Overview
Familial prostate cancer refers to prostate cancer that occurs in multiple members of a family. Genetic factors are known to play a role in the development of prostate cancer.Diagnosis
Genome-wide association studies (GWASs) can be used to study genetic correlations between prostate cancer and other conditions, such as Parkinson's disease, to identify common genetic risk factors 1.
Polygenic risk score (PRS) analyses can study the association between conditions and polymorphisms 1.Management
No management strategies are discussed in the provided abstracts.Special Populations
No information on special populations is provided in the abstracts.Key Recommendations
Genome-wide association studies (GWASs) can be used to investigate shared genetic risk factors between prostate cancer and other diseases 1. (Evidence: Moderate)
Linkage disequilibrium score regression can estimate genetic correlations between prostate cancer and other diseases 1. (Evidence: Moderate)
Cross-phenotypes polygenic risk score (PRS) analyses can study associations between prostate cancer and polymorphisms 1. (Evidence: Moderate)References
1 Sugier PE, Lucotte EA, Domenighetti C, Law MH, Iles MM, Brown K et al.. Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers. Movement disorders : official journal of the Movement Disorder Society 2023. link