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Peliosis hepatis

Last edited: 4/16/2026

Overview

Peliosis hepatis is a rare hepatic condition characterized by the development of blood-filled cystic spaces within liver parenchyma, often communicating with hepatic sinusoids 1. It can be associated with certain therapeutic agents, notably steroid therapy 1.

Diagnosis

  • Histological Features: Multiple blood-filled cystic spaces communicating with hepatic sinusoids 1.
  • Imaging: Angiographic findings can be characteristic, showing cystic dilatations 1.
  • Differential Diagnosis: Includes hepatic abscesses, cavernous hemangiomas, and Budd-Chiari syndrome 1.
  • Management

  • Discontinuation of Causative Agents: If steroid therapy is implicated, cessation is recommended 1.
  • Supportive Care: Focus on managing complications and symptoms, including monitoring for hemorrhage or infection 1.
  • No Specific Pharmacological Treatment: No universally recommended pharmacological intervention beyond addressing underlying causes 1.
  • Special Populations

  • Steroid Therapy Concerns: Particular vigilance in patients on long-term steroid therapy 1.
  • Limited Data: Abstracts do not provide specific guidance for pregnancy, pediatrics, or elderly populations 1.
  • Key Recommendations

  • Identify and Discontinue Potential Causative Agents, particularly steroids, if peliosis hepatis is suspected 1 (Evidence: Moderate).
  • Histological Confirmation is essential for definitive diagnosis 1 (Evidence: Strong).
  • Monitor for Complications such as hemorrhage or infection in managed cases 1 (Evidence: Expert opinion).
  • References

    1 Pliskin M. Peliosis hepatitis. Radiology 1975. link

    Original source

    1. [1]
      Peliosis hepatitis.Pliskin M Radiology (1975)

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