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Infectious Disease1824 papers

Tuberculosis

Last edited: 28 days ago

Overview

Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a major global health issue affecting primarily the lungs but also extrapulmonary sites. It remains a leading cause of infectious disease mortality worldwide, exacerbated by drug resistance and comorbidities like diabetes and malnutrition.

Diagnosis

  • Clinical Symptoms: Persistent cough, fever, night sweats, weight loss 12.
  • Diagnostic Tests:
  • - Sputum smear microscopy and culture 737. - Xpert MTB/RIF Ultra assay for rapid diagnosis and rifampicin resistance detection 1545. - Targeted next-generation sequencing (NGS) for drug resistance mutations 39.
  • Latent TB Infection: Tuberculin skin test (TST) or interferon-gamma release assays (IGRAs) 744.
  • Extrapulmonary TB: Imaging studies (CT, MRI) and specific tissue biopsies 559.
  • Management

  • First-Line Treatment:
  • - Isoniazid, Rifampin, Ethambutol, Pyrazinamide for initial intensive phase (2 months) 3744. - Continued with Isoniazid and Rifampin for a total of 6 months 3744.
  • Drug-Resistant TB:
  • - Bedaquiline, Delamanid, Pretomanid in combination regimens 3433. - Clofazimine as adjunctive therapy to improve outcomes 66.
  • Monitoring: Regular sputum cultures and clinical assessments to monitor treatment response and toxicity 3752.
  • Special Populations

  • Pregnancy: Isoniazid is generally considered safe; consult guidelines for specific regimens 737.
  • Pediatrics: Age-adjusted dosing and shorter treatment durations; close monitoring for adverse effects 1544.
  • Elderly: Increased risk of comorbidities like diabetes; tailored treatment plans considering renal and hepatic function 849.
  • Comorbidities:
  • - Diabetes: Higher risk of TB progression and poorer outcomes; intensified monitoring and management 2242. - Malnutrition: Poor prognosis; nutritional support is crucial 3343.

    Key Recommendations

  • Use Xpert MTB/RIF Ultra for rapid diagnosis and detection of rifampicin resistance in all suspected TB cases (Evidence: Strong 15).
  • Implement isoniazid preventive therapy (IPT) in high-risk groups, such as individuals living with HIV, to reduce TB incidence (Evidence: Moderate 68).
  • Incorporate vitamin D supplementation into TB prevention strategies, given its potential role in immune modulation (Evidence: Moderate 11).
  • Regularly monitor for adverse drug reactions, especially hepatotoxicity, in patients receiving novel anti-TB drugs like bedaquiline and delamanid (Evidence: Moderate 3352).
  • Tailor TB treatment regimens considering patient comorbidities, such as diabetes and malnutrition, to improve outcomes (Evidence: Moderate 4243).
  • References

    Showing 100 most recent of 772 indexed papers.

    1 Loeb J. What puts herds at risk of recurrent bovine TB?. The Veterinary record 2026. link 2 Monedero-Recuero I, Wei X, Jouberton F, Duarte R, Rodríguez-Ortega M, Santiago MRT et al.. Drug-resistant tuberculosis in war and complex emergencies: jeopardising progress towards TB elimination and antimicrobial resistance control - a scoping review and perspective. BMJ global health 2026. link 3 Hittel N, Lazarevic N, Martin A, Schorn B, Leporowski A, Zhang V et al.. A Comprehensive Approach to Selection of Adverse Drug Reactions for a Drug with Conditional Marketing Authorisation in the European Union. Advances in therapy 2026. link 4 Abdelwahab MT, Svensson EM, Diacon AH, Conradie A, Olugbosi M, Dawson R et al.. Exposure-QTc modeling of bedaquiline, pretomanid, and clofazimine in adults with tuberculosis. Antimicrobial agents and chemotherapy 2026. link 5 Donohue S, Leisching G, Keane J. The Emerging Role of Immunothrombosis in the Control and Pathogenesis of Mycobacterium tuberculosis. The Journal of infectious diseases 2026. link 6 Tanaka K, Fukushima S, Oguni K, Yoshida S, Ihoriya H, Hagiya H et al.. Tuberculosis-associated nonbacterial thrombotic endocarditis: A case report. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2026. link 7 Koçak FM, Yargı Özkoçak B. Minimizing missed latent tuberculosis infection under adalimumab: real-world data from a BCG-vaccinated cohort. Clinical rheumatology 2026. link 8 Lee SJ, Kim J, Pak H, Lee WR, Ahn JY, Jeong SJ et al.. Tuberculosis and increased risk of cardio-cerebrovascular disease: A nationwide cohort study. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2026. link 9 Madden AE, Ofori SK, Budu M, Sisay E, Dooley B, Murray MB. A Systematic Review of Chronic Pulmonary Aspergillosis Among Patients Treated for Pulmonary Tuberculosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2025. link 10 Zheng S, Li M, Chen H, Qin Y. Total hip arthroplasty in hip tuberculosis: a systematic review. BMC musculoskeletal disorders 2025. link 11 Liu S, Lin T, Pan Y. Vitamin D supplementation for tuberculosis prevention: A meta-analysis. Biomolecules & biomedicine 2025. link 12 Kohli M, Inbaraj LR, Salomon A, Scandrett K, Korobitsyn A, Ismail N et al.. Low-complexity automated nucleic acid amplification tests for extrapulmonary tuberculosis and rifampicin resistance in adults and adolescents. The Cochrane database of systematic reviews 2025. link 13 de Souza VA, Caparroz ALMA, Trevisani VFM, Gomes Tavares ACFM, de Melo AKG, Trajman A et al.. Brazilian recommendations for the management of tuberculosis infection in immune-mediated inflammatory diseases. Advances in rheumatology (London, England) 2025. link 14 Ling Y, Wang M, Chen S, Wu Q, Zhang Y, Liu K et al.. Prevalence of latent tuberculosis infection in older adults: a systematic review and meta-analysis. Age and ageing 2025. link 15 Kay AW, Madison M, Scandrett K, Ness T, Amuge P, Inbaraj LR et al.. Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children. The Cochrane database of systematic reviews 2025. link 16 Hailu BK, Demessie Y, Gessese AT, Dagnaw GG, Dejene H. Multidrug Resistance Tuberculosis in the Context of Co-Infection in Ethiopia: A Systematic Review and Meta-Analysis. Journal of epidemiology and global health 2025. link 17 Semugenze D, Kasule GW, Katamba A, Joloba ML, García-Basteiro A, Cobelens F et al.. Association of viral exposure with tuberculosis disease progression: A systematic review. Microbial pathogenesis 2025. link 18 Gray A. Bridging gaps in bovine TB support. The Veterinary record 2025. link 19 Gandotra S, Singh Y. A surprising new hiding place for a dangerous pathogen. eLife 2025. link 20 Kumar S, O'Connor KC. TB or not TB: That depends on the antibody Fc. Science immunology 2025. link 21 Ariyaratne S, Mohan R, Botchu R. An unusual case of primary tuberculosis of the patella and patellar tendon masquerading as gout. Journal of ultrasound 2025. link 22 Kim CY, Ha JW, Jung I, Han M, Ahn SS. Risk of Gout Among Patients With Tuberculosis: A Nationwide Cohort Study in South Korea. International journal of rheumatic diseases 2025. link 23 Kabwama SN, Wanyenze RK, Lindgren H, Razaz N, Ssenkusu JM, Alfvén T. Interventions to Maintain HIV/AIDS, Tuberculosis, and Malaria Service Delivery During Public Health Emergencies in Low- and Middle-Income Countries: Protocol for a Systematic Review. JMIR research protocols 2025. link 24 Lima LV, Pelissari DM, Pavinati G, Dockhorn Costa Johansen F, Barreira Filho EB, Magnabosco GT et al.. Coordinated responses to maintain tuberculosis care amid climate emergencies: challenges and perspectives based on the events of Brazil. BMJ global health 2025. link 25 Zhong Y, Xie H, Cai F, Liu M, Gan H, Tang Z et al.. Global burden of multidrug-resistant tuberculosis in children and adolescents. Pediatric research 2025. link 26 Ayadi S, Ghorbel S, Ben Ayed M, Kharrat R, Sallami M, Kallel S et al.. Primary tonsillar tuberculosis: A challenging clinical diagnosis a cases series. The Indian journal of tuberculosis 2025. link 27 Ghafari AT, Zakaria Y, Hasan MH, Majeed ABA, Nazari QA. PolyCheck: A hybrid model for predicting polypharmacy-induced adverse drug reactions in tuberculosis treatment using heterogenous drug-target-ADR networks. Journal of pharmacological and toxicological methods 2025. link 28 O'Garra A. From Cytokines to Tuberculosis and Back: My Journey to Understanding the Immune Response to Infection. Annual review of immunology 2025. link 29 Arif S, Aslam F. Immunoinformatics-driven construction of a next-generation epitope-based vaccine from conserved hypothetical proteins of M. tuberculosis for enhanced TB control. Computers in biology and medicine 2025. link 30 Loureiro RTO, Andrade SJT, do Carmo EJ, Higa AM, de Lima Procópio RE. Immunoinformatics analysis of the proteins MPT83 and MPT51 to design a possible chimeric vaccine against Mycobacterium tuberculosis. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 2025. link 31 Ryu J, Lee Y, Kwon JW. Analysis of nationwide adverse event reports on Isoniazid and Rifampin in tuberculosis prevention and treatment in South Korea. Scientific reports 2025. link 32 He Q, Li Y, Liu S, Xue H, Xiang X, Wang T et al.. Drug-induced liver injury associated with pretomanid, bedaquiline, and linezolid: Insights from FAERS database analysis. British journal of clinical pharmacology 2025. link 33 Zhao L, Zeng L, Qian Y, Zhao W, Xie R. Real-world safety profile of novel anti-multidrug-resistant tuberculosis drugs: a disproportionality analysis based on the FAERS database. BMJ open 2025. link 34 Burman W, Luczynski P, Horsburgh CR, Phillips PPJ, Johnston J. Representativeness and adverse event reporting in late-phase clinical trials for rifampin-susceptible tuberculosis: a systematic review. The Lancet. Infectious diseases 2025. link00597-8) 35 Goussard P, Eber E, Janson J, Gie AG, Fourie B, Jacobs CM et al.. PTB airway compression complicated by vascular abnormalities and cardiac involvement: A case series demonstrating diagnosis and management. Pediatric pulmonology 2025. link 36 . [Guidelines for diagnosis and management of drug-induced liver injury caused by anti-tuberculosis drugs (2024 version)]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 2024. link 37 MacLean EL, Zimmer AJ, den Boon S, Gupta-Wright A, Cirillo DM, Cobelens F et al.. Tuberculosis treatment monitoring tests during routine practice: study design guidance. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2024. link 38 Badawi MM, SalahEldin MA, Idris AB, Idris EB, Mohamed SG. Tuberculosis in Sudan: systematic review and meta analysis. BMC pulmonary medicine 2024. link 39 Schwab TC, Perrig L, Göller PC, Guebely De la Hoz FF, Lahousse AP, Minder B et al.. Targeted next-generation sequencing to diagnose drug-resistant tuberculosis: a systematic review and meta-analysis. The Lancet. Infectious diseases 2024. link00263-9) 40 Khattak M, Rehman AU, Muqaddas T, Hussain R, Rasool MF, Saleem Z et al.. Tuberculosis (TB) treatment challenges in TB-diabetes comorbid patients: a systematic review and meta-analysis. Annals of medicine 2024. link 41 Martinez L, Seddon JA, Horsburgh CR, Lange C, Mandalakas AM. Effectiveness of preventive treatment among different age groups and Mycobacterium tuberculosis infection status: a systematic review and individual-participant data meta-analysis of contact tracing studies. The Lancet. Respiratory medicine 2024. link00083-3) 42 Franco JV, Bongaerts B, Metzendorf MI, Risso A, Guo Y, Peña Silva L et al.. Diabetes as a risk factor for tuberculosis disease. The Cochrane database of systematic reviews 2024. link 43 Franco JV, Bongaerts B, Metzendorf MI, Risso A, Guo Y, Peña Silva L et al.. Undernutrition as a risk factor for tuberculosis disease. The Cochrane database of systematic reviews 2024. link 44 Lima RS, Silva RND, André SR, Pinheiro AKC, Sousa AI, Silva IFSD et al.. Mycobacterium tuberculosis latent infection in healthcare students: systematic review of prevalence. Revista da Escola de Enfermagem da U S P 2024. link 45 Ding YL, Yan RC, Chen HK, Guo XG. A meta-analysis of the accuracy of Xpert MTB/RIF in diagnosing intestinal tuberculosis. Laboratory medicine 2024. link 46 Huda MH, Rahman MF, Zalaya Y, Mukminin MA, Purnamasari T, Hendarwan H et al.. A meta-analysis of technology-based interventions on treatment adherence and treatment success among TBC patients. PloS one 2024. link 47 Ang MLT, Chan SM, Cheng LT, Cheong HY, Chew KL, Chlebicki PM et al.. Singapore tuberculosis (TB) clinical management guidelines 2024: A modified Delphi adaptation of international guidelines for drug-susceptible TB infection and pulmonary disease. Annals of the Academy of Medicine, Singapore 2024. link 48 Liang L, Su Q. Prediabetes and the treatment outcome of tuberculosis: A meta-analysis. Tropical medicine & international health : TM & IH 2024. link 49 Zhou Y, Wang F, Chen S, Zhang Y, Wang W, Wu Q et al.. The asymptomatic tuberculosis proportion among the elderly population: a systematic review and meta-analysis. BMC public health 2024. link 50 Gaeddert M, Glaser K, Chendi BH, Sultanli A, Koeppel L, MacLean EL et al.. Host blood protein biomarkers to screen for tuberculosis disease: a systematic review and meta-analysis. Journal of clinical microbiology 2024. link 51 Chauhan A, Parmar M, Dash GC, Chauhan S, Sahoo KC, Samantaray K et al.. Health literacy and tuberculosis control: systematic review and meta-analysis. Bulletin of the World Health Organization 2024. link 52 Song L, Zhang Y, Sun F, Lan Y, Tong J, Ge S et al.. Assessing hepatotoxicity in novel and standard short regimens for rifampicin-resistant tuberculosis: Insights from the TB-TRUST and TB-TRUST-plus trials. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2024. link 53 B K, Appaji R, Thomas L, Baral T, N S, Chaithra et al.. Characteristics of isoniazid-induced psychosis: a systematic review of case reports and case series. European journal of clinical pharmacology 2024. link 54 Dias JV, Varandas L, Gonçalves L, Kagina B. Outcomes of childhood TB in countries with a universal BCG vaccination policy. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2024. link 55 Michel AL. Vaccines to control tuberculosis in cattle. Science (New York, N.Y.) 2024. link 56 Watt NJ, Cutler K. 'It is impossible to meet our officially bTB-free targets with the current testing policy'. The Veterinary record 2024. link 57 Lee J, Seo H, Kim D, Hwang J, Kwon JW. Influenza and the risk of active tuberculosis occurrence among individuals with latent tuberculosis infection: A national cohort study in South Korea (2015-2020). Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2024. link 58 Chen RT, Liu CY, Lin SY, Shu CC, Sheng WH. The prevalence, clinical reasoning and impact of non-standard anti-tuberculosis regimens at the initial prescription. Scientific reports 2024. link 59 Bausch K, Mantica G, Smith EJ, Bartoletti R, Bruyère F, Cai T et al.. Genitourinary Tuberculosis: A Brief Manual for Urologists on Diagnosis and Treatment from the European Association of Urology Urological Infections Panel. European urology focus 2024. link 60 Motevalian SA, Asghar MN, Afzal S, Khan EA, Siddiqui AR, Ali TS et al.. Health research priorities in Pakistan: A Child Health and Nutrition Research Initiative (CHNRI) exercise. Journal of global health 2024. link 61 Kumari R S, Sethi G, Krishna R. Development of multi-epitope based subunit vaccine against . Journal of biomolecular structure & dynamics 2024. link 62 Arega AM, Dhal AK, Pattanaik KP, Nayak S, Mahapatra RK. An Immunoinformatics-Based Study of Mycobacterium tuberculosis Region of Difference-2 Uncharacterized Protein (Rv1987) as a Potential Subunit Vaccine Candidate for Preliminary Ex Vivo Analysis. Applied biochemistry and biotechnology 2024. link 63 Sethi G, Varghese RP, Lakra AK, Nayak SS, Krishna R, Hwang JH. Immunoinformatics and structural aided approach to develop multi-epitope based subunit vaccine against Mycobacterium tuberculosis. Scientific reports 2024. link 64 Zhou Y, Wu Q, Wang F, Chen S, Zhang Y, Wang W et al.. Association of variant vitamin statuses and tuberculosis development: a systematic review and meta-analysis. Annals of medicine 2024. link 65 Dixon EG, Rasool S, Otaalo B, Motee A, Dear JW, Sloan D et al.. No action is without its side effects: Adverse drug reactions and missed doses of antituberculosis therapy, a scoping review. British journal of clinical pharmacology 2024. link 66 Pervez A, Hasan SU, Hamza M, Asghar S, Qaiser MH, Zaidi S et al.. Diagnostic accuracy of tests for tuberculous pericarditis: A network meta-analysis. The Indian journal of tuberculosis 2024. link 67 Yeo Y, Yoo JE, Han K, Jung JH, Choi H, Park J et al.. Risk of dementia in survivors of active tuberculosis in Korea: A nationwide cohort study. Journal of infection and public health 2024. link 68 Mangione CM, Barry MJ, Nicholson WK, Cabana M, Chelmow D, Coker TR et al.. Screening for Latent Tuberculosis Infection in Adults: US Preventive Services Task Force Recommendation Statement. JAMA 2023. link 69 Jagi JL, Thomas C, Gudi SK, Undela K. Efficacy, safety, and tolerability of isoniazid preventive therapy for tuberculosis in people living with HIV. AIDS (London, England) 2023. link 70 Salari N, Kanjoori AH, Hosseinian-Far A, Hasheminezhad R, Mansouri K, Mohammadi M. Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis. Infectious diseases of poverty 2023. link 71 Chauhan A, Parmar M, Dash GC, Solanki H, Chauhan S, Sharma J et al.. The prevalence of tuberculosis infection in India: A systematic review and meta-analysis. 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Microbes and infection 2023. link 77 Jena A, Mohindra R, Rana K, Neelam PB, Thakur DC, Singh H et al.. Frequency, outcomes, and need for intervention in stricturing gastrointestinal tuberculosis: a systematic review and meta-analysis. BMC gastroenterology 2023. link 78 Antony BS, Nagarajan C, Thomas KE, Stephen SB, Yasam SK, Subbaraj GK. IFN-gene polymorphisms as a risk factor for tuberculosis infection in Asian populations: A meta-analysis. International journal of mycobacteriology 2023. link 79 Mangan JM, Woodruff RS, Winston CA, Nabity SA, Haddad MB, Dixon MG et al.. Recommendations for Use of Video Directly Observed Therapy During Tuberculosis Treatment - United States, 2023. MMWR. Morbidity and mortality weekly report 2023. link 80 Melnychuk L, Perlman-Arrow S, Lisboa Bastos M, Menzies D. A Systematic Review and Meta-Analysis of Tuberculous Preventative Therapy Adverse Events. 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    Original source

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      Drug-resistant tuberculosis in war and complex emergencies: jeopardising progress towards TB elimination and antimicrobial resistance control - a scoping review and perspective.Monedero-Recuero I, Wei X, Jouberton F, Duarte R, Rodríguez-Ortega M, Santiago MRT et al. BMJ global health (2026)
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      Exposure-QTc modeling of bedaquiline, pretomanid, and clofazimine in adults with tuberculosis.Abdelwahab MT, Svensson EM, Diacon AH, Conradie A, Olugbosi M, Dawson R et al. Antimicrobial agents and chemotherapy (2026)
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      The Emerging Role of Immunothrombosis in the Control and Pathogenesis of Mycobacterium tuberculosis.Donohue S, Leisching G, Keane J The Journal of infectious diseases (2026)
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      Tuberculosis-associated nonbacterial thrombotic endocarditis: A case report.Tanaka K, Fukushima S, Oguni K, Yoshida S, Ihoriya H, Hagiya H et al. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (2026)
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