Overview
Malaria is a life-threatening parasitic disease caused by Plasmodium species, transmitted through the bite of infected Anopheles mosquitoes. It affects multiple organ systems and can lead to severe complications including cerebral malaria, multi-organ dysfunction, and hemophagocytic lymphohistiocytosis 1234510263233.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 217 indexed papers.
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The blood purification therapy-based strategy effectively rescued the severe falciparum malaria patient experiencing cytokine storm-driven MODS. Frontiers in cellular and infection microbiology 2025. link 6 Pereira DB, Lacerda MVG, Bilkhu P, Duarte C, Fiţa IG, Jackson F et al.. An observational pilot study of an active surveillance tool to enhance pharmacovigilance in Brazil. Malaria journal 2025. link 7 Mulatie Z, Kelem A, Chane E, Tarekegn AM, Teketelew BB, Yenesew A et al.. Diagnostic role of Sysmex hematology analyzer in the detection of malaria: A systematic review and meta-analysis. PloS one 2024. link 8 Jebiwott S, Gutapaka N, Sumari D, Loss G, Athuman T, Nyandele JP et al.. Child Health and Infection with Low Density (CHILD) malaria: a protocol for a randomised controlled trial to assess the long-term health and socioeconomic impacts of testing and treating low-density malaria infection among children in Tanzania. BMJ open 2024. link 9 Ogbuanu IU, Otieno K, Varo R, Sow SO, Ojulong J, Duduyemi B et al.. Burden of child mortality from malaria in high endemic areas: Results from the CHAMPS network using minimally invasive tissue sampling. The Journal of infection 2024. link 10 Orth HM, Wiemer D, Schneitler S, Schönfeld A, Holtfreter MC, Gliga S et al.. Hemophagocytic lymphohistiocytosis-how common and how severe is it as a complication of malaria? Retrospective case series and review of the literature. Infection 2024. link 11 Rotimi K, Fagbemi B, Omole G, Biambo AA, Ibinaiye T, Iwegbu A et al.. Awareness, knowledge, attitude, and practice of adverse drug reaction reporting among health workers in primary health centres participating in seasonal malaria chemoprevention campaign in Nigeria in 2022: a cross-sectional survey. BMC health services research 2024. link 12 Antwi-Baffour S, Mensah BT, Johnson G, Armah DNO, Ali-Mustapha S, Annison L. Haematological parameters and their correlation with the degree of malaria parasitaemia among outpatients attending a polyclinic. Malaria journal 2023. link 13 Messenger LA, Furnival-Adams J, Chan K, Pelloquin B, Paris L, Rowland M. Vector control for malaria prevention during humanitarian emergencies: a systematic review and meta-analysis. The Lancet. Global health 2023. link00044-X) 14 Tripathy R, Das BK, Panda AK. Procalcitonin is elevated in severe malaria and is a promising biomarker of severe malaria and multi-organ dysfunction: A cross-sectional study and meta-analysis. International immunopharmacology 2023. link 15 Brainin P, Gomes LC, Holm AE, Matos LO, Wegener A, Lima KO et al.. Left ventricular function by strain in uncomplicated malaria: a prospective study from the Brazilian Amazon. The international journal of cardiovascular imaging 2023. link 16 Phyo AP, Dahal P, Mayxay M, Ashley EA. Clinical impact of vivax malaria: A collection review. PLoS medicine 2022. link 17 Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C et al.. Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas. The Cochrane database of systematic reviews 2022. link 18 Sheikh S. Back to Ivermectin: Is History Repeating Itself?. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2022. link 19 Yun SG, Yoon J, Kim K, Choi JM, Jeon Y, Kim GA et al.. Detection of Plasmodium vivax using Automated Hematology Analyzer in the Korean Army. Clinical laboratory 2022. link 20 Sharma D, Priest H, Wilcox A. Pseudoreticulocytosis by the ADVIA 2120 Hematology Analyzer and Other Hematologic Changes in a Cynomolgus Macaque (. Toxicologic pathology 2022. link 21 Tougan T, Hiyoshi F, Itagaki S, Horii T. Detection of histidine-rich protein 2- and/or 3-deleted Plasmodium falciparum using the automated hematology analyzer XN-31: A proof-of-concept study. Parasitology international 2022. link 22 Kagaya W, Takehara I, Kurihara K, Maina M, Chan CW, Okomo G et al.. Potential application of the haematology analyser XN-31 prototype for field malaria surveillance in Kenya. Malaria journal 2022. link 23 Komaki-Yasuda K, Kutsuna S, Kawaguchi M, Kamei M, Uchihashi K, Nakamura K et al.. Clinical performance testing of the automated haematology analyzer XN-31 prototype using whole blood samples from patients with imported malaria in Japan. Malaria journal 2022. link 24 Young AJ, Eaton W, Worges M, Hiruy H, Maxwell K, Audu BM et al.. A practical approach for geographic prioritization and targeting of insecticide-treated net distribution campaigns during public health emergencies and in resource-limited settings. Malaria journal 2022. link 25 Obisesan O, Akinyemi JO, Morhason-Bello IO, Yusuf OB, Eyelade RO, Ilori T et al.. Assessment of diagnostic accuracy and adherence to maternal and child health guidelines as a measure of clinical competence of frontline healthcare workers in Nigeria. African journal of reproductive health 2022. link 26 Ngai M, Hawkes MT, Erice C, Weckman AM, Wright J, Stefanova V et al.. Intestinal Injury in Ugandan Children Hospitalized With Malaria. The Journal of infectious diseases 2022. link 27 Kaagaard MD, Matos LO, Holm AE, Gomes LC, Wegener A, Lima KO et al.. Frequency of Electrocardiographic Alterations and Pericardial Effusion in Patients With Uncomplicated Malaria. The American journal of cardiology 2022. link 28 Chan XHS, Haeusler IL, Win YN, Pike J, Hanboonkunupakarn B, Hanafiah M et al.. The cardiovascular effects of amodiaquine and structurally related antimalarials: An individual patient data meta-analysis. PLoS medicine 2021. link 29 Toya Y, Tougan T, Horii T, Uchihashi K. Lysercell M enhances the detection of stage-specific Plasmodium-infected red blood cells in the automated hematology analyzer XN-31 prototype. Parasitology international 2021. link 30 Messenger LA, Furnival-Adams J, Pelloquin B, Rowland M. Vector control for malaria prevention during humanitarian emergencies: protocol for a systematic review and meta-analysis. BMJ open 2021. link 31 Gelfman DM. Reflections on quinine and its importance in dermatology today. Clinics in dermatology 2021. link 32 Fett N, Werth VP. A Multidisciplinary Collaborative Approach to Retinal Toxic Effects Screening for Dermatology Patients Taking Antimalarials. JAMA dermatology 2021. link 33 Bangirana P, Birabwa A, Nyakato M, Nakitende AJ, Kroupina M, Ssenkusu JM et al.. Use of the creating opportunities for parent empowerment programme to decrease mental health problems in Ugandan children surviving severe malaria: a randomized controlled trial. Malaria journal 2021. link 34 Papazisis G, Siafis S, Cepatyte D, Giannis D, Stamoula E, Tzachanis D et al.. Safety profile of chloroquine and hydroxychloroquine: a disproportionality analysis of the FDA Adverse Event Reporting System database. European review for medical and pharmacological sciences 2021. link 35 Brainin P, Mohr GH, Modin D, Claggett B, Silvestre OM, Shah A et al.. Heart failure associated with imported malaria: a nationwide Danish cohort study. ESC heart failure 2021. link 36 Boëte C, Guardiola M, Lasry E, Burza S, Moriana S, Robertson W. Needs and Challenges in Modelling Malaria for Emergency Contexts. Trends in parasitology 2020. link 37 Dumas C, Tirard-Collet P, Mestrallet F, Girard S, Jallades L, Picot S et al.. Flagging performance of Sysmex XN-10 haematology analyser for malaria detection. Journal of clinical pathology 2020. link 38 Kedarisetty CK, Samaga BL, Vidyasagar S, Venkataraman J. Oral melatonin improves the detection of parasitemia in malaria. Journal of infection in developing countries 2020. link 39 Roberts DJ, Zewotir T. Copula geoadditive modelling of anaemia and malaria in young children in Kenya, Malawi, Tanzania and Uganda. Journal of health, population, and nutrition 2020. link 40 Aychiluhm SB, Gelaye KA, Angaw DA, Dagne GA, Tadesse AW, Abera A et al.. Determinants of malaria among under-five children in Ethiopia: Bayesian multilevel analysis. BMC public health 2020. link 41 Hung YW, Hoxha K, Irwin BR, Law MR, Grépin KA. Using routine health information data for research in low- and middle-income countries: a systematic review. BMC health services research 2020. link 42 Sié A, Bountogo M, Ouattara M, Zabre P, Bagagnan C, Zakane A et al.. Insecticide-treated bed net access and use among preschool children in Nouna District, Burkina Faso. International health 2020. link 43 Guo ZK, Huo HF, Xiang H. Global dynamics of an age-structured malaria model with prevention. Mathematical biosciences and engineering : MBE 2019. link 44 Vanstreels RET, Dutra DA, Ferreira-Junior FC, Hurtado R, Egert L, Mayorga LFSP et al.. Epidemiology, hematology, and unusual morphological characteristics of Plasmodium during an avian malaria outbreak in penguins in Brazil. Parasitology research 2019. link 45 Tougan T, Toya Y, Uchihashi K, Horii T. Application of the automated haematology analyzer XN-30 for discovery and development of anti-malarial drugs. Malaria journal 2019. link 46 Sun Y, Xiang D, Chen C, He S, Qi H, Wang C. Infected RBC flag/parameter provided by Mindray BC-6800 haematology analyzer aid the diagnosis of malaria. Malaria journal 2019. link 47 Post A, Kaboré B, Reuling IJ, Bognini J, van der Heijden W, Diallo S et al.. The XN-30 hematology analyzer for rapid sensitive detection of malaria: a diagnostic accuracy study. BMC medicine 2019. link 48 Amimo F, Moon TD, Magit A, Sacarlal J, Lambert B, Nomura S. Trends in comparative efficacy and safety of malaria control interventions for maternal and child health outcomes in Africa: a study protocol for a Bayesian network meta-regression exploring the effect of HIV and malaria endemicity spectrum. BMJ open 2019. link 49 Yoshii A, Sekihara M, Furusawa T, Hombhanje F, Tsukahara T. Factors associated with children's health facility visits for primaquine treatment in rural Papua New Guinea. Malaria journal 2019. link 50 Dhangadamajhi G, Panigrahi S, Roy S, Tripathy S. Effect of Plasmodium falciparum infection on blood parameters and their association with clinical severity in adults of Odisha, India. Acta tropica 2019. link 51 Dayanand KK, Kishore P, Chandrashekar V, Achur RN, Ghosh SK, Kakkilaya SB et al.. Malaria Severity in Mangaluru City in the Southwestern Coastal Region of India. The American journal of tropical medicine and hygiene 2019. link 52 Cheikhrouhou F, Ammar R, Bellili S, Jdidi I, Bahloul M, Ayadi A et al.. Macrophage activation syndrome in a patient affected by Plasmodium falciparum Aeroport malaria. La Tunisie medicale 2019. link 53 Teparrukkul P, Hantrakun V, Imwong M, Teerawattanasook N, Wongsuvan G, Day NP et al.. Utility of qSOFA and modified SOFA in severe malaria presenting as sepsis. PloS one 2019. link 54 Smit MR, Ochomo EO, Waterhouse D, Kwambai TK, Abong'o BO, Bousema T et al.. Pharmacokinetics-Pharmacodynamics of High-Dose Ivermectin with Dihydroartemisinin-Piperaquine on Mosquitocidal Activity and QT-Prolongation (IVERMAL). Clinical pharmacology and therapeutics 2019. link 55 Sangani NK, Naliath SM. Fever and large pericardial effusion after valve surgery: can be malaria. Asian cardiovascular & thoracic annals 2019. link 56 Wirth DF, Casamitjana N, Tanner M, Reich MR. Global action for training in malaria elimination. Malaria journal 2018. link 57 Zodda D, Procopio G, Hewitt K, Parrish A, Balani B, Feldman J. Severe malaria presenting to the ED: A collaborative approach utilizing exchange transfusion and artesunate. The American journal of emergency medicine 2018. link 58 Buoro S, Manenti B, Seghezzi M, Moioli V, Bagorria M, Callegaro A et al.. Abnormal scattergrams and cell population data generated by fully automated hematological analyzers: New tools for screening malaria infection?. International journal of laboratory hematology 2018. link 59 Chen LH, Leder K, Barbre KA, Schlagenhauf P, Libman M, Keystone J et al.. Business travel-associated illness: a GeoSentinel analysis. Journal of travel medicine 2018. link 60 Souza ACM, Mosqueira VCF, Silveira APA, Antunes LR, Richard S, Guimarães HN et al.. Reduced cardiotoxicity and increased oral efficacy of artemether polymeric nanocapsules in Plasmodium berghei-infected mice. Parasitology 2018. link 61 Saito M, Gilder ME, Nosten F, Guérin PJ, McGready R. Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review. Malaria journal 2017. link 62 Sadoh WE, Uduebor JO. Electrocardiographic changes and troponin T levels in children with severe malaria anemia and heart failure. Nigerian journal of clinical practice 2017. link 63 Hegge SR, Hickey BW, Mcgrath SM, Stewart VA. Using Hematology Data from Malaria Vaccine Research Trials in Humans and Rhesus Macaques (. Comparative medicine 2016. link 64 Yoon J, Yun SG, Kim J, Jung YN, Koh YE, Nam JH et al.. Evaluation of the LH780 hematology analyzer for detection and therapeutic monitoring of malaria: Cross-reactivity with nucleated RBCs. Acta tropica 2016. link 65 Sidorov P, Desta I, Chessé M, Horvath D, Marcou G, Varnek A et al.. Redox Polypharmacology as an Emerging Strategy to Combat Malarial Parasites. ChemMedChem 2016. link 66 Shukshin A. Boosting health skills in Ukraine. Bulletin of the World Health Organization 2015. link 67 Herbert F, Tchitchek N, Bansal D, Jacques J, Pathak S, Bécavin C et al.. Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria. Journal of translational medicine 2015. link 68 Kukula VA, Dodoo AA, Akpakli J, Narh-Bana SA, Clerk C, Adjei A et al.. Feasibility and cost of using mobile phones for capturing drug safety information in peri-urban settlement in Ghana: a prospective cohort study of patients with uncomplicated malaria. Malaria journal 2015. link 69 Mohandas N, Hillyer CD. The iron fist: malaria and hepcidin. Blood 2014. link 70 Munoz-Urbano M, Lopez-Isaza AF, Hurtado-Hurtado N, Gomez-Suta D, Murillo-Abadia J, Delgado-Osorio N et al.. Scientific research in malaria: bibliometric assessment of the Latin-American contributions. Recent patents on anti-infective drug discovery 2014. link 71 Deroost K, Opdenakker G, Van den Steen PE. MalarImDB: an open-access literature-based malaria immunology database. Trends in parasitology 2014. link 72 Walton E, Oliveros H, Villamor E. Hemoglobin concentration and parasitemia on hospital admission predict risk of multiple organ dysfunction syndrome among adults with malaria. The American journal of tropical medicine and hygiene 2014. link 73 Azidah AK, Mohd Faizal MA, Lili HY, Zeehaida M. Severe Plasmodium knowlesi infection with multiorgan involvement in north east peninsular Malaysia. Tropical biomedicine 2014. link 74 Seilmaier M, Hartmann W, Beissner M, Fenzl T, Haller C, Guggemos W et al.. Severe Plasmodium knowlesi infection with multi-organ failure imported to Germany from Thailand/Myanmar. Malaria journal 2014. link 75 Hanson J, Anstey NM, Bihari D, White NJ, Day NP, Dondorp AM. The fluid management of adults with severe malaria. Critical care (London, England) 2014. link 76 Bresnahan KA, Chileshe J, Tanumihardjo SA. Quantification of food and nutrient intakes in Zambian children with and without malaria under controlled feeding conditions. Experimental biology and medicine (Maywood, N.J.) 2014. link 77 Kajungu DK, Erhart A, Talisuna AO, Bassat Q, Karema C, Nabasumba C et al.. Paediatric pharmacovigilance: use of pharmacovigilance data mining algorithms for signal detection in a safety dataset of a paediatric clinical study conducted in seven African countries. PloS one 2014. link 78 Dodoo AN, Fogg C, Nartey ET, Ferreira GL, Adjei GO, Kudzi W et al.. Profile of adverse events in patients receiving treatment for malaria in urban Ghana: a cohort-event monitoring study. Drug safety 2014. link 79 Aggarwal V, Nagpal A, Agrawal Y, Kumar V, Kanwal SK, Dhingra B. Plasmodium vivax malaria complicated by splenic infarct. Paediatrics and international child health 2014. link 80 Hempelmann E, Krafts K. Bad air, amulets and mosquitoes: 2,000 years of changing perspectives on malaria. Malaria journal 2013. link 81 Sharma S, Sethi N, Pujani M, Kushwaha S, Sehgal S. Abnormal WBC scattergram: a clue to the diagnosis of malaria. Hematology (Amsterdam, Netherlands) 2013. link 82 Lee HJ, Baek JH, Chae MH, Joo H, Lee JS, Chung MH et al.. A case of vivax malaria complicated by adult respiratory distress syndrome and successful management with extracorporeal membrane oxygenation. The Korean journal of parasitology 2013. link 83 Saini T, Kumhar M, Barjartya HC. Plasmodium vivax malaria--is it really benign?. Journal of the Indian Medical Association 2013. link 84 Ritchie EC, Block J, Nevin RL. Psychiatric side effects of mefloquine: applications to forensic psychiatry. The journal of the American Academy of Psychiatry and the Law 2013. link 85 Allen EN, Chandler CI, Mandimika N, Pace C, Mehta U, Barnes KI. Evaluating harm associated with anti-malarial drugs: a survey of methods used by clinical researchers to elicit, assess and record participant-reported adverse events and related data. Malaria journal 2013. link 86 Ross A, Koepfli C, Li X, Schoepflin S, Siba P, Mueller I et al.. Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data. PloS one 2012. link 87 Siriez JY, Lupoglazoff JM, Bouchy-Bagros ML, Pull L, Denjoy I. Effect of halofantrine on QT interval in children. Pathogens and global health 2012. link 88 Sharma R, Gohain S, Chandra J, Kumar V, Chopra A, Chatterjee S et al.. Plasmodium vivax malaria admissions and risk of mortality in a tertiary-care children's hospital in North India. Paediatrics and international child health 2012. link 89 Brasseur P, Vaillant MT, Olliaro PL. Anti-malarial drug safety information obtained through routine monitoring in a rural district of South-Western Senegal. Malaria journal 2012. link 90 McEwen J. Artesunate- and amodiaquine-associated extrapyramidal reactions: a series of 49 cases in VigiBase™. Drug safety 2012. link 91 Davies EC, Chandler CI, Innocent SH, Kalumuna C, Terlouw DJ, Lalloo DG et al.. Designing adverse event forms for real-world reporting: participatory research in Uganda. PloS one 2012. link 92 Saka WA, Akhigbe RE, Azeez OM, Babatunde TR. Effects of pyrethroid insecticide exposure on haematological and haemostatic profiles in rats. Pakistan journal of biological sciences : PJBS 2011. link 93 Mandal B, Das BK, Chatterjee SK, Guh P, Shai S, Sharma A et al.. Acute pancreatitis in a case of falciparum malaria--a rare presentation. The Journal of the Association of Physicians of India 2011. link 94 Ahmed S, Adil F, Shahzad T, Yahiya Y. Severe malaria in children: factors predictive of outcome and response to Quinine. JPMA. The Journal of the Pakistan Medical Association 2011. link 95 Adedeji AA, Sanusi B, Tella A, Akinsanya M, Ojo O, Akinwunmi MO et al.. Exposure to anti-malarial drugs and monitoring of adverse drug reactions using toll-free mobile phone calls in private retail sector in Sagamu, Nigeria: implications for pharmacovigilance. Malaria journal 2011. link 96 Kuemmerle A, Dodoo AN, Olsson S, Van Erps J, Burri C, Lalvani PS. Assessment of global reporting of adverse drug reactions for anti-malarials, including artemisinin-based combination therapy, to the WHO Programme for International Drug Monitoring. Malaria journal 2011. link 97 Mocumbi AO, Songane M, Salomão C, Ulibarri R, Ferreira MB, Yacoub MH. Lack of evidence of myocardial damage in children with Plasmodium falciparum severe and complicated malaria from an endemic area for endomyocardial fibrosis. Journal of tropical pediatrics 2011. link 98 Conroy AL, Phiri H, Hawkes M, Glover S, Mallewa M, Seydel KB et al.. Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study. 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