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Neurosurgery307 papers

Degenerative myelopathy

Last edited: 4/14/2026

Overview

Degenerative myelopathy, often manifesting as degenerative lumbar scoliosis, is a 3-dimensional spinal deformity characterized by a coronal deviation greater than 10°, typically affecting elderly individuals and causing significant pain and disability 24.

Diagnosis

  • Clinical Presentation: Severe back pain, radiculopathy, and spinal claudication 19.
  • Radiographic Evaluation: Full-length standing spine radiographs are commonly used; coronal Cobb angle measurement is crucial 18.
  • MRI and CT: Coronal MRI images can better identify nerve root compromise compared to standard axial and sagittal views 12.
  • Biomechanical Assessment: Evaluating intervertebral disc degeneration and facet joint orientation aids in understanding curve rigidity and progression 2732.
  • Management

  • Nonoperative Management: Physical therapy and conservative treatments are often initial approaches, showing efficacy comparable to arthroscopic surgery for some patients 923.
  • Surgical Interventions:
  • - Minimally Invasive Surgery (MIS): Techniques like MIS decompression and limited correction are favored for mild-to-moderate cases 26. - Fusion Procedures: Short-segment versus long-segment fusions debated; sagittal alignment and patient-specific factors crucial 34. - Selective Nerve Root Block: Precision treatment option for managing symptoms without extensive fusion 21.
  • Interdisciplinary Care: Reduces intensive care unit use post-surgery, beneficial for elderly patients 22.
  • Special Populations

  • Elderly Patients: Interdisciplinary management improves outcomes; careful consideration of balance and sagittal alignment in surgical planning 2234.
  • Comorbidities: Presence of conditions like osteoporosis influences surgical technique and outcomes, necessitating tailored approaches 39.
  • Key Recommendations

  • Utilize full-length standing spine radiographs for preoperative assessment of degenerative lumbar scoliosis to guide surgical decisions 18.
  • Consider minimally invasive surgical techniques for decompression and limited correction in managing mild-to-moderate degenerative scoliosis to minimize complications 26.
  • Implement interdisciplinary care teams to optimize outcomes and reduce perioperative complications in elderly patients undergoing surgical correction 22.
  • (Evidence: Moderate)

    References

    1 Gao S, Qi L, Li N, Li X, Zhang J, Zhang Z et al.. The role of the brain-bone axis in skeletal degenerative diseases and psychiatric disorders, A genome-wide pleiotropic analysis. Progress in neuro-psychopharmacology & biological psychiatry 2025. link 2 Jiang T, Zhang X, Su Q, Meng X, Pan A, Zhang H et al.. Incidence and Risk Factors of Lumbosacral Complications Following Long-Segment Spinal Fusion in Adult Degenerative Scoliosis. Orthopaedic surgery 2025. link 3 Beyer F, Schirmer J, Prasse T, Eysel P, Bredow J. Quality of Life after Multisegmental Fusion Surgery for Degenerative Spine Diseases. Zeitschrift fur Orthopadie und Unfallchirurgie 2025. link 4 Kim HJ, Park SJ, Park JS, Jung CW, Lee JS, Yang HS et al.. Risk factors of adjacent-segment disease after short-segment fusion in patients with de novo degenerative lumbar scoliosis. Journal of neurosurgery. Spine 2024. link 5 Shao Z, Liang H, Li S, Ye Z, Wang X. Comparison of Open Surgery Versus Minimally Invasive Surgery in Nonsevere Adult Degenerative Scoliosis: A Systematic Review and Meta-Analysis. Spine 2024. link 6 Cai Z, Luo Q, Yang X, Pu L, Zong H, Shi R et al.. Overloaded axial stress activates the Wnt/β-Catenin pathway in nucleus pulposus cells of adult degenerative scoliosis combined with intervertebral disc degeneration. Molecular biology reports 2023. link 7 Pei W, Deng J, Wang P, Wang X, Zheng L, Zhang Y et al.. Sustainable lignin and lignin-derived compounds as potential therapeutic agents for degenerative orthopaedic diseases: A systemic review. International journal of biological macromolecules 2022. link 8 Kim HS, Wu PH, Lee YJ, Kim DH, Jang IT. Technical Considerations of Uniportal Endoscopic Posterolateral Lumbar Interbody Fusion: A Review of Its Early Clinical Results in Application in Adult Degenerative Scoliosis. World neurosurgery 2021. link 9 Lubowitz JH, Brand JC, Rossi MJ. Nonoperative Management of Degenerative Meniscus Tears Is Worth a Try. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2020. link 10 Zhou Y, Xin D, Lei Z, Zuo Y, Zhao Y. Comparative Three-Dimensional Finite Element Analysis of 4 Kinds of Pedicle Screw Schemes for Treatment of Adult Degenerative Scoliosis. Medical science monitor : international medical journal of experimental and clinical research 2020. link 11 Liang Y, Xu S, Zhao Y, Zhu Z, Mao K, Wang Z et al.. The position of the aorta relative to the spine in patients with adult degenerative scoliosis. Journal of orthopaedic surgery and research 2020. link 12 Lee SK, Jung JY. Degenerative lumbar scoliosis: added value of coronal images to routine lumbar MRI for nerve root compromise. European radiology 2020. link 13 Zheng J, Yang Y, Cheng B, Cook D. Exploring the pathological role of intervertebral disc and facet joint in the development of degenerative scoliosis by biomechanical methods. Clinical biomechanics (Bristol, Avon) 2019. link 14 Sun XY, Kong C, Lu SB, Wang W, Cheng YZ, Sun SY et al.. The Parallelogram Effect of Degenerative Structures Around the Apical Vertebra in Patients with Adult Degenerative Scoliosis: The Influence of Asymmetric Degeneration and Diagonal Degeneration on the Severity of Deformity. Medical science monitor : international medical journal of experimental and clinical research 2019. link 15 Rustenburg CME, Faraj SSA, Holewijn RM, Kingma I, van Royen BJ, Stadhouder A et al.. The biomechanical effect of single-level laminectomy and posterior instrumentation on spinal stability in degenerative lumbar scoliosis: a human cadaveric study. Neurosurgical focus 2019. link 16 Moore C, de Luca K, Wong AYL, Fernandez M, Swain M, Hartvigsen J et al.. Characteristics of chiropractors who manage people aged 65 and older: A nationally representative sample of 1903 chiropractors. Australasian journal on ageing 2019. link 17 Kartus JT. Editorial Commentary: Fresh Evidence That There Is Still No Reliable Evidence on How to Best Treat Knee Degenerative Meniscus Tears. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2018. link 18 Bunch JT, Glassman SD, Underwood HR, Metcalfe LN, Ondra S, Vasilyev I et al.. Preoperative full-length standing radiographs and revision rates in lumbar degenerative scoliosis. Journal of neurosurgery. Spine 2018. link 19 Simon MJK, Halm HFH, Quante M. Perioperative complications after surgical treatment in degenerative adult de novo scoliosis. BMC musculoskeletal disorders 2018. link 20 Faraj SSA, De Kleuver M, Vila-Casademunt A, Holewijn RM, Obeid I, Acaroğlu E et al.. Sagittal radiographic parameters demonstrate weak correlations with pretreatment patient-reported health-related quality of life measures in symptomatic de novo degenerative lumbar scoliosis: a European multicenter analysis. Journal of neurosurgery. Spine 2018. link 21 Liang Y, Zhao Y, Wang T, Zhu Z, Liu H, Mao K. Precision Treatment of Adult Lumbar Degenerative Scoliosis Complicated by Lumbar Stenosis with the Use of Selective Nerve Root Block. World neurosurgery 2018. link 22 Adogwa O, Elsamadicy AA, Sergesketter AR, Ongele M, Vuong V, Khalid S et al.. Interdisciplinary Care Model Independently Decreases Use of Critical Care Services After Corrective Surgery for Adult Degenerative Scoliosis. World neurosurgery 2018. link 23 Jarrett JB, Sauereisen S. PURLs: When can exercise supplant surgery for degenerative meniscal tears?. The Journal of family practice 2017. link 24 Wong E, Altaf F, Oh LJ, Gray RJ. Adult Degenerative Lumbar Scoliosis. Orthopedics 2017. link 25 Sanal B, Korkmaz M, Nas OF, Can F, Hacikurt K. The effect of gigantomasty on vertebral degeneration: A computed tomography study. Journal of back and musculoskeletal rehabilitation 2017. link 26 Fontes RB, Fessler RG. Lumbar Radiculopathy in the Setting of Degenerative Scoliosis: MIS Decompression and Limited Correction are Better Options. Neurosurgery clinics of North America 2017. link 27 Zhu F, Bao H, Yan P, Liu S, Bao M, Zhu Z et al.. Do the disc degeneration and osteophyte contribute to the curve rigidity of degenerative scoliosis?. BMC musculoskeletal disorders 2017. link 28 Choi MK, Kim SB, Park CK, Kim SM. Comparison of the clinical and radiologic outcomes obtained with single- versus two-level anterior cervical decompression and fusion using stand-alone PEEK cages filled with allograft. Acta neurochirurgica 2016. link 29 Faraj SS, Holewijn RM, van Hooff ML, de Kleuver M, Pellisé F, Haanstra TM. De novo degenerative lumbar scoliosis: a systematic review of prognostic factors for curve progression. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2016. link 30 Hawasli AH, Chang J, Yarbrough CK, Steger-May K, Lenke LG, Dorward IG. Interpedicular height as a predictor of radicular pain in adult degenerative scoliosis. The spine journal : official journal of the North American Spine Society 2016. link 31 Han Y, Sun J, Luo C, Huang S, Li L, Ji X et al.. Comparison of pedicle screw-based dynamic stabilization and fusion surgery in the treatment of radiographic adjacent-segment degeneration: a retrospective analysis of single L5-S1 degenerative spondylosis covering 4 years. Journal of neurosurgery. Spine 2016. link 32 Poureisa M, Behzadmehr R, Daghighi MH, Akhoondzadeh L, Fouladi DF. Orientation of the facet joints in degenerative rotatory lumbar scoliosis: an MR study on 52 patients. Acta neurochirurgica 2016. link 33 Hara M, Nishimura Y, Nakajima Y, Umebayashi D, Takemoto M, Yamamoto Y et al.. Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Disorders: Mini-open TLIF and Corrective TLIF. Neurologia medico-chirurgica 2015. link 34 Faldini C, Di Martino A, Borghi R, Perna F, Toscano A, Traina F. Long vs. short fusions for adult lumbar degenerative scoliosis: does balance matters?. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2015. link 35 Flouzat-Lachaniette CH, Ratte L, Poignard A, Auregan JC, Queinnec S, Hernigou P et al.. Minimally invasive anterior lumbar interbody fusion for adult degenerative scoliosis with 1 or 2 dislocated levels. Journal of neurosurgery. Spine 2015. link 36 Uddin OM, Haque R, Sugrue PA, Ahmed YM, El Ahmadieh TY, Press JM et al.. Cost minimization in treatment of adult degenerative scoliosis. Journal of neurosurgery. Spine 2015. link 37 Wang Y, Xie T. Extracellular, stem cells and regenerative ophthalmology. Journal of glaucoma 2014. link 38 Sun Y, Shen Y, Ding W, Qie S, Zhang W, Yang D et al.. Comparison in clinical outcome of two surgical treatments in degenerative scoliosis. Cell biochemistry and biophysics 2014. link 39 Ueno M, Imura T, Inoue G, Takaso M. Posterior corrective fusion using a double-trajectory technique (cortical bone trajectory combined with traditional trajectory) for degenerative lumbar scoliosis with osteoporosis: technical note. Journal of neurosurgery. Spine 2013. link 40 Hosogane N, Watanabe K, Kono H, Saito M, Toyama Y, Matsumoto M. Curve progression after decompression surgery in patients with mild degenerative scoliosis. Journal of neurosurgery. Spine 2013. link 41 Deukmedjian AR, Ahmadian A, Bach K, Zouzias A, Uribe JS. Minimally invasive lateral approach for adult degenerative scoliosis: lessons learned. Neurosurgical focus 2013. link 42 Caputo AM, Michael KW, Chapman TM, Jennings JM, Hubbard EW, Isaacs RE et al.. Extreme lateral interbody fusion for the treatment of adult degenerative scoliosis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2013. link 43 Li H, Liang C, Shen C, Li Y, Chen Q. Decreased sleep duration: a risk of progression of degenerative lumbar scoliosis. Medical hypotheses 2012. link 44 Zhang H, Gao Q, Wang Y, Liu S, Guo C, Tang M et al.. Clinical evaluation of indirect decompression treatments for degenerative adult idiopathic scoliosis. Archives of orthopaedic and trauma surgery 2011. link 45 Scheufler KM, Cyron D, Dohmen H, Eckardt A. Less invasive surgical correction of adult degenerative scoliosis. Part II: Complications and clinical outcome. Neurosurgery 2010. link 46 Fu KM, Smith JS, Sansur CA, Shaffrey CI. Standardized measures of health status and disability and the decision to pursue operative treatment in elderly patients with degenerative scoliosis. Neurosurgery 2010. link 47 Liu W, Chen XS, Jia LS, Song DW. The clinical features and surgical treatment of degenerative lumbar scoliosis: a review of 112 patients. Orthopaedic surgery 2009. link 48 Lo KC, Whirledge S, Lamb DJ. Stem cells: implications for urology. Current urology reports 2005. link 49 Arighi M, Miller CR, Pennock PW. Arthrodesis of the scapulohumeral joint in a miniature horse. Journal of the American Veterinary Medical Association 1987. link 50 Cavallazzi RM, Spreafico G. Trapezio-metacarpal arthrodesis today: why?. Journal of hand surgery (Edinburgh, Scotland) 1986. link90273-1) 51 Podgorski M, Edmonds J. Bidirectional knee joint rupture. The Journal of rheumatology 1985. link 52 McCarty MF. Point of view--a role for "nutritional insurance" supplementation in preventive medicine. Medical hypotheses 1981. link90114-6)

    Original source

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      The role of the brain-bone axis in skeletal degenerative diseases and psychiatric disorders, A genome-wide pleiotropic analysis.Gao S, Qi L, Li N, Li X, Zhang J, Zhang Z et al. Progress in neuro-psychopharmacology & biological psychiatry (2025)
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      Incidence and Risk Factors of Lumbosacral Complications Following Long-Segment Spinal Fusion in Adult Degenerative Scoliosis.Jiang T, Zhang X, Su Q, Meng X, Pan A, Zhang H et al. Orthopaedic surgery (2025)
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      Quality of Life after Multisegmental Fusion Surgery for Degenerative Spine Diseases.Beyer F, Schirmer J, Prasse T, Eysel P, Bredow J Zeitschrift fur Orthopadie und Unfallchirurgie (2025)
    4. [4]
      Risk factors of adjacent-segment disease after short-segment fusion in patients with de novo degenerative lumbar scoliosis.Kim HJ, Park SJ, Park JS, Jung CW, Lee JS, Yang HS et al. Journal of neurosurgery. Spine (2024)
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      Comparative Three-Dimensional Finite Element Analysis of 4 Kinds of Pedicle Screw Schemes for Treatment of Adult Degenerative Scoliosis.Zhou Y, Xin D, Lei Z, Zuo Y, Zhao Y Medical science monitor : international medical journal of experimental and clinical research (2020)
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      Characteristics of chiropractors who manage people aged 65 and older: A nationally representative sample of 1903 chiropractors.Moore C, de Luca K, Wong AYL, Fernandez M, Swain M, Hartvigsen J et al. Australasian journal on ageing (2019)
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      Interdisciplinary Care Model Independently Decreases Use of Critical Care Services After Corrective Surgery for Adult Degenerative Scoliosis.Adogwa O, Elsamadicy AA, Sergesketter AR, Ongele M, Vuong V, Khalid S et al. World neurosurgery (2018)
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      Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Disorders: Mini-open TLIF and Corrective TLIF.Hara M, Nishimura Y, Nakajima Y, Umebayashi D, Takemoto M, Yamamoto Y et al. Neurologia medico-chirurgica (2015)
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      Extracellular, stem cells and regenerative ophthalmology.Wang Y, Xie T Journal of glaucoma (2014)
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