Overview
Transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) are treatments for severe aortic stenosis, leading to the implantation of a prosthetic aortic valve 12. TAVR is the preferred treatment for high-risk patients with severe aortic stenosis 1.Management
For patients undergoing TAVR, vascular closure device strategies are employed to manage large-bore femoral arterial access complications 1.
FemoSeal-ProGlide is associated with lower risks of major vascular complications and major bleeding events post-TAVR 1.
AngioSeal-ProGlide demonstrates the lowest device failure rate for vascular closure post-TAVR 1.
Prostar is associated with a higher risk of nonmajor vascular complications post-TAVR 1.
In women, TAVR and SAVR show no significant difference in the composite of all-cause mortality or disabling stroke at 5 years 2.Special Populations
Women: Women with aortic stenosis exhibit distinct anatomic and physiologic features 2. While TAVR shows an advantage over SAVR at 1-year follow-up in women, no significant difference is observed in all-cause mortality or disabling stroke between TAVR and SAVR at 5 years 2.Key Recommendations
For patients undergoing transcatheter aortic valve replacement (TAVR), FemoSeal-ProGlide is associated with lower risks of major vascular complications and major bleeding events 1. (Evidence: Strong)
AngioSeal-ProGlide demonstrates the lowest device failure rate for vascular closure post-TAVR 1. (Evidence: Strong)
In women with aortic stenosis, transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) show no significant difference in the composite of all-cause mortality or disabling stroke at 5 years 2. (Evidence: Strong)References
1 Deng Y, Feng Y, He S, Zhou W, Zhang J. Comparative Effectiveness of Vascular Closure Device Strategies in Transcatheter Aortic Valve Replacement: A Network Meta-Analysis. Annals of vascular surgery 2026. link
2 Wolf SEM, Kucera JA, Gregg AC, Di Franco A, Rahouma M, Redfors B et al.. Five-Year Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Women: A Systematic Review and Meta-Analysis. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2025. link