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Huntington's chorea

Last edited: 4/10/2026

Overview

Huntington's chorea is a neurological disorder characterized by involuntary movements (chorea) and often associated with psychiatric symptoms and cognitive decline 1. The age of onset can vary, with median onset potentially older than previously reported 3.

Diagnosis

  • Diagnostic issues can be complex, particularly regarding psychiatric assessment 1.

    • Management

  • Surgical correction, such as eminectomy, may be successful for specific complications like recurrent mandibular dislocation 2.
  • Anesthesia techniques involving thiopentone, nitrous oxide, narcotic analgesics or halothane, and pancuronium have been used successfully in patients with Huntington's chorea 4.

    • Key Recommendations

  • Surgical correction may be considered for complications such as recurrent mandibular dislocation 2. (Evidence: Weak)
  • Anesthesia protocols including thiopentone, nitrous oxide, narcotic analgesics or halothane, and pancuronium are reported as successful 4. (Evidence: Weak)
  • The interrelation between cerebral neuronal damage and hepatocyte damage in Huntington's chorea was not substantiated by liver biopsy findings 5. (Evidence: Moderate)

    • References

    1 Turner TH. Huntington's chorea without dementia. A problem case. The British journal of psychiatry : the journal of mental science 1985. link 2 Price RB. Surgical correction of recurrent dislocation of a mandibular condyle in a patient with Huntington's chorea: a case report. The British journal of oral & maxillofacial surgery 1985. link90061-0) 3 Newcombe RG. A life table for onset of Huntington's chorea. Annals of human genetics 1981. link 4 Farina J, Rauscher LA. Anaesthesia and Huntington's chorea. A report of two cases. British journal of anaesthesia 1977. link 5 Chiu E, Mackay IR, Bhathal PB. Hepatic morphology in Huntington's chorea. Journal of neurology, neurosurgery, and psychiatry 1975. link

    Original source

    1. [1]
      Huntington's chorea without dementia. A problem case. — Turner TH The British journal of psychiatry : the journal of mental science (1985)
    2. [2]
      Surgical correction of recurrent dislocation of a mandibular condyle in a patient with Huntington's chorea: a case report. — Price RB The British journal of oral & maxillofacial surgery (1985)
    3. [3]
      A life table for onset of Huntington's chorea. — Newcombe RG Annals of human genetics (1981)
    4. [4]
      Anaesthesia and Huntington's chorea. A report of two cases. — Farina J, Rauscher LA British journal of anaesthesia (1977)
    5. [5]
      Hepatic morphology in Huntington's chorea. — Chiu E, Mackay IR, Bhathal PB Journal of neurology, neurosurgery, and psychiatry (1975)
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