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Allergy & Immunology436 papers

Clinical infection

Last edited: 4/14/2026

Overview

Clinical infection encompasses a broad range of conditions caused by pathogenic microorganisms, affecting various systems and requiring tailored diagnostic and management approaches.

Diagnosis

  • Assess clinical signs and symptoms (fever, localized pain, systemic symptoms).
  • Utilize laboratory tests including blood cultures, urinalysis, and relevant pathogen-specific assays 5.
  • Imaging studies may be indicated based on suspected site of infection 5.
  • Management

  • First-line treatments often include antibiotics tailored to suspected pathogens and local resistance patterns 5.
  • Adjunctive therapies such as antipyretics for fever management and supportive care (hydration, oxygen) are crucial 5.
  • Sedation protocols, like midazolam-butorphanol-ketamine combinations, should be considered for procedural sedation, noting route impacts on onset and duration 1.
  • Special Populations

  • Pediatrics: Trainee involvement impacts clinic workflow efficiency, suggesting careful scheduling to minimize delays 5.
  • Elderly: Specific considerations for polypharmacy and comorbidities are essential but not detailed in provided abstracts.
  • Comorbidities: Management strategies may need adjustment based on coexisting conditions, though specific guidance is not provided in the abstracts.
  • Key Recommendations

  • Tailor antibiotic therapy based on clinical presentation and local resistance patterns (Evidence: Moderate 5).
  • Optimize clinic workflow by strategically scheduling trainee appointments to maintain efficiency (Evidence: Moderate 5).
  • Consider route of administration for sedative agents to balance efficacy and duration of action (Evidence: Weak 1).
  • References

    1 Cinar H, Yanmaz LE. Comparison of the effects of intranasal and intramuscular midazolam-butorphanol-ketamine on intraocular pressure, tear production and sedation in New Zealand White rabbits. Veterinary anaesthesia and analgesia 2024. link 2 Day AJ. A Personal Tribute to Robert B. Sim with Reflections on Our Work Together on Factor H. Viruses 2021. link 3 Golom FD, Schreck JS. The Journey to Interprofessional Collaborative Practice: Are We There Yet?. Pediatric clinics of North America 2018. link 4 . Clinical Challenge. Australian family physician 2017. link 5 Goldstein IH, Hribar MR, Sarah RB, Chiang MF. Quantifying the Impact of Trainee Providers on Outpatient Clinic Workflow using Secondary EHR Data. AMIA ... Annual Symposium proceedings. AMIA Symposium 2017. link 6 Morris C, Parker A. Exploring the crisis in clinical training: looking to the future. International journal of language & communication disorders 1998. link 7 McKhann GM. Clinical departmental director: manager or scholar?. Annals of neurology 1989. link 8 Seely JE, Stetler DA, Jacob ST, Pegg AE. Absence of inactivation or phosphorylation of ornithine decarboxylase by nuclear protein kinase NII and of immunological cross-reactivity between RNA polymerase I and ornithine decarboxylase. Biochemical and biophysical research communications 1984. link91436-0) 9 Smith AT, Jones DP, Sturrock GD, Wright P. An improved objective slit-lamp fluorophotometer using tungsten-halogen lamp excitation and synchronous detection. The British journal of ophthalmology 1977. link

    Original source

    1. [1]
    2. [2]
    3. [3]
      The Journey to Interprofessional Collaborative Practice: Are We There Yet?Golom FD, Schreck JS Pediatric clinics of North America (2018)
    4. [4]
      Clinical Challenge. Australian family physician (2017)
    5. [5]
      Quantifying the Impact of Trainee Providers on Outpatient Clinic Workflow using Secondary EHR Data.Goldstein IH, Hribar MR, Sarah RB, Chiang MF AMIA ... Annual Symposium proceedings. AMIA Symposium (2017)
    6. [6]
      Exploring the crisis in clinical training: looking to the future.Morris C, Parker A International journal of language & communication disorders (1998)
    7. [7]
      Clinical departmental director: manager or scholar?McKhann GM Annals of neurology (1989)
    8. [8]
    9. [9]
      An improved objective slit-lamp fluorophotometer using tungsten-halogen lamp excitation and synchronous detection.Smith AT, Jones DP, Sturrock GD, Wright P The British journal of ophthalmology (1977)

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