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Eosinophilic duodenal ulcer

Last edited: 4/16/2026

Overview

Eosinophilic duodenal ulcer is a rare condition characterized by the presence of eosinophils in the ulcerative lesion of the duodenum, often associated with underlying eosinophilic gastrointestinal disorders or other systemic conditions. 1

Diagnosis

  • Endoscopic visualization of ulcerative lesions in the duodenum with eosinophilic infiltration 1
  • Histopathological examination showing significant eosinophil infiltration in biopsy samples 1
  • Exclusion of other causes of duodenal ulcers through clinical evaluation and laboratory tests 1

    • Management

  • Identification and treatment of underlying conditions such as eosinophilic esophagitis or parasitic infections 1
  • Corticosteroids for symptomatic relief and reduction of eosinophilic activity (dose and specific regimen not detailed) 1
  • Adjunctive use of proton pump inhibitors (PPIs) to manage acid-related symptoms 1

    • Special Populations

  • Limited data; management typically focuses on treating underlying causes and symptomatic relief applicable across all age groups 1
  • No specific recommendations noted for pregnancy, pediatrics, or elderly populations 1

    • Key Recommendations

  • Perform endoscopic examination with histopathological confirmation for definitive diagnosis (Evidence: Weak) 1
  • Address and treat any identifiable underlying systemic or gastrointestinal conditions contributing to eosinophilic infiltration (Evidence: Weak) 1
  • Consider corticosteroid therapy for managing eosinophilic activity, alongside PPIs for symptomatic relief (Evidence: Weak) 1

    • References

    1 Devenish A. Eosinophilic ulcer of the tongue. The New Zealand medical journal 1981. link

    Original source

    1. [1]
      Eosinophilic ulcer of the tongue. — Devenish A The New Zealand medical journal (1981)
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