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Acute myocardial infarction of inferolateral wall

Last edited: 4/10/2026

Overview

Acute myocardial infarction (MI) is defined as myocardial necrosis resulting from acute imbalance between myocardial oxygen supply and demand. Inferolateral wall MI is a specific type of MI affecting the inferior and lateral walls of the left ventricle.

Diagnosis

  • Diagnosis is typically made based on clinical symptoms, electrocardiogram (ECG) findings, and cardiac biomarker elevation 1.
  • ECG may show ST-segment elevation in leads corresponding to the inferolateral wall (e.g., II, III, aVF, V5, V6) 1.
  • Elevated cardiac biomarkers, such as high-sensitivity troponin T (hs-TnT), are indicative of myocardial injury 1.

    • Management

  • N-acetylcysteine (NAC) treatment in ST-segment elevation myocardial infarction (STEMI) was associated with a reduction in all-cause mortality and major adverse cardiovascular events (MACE) 1.
  • NAC treatment did not significantly affect the incidence of new congestive heart failure or ejection fraction 1.
  • NAC treatment did not significantly alter myocardial enzyme levels such as CK-MB 1.
  • No significant difference in adverse reactions was noted between NAC and control groups 1.

    • Key Recommendations

  • N-acetylcysteine (NAC) may reduce all-cause mortality and major adverse cardiovascular events (MACE) in patients with ST-segment elevation myocardial infarction (STEMI) 1. (Evidence: Moderate)
  • N-acetylcysteine (NAC) treatment is not associated with a significant difference in the occurrence of new congestive heart failure or improvement in ejection fraction in STEMI patients 1. (Evidence: Moderate)
  • N-acetylcysteine (NAC) treatment does not significantly impact myocardial enzyme levels like CK-MB in STEMI patients 1. (Evidence: Moderate)

    • References

    1 Jiang SJ, Huang CH. The Clinical Efficacy of N-Acetylcysteine in the Treatment of ST Segment Elevation Myocardial Infarction. International heart journal 2021. link

    Original source

    1. [1]
      The Clinical Efficacy of N-Acetylcysteine in the Treatment of ST Segment Elevation Myocardial Infarction. — Jiang SJ, Huang CH International heart journal (2021)
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