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Concussion with loss of consciousness

Last edited: 4/16/2026

Overview

Concussion with loss of consciousness (LOC) involves a transient alteration of mental status following a traumatic brain injury, often characterized by impaired consciousness lasting seconds to minutes 1.

Diagnosis

  • Clinical assessment focusing on history of head trauma and observed changes in mental status.
  • Neurological examination to identify signs of altered consciousness, focal deficits, or worsening symptoms.
  • Imaging (CT/MRI) typically reserved for cases with persistent symptoms, worsening condition, or suspicion of intracranial pathology 1.
  • Management

  • Initial Management: Immediate removal from play/activity, rest, and monitoring in a quiet environment.
  • Symptom-Limited Activity: Gradual return to normal activities based on symptom resolution, avoiding cognitive and physical overexertion 1.
  • Medication: No specific pharmacological treatment recommended for acute management; symptomatic relief with analgesics if needed (e.g., acetaminophen) 1.
  • Special Populations

  • Pediatrics: Similar management principles apply, with emphasis on gradual return to play protocols tailored to age and symptom recovery 1.
  • Elderly: Increased vigilance for delayed onset of symptoms and comorbid conditions affecting recovery and management 1.
  • Key Recommendations

  • Immediate Removal from Activity: Remove individuals from physical activities post-concussion with LOC until fully asymptomatic 1 (Evidence: Strong).
  • Gradual Return to Play: Implement a stepwise return-to-play protocol based on symptom-free intervals 1 (Evidence: Strong).
  • Avoid Cognitive Overload: Limit cognitive and physical demands until symptoms resolve to prevent exacerbation 1 (Evidence: Moderate).
  • References

    1 Boveroux P, Vanhaudenhuyse A, Bruno MA, Noirhomme Q, Lauwick S, Luxen A et al.. Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness. Anesthesiology 2010. link

    Original source

    1. [1]
      Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness.Boveroux P, Vanhaudenhuyse A, Bruno MA, Noirhomme Q, Lauwick S, Luxen A et al. Anesthesiology (2010)

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