← Back to guidelines
Allergy & Immunology9605 papers

Allergic rhinitis

Last edited: 4/17/2026

Overview

Allergic rhinitis (AR) is a common IgE-mediated hypersensitivity disease affecting the nasal passages, characterized by symptoms such as sneezing, nasal congestion, and itching, often impacting quality of life and productivity 127.

Diagnosis

  • Symptoms: Sneezing, nasal congestion, rhinorrhea, itching of the nose, eyes, and palate 127.
  • Allergy Testing: Skin prick tests and specific IgE blood tests for allergen identification 1227.
  • Nasal Endoscopy: To rule out other causes of nasal symptoms 27.
  • Grading: Mild, moderate, severe based on symptom frequency and impact on daily activities 127.
  • Management

  • First-Line Treatments:
  • - Intranasal Corticosteroids: Fluticasone, mometasone (evidence-based first choice) 1. - Antihistamines: Levocetirizine, desloratadine (second-generation preferred to minimize sedation) 455.
  • Adjunctive Treatments:
  • - Montelukast: For comorbid asthma or persistent symptoms 4. - Immunotherapy: Subcutaneous (SCIT) or sublingual (SLIT) for long-term control, especially in severe cases 56112029. - Probiotics: Emerging interest but evidence is preliminary 16.

    Special Populations

  • Pediatrics: Early intervention with intranasal corticosteroids and consideration of immunotherapy for persistent cases 281520.
  • Elderly: Similar management principles apply, with careful monitoring for polypharmacy interactions 27.
  • Comorbidities: Close management of asthma alongside AR, considering combination therapies like montelukast-levocetirizine 4.
  • Key Recommendations

  • Initiate intranasal corticosteroids as first-line therapy for symptom control in allergic rhinitis (Evidence: Strong 1).
  • Consider second-generation antihistamines for additional relief, particularly in managing ocular symptoms (Evidence: Moderate 455).
  • Evaluate and implement allergen immunotherapy for patients with persistent symptoms despite optimal pharmacotherapy (Evidence: Moderate 529).
  • Monitor and manage comorbid conditions such as asthma in patients with allergic rhinitis to optimize overall outcomes (Evidence: Moderate 4).
  • Use sublingual immunotherapy as a viable alternative to subcutaneous immunotherapy, especially in pediatric populations (Evidence: Moderate 1120).
  • Promote patient education and adherence to treatment plans to improve quality of life and symptom control (Evidence: Expert opinion 44).
  • References

    Showing 100 most recent of 125 indexed papers.

    1 Sousa-Pinto B, Bousquet J, Vieira RJ, Schünemann HJ, Zuberbier T, Bognanni A et al.. Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines-2024-2025 Revision: Part I-Guidelines on Intranasal Treatments. Allergy 2026. link 2 Tosca MA, Trincianti C, Burgos AM, Ribeiro L, Del Castillo MM, Neves A et al.. Creation of an international Inter-Society Pediatric Allergology Network (ISPAN): preliminary data from a survey of pediatric allergist in Italy, Spain, and Portugal. Allergologia et immunopathologia 2026. link 3 Zhang ZQ, Li JY, Guo Q, Li YL, Bao YW, Song YQ et al.. Association between air pollution and allergic upper respiratory diseases: a meta-analysis. European respiratory review : an official journal of the European Respiratory Society 2025. link 4 Shao M, Sun J, Zheng Q. Efficacy and safety of montelukast-levocetirizine combination therapy in combined allergic rhinitis and asthma syndrome: a systematic review and meta-analysis. The Journal of asthma : official journal of the Association for the Care of Asthma 2025. link 5 Gurgel RK, Baroody FM, Damask CC, Mims JW, Ishman SL, Baker DP et al.. Clinical Practice Guideline: Immunotherapy for Inhalant Allergy. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2024. link 6 Arshad H, Lack G, Durham SR, Penagos M, Larenas-Linnemann D, Halken S. Prevention Is Better than Cure: Impact of Allergen Immunotherapy on the Progression of Airway Disease. The journal of allergy and clinical immunology. In practice 2024. link 7 White AA, Ramsey A, Guyer A, Israelsen RB, Khan F, Kaplan B et al.. AAAAI Position Statement on Changing Electronic Health Record Allergy Documentation to "Alerts" to Lead to Easily Understood, Actionable Labels. The journal of allergy and clinical immunology. In practice 2024. link 8 Miraglia Del Giudice M, Marseglia GL, Peroni DG, Zicari AM, Dinardo G, Ciprandi G. Allergic rhinitis management: a Delphi Consensus promoted by the Italian Society of Pediatric Allergy and Immunology (SIAIP). Italian journal of pediatrics 2024. link 9 Kausar MA, Bhardwaj T, Alenazi F, Alshammari KF, Anwar S, Ali A et al.. A comprehensive immunoinformatics study to explore and characterize potential vaccine constructs against Ole e 9 allergen of . Journal of biomolecular structure & dynamics 2024. link 10 Licari A, Magri P, De Silvestri A, Giannetti A, Indolfi C, Mori F et al.. Epidemiology of Allergic Rhinitis in Children: A Systematic Review and Meta-Analysis. The journal of allergy and clinical immunology. In practice 2023. link 11 Yang J, Lei S. Efficacy and safety of sublingual versus subcutaneous immunotherapy in children with allergic rhinitis: a systematic review and meta-analysis. Frontiers in immunology 2023. link 12 Colás C, Álvarez-Suárez ME, Benedito-Palos L, Alobid I. Therapeutic management of allergic rhinitis: a survey of otolaryngology and allergology specialists. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2023. link 13 Michel JJ, Schwartz SR, Dawson DE, Denneny JC, Erinoff E, Dhepyasuwan N et al.. Quality Improvement in Otolaryngology-Head and Neck Surgery: Developing Registry-Enabled Quality Measures From Guidelines for Cerumen Impaction and Allergic Rhinitis Through a Transparent and Systematic Process. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2022. link 14 Reddy KRBK, Gupta N, Bhattacharya BG, Deka NM, Chandane P, Kapoor R et al.. Impact of Air Pollution on Allergic Rhinitis and Asthma: Consensus Statement by Indian Academy of Pediatrics. Indian pediatrics 2021. link 15 Martinez A, Torres J, Molina AB, Muños C, Diaz M, Corzo JL et al.. Evaluation of a pre-co-seasonal and a perennial schedule of a single multiallergen depigmented-polymerized subcutaneous immunotherapy in paediatric patients. Allergologia et immunopathologia 2021. link 16 Bourdillon AT, Edwards HA. Review of probiotic use in otolaryngology. American journal of otolaryngology 2021. link 17 Schmalbach CE, Brereton J, Bowman C, Denneny JC. American Academy of Otolaryngology-Head and Neck Surgery/Foundation Reg-ent Registry: Purpose, Properties, and Priorities. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2021. link 18 Bousquet J, Schröder-Bernhardi D, Bachert C, Canonica GW, Cardona V, Costa EM et al.. Heterogeneity of the pharmacologic treatment of allergic rhinitis in Europe based on MIDAS and OTCims platforms. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2021. link 19 Alvaro-Lozano M, Akdis CA, Akdis M, Alviani C, Angier E, Arasi S et al.. EAACI Allergen Immunotherapy User's Guide. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2020. link 20 Ameli F, Tosca MA, Licari A, Gallo F, Ciprandi G. Can an otorhinolaryngological visit induce the suspect of allergic rhinitis in children?. European annals of allergy and clinical immunology 2019. link 21 Yücel Ekici N, Külahci Ö. Relationship between tissue and serum eosinophilia in children undergoing adenotonsillectomy with allergic rhinitis. Turkish journal of medical sciences 2019. link 22 Bakhshaee M, Sharifian M, Esmatinia F, Rasoulian B, Mohebbi M. Therapeutic effect of vitamin D supplementation on allergic rhinitis. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2019. link 23 Ridolo E, Martignago I, Masieri S. Mechanisms of allergic diseases in Otorhinolaryngology. Journal of biological regulators and homeostatic agents 2018. link 24 Crowson MG, Schulz K, Ulvila A, Witsell DL. Payer database and geospatial analysis to evaluate practice patterns in treating allergy in North Carolina. American journal of otolaryngology 2018. link 25 Castelli S, Arasi S, Pawankar R, Matricardi PM. Collection of nasal secretions and tears and their use in allergology. Current opinion in allergy and clinical immunology 2018. link 26 Nolte H, Bernstein DI, Sussman GL, Svanholm Fogh B, Lu S, Husøy B et al.. Impact of Adverse Event Solicitation on the Safety Profile of SQ House Dust Mite Sublingual Immunotherapy Tablet. The journal of allergy and clinical immunology. In practice 2018. link 27 Brożek JL, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S et al.. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision. The Journal of allergy and clinical immunology 2017. link 28 Calabria CW, Hauswirth DW, Rank M, Sher L, Larenas-Linnemann D. American Academy of Asthma, Allergy & Immunology membership experience with venom immunotherapy in chronic medical conditions and pregnancy, and in young children. Allergy and asthma proceedings 2017. link 29 Rodríguez Del Río P, Vidal C, Just J, Tabar AI, Sanchez-Machin I, Eberle P et al.. The European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI): A paediatric assessment. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2017. link 30 Saporta D. Sublingual Immunotherapy: A Useful Tool for the Allergist in Private Practice. BioMed research international 2016. link 31 Ng CL, Wang DY. Latest developments in allergic rhinitis in Allergy for clinicians and researchers. Allergy 2015. link 32 Lombardi C, Canonica GW, Passalacqua G. The perception of allergen-specific immunotherapy among chest physicians: an Italian survey. European annals of allergy and clinical immunology 2014. link 33 Cornelis M, Rombaux P, Jorissen M, Hellings PW. Nationwide survey on immunotherapy practice by ENT specialists. Rhinology 2014. link 34 Rachelefsky G, Farrar JR. Are you comfortable with over-the-counter intranasal steroids for children? A call to action. The journal of allergy and clinical immunology. In practice 2014. link 35 He Y, Liu X, Huang Y, Zou Z, Chen H, Lai H et al.. Reduction of the number of major representative allergens: from clinical testing to 3-dimensional structures. Mediators of inflammation 2014. link 36 Luzzi V, Ierardo G, Viscogliosi A, Fabbrizi M, Consoli G, Vozza I et al.. Allergic rhinitis as a possible risk factor for malocclusion: a case-control study in children. International journal of paediatric dentistry 2013. link 37 San T, Muluk NB, Cingi C. 1,25(OH)₂D₃ and specific IgE levels in children with recurrent tonsillitis, and allergic rhinitis. International journal of pediatric otorhinolaryngology 2013. link 38 Ridolo E, Incorvaia C, Senna GE, Montagni M, Olivieri E, Canonica GW. Allergen immunotherapy: clinical and practical education of Italian trainees in allergy and clinical immunology schools. European annals of allergy and clinical immunology 2013. link 39 Epstein TG, Liss GM, Murphy-Berendts K, Bernstein DI. AAAAI and ACAAI surveillance study of subcutaneous immunotherapy, Year 3: what practices modify the risk of systemic reactions?. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2013. link 40 Roger A, Quilez E, Depreux N, Farre M. DIRAE study: seasonal allergic rhinitis distribution in Spain. Allergologia et immunopathologia 2013. link 41 Quiralte J, Justicia JL, Cardona V, Dávila I, Moreno E, Ruiz B et al.. Is faster safer? Cluster versus short conventional subcutaneous allergen immunotherapy. Immunotherapy 2013. link 42 Larenas-Linnemann DE, Gupta P, Mithani S, Ponda P. Survey on immunotherapy practice patterns: dose, dose adjustments, and duration. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2012. link 43 Epstein TG, Liss GM, Murphy-Berendts K, Bernstein DI. Immediate and delayed-onset systemic reactions after subcutaneous immunotherapy injections: ACAAI/AAAAI surveillance study of subcutaneous immunotherapy: year 2. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2011. link 44 Brozek JL, Bousquet J, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB et al.. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. The Journal of allergy and clinical immunology 2010. link 45 Van Hoecke H, Van Cauwenberge P, Thas O, Watelet JB. The ARIA guidelines in specialist practice: a nationwide survey. Rhinology 2010. link 46 Kaliner MA, Oppenheimer J, Farrar JR. Comprehensive review of olopatadine: the molecule and its clinical entities. Allergy and asthma proceedings 2010. link 47 Webber CM, Calabria CW. Assessing the safety of subcutaneous immunotherapy dose adjustments. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2010. link 48 Gane SB, Scadding GK. Diseases mimicking allergic rhinitis. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2010. link 49 Takahashi G, Matsuzaki Z, Nakayama T, Masuyama K. Patterns of drug prescription for Japanese cedar pollinosis using a clinical vignette questionnaire. Allergology international : official journal of the Japanese Society of Allergology 2008. link 50 Focke M, Marth K, Flicker S, Valenta R. Heterogeneity of commercial timothy grass pollen extracts. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008. link 51 Lin SY, Houser SM, Rodriguez HP. The implications of regulatory guidelines on allergen vial mixing for the practicing otolaryngologist. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2007. link 52 Lin SY, Houser SM, Rodriguez HP. The implications of regulatory guidelines on allergen vial mixing for the practicing otolaryngologist. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2007. link 53 Blaiss MS. Safety considerations of intranasal corticosteroids for the treatment of allergic rhinitis. Allergy and asthma proceedings 2007. link 54 Marple BF, Fornadley JA, Patel AA, Fineman SM, Fromer L, Krouse JH et al.. Keys to successful management of patients with allergic rhinitis: focus on patient confidence, compliance, and satisfaction. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2007. link 55 Layton D, Wilton L, Boshier A, Cornelius V, Harris S, Shakir SA. Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England. Drug safety 2006. link 56 Dake Y, Enomoto T, Cheng L, Enomoto K, Shibano A, Ikeda H et al.. Effect of antihistamine eye drops on the conjunctival provocation test with Japanese cedar pollen allergen. Allergology international : official journal of the Japanese Society of Allergology 2006. link 57 Walls RS, Heddle RJ, Tang ML, Basger BJ, Solley GO, Yeo GT. Optimising the management of allergic rhinitis: an Australian perspective. The Medical journal of Australia 2005. link 58 . Creating a dust-free environment. Mayo Clinic women's healthsource 2004. link 59 Sanico AM. Latest developments in the management of allergic rhinitis. Clinical reviews in allergy & immunology 2004. link 60 Iglesias-Cadarso A, Hernández-Weigand P, Reaño M, Herrera I, Sánchez-Morillas L, Pérez-Pimiento A. A prospective safety study of allergen immunotherapy in daily clinical practice. Allergologia et immunopathologia 2004. link79255-1) 61 Bloebaum RM, Grant JA. Levocetirizine: the allergist's arsenal grows larger. Expert opinion on pharmacotherapy 2004. link 62 Katelaris CH, Carrozzi FM, Burke TV. Allergic rhinoconjunctivitis in elite athletes: optimal management for quality of life and performance. Sports medicine (Auckland, N.Z.) 2003. link 63 King MJ, Lockey RF. Allergen prick-puncture skin testing in the elderly. Drugs & aging 2003. link 64 Grönlund H, Bergman T, Sandström K, Alvelius G, Reininger R, Verdino P et al.. Formation of disulfide bonds and homodimers of the major cat allergen Fel d 1 equivalent to the natural allergen by expression in Escherichia coli. The Journal of biological chemistry 2003. link 65 Saito I, Mori M, Shibata H, Hirose H, Tsujioka M, Kawabe H. Relation between blood pressure and rhinitis in a Japanese adolescent population. Hypertension research : official journal of the Japanese Society of Hypertension 2003. link 66 Fountain DW. Pollen and inhalant allergy. Biologist (London, England) 2002. link 67 Crystal-Peters J, Neslusan CA, Smith MW, Togias A. Health care costs of allergic rhinitis-associated conditions vary with allergy season. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2002. link62081-9) 68 Greaves MW. Antihistamines. Dermatologic clinics 2001. link70229-1) 69 Lane AP, Pine HS, Pillsbury HC. Allergy testing and immunotherapy in an academic otolaryngology practice: a 20-year review. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2001. link 70 van Oort E, de Heer PG, Lerouge P, Faye L, Aalberse RC, van Ree R. Immunochemical characterization of two Pichia pastoris-derived recombinant group 5 Dactylis glomerata isoallergens. International archives of allergy and immunology 2001. link 71 Allen DB. Systemic effects of intranasal steroids: an endocrinologist's perspective. The Journal of allergy and clinical immunology 2000. link 72 Frenz DA. Foundational readings concerning pollen for allergists and aerobiologists. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2000. link62780-9) 73 Nelson HS. The use of standardized extracts in allergen immunotherapy. The Journal of allergy and clinical immunology 2000. link 74 Mann RD, Pearce GL, Dunn N, Shakir S. Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice. BMJ (Clinical research ed.) 2000. link 75 Kaise T, Ukai K, Pedersen OF, Sakakura Y. Accuracy of measurement of acoustic rhinometry applied to small experimental animals. American journal of rhinology 1999. link 76 Bagenstose SE, Bernstein JA. Treatment of chronic rhinitis by an allergy specialist improves quality of life outcomes. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 1999. link62863-3) 77 Hoffmann A, Jamin A, Foetisch K, May S, Aulepp H, Haustein D et al.. Determination of the allergenic activity of birch pollen and apple prick test solutions by measurement of beta-hexosaminidase release from RBL-2H3 cells. Comparison with classical methods in allergen standardization. Allergy 1999. link 78 Routledge PA, Lindquist M, Edwards IR. Spontaneous reporting of suspected adverse reactions to antihistamines: a national and international perspective. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999. link 79 Tanaka M, Okada M, Zhen YX, Inamura N, Kitano T, Shirai S et al.. Decreased hydration state of the stratum corneum and reduced amino acid content of the skin surface in patients with seasonal allergic rhinitis. The British journal of dermatology 1998. link 80 Cervin A, Andersson M. Intranasal steroids and septum perforation--an overlooked complication? A description of the course of events and a discussion of the causes. Rhinology 1998. link 81 Bousquet J. Antihistamines in severe/chronic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998. link 82 al Anazy FH, Zakzouk SM. The impact of social and environmental changes on allergic rhinitis among Saudi children. A clinical and allergological study. International journal of pediatric otorhinolaryngology 1997. link00103-1) 83 Wu CH, Lee MF, Wang NM, Luo SF. Sequencing and immunochemical characterization of the American cockroach per a 3 (Cr-PI) isoallergenic variants. Molecular immunology 1997. link00009-6) 84 Ashworth L. Is my antihistamine safe?. Home care provider 1997. link90134-9) 85 Kesavanathan J, Swift DL, Fitzgerald TK, Permutt T, Bascom R. Evaluation of acoustic rhinometry and posterior rhinomanometry as tools for inhalation challenge studies. Journal of toxicology and environmental health 1996. link 86 Rønborg SM, Mosbech H, Johnsen CR, Poulsen LK. Exposure chamber for allergen challenge. The development and validation of a new concept. Allergy 1996. link 87 Francillon C, Burnand B, Frei P, Duc J, Lantin JP, Leimgruber A et al.. Referral pattern to the allergist for hay fever in a health-care system with open access to specialists. Allergy 1995. link 88 Aki T, Kodama T, Fujikawa A, Miura K, Shigeta S, Wada T et al.. Immunochemical characterization of recombinant and native tropomyosins as a new allergen from the house dust mite, Dermatophagoides farinae. The Journal of allergy and clinical immunology 1995. link70035-8) 89 D'Amato G, Gentili M, Russo M, Mistrello G, Saggese M, Liccardi G et al.. Detection of Parietaria judaica airborne allergenic activity: comparison between immunochemical and morphological methods including clinical evaluation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1994. link 90 García-Ortega P, Martínez A, Martínez J. Sensitization to a weed pollen in a non-atopic subject during a clinical study. A case report. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1993. link 91 Johnsen CR, Weeke ER, Nielsen J, Jensen J, Mosbech H, Frølund L et al.. Aeroallergen analyses and their clinical relevance. II. Sampling by high-volume airsampler with immunochemical quantification versus Burkard pollen trap sampling with morphologic quantification. Allergy 1992. link 92 Ventas P, Carreira J, Polo F. Purification and characterization of Lep d I, a major allergen from the mite Lepidoglyphus destructor. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1992. link 93 Klysner S, Welinder KG, Løwenstein H, Matthiesen F. Group V allergens in grass pollens: IV. Similarities in amino acid compositions and NH2-terminal sequences of the group V allergens from Lolium perenne, Poa pratensis and Dactylis glomerata. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1992. link 94 Bolzacchini E, Di Gennaro P, Di Gregorio G, Rindone B, Falagiani P, Mistrello G et al.. Purification of Phleum pratense pollen extract by immunoaffinity chromatography and high-performance ion-exchange chromatography. Journal of chromatography 1991. link88604-0) 95 Moscoso del Prado J, Jimeno L, Obispo T, Carreira J. Monoclonal antibodies against human IgE. Identification of an epitope sharing properties with the high-affinity receptor binding site. Molecular immunology 1991. link90047-n) 96 Wakeel RA, White MI. Cutaneous granulomata complicating desensitization. Clinical and experimental dermatology 1990. link 97 Nilsen BM, Paulsen BS. Isolation and characterization of a glycoprotein allergen, Art v II, from pollen of mugwort (Artemisia vulgaris L.). Molecular immunology 1990. link90128-m) 98 Heymann PW, Chapman MD. Recent progress in mite allergen immunochemistry. Clinical reviews in allergy 1990. link 99 Takenaka H, Kusumi T, Mizukoshi O. In vitro synthesis of IgE antibody by human tonsil mononuclear cells. Preliminary report. Acta oto-laryngologica. Supplementum 1988. link 100 Schumacher MJ. Fiberoptic nasopharyngolaryngoscopy: a procedure for allergists?. The Journal of allergy and clinical immunology 1988. link90160-1)

    Original source

    1. [1]
      Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines-2024-2025 Revision: Part I-Guidelines on Intranasal Treatments.Sousa-Pinto B, Bousquet J, Vieira RJ, Schünemann HJ, Zuberbier T, Bognanni A et al. Allergy (2026)
    2. [2]
      Creation of an international Inter-Society Pediatric Allergology Network (ISPAN): preliminary data from a survey of pediatric allergist in Italy, Spain, and Portugal.Tosca MA, Trincianti C, Burgos AM, Ribeiro L, Del Castillo MM, Neves A et al. Allergologia et immunopathologia (2026)
    3. [3]
      Association between air pollution and allergic upper respiratory diseases: a meta-analysis.Zhang ZQ, Li JY, Guo Q, Li YL, Bao YW, Song YQ et al. European respiratory review : an official journal of the European Respiratory Society (2025)
    4. [4]
      Efficacy and safety of montelukast-levocetirizine combination therapy in combined allergic rhinitis and asthma syndrome: a systematic review and meta-analysis.Shao M, Sun J, Zheng Q The Journal of asthma : official journal of the Association for the Care of Asthma (2025)
    5. [5]
      Clinical Practice Guideline: Immunotherapy for Inhalant Allergy.Gurgel RK, Baroody FM, Damask CC, Mims JW, Ishman SL, Baker DP et al. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2024)
    6. [6]
      Prevention Is Better than Cure: Impact of Allergen Immunotherapy on the Progression of Airway Disease.Arshad H, Lack G, Durham SR, Penagos M, Larenas-Linnemann D, Halken S The journal of allergy and clinical immunology. In practice (2024)
    7. [7]
      AAAAI Position Statement on Changing Electronic Health Record Allergy Documentation to "Alerts" to Lead to Easily Understood, Actionable Labels.White AA, Ramsey A, Guyer A, Israelsen RB, Khan F, Kaplan B et al. The journal of allergy and clinical immunology. In practice (2024)
    8. [8]
      Allergic rhinitis management: a Delphi Consensus promoted by the Italian Society of Pediatric Allergy and Immunology (SIAIP).Miraglia Del Giudice M, Marseglia GL, Peroni DG, Zicari AM, Dinardo G, Ciprandi G Italian journal of pediatrics (2024)
    9. [9]
      A comprehensive immunoinformatics study to explore and characterize potential vaccine constructs against Ole e 9 allergen of Kausar MA, Bhardwaj T, Alenazi F, Alshammari KF, Anwar S, Ali A et al. Journal of biomolecular structure & dynamics (2024)
    10. [10]
      Epidemiology of Allergic Rhinitis in Children: A Systematic Review and Meta-Analysis.Licari A, Magri P, De Silvestri A, Giannetti A, Indolfi C, Mori F et al. The journal of allergy and clinical immunology. In practice (2023)
    11. [11]
    12. [12]
      Therapeutic management of allergic rhinitis: a survey of otolaryngology and allergology specialists.Colás C, Álvarez-Suárez ME, Benedito-Palos L, Alobid I European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2023)
    13. [13]
      Quality Improvement in Otolaryngology-Head and Neck Surgery: Developing Registry-Enabled Quality Measures From Guidelines for Cerumen Impaction and Allergic Rhinitis Through a Transparent and Systematic Process.Michel JJ, Schwartz SR, Dawson DE, Denneny JC, Erinoff E, Dhepyasuwan N et al. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2022)
    14. [14]
      Impact of Air Pollution on Allergic Rhinitis and Asthma: Consensus Statement by Indian Academy of Pediatrics.Reddy KRBK, Gupta N, Bhattacharya BG, Deka NM, Chandane P, Kapoor R et al. Indian pediatrics (2021)
    15. [15]
      Evaluation of a pre-co-seasonal and a perennial schedule of a single multiallergen depigmented-polymerized subcutaneous immunotherapy in paediatric patients.Martinez A, Torres J, Molina AB, Muños C, Diaz M, Corzo JL et al. Allergologia et immunopathologia (2021)
    16. [16]
      Review of probiotic use in otolaryngology.Bourdillon AT, Edwards HA American journal of otolaryngology (2021)
    17. [17]
      American Academy of Otolaryngology-Head and Neck Surgery/Foundation Reg-ent Registry: Purpose, Properties, and Priorities.Schmalbach CE, Brereton J, Bowman C, Denneny JC Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2021)
    18. [18]
      Heterogeneity of the pharmacologic treatment of allergic rhinitis in Europe based on MIDAS and OTCims platforms.Bousquet J, Schröder-Bernhardi D, Bachert C, Canonica GW, Cardona V, Costa EM et al. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)
    19. [19]
      EAACI Allergen Immunotherapy User's Guide.Alvaro-Lozano M, Akdis CA, Akdis M, Alviani C, Angier E, Arasi S et al. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2020)
    20. [20]
      Can an otorhinolaryngological visit induce the suspect of allergic rhinitis in children?Ameli F, Tosca MA, Licari A, Gallo F, Ciprandi G European annals of allergy and clinical immunology (2019)
    21. [21]
    22. [22]
      Therapeutic effect of vitamin D supplementation on allergic rhinitis.Bakhshaee M, Sharifian M, Esmatinia F, Rasoulian B, Mohebbi M European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2019)
    23. [23]
      Mechanisms of allergic diseases in Otorhinolaryngology.Ridolo E, Martignago I, Masieri S Journal of biological regulators and homeostatic agents (2018)
    24. [24]
      Payer database and geospatial analysis to evaluate practice patterns in treating allergy in North Carolina.Crowson MG, Schulz K, Ulvila A, Witsell DL American journal of otolaryngology (2018)
    25. [25]
      Collection of nasal secretions and tears and their use in allergology.Castelli S, Arasi S, Pawankar R, Matricardi PM Current opinion in allergy and clinical immunology (2018)
    26. [26]
      Impact of Adverse Event Solicitation on the Safety Profile of SQ House Dust Mite Sublingual Immunotherapy Tablet.Nolte H, Bernstein DI, Sussman GL, Svanholm Fogh B, Lu S, Husøy B et al. The journal of allergy and clinical immunology. In practice (2018)
    27. [27]
      Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision.Brożek JL, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S et al. The Journal of allergy and clinical immunology (2017)
    28. [28]
    29. [29]
      The European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI): A paediatric assessment.Rodríguez Del Río P, Vidal C, Just J, Tabar AI, Sanchez-Machin I, Eberle P et al. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2017)
    30. [30]
    31. [31]
    32. [32]
      The perception of allergen-specific immunotherapy among chest physicians: an Italian survey.Lombardi C, Canonica GW, Passalacqua G European annals of allergy and clinical immunology (2014)
    33. [33]
      Nationwide survey on immunotherapy practice by ENT specialists.Cornelis M, Rombaux P, Jorissen M, Hellings PW Rhinology (2014)
    34. [34]
      Are you comfortable with over-the-counter intranasal steroids for children? A call to action.Rachelefsky G, Farrar JR The journal of allergy and clinical immunology. In practice (2014)
    35. [35]
      Reduction of the number of major representative allergens: from clinical testing to 3-dimensional structures.He Y, Liu X, Huang Y, Zou Z, Chen H, Lai H et al. Mediators of inflammation (2014)
    36. [36]
      Allergic rhinitis as a possible risk factor for malocclusion: a case-control study in children.Luzzi V, Ierardo G, Viscogliosi A, Fabbrizi M, Consoli G, Vozza I et al. International journal of paediatric dentistry (2013)
    37. [37]
      1,25(OH)₂D₃ and specific IgE levels in children with recurrent tonsillitis, and allergic rhinitis.San T, Muluk NB, Cingi C International journal of pediatric otorhinolaryngology (2013)
    38. [38]
      Allergen immunotherapy: clinical and practical education of Italian trainees in allergy and clinical immunology schools.Ridolo E, Incorvaia C, Senna GE, Montagni M, Olivieri E, Canonica GW European annals of allergy and clinical immunology (2013)
    39. [39]
      AAAAI and ACAAI surveillance study of subcutaneous immunotherapy, Year 3: what practices modify the risk of systemic reactions?Epstein TG, Liss GM, Murphy-Berendts K, Bernstein DI Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (2013)
    40. [40]
      DIRAE study: seasonal allergic rhinitis distribution in Spain.Roger A, Quilez E, Depreux N, Farre M Allergologia et immunopathologia (2013)
    41. [41]
      Is faster safer? Cluster versus short conventional subcutaneous allergen immunotherapy.Quiralte J, Justicia JL, Cardona V, Dávila I, Moreno E, Ruiz B et al. Immunotherapy (2013)
    42. [42]
      Survey on immunotherapy practice patterns: dose, dose adjustments, and duration.Larenas-Linnemann DE, Gupta P, Mithani S, Ponda P Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (2012)
    43. [43]
      Immediate and delayed-onset systemic reactions after subcutaneous immunotherapy injections: ACAAI/AAAAI surveillance study of subcutaneous immunotherapy: year 2.Epstein TG, Liss GM, Murphy-Berendts K, Bernstein DI Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (2011)
    44. [44]
      Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision.Brozek JL, Bousquet J, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB et al. The Journal of allergy and clinical immunology (2010)
    45. [45]
      The ARIA guidelines in specialist practice: a nationwide survey.Van Hoecke H, Van Cauwenberge P, Thas O, Watelet JB Rhinology (2010)
    46. [46]
      Comprehensive review of olopatadine: the molecule and its clinical entities.Kaliner MA, Oppenheimer J, Farrar JR Allergy and asthma proceedings (2010)
    47. [47]
      Assessing the safety of subcutaneous immunotherapy dose adjustments.Webber CM, Calabria CW Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (2010)
    48. [48]
      Diseases mimicking allergic rhinitis.Gane SB, Scadding GK Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2010)
    49. [49]
      Patterns of drug prescription for Japanese cedar pollinosis using a clinical vignette questionnaire.Takahashi G, Matsuzaki Z, Nakayama T, Masuyama K Allergology international : official journal of the Japanese Society of Allergology (2008)
    50. [50]
      Heterogeneity of commercial timothy grass pollen extracts.Focke M, Marth K, Flicker S, Valenta R Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2008)
    51. [51]
      The implications of regulatory guidelines on allergen vial mixing for the practicing otolaryngologist.Lin SY, Houser SM, Rodriguez HP Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2007)
    52. [52]
      The implications of regulatory guidelines on allergen vial mixing for the practicing otolaryngologist.Lin SY, Houser SM, Rodriguez HP Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2007)
    53. [53]
    54. [54]
      Keys to successful management of patients with allergic rhinitis: focus on patient confidence, compliance, and satisfaction.Marple BF, Fornadley JA, Patel AA, Fineman SM, Fromer L, Krouse JH et al. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2007)
    55. [55]
    56. [56]
      Effect of antihistamine eye drops on the conjunctival provocation test with Japanese cedar pollen allergen.Dake Y, Enomoto T, Cheng L, Enomoto K, Shibano A, Ikeda H et al. Allergology international : official journal of the Japanese Society of Allergology (2006)
    57. [57]
      Optimising the management of allergic rhinitis: an Australian perspective.Walls RS, Heddle RJ, Tang ML, Basger BJ, Solley GO, Yeo GT The Medical journal of Australia (2005)
    58. [58]
      Creating a dust-free environment. Mayo Clinic women's healthsource (2004)
    59. [59]
      Latest developments in the management of allergic rhinitis.Sanico AM Clinical reviews in allergy & immunology (2004)
    60. [60]
      A prospective safety study of allergen immunotherapy in daily clinical practice.Iglesias-Cadarso A, Hernández-Weigand P, Reaño M, Herrera I, Sánchez-Morillas L, Pérez-Pimiento A Allergologia et immunopathologia (2004)
    61. [61]
      Levocetirizine: the allergist's arsenal grows larger.Bloebaum RM, Grant JA Expert opinion on pharmacotherapy (2004)
    62. [62]
      Allergic rhinoconjunctivitis in elite athletes: optimal management for quality of life and performance.Katelaris CH, Carrozzi FM, Burke TV Sports medicine (Auckland, N.Z.) (2003)
    63. [63]
      Allergen prick-puncture skin testing in the elderly.King MJ, Lockey RF Drugs & aging (2003)
    64. [64]
      Formation of disulfide bonds and homodimers of the major cat allergen Fel d 1 equivalent to the natural allergen by expression in Escherichia coli.Grönlund H, Bergman T, Sandström K, Alvelius G, Reininger R, Verdino P et al. The Journal of biological chemistry (2003)
    65. [65]
      Relation between blood pressure and rhinitis in a Japanese adolescent population.Saito I, Mori M, Shibata H, Hirose H, Tsujioka M, Kawabe H Hypertension research : official journal of the Japanese Society of Hypertension (2003)
    66. [66]
      Pollen and inhalant allergy.Fountain DW Biologist (London, England) (2002)
    67. [67]
      Health care costs of allergic rhinitis-associated conditions vary with allergy season.Crystal-Peters J, Neslusan CA, Smith MW, Togias A Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (2002)
    68. [68]
      Antihistamines.Greaves MW Dermatologic clinics (2001)
    69. [69]
      Allergy testing and immunotherapy in an academic otolaryngology practice: a 20-year review.Lane AP, Pine HS, Pillsbury HC Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2001)
    70. [70]
      Immunochemical characterization of two Pichia pastoris-derived recombinant group 5 Dactylis glomerata isoallergens.van Oort E, de Heer PG, Lerouge P, Faye L, Aalberse RC, van Ree R International archives of allergy and immunology (2001)
    71. [71]
      Systemic effects of intranasal steroids: an endocrinologist's perspective.Allen DB The Journal of allergy and clinical immunology (2000)
    72. [72]
      Foundational readings concerning pollen for allergists and aerobiologists.Frenz DA Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (2000)
    73. [73]
      The use of standardized extracts in allergen immunotherapy.Nelson HS The Journal of allergy and clinical immunology (2000)
    74. [74]
      Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice.Mann RD, Pearce GL, Dunn N, Shakir S BMJ (Clinical research ed.) (2000)
    75. [75]
      Accuracy of measurement of acoustic rhinometry applied to small experimental animals.Kaise T, Ukai K, Pedersen OF, Sakakura Y American journal of rhinology (1999)
    76. [76]
      Treatment of chronic rhinitis by an allergy specialist improves quality of life outcomes.Bagenstose SE, Bernstein JA Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (1999)
    77. [77]
    78. [78]
      Spontaneous reporting of suspected adverse reactions to antihistamines: a national and international perspective.Routledge PA, Lindquist M, Edwards IR Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (1999)
    79. [79]
      Decreased hydration state of the stratum corneum and reduced amino acid content of the skin surface in patients with seasonal allergic rhinitis.Tanaka M, Okada M, Zhen YX, Inamura N, Kitano T, Shirai S et al. The British journal of dermatology (1998)
    80. [80]
    81. [81]
      Antihistamines in severe/chronic rhinitis.Bousquet J Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (1998)
    82. [82]
      The impact of social and environmental changes on allergic rhinitis among Saudi children. A clinical and allergological study.al Anazy FH, Zakzouk SM International journal of pediatric otorhinolaryngology (1997)
    83. [83]
    84. [84]
      Is my antihistamine safe?Ashworth L Home care provider (1997)
    85. [85]
      Evaluation of acoustic rhinometry and posterior rhinomanometry as tools for inhalation challenge studies.Kesavanathan J, Swift DL, Fitzgerald TK, Permutt T, Bascom R Journal of toxicology and environmental health (1996)
    86. [86]
      Exposure chamber for allergen challenge. The development and validation of a new concept.Rønborg SM, Mosbech H, Johnsen CR, Poulsen LK Allergy (1996)
    87. [87]
      Referral pattern to the allergist for hay fever in a health-care system with open access to specialists.Francillon C, Burnand B, Frei P, Duc J, Lantin JP, Leimgruber A et al. Allergy (1995)
    88. [88]
      Immunochemical characterization of recombinant and native tropomyosins as a new allergen from the house dust mite, Dermatophagoides farinae.Aki T, Kodama T, Fujikawa A, Miura K, Shigeta S, Wada T et al. The Journal of allergy and clinical immunology (1995)
    89. [89]
      Detection of Parietaria judaica airborne allergenic activity: comparison between immunochemical and morphological methods including clinical evaluation.D'Amato G, Gentili M, Russo M, Mistrello G, Saggese M, Liccardi G et al. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (1994)
    90. [90]
      Sensitization to a weed pollen in a non-atopic subject during a clinical study. A case report.García-Ortega P, Martínez A, Martínez J Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (1993)
    91. [91]
    92. [92]
      Purification and characterization of Lep d I, a major allergen from the mite Lepidoglyphus destructor.Ventas P, Carreira J, Polo F Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (1992)
    93. [93]
      Group V allergens in grass pollens: IV. Similarities in amino acid compositions and NH2-terminal sequences of the group V allergens from Lolium perenne, Poa pratensis and Dactylis glomerata.Klysner S, Welinder KG, Løwenstein H, Matthiesen F Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (1992)
    94. [94]
      Purification of Phleum pratense pollen extract by immunoaffinity chromatography and high-performance ion-exchange chromatography.Bolzacchini E, Di Gennaro P, Di Gregorio G, Rindone B, Falagiani P, Mistrello G et al. Journal of chromatography (1991)
    95. [95]
    96. [96]
      Cutaneous granulomata complicating desensitization.Wakeel RA, White MI Clinical and experimental dermatology (1990)
    97. [97]
    98. [98]
      Recent progress in mite allergen immunochemistry.Heymann PW, Chapman MD Clinical reviews in allergy (1990)
    99. [99]
      In vitro synthesis of IgE antibody by human tonsil mononuclear cells. Preliminary report.Takenaka H, Kusumi T, Mizukoshi O Acta oto-laryngologica. Supplementum (1988)
    100. [100]
      Fiberoptic nasopharyngolaryngoscopy: a procedure for allergists?Schumacher MJ The Journal of allergy and clinical immunology (1988)

    HemoChat

    by SPINAI

    Evidence-based clinical decision support powered by SNOMED-CT, Neo4j GraphRAG, and NASS/AO/NICE guidelines.

    ⚕ For clinical reference only. Not a substitute for professional judgment.

    © 2026 HemoChat. All rights reserved.
    Research·Pricing·Privacy & Terms·Refund·SNOMED-CT · NASS · AO Spine · NICE · GraphRAG