Overview
Inflammatory fibroid polyps (IFPs) of the large intestine are rare, benign lesions characterized by proliferation of fibroblast-like cells, often associated with chronic inflammation. These polyps can mimic malignancies radiographically and have been reported across the gastrointestinal tract, including the colon and rectum, though they are uncommon in pediatric populations 23.Diagnosis
Clinical Presentation: Typically asymptomatic, but can present with gastrointestinal bleeding, abdominal pain, or obstruction 3.
Imaging: Air-contrast barium enema may simulate malignancy; colonoscopy is crucial for definitive diagnosis 3.
Histological Evaluation: Essential for confirming the presence of characteristic fibrovascular stroma with inflammatory cells; immunohistochemistry often shows fibroblastic ultrastructure 1.
Differential Diagnosis: Primary colon carcinoma, inflammatory bowel disease, and other polypoid lesions 3.Management
Surgical Resection: Primary treatment, often endoscopic or surgical depending on size and location 3.
Follow-Up: Regular surveillance recommended due to potential recurrence, though rare 3.
No Specific Medical Therapy: No pharmacological treatment is typically required beyond addressing complications 13.Special Populations
Pediatrics: Rare occurrence; one reported case in an 8-year-old boy 2.
Comorbidities: No specific management adjustments noted for comorbidities; focus remains on surgical intervention 13.Key Recommendations
Endoscopic or Surgical Resection for Definitive Treatment (Evidence: Moderate 3)
Histological Confirmation Essential for Diagnosis (Evidence: Strong 13)
Regular Follow-Up Post-Resection Due to Potential Recurrence (Evidence: Expert opinion 3)References
1 Ishikura H, Sato F, Naka A, Kodama T, Aizawa M. Inflammatory fibroid polyp of the stomach. Acta pathologica japonica 1986. link
2 Pollice L, Bufo P. Inflammatory fibroid polyp of the rectum. Pathology, research and practice 1984. link80012-6)
3 Ferin P, Skucas J. Inflammatory fibroid polyp of the colon simulating malignancy. Radiology 1983. link