Overview
Acute psychosis is a sudden onset of psychotic symptoms, including hallucinations, delusions, disorganized thinking, and behavioral disturbances. It can be a symptom of various psychiatric and medical conditions.Diagnosis
Management
Second-generation long-acting injectable antipsychotics (SGA-LAIs) such as olanzapine, aripiprazole, risperidone, and paliperidone reduced overall symptoms of schizophrenia more than placebo in acutely ill patients 1.
The efficacy of SGA-LAIs compared to their oral formulations in acute schizophrenia was only assessed in one study comparing aripiprazole 1.
The side-effect profiles of LAIs corresponded to the known patterns of their oral formulations 1.Special Populations
Key Recommendations
Second-generation long-acting injectable antipsychotics are effective in reducing overall symptoms of schizophrenia in acutely ill patients 1. (Evidence: Strong)
The side-effect profiles of long-acting injectable antipsychotics are consistent with their oral counterparts 1. (Evidence: Strong)References
1 Wang D, Schneider-Thoma J, Siafis S, Burschinski A, Dong S, Wu H et al.. Long-Acting Injectable Second-Generation Antipsychotics vs Placebo and Their Oral Formulations in Acute Schizophrenia: A Systematic Review and Meta-Analysis of Randomized-Controlled-Trials. Schizophrenia bulletin 2024. link