloremia, which is associated with poor outcomes 348.
  • Renal Function: Assess serum creatinine-to-albumin ratio (CAR) for prognosis 8.
  • Imaging: Echocardiography to evaluate cardiac function and structure 13.
  • Urine Output: Evaluate diuretic response using urine sodium levels and output 744.
  • Management

  • Diuretics: Initiate intravenous loop diuretics (e.g., furosemide); monitor response via urine output and sodium levels 744.
  • SGLT2 Inhibitors: Early initiation may improve diuresis and renal protection 512.
  • Vasodilators: Consider nitroglycerin for vasodilation and potential improvement in stroke volume 42.
  • Inotropic Support: Use cautiously in patients with preserved ejection fraction; avoid inotropic agents in those with low ejection fraction unless hemodynamic instability 60.
  • Beta-Blockers: Initiation during hospitalization remains controversial; individualized based on hemodynamic stability 66.
  • Corticosteroids: Consider burst steroid therapy in patients with pro-inflammatory activation 11.
  • Special Populations

  • Elderly: SGLT2 inhibitors show efficacy and safety in elderly patients with AHF 5.
  • Comorbidities: Diabetes mellitus impacts clinical outcomes; consider specific management strategies 41.
  • Renal Impairment: Monitor for AKI and adjust diuretic therapy accordingly 929.
  • Key Recommendations

  • Initiate early mobilization and exercise training to improve outcomes in AHF patients 1 (Evidence: Moderate).
  • Monitor and manage electrolyte imbalances, particularly hypochloremia, as it correlates with poor prognosis 348 (Evidence: Moderate).
  • Use spot urinary sodium levels to guide diuretic therapy and assess response 744 (Evidence: Moderate).
  • Consider early use of SGLT2 inhibitors for elderly patients with AHF to enhance diuresis and renal protection 5 (Evidence: Strong).
  • Evaluate and manage intra-abdominal pressure using POCUS to guide decongestive therapies 17 (Evidence: Moderate).
  • Assess for and manage delirium during hospitalization as it impacts short-term and long-term outcomes 50 (Evidence: Moderate).
  • References

    Showing 100 most recent of 306 indexed papers.

    1 Satyamurthy A, Padmakumar R, Prabhu MA, Harikrishnan S, Jeemon P, Contractor A et al.. Phase-1 Cardiac Rehabilitation in Acute Heart Failure: Development of an Early Mobilization Algorithm Through Delphi Consensus. Journal of cardiopulmonary rehabilitation and prevention 2026. link 2 Shirakabe A, Ikeda Y, Uchikado Y, Okazaki H, Matsushita M, Sawatani T et al.. Clinical significance of mitochondrial dynamics-related miRNAs in the superacute phase of acute heart failure in patients presenting to the emergency department. International journal of cardiology 2026. link 3 Gebrie BM, Kebede MA, Tukeni KN, Abafogi MM, Abadiga TA, Sequr BY et al.. Hypochloremia, non-medication related associated factors, and impact on clinical outcomes in patients with acute heart failure: Insights from resource limited setups. PloS one 2026. link 4 Horiuchi Y, Duff S, van Veldhuisen DJ, Estrella MM, Shlipak MG, Takaoka Y et al.. Kidney tubule injury is associated with sodium avidity and diuretic responsiveness in acute heart failure. ESC heart failure 2026. link 5 Raya-Cruz M, Bustos-Merlo A, Soriano-Pérez MJ, Rico-López D, Córdoba-Peinado R, Pardo-Cabello AJ et al.. Real-world evidence on the use of SGLT2 inhibitors in elderly patients with acute heart failure. Revista clinica espanola 2026. link 6 Ren X, Zhu Y, Wang W, Bian X. The Association between Hematocrit and All-Cause Mortality in Patients with Acute Congestive Heart Failure. International heart journal 2026. link 7 Alsagaff MY, Susilo H, Pramudia C, Wardhani LFK, Maghfirah I, Azmi Y et al.. Two hours of urine output are a reliable parameter for intravenous furosemide adequacy and the need for doubling dose in acute heart failure: a prospective study. Journal of basic and clinical physiology and pharmacology 2026. link 8 Liu S, Zhang C, Feng Y. The relationship between serum creatinine-to-albumin ratio (CAR) and prognosis in critically ill patients with acute heart failure admitted to the ICU: A retrospective study based on the MIMIC-IV database. Medicine 2026. link 9 Li J, Sun Y, Ren J, Wu Y, He Z. Machine Learning for In-hospital Mortality Prediction in Critically Ill Patients With Acute Heart Failure: A Retrospective Analysis Based on the MIMIC-IV Database. Journal of cardiothoracic and vascular anesthesia 2025. link 10 Vanhentenrijk S, Verbeeck J, Kalpakos T, Vandoren V, Braeckeveldt L, L'hoyes W et al.. Rationale and Design of the DECONGEST (Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment) Study. Journal of cardiac failure 2025. link 11 Biegus J, Cotter G, Davison BA, Freund Y, Voors AA, Edwards C et al.. The Effects of Burst Steroid Therapy on Short-term Decongestion in Acute Heart Failure Patients With Pro-inflammatory Activation: A Post Hoc Analysis of the CORTAHF Randomized, Open-label, Pilot Trial. Journal of cardiac failure 2025. link 12 Hammer A, Niessner A, Sulzgruber P. Early Initiation of SGLT2 Inhibitors in Acute Heart Failure: a Focus on Diuresis and Renal Protection. Cardiovascular drugs and therapy 2025. link 13 Bouzidi H, Hammami S, Zairi I, Kammoun S, Kraiem S, Jabeur M et al.. Role of pulmonary ultrasonography in diagnosis of acute heart failure. Current problems in cardiology 2025. link 14 Biegus J, Lindenfeld J, Felker GM, Bakris G, Jonas M, Lala A et al.. Design and rationale of the eLym™ System for Decompensation of Excess Lymphatic Fluid via the Thoracic Duct in Acute Heart Failure (DELTA-HF). ESC heart failure 2025. link 15 Yagin FH, Görmez Y, Algarni A, Al-Hashem F, Dutta AK, Aghaei M. HearteXplain: explainable prediction of acute heart failure and identification of hematologic biomarkers using EBMs and Morris sensitivity analysis. Scientific reports 2025. link 16 Olaoye OB, Ajayi EA, Busari OA, Ojo OE, Adeoti AO, Adewuya O. Prevalence of Acute Heart Failure and The Role of N-Terminal Prohormone Brain Natriuretic Peptide among Acute Dyspnoeic Patients in the Emergency Room. West African journal of medicine 2025. link 17 Josa-Laorden C, Campos-Saenz de Santamaría A, Crespo-Aznarez S, Pérez-Silvestre J, Montero-Hernandez E, Llacer-Iborra P et al.. The role of intra-abdominal pressure and point of care ultrasound to guide decongestive therapies in acute heart failure. ESC heart failure 2025. link 18 Miró Ò, Ivars N, Espinosa B, Jacob J, Alquézar-Arbé A, Gil V et al.. Use of nebulized bronchodilators in acute heart failure: impact on outcomes. Internal and emergency medicine 2025. link 19 Miró Ò, Fortuny MJ, Espinosa B, Alquézar-Arbé A, Jacob J, Trullàs JC et al.. Alkalosis during emergency department evaluation of acute heart failure: Is there an association with mortality?. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias 2025. link 20 Xu T, Zhang H, Peng Z, Huang Y, Zhan Q, Ma Z et al.. The addition of alpha-ketoglutarate to NT-proBNP improves the prediction of long-term all-cause mortality in acute heart failure patients. Annals of medicine 2025. link 21 Prata AA, Prata AA, Coan ACC, Scardini PG, Fernandes JM, Neto WF et al.. Protocolized natriuresis-guided diuretic therapy in acute heart failure: a systematic review and meta-analysis. Critical care (London, England) 2025. link 22 Davison BA, Abbate A, Cotter G, Pascual-Figal D, Van Tassell B, Villota JN et al.. Effects of anti-inflammatory therapy in acute heart failure: a systematic review and meta-analysis. Heart failure reviews 2025. link 23 Maita-Arauco SA, Quispe-Vasquez SM, Benites-Zapata VA, Segura-Saldaña PA. Impact of anemia on the association between red cell distribution width and 1-year mortality in acute heart failure patients. Therapeutic advances in cardiovascular disease 2025. link 24 Mert GÖ, Spartalis M, Murat S, Gorenek B. Commentary on ventricular arrhythmias in acute heart failure: Critical insights into the 2024 ACVC-EHRA- HFA consensus statement. International journal of cardiology 2025. link 25 Takaoka Y, Horiuchi Y, Strader M, Murray P, Wettersten N. Albuminuria is associated with worse outcomes in non-diabetics hospitalized with acute heart failure. ESC heart failure 2025. link 26 Kapelios CJ, Vazir A, Lund LH, Filippatos G, Fang JC. Pharmacological options to relieve congestion in acute heart failure. Heart failure reviews 2025. link 27 Antit S, Mrabet A, Fathi M, Fekih R, Boussabeh E, Zakhama L. Tricuspid annular plane systolic excursion/pulmonary arterial systolic pressure ratio as a predictor of outcome in acute heart failure. La Tunisie medicale 2025. link 28 Heyman ET, Ashfaq A, Ekelund U, Ohlsson M, Björk J, Schubert AM et al.. Utilizing artificial intelligence and medical experts to identify predictors for common diagnoses in dyspneic adults: A cross-sectional study of consecutive emergency department patients from Southern Sweden. International journal of medical informatics 2025. link 29 Jin Y, Feng C, Jiang H, Ren B, Zhang Y, Zhang Y et al.. Prognostic value of dynamic KDIGO staging in acute kidney injury after acute heart failure: a doubly robust analysis. Scientific reports 2025. link 30 Revuelta-López E, de la Espriella R, Miñana G, Santas E, Villar S, Sanchis J et al.. The modulating effect of circulating carbohydrate antigen 125 on ST2 and long-term recurrent morbidity burden. Scientific reports 2025. link 31 Freund Y, Cotter G, Davison B, Mirò O. Causes and predictors of recurrent unplanned hospital admissions in heart failure patients: a cohort study: a comment. Internal and emergency medicine 2025. link 32 Tanimoto K, Iwai S, Komori M, Tadokoro N, Fukushima S, Ichikawa H. The first case of central Y-Y extra-corporeal membrane oxygenation system in a pediatric patient. Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 2025. link 33 Taleghani S, Lukoschewitz JD, Tonning S, Taraldsen IA, Sørensen CC, Cannata A et al.. Efficacy and Safety of Hypertonic Saline Solution With Loop Diuretics in Patients With Acute Heart Failure: A Protocol for Systematic Review and Meta-Analysis. Acta anaesthesiologica Scandinavica 2025. link 34 Khorramshahi Bayat M, Chan W, Hay K, McKenzie S, Adhikari P, Fincher G et al.. Spot urinary sodium-guided titration of intravenous diuretic therapy in acute heart failure: a pilot randomized controlled trial. European heart journal. Quality of care & clinical outcomes 2025. link 35 Palazzuoli A, Dini FL, Pugliese NR, Ruocco G, Severino P, Vizza D et al.. Right Ventricular-Pulmonary Artery Uncoupling and Strain in Acute Heart Failure. Journal of the American Heart Association 2025. link 36 Zhou Z, Wang H, Wang W, Li J, Lei L, Zhang L et al.. In-hospital use of beta-blockers for critically ill patients with acute heart failure: Whether and when to initiate. Journal of clinical anesthesia 2025. link 37 Bazoge A, Wargny M, Constant Dit Beaufils P, Morin E, Daille B, Gourraud PA et al.. Assessing large language models for acute heart failure classification and information extraction from French clinical notes. Computers in biology and medicine 2025. link 38 Beaudeau M, Nesseler N, Verhoye JP, Flecher E, Cuggia M, Delange B. Predicting Successful Weaning from Veno-Arterial ECMO Using Machine Learning. Studies in health technology and informatics 2025. link 39 You X, Zhang H, Li T, Zhu Y, Zhang Z, Chen X et al.. Stress hyperglycemia ratio and 30-day mortality among critically ill patients with acute heart failure: analysis of the MIMIC-IV database. Acta diabetologica 2025. link 40 Biegus J, Mebazaa A, Metra M, Pagnesi M, Chioncel O, Davison B et al.. Safety and efficacy intravenous istaroxime up to 60 hours for patients with pre-cardiogenic shock. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2025. link 41 Zhao L, Zhang J, Liu W, Dai C, Li A. GV effects of diabetes mellitus on clinical outcomes of patients with acute heart failure: A systematic review and meta-analysis. PloS one 2025. link 42 Lau FF, El Caidi NO, Hristovska AM, Noory M, Lukoschewitz JD, Hove JD et al.. Impact of nitroglycerin-induced vasodilation on stroke volume and diuretic response in acute heart failure: A protocol for a mechanistic trial. Acta anaesthesiologica Scandinavica 2025. link 43 Khalid N, Afzal MA, Abdullah M, Haiy AU, Shamoon Y, Elkattawy S et al.. Efficacy and safety of empagliflozin in acute heart failure: a systematic review and meta-analysis. Future cardiology 2025. link 44 Lukoschewitz JD, Miger KC, Olesen ASO, Caidi NOE, Jørgensen CK, Nielsen OW et al.. Vasodilators for Acute Heart Failure - A Systematic Review with Meta-Analysis. NEJM evidence 2024. link 45 Marjanovic N, Piton M, Lamarre J, Alleyrat C, Couvreur R, Guenezan J et al.. High-flow nasal cannula oxygen versus noninvasive ventilation for the management of acute cardiogenic pulmonary edema: a randomized controlled pilot study. European journal of emergency medicine : official journal of the European Society for Emergency Medicine 2024. link 46 Okada A, Kaneko H, Konishi M, Kamiya K, Sugimoto T, Matsuoka S et al.. A machine-learning-based prediction of non-home discharge among acute heart failure patients. Clinical research in cardiology : official journal of the German Cardiac Society 2024. link 47 Solela G. Prevalence and prognostic role of hypochloremia in patients with acute heart failure in Ethiopia: A single-center retrospective analysis. PloS one 2024. link 48 Wei D, Chen S, Xiao D, Chen R, Meng Y. Positive association between sodium-to-chloride ratio and in-hospital mortality of acute heart failure. Scientific reports 2024. link 49 Heyman ET, Ashfaq A, Ekelund U, Ohlsson M, Björk J, Khoshnood AM et al.. A novel interpretable deep learning model for diagnosis in emergency department dyspnoea patients based on complete data from an entire health care system. PloS one 2024. link 50 Aikawa Y, Ogata S, Honda S, Nagai T, Murata S, Morii I et al.. Prolonged delirium during hospitalization is associated with worse long-term and short-term outcomes in patients with acute heart failure. International journal of cardiology 2024. link 51 Cotter G, Davison B, Chioncel O. Enhanced Decongestive Therapy in Patients With Acute Heart Failure: JACC Review Topic of the Week. Journal of the American College of Cardiology 2024. link 52 Zhang L, Sun Y, Sui X, Zhang J, Zhao J, Zhou R et al.. Hypocapnia is associated with increased in-hospital mortality and 1 year mortality in acute heart failure patients. ESC heart failure 2024. link 53 Cotter G, Davison B, Freund Y, Mebazaa A, Voors A, Edwards C et al.. Corticosteroid burst therapy in patients with acute heart failure: Design of the CORTAHF pilot study. ESC heart failure 2024. link 54 Bouleti C, Alos B, Legallois D, Eschalier R, Costa J, Tea V et al.. Rationale and design of the French Observatory of Acute Heart Failure (OFICA2). Archives of cardiovascular diseases 2024. link 55 Miró Ò, Martín Mojarro E, Lopez-Ayala P, Llorens P, Gil V, Alquézar-Arbé A et al.. Association of intravenous digoxin use in acute heart failure with rapid atrial fibrillation and short-term mortality according to patient age, renal function, and serum potassium. European journal of emergency medicine : official journal of the European Society for Emergency Medicine 2024. link 56 Fang Y, Xu J, Huang R. AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte. The heart surgery forum 2024. link 57 Scatularo CE, Battioni L, Guazzone A, Esperón G, Corsico L, Grancelli HO. Basal natriuresis as a predictor of diuretic resistance and clinical evolution in acute heart failure. Current problems in cardiology 2024. link 58 El Caidi NO, Lukoschewitz JD, Nielsen OW, Hove J, Seven E, Dixen U et al.. The acute effects of furosemide in acute heart failure assessed by remote dielectric sensing. A protocol. Danish medical journal 2024. link 59 Shirahige T, Matsumoto T, Shigeno A, Funatomi H, Takahashi J, Funakoshi H. Impact of the COVID-19 pandemic on management and outcomes of patients with acute heart failure. ESC heart failure 2024. link 60 Huang J, Cai Y, Wu X, Huang X, Liu J, Hu D. Prediction of mortality events of patients with acute heart failure in intensive care unit based on deep neural network. Computer methods and programs in biomedicine 2024. link 61 Pan J, Liu M, Huang J, Chen L, Xu Y. Impact of anemia on clinical outcomes in patients with acute heart failure: A systematic review and meta-analysis. Clinical cardiology 2024. link 62 Biegus J, Mebazaa A, Davison B, Cotter G, Edwards C, Čelutkienė J et al.. Effects of Rapid Uptitration of Neurohormonal Blockade on Effective, Sustainable Decongestion and Outcomes in STRONG-HF. Journal of the American College of Cardiology 2024. link 63 Ostrowska M, Kasprzak M, Stolarek W, Grzelakowska K, Kryś J, Kubica A et al.. Comparison of reorganized versus unaltered cardiology departments during the COVID-19 era: A subanalysis of the COV-HF-SIRIO 6 study. Cardiology journal 2023. link 64 Saijo T, Yasumoto K, Ryomoto K, Momoki C, Habu D. Effect of protein underdosing on the prognosis of patients with severe acute heart failure in the early acute phase: A single-institutional retrospective cohort study. Clinical nutrition ESPEN 2023. link 65 Toda K, Ako J, Hirayama A, Kinugawa K, Kobayashi Y, Ono M et al.. Three-year experience of catheter-based micro-axial left ventricular assist device, Impella, in Japanese patients: the first interim analysis of Japan registry for percutaneous ventricular assist device (J-PVAD). Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 2023. link 66 Kurashima S, Kitai T, Matsue Y, Nogi K, Kagiyama N, Oishi S et al.. Trajectory of serum chloride levels during decongestive therapy in acute heart failure. International journal of cardiology 2023. link 67 Siddiqua N, Bhaskararayuni J, Sahu AK, Kumar A, Nayer J. Taming the Tiger: Ultra high dose nitroglycerin in managing sympathetic crashing acute pulmonary edema patient. The American journal of emergency medicine 2023. link 68 Harrison NE, Ehrman R, Pang P, Armitage S, Abidov A, Perkins D et al.. The significance of historical troponin elevation in acute heart failure: Not as reassuring as previously assumed. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2023. link 69 Martín-Mojarro E, Gil V, Llorens P, Flores-Quesada S, Troiano-Ungerer OJ, Alquézar-Arbé A et al.. Factors associated with unjustified chronic treatment with digoxin in patients with acute heart failure and relationship with short-term prognosis. Revista clinica espanola 2023. link 70 Takimura H, Kurozumi A, Taniguchi R, Tsuzuki I, Tajima E, Yamaguchi Y et al.. Predictors of Poor Very Early Diuretic Response and Effectiveness of Early Tolvaptan in Symptomatic Acute Heart Failure. American journal of cardiovascular drugs : drugs, devices, and other interventions 2023. link 71 Martín Mojarro E, Gil V, Llorens P, Álvarez J, Flores Quesada S, Troiano Ungerer OJ et al.. Use of digoxin in the emergency department to treat patients with acute heart failure and its impact on short-term outcomes. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias 2023. link 72 Sánchez-Marcos C, Jacob J, Llorens P, López-Díez MP, Millán J, Martín-Sánchez FJ et al.. Emergency department direct discharge compared to short-stay unit admission for selected patients with acute heart failure: analysis of short-term outcomes. Internal and emergency medicine 2023. link 73 Ma T, Huang R, Xu Y, Lv Y, Liu Y, Pan X et al.. Plasma GAS6 predicts mortality risk in acute heart failure patients: insights from the DRAGON-HF trial. Journal of translational medicine 2023. link 74 Michou E, Wussler D, Belkin M, Simmen C, Strebel I, Nowak A et al.. Quantifying inflammation using interleukin-6 for improved phenotyping and risk stratification in acute heart failure. European journal of heart failure 2023. link 75 Cox ZL, Siddiqi HK, Stevenson LW, Bales B, Han JH, Hart K et al.. Randomized controlled trial of urinE chemiStry guided aCute heArt faiLure treATmEnt (ESCALATE): Rationale and design. American heart journal 2023. link 76 Tamaki Y, Iwano H, Murayama M, Ishizaka S, Motoi K, Aoyagi H et al.. Application of an echocardiographic scoring system of left ventricular filling pressure to diagnose acute heart failure in patients complaining dyspnea. Journal of cardiology 2023. link 77 Goldsmith AJ, Jin M, Lucassen R, Duggan NM, Harrison NE, Wells W et al.. Comparison of pulmonary congestion severity using artificial intelligence-assisted scoring versus clinical experts: A secondary analysis of BLUSHED-AHF. European journal of heart failure 2023. link 78 Kisiel O, Siennicka AE, Josiak K, Zymliński R, Banasiak W, Węgrzynowska-Teodorczyk K. Impact of assisted exercises on skeletal muscle oxygenation levels in men with acutely decompensated heart failure. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023. link 79 Rafique Z, Fortuny MJ, Kuo D, Szarpak L, Llauger L, Espinosa B et al.. Hyperkalemia in acute heart failure: Short term outcomes from the EAHFE registry. The American journal of emergency medicine 2023. link 80 Dhont S, Martens P, Meekers E, Dauw J, Verbrugge FH, Nijst P et al.. Sodium and potassium changes during decongestion with acetazolamide - A pre-specified analysis from the ADVOR trial. European journal of heart failure 2023. link 81 Yokota J, Endo R, Takahashi R. Improving physical performance reduces dysphagia via improvement of tongue strength in patients with acute heart failure: a two-wave cross-lagged mediation model analysis. Aging clinical and experimental research 2023. link 82 Arvig MD, Lassen AT, Gæde PH, Gärtner SW, Falster C, Skov IR et al.. Impact of serial cardiopulmonary point-of-care ultrasound exams in patients with acute dyspnoea: a randomised, controlled trial. Emergency medicine journal : EMJ 2023. link 83 Iwanek G, Ponikowska B, Zdanowicz A, Fudim M, Hurkacz M, Zymliński R et al.. Relationship of Vascular Endothelial Growth Factor C, a Lymphangiogenesis Modulator, With Edema Formation, Congestion and Outcomes in Acute Heart Failure. Journal of cardiac failure 2023. link 84 Tang WJ, Xie BK, Liang W, Zhou YZ, Kuang WL, Chen F et al.. Hypocapnia is an independent predictor of in-hospital mortality in acute heart failure. ESC heart failure 2023. link 85 Liu L, Qian J, Li Y, Ni Y, Zhao Y, Che L. Effects of obesity on short-term mortality in patients with acute heart failure under different nutritional status. BMC cardiovascular disorders 2023. link 86 Arnone MI, Sforza A, Carlino MV, Guarino M, Candido R, Bertolone D et al.. Assessment of E/A ratio helps emergency clinicians in the management of patients with acute dyspnea. Internal and emergency medicine 2023. link 87 Wang Z, Dong Y, Gao Q, Zhang Q, Jiang H. The role of acute heart failure index (AHFI) combined with emergency heart failure mortality risk grade (EHMRG) in the evaluation of clinical outcomes and prognosis in patients with acute heart failure. Acta cardiologica 2022. link 88 Yamamoto M, Ishizu T, Seo Y, Nakagawa D, Sato K, Kawamatsu N et al.. Pathophysiological role of right ventricular function and interventricular functional mismatch in the development of pulmonary edema in acute heart failure. Journal of cardiology 2022. link 89 Trambaiolo P, Figliuzzi I, Salvati M, Bertini P, Brizzi G, Tocci G et al.. Ventriculo-arterial coupling in the intensive cardiac care unit: A non-invasive prognostic parameter. International journal of cardiology 2022. link 90 Matsuo K, Yoneki K, Tatsuki H, Mibu K, Furuzono K, Kobayashi K et al.. Effect of Electrical Muscle Stimulation on the Reduction of Muscle Volume Loss in Acute Heart Failure Patients. International heart journal 2022. link 91 Shirotani S, Jujo K, Abe T, Kametani M, Minami Y, Suzuki A et al.. Prognostic Impact of Landiolol in Patients with Acute Heart Failure and Atrial Fibrillation with Rapid Ventricular Rates: A Pilot Observational Study. Pharmacology 2022. link 92 Srivastava M, Harrison N, Caetano AFS, Tan AR, Law M. Ultrafiltration for acute heart failure. The Cochrane database of systematic reviews 2022. link 93 Miró Ò, Takagi K, Davison BA, Edwards C, Freund Y, Jacob J et al.. Effect of systemic corticosteroid therapy for acute heart failure patients with elevated C-reactive protein. ESC heart failure 2022. link 94 Miger K, Fabricius-Bjerre A, Overgaard Olesen AS, Sajadieh A, Høst N, Køber N et al.. Chest computed tomography features of heart failure: A prospective observational study in patients with acute dyspnea. Cardiology journal 2022. link 95 Yoshioka K, Maeda D, Okumura T, Kida K, Oishi S, Akiyama E et al.. Clinical implication of initial intravenous diuretic dose for acute decompensated heart failure. Scientific reports 2022. link 96 Stephens AF, Wickramarachchi A, Burrell AJC, Bellomo R, Raman J, Gregory SD. Hemodynamics of small arterial return cannulae for venoarterial extracorporeal membrane oxygenation. Artificial organs 2022. link 97 Miró Ò, Sánchez C, Gil V, Repullo D, García-Lamberechts EJ, González Del Castillo J et al.. Current Spanish emergency department organization and clinical practicesin caring for patients with acute heart failure. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias 2022. link 98 Palacios García L, Enguita Germán M, Ruiz Sada P, Echeverría Echeverría A, González Gómez M, Rubio Obanos MT. Impact of clinical ultrasound in patients with heart failure treated in home. Medicina clinica 2022. link 99 Rubio-Gracia J, Crespo-Aznarez S, De la Espriella R, Nuñez G, Sánchez-Marteles M, Garcés-Horna V et al.. Utility of plasma CA125 as a proxy of intra-abdominal pressure in patients with acute heart failure. European heart journal. Acute cardiovascular care 2022. link 100 Saijo T, Yasumoto K, Ohashi M, Momoki C, Habu D. Association between early enteral nutrition and clinical outcome in patients with severe acute heart failure who require invasive mechanical ventilation. JPEN. Journal of parenteral and enteral nutrition 2022. link

    Original source

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      Phase-1 Cardiac Rehabilitation in Acute Heart Failure: Development of an Early Mobilization Algorithm Through Delphi Consensus.Satyamurthy A, Padmakumar R, Prabhu MA, Harikrishnan S, Jeemon P, Contractor A et al. Journal of cardiopulmonary rehabilitation and prevention (2026)
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      Clinical significance of mitochondrial dynamics-related miRNAs in the superacute phase of acute heart failure in patients presenting to the emergency department.Shirakabe A, Ikeda Y, Uchikado Y, Okazaki H, Matsushita M, Sawatani T et al. International journal of cardiology (2026)
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      Kidney tubule injury is associated with sodium avidity and diuretic responsiveness in acute heart failure.Horiuchi Y, Duff S, van Veldhuisen DJ, Estrella MM, Shlipak MG, Takaoka Y et al. ESC heart failure (2026)
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      Real-world evidence on the use of SGLT2 inhibitors in elderly patients with acute heart failure.Raya-Cruz M, Bustos-Merlo A, Soriano-Pérez MJ, Rico-López D, Córdoba-Peinado R, Pardo-Cabello AJ et al. Revista clinica espanola (2026)
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      Two hours of urine output are a reliable parameter for intravenous furosemide adequacy and the need for doubling dose in acute heart failure: a prospective study.Alsagaff MY, Susilo H, Pramudia C, Wardhani LFK, Maghfirah I, Azmi Y et al. Journal of basic and clinical physiology and pharmacology (2026)
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      Rationale and Design of the DECONGEST (Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment) Study.Vanhentenrijk S, Verbeeck J, Kalpakos T, Vandoren V, Braeckeveldt L, L'hoyes W et al. Journal of cardiac failure (2025)
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      Early Initiation of SGLT2 Inhibitors in Acute Heart Failure: a Focus on Diuresis and Renal Protection.Hammer A, Niessner A, Sulzgruber P Cardiovascular drugs and therapy (2025)
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      Role of pulmonary ultrasonography in diagnosis of acute heart failure.Bouzidi H, Hammami S, Zairi I, Kammoun S, Kraiem S, Jabeur M et al. Current problems in cardiology (2025)
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      Design and rationale of the eLym™ System for Decompensation of Excess Lymphatic Fluid via the Thoracic Duct in Acute Heart Failure (DELTA-HF).Biegus J, Lindenfeld J, Felker GM, Bakris G, Jonas M, Lala A et al. ESC heart failure (2025)
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      Prevalence of Acute Heart Failure and The Role of N-Terminal Prohormone Brain Natriuretic Peptide among Acute Dyspnoeic Patients in the Emergency Room.Olaoye OB, Ajayi EA, Busari OA, Ojo OE, Adeoti AO, Adewuya O West African journal of medicine (2025)
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      The role of intra-abdominal pressure and point of care ultrasound to guide decongestive therapies in acute heart failure.Josa-Laorden C, Campos-Saenz de Santamaría A, Crespo-Aznarez S, Pérez-Silvestre J, Montero-Hernandez E, Llacer-Iborra P et al. ESC heart failure (2025)
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