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Pathology18 papers

Endometrial stromal tumor of uncertain behavior

Last edited: 4/16/2026

Overview

Endometrial stromal tumors of uncertain behavior (ESUBs) are rare uterine neoplasms with uncertain malignant potential, often initially misdiagnosed as benign conditions like leiomyomas due to overlapping clinical features 1.

Diagnosis

  • Pathological Confirmation: Essential through biopsy or resection specimens obtained during procedures like hysteroscopic endometrial ablation 1.
  • Imaging Limitations: Ultrasound may not detect these tumors, highlighting the need for histopathological examination 1.
  • Clinical Presentation: Often presents with abnormal uterine bleeding 1.
  • Management

  • Surgical Intervention: Hysterectomy is often recommended to ensure complete removal and rule out residual disease 1.
  • Follow-Up: Long-term follow-up is necessary to monitor recurrence, with reported outcomes favorable in cases where complete resection was achieved 1.
  • Special Populations

  • No Specific Data: The provided abstracts do not cover specific management considerations for pregnancy, pediatrics, elderly patients, or those with comorbidities 1.
  • Key Recommendations

  • Perform additional tissue sampling via curettage before endometrial ablation to identify unexpected endometrial lesions 1 (Evidence: Weak).
  • Consider hysterectomy for definitive management of ESUBs to ensure complete removal and accurate staging 1 (Evidence: Weak).
  • Routine long-term follow-up is advised post-surgery to monitor patient outcomes and detect potential recurrence 1 (Evidence: Weak).
  • References

    1 Vilos AG, Zhu C, Abu-Rafea B, Ettler HC, Weir MM, Vilos GA. Uterine Tumors Resembling Ovarian Sex Cord Tumors Identified at Resectoscopic Endometrial Ablation: Report of 2 Cases. Journal of minimally invasive gynecology 2019. link

    Original source

    1. [1]
      Uterine Tumors Resembling Ovarian Sex Cord Tumors Identified at Resectoscopic Endometrial Ablation: Report of 2 Cases.Vilos AG, Zhu C, Abu-Rafea B, Ettler HC, Weir MM, Vilos GA Journal of minimally invasive gynecology (2019)

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