Overview
Invasive carcinoma of the breast is a condition with an evolving treatment landscape, encompassing early-stage, nonmetastatic, and metastatic forms 1. Its management requires a multidisciplinary approach involving surgical, radiation, and medical oncology 2.Diagnosis
The NCCN Guidelines include recommendations for the workup of invasive, nonmetastatic breast cancer 1.Management
Treatment involves a multidisciplinary approach, including surgical oncology, radiation oncology, and medical oncology 2.
Locoregional therapy is a component of management for invasive, nonmetastatic breast cancer 1.
Systemic neoadjuvant/adjuvant therapy options are recommended for nonmetastatic invasive breast cancer 12.
Surveillance recommendations are provided for invasive, nonmetastatic breast cancer 1.Special Populations
Guidelines address the management of breast cancer during pregnancy 2.Key Recommendations
Management of invasive breast cancer should employ a multidisciplinary approach involving surgical oncology, radiation oncology, and medical oncology 2. (Evidence: Strong)
Systemic neoadjuvant/adjuvant therapy is a key component of overall management for nonmetastatic invasive breast cancer 12. (Evidence: Strong)
Guidelines provide recommendations for the workup, locoregional therapy, and surveillance of invasive, nonmetastatic breast cancer 1. (Evidence: Strong)
Specific guidance is available for the management of breast cancer during pregnancy 2. (Evidence: Expert opinion)References
1 Gradishar WJ, Moran MS, Abraham J, Abramson V, Aft R, Agnese D et al.. NCCN Guidelines® Insights: Breast Cancer, Version 5.2025. Journal of the National Comprehensive Cancer Network : JNCCN 2025. link
2 Gradishar WJ, Moran MS, Abraham J, Abramson V, Aft R, Agnese D et al.. Breast Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network : JNCCN 2024. link