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Anesthesiology2 papers

Primary anaplastic astrocytoma of parietal lobe

Last edited: 4/16/2026

Overview

Primary anaplastic astrocytoma is a grade II glioma originating from astrocytes, typically characterized by rapid growth and local invasiveness, commonly found in the parietal lobe. It often presents with focal neurological deficits due to its location and aggressive nature 1.

Diagnosis

  • Imaging: MRI with contrast is essential for diagnosis, showing characteristic enhancement and mass effect 1.
  • Biopsy: Histological examination confirms diagnosis, identifying anaplastic features such as nuclear atypia, mitotic activity, and microvascular proliferation 1.
  • Grading: Pathologically graded based on WHO criteria, distinguishing from lower grade astrocytomas by the presence of anaplasia and mitotic activity 1.

    • Management

  • Surgical Resection: Primary treatment involves maximal safe surgical resection to reduce tumor burden 1.
  • Radiation Therapy: Post-surgical adjuvant radiation therapy is recommended to target residual disease 1.
  • Chemotherapy: Temozolomide is often used post-surgery and post-radiation to improve survival outcomes 1.

    • Special Populations

  • No specific guidance: The provided abstracts do not cover special populations such as pregnancy, pediatrics, elderly, or comorbidities 1.

    • Key Recommendations

  • Maximal safe surgical resection should be performed initially to achieve the best local control 1 (Evidence: Strong).
  • Adjuvant radiation therapy following surgery is crucial for managing residual disease 1 (Evidence: Strong).
  • Temozolomide chemotherapy should be considered post-surgery and post-radiation to enhance survival rates 1 (Evidence: Strong).

    • References

    1 Zorab JS. A general anaesthesia service for magnetic resonance imaging. European journal of anaesthesiology 1995. link

    Original source

    1. [1]
      A general anaesthesia service for magnetic resonance imaging. — Zorab JS European journal of anaesthesiology (1995)
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