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Cardiology2687 papers

Ischemia reperfusion injury of liver

Last edited: 4/23/2026

Overview

Hepatic ischemia-reperfusion injury (HIRI) occurs when blood flow is restored to the liver after a period of ischemia, leading to oxidative stress, inflammation, and cell death, significantly impacting outcomes in liver surgery, transplantation, and trauma 4 41 46.

Diagnosis

Elevated liver enzymes (AST, ALT) 4.

Increased levels of inflammatory markers (e.g., TNF-α, IL-6) 4 18.

Imaging findings consistent with liver damage (MRI, CT scans) 44.

Histopathological evidence of necrosis and inflammation on biopsy 4.

Management

First-line treatments:

- Minimizing warm ischemia time during surgery 4. - Use of cold preservation solutions to reduce reperfusion injury 4.

Adjunctive therapies:

- Pharmacological agents targeting specific pathways: - Ferroptosis inhibitors (e.g., ferrostain inhibitors) 8 49. - Antioxidants (e.g., alpha-pinene) to mitigate oxidative stress 48. - Notch1-DLL4 inhibitors to reduce proinflammatory responses 2.

Emerging treatments:

- Exosome nanoplatforms targeting M2 macrophages 4. - Electroacupuncture at specific acupoints (e.g., Zusanli ST36) to regulate pathways like cholinergic-miRNA 124 1.

Special Populations

Elderly: Aging exacerbates HIRI through mechanisms like Nrf2 deficiency and ferroptosis 31.

Comorbidities: Conditions like renal impairment may influence the choice of pharmacological interventions due to drug clearance and interactions 6 13 20.

Key Recommendations

Minimize warm ischemia time during liver surgery to reduce HIRI severity (Evidence: Strong 4).

Utilize cold preservation solutions to mitigate reperfusion injury (Evidence: Moderate 4).

Consider pharmacological interventions targeting ferroptosis and oxidative stress pathways in severe cases (Evidence: Moderate 8 48).

Explore adjunct therapies like electroacupuncture for modulation of inflammatory pathways (Evidence: Expert opinion 1).

Tailor management strategies in elderly patients considering exacerbated injury mechanisms (Evidence: Moderate 31).

References

Showing 100 most recent of 1818 indexed papers.

1 Geng Y, Lv H, Liu Y, Guo D, Zheng J, Li Y et al.. Electroacupuncture at Zusanli (ST36) Alleviate Intestinal Ischemia-Reperfusion Injury by Regulating the Cholinergic-miRNA 124 Pathway. Neurogastroenterology and motility 2026. link 2 Tenet M, Jin H, Holland S, Hollis R, Aziz M, Wang P. A novel Notch1-DLL4 inhibitor attenuates intestinal ischemia-reperfusion injuries. Surgery 2026. link 3 Chen GS, Xiong WH, Li DZ, Zhang PH, Wang YT, Zhang YC et al.. Overexpression of Soluble Fibrinogen-like Protein 2 in MSCs Ameliorates Renal Ischemia-Reperfusion Injury in Mice by Modulating Neutrophils. Balkan medical journal 2026. link 4 Zuo T, Shi C, Li J, Li D, Luo X, Xu M et al.. M2 macrophage-derived exosome nanoplatform for targeted H. Acta biomaterialia 2026. link 5 Marton J, Ciocan RA, Bâldea I, Gherman ML, Gheban D, Filip A et al.. Molecular Mechanisms, Dynamic Lesions, and Therapeutic Targets in Intestinal Ischemia-Reperfusion Injury: A Systematic Review. International journal of molecular sciences 2026. link 6 Xin L, Kanghao N, Jiacheng L, Xiaodong Y, Juhan Y, Xinyang Z et al.. Panax Notoginseng Saponins Inhibit Apoptosis and Alleviate Renal Ischemia-Reperfusion Injury Through the ROCK2/NF-κB Pathway. Molecular biotechnology 2026. link 7 Sun J, Xu B, Chen Y, Sui M, Wang M, Ma R et al.. Unveiling a novel function of Aconitase-2: attenuating lung ischemia-reperfusion injury via inhibition of pulmonary endothelial apoptosis. Redox biology 2026. link 8 Yang Z, Wang Z, Huang J, Luo M, Luo X, Zeng W et al.. EMP1-driven ferroptosis in liver sinusoidal endothelial cells exacerbates hepatic ischemia-reperfusion injury via P38 MAPK. Free radical biology & medicine 2026. link 9 Ergün Y, Baykişi Y, Kılınç M, Toksözlü F, Aykan DA, Mavigök AN et al.. Rutin and skeletal muscle ischemia-reperfusion injury: Effects of acute treatment. Tissue & cell 2026. link 10 Ren X, Lu X, Song Y, Li M, Shao T, Guo M et al.. HPCAL1-BNIP3 axis promotes mitophagy-ferroptosis feedback loop that exacerbates intestinal ischemia-reperfusion injury. Free radical biology & medicine 2026. link 11 Kawamoto H, Uchida Y, Hirao H, Saga K, Kawasoe J, Kadono K et al.. Role of Histamine in Liver Ischemia-Reperfusion Injury-Implication for H1 Receptor Antagonist in the Clinical Application. Transplantation 2026. link 12 Tao S, Hu W, Hu Y, Cheng Q, Lin Z, Xu H et al.. Sfrp2 in Microglia Inhibited S100a8-Mediated Neuroinflammation and Protected Neural Damage Following Retinal Ischemia-Reperfusion. Investigative ophthalmology & visual science 2026. link 13 Mao Y, Lin S, Wu M, Ma H, Ji J, Zhou H. Shenkangling alleviates renal fibrosis induced by renal ischemia-reperfusion injury by mitigating mitochondrial damage through modulation of the STING signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology 2026. link 14 Li M, Mao Z, Lu L, Xu H, Guo Y, Song C et al.. Licochalcone A promotes SP1/DNA-PKcs-dependent NHEJ repair to prevent ferroptosis and attenuate hepatic ischemia-reperfusion injury. Phytomedicine : international journal of phytotherapy and phytopharmacology 2026. link 15 Liang Y, Sheng R, Hu Y, Huang D, Li X, Deng H et al.. Propionate intervenes mast cell function to alleviate intestinal ischemia-reperfusion injury by regulating AhR/Notch1 pathway. Microbial pathogenesis 2026. link 16 Chao JJ, Chen LY, Chen J, Ding YX, Mao GJ, Hu L et al.. A Visible/NIR-II Dual-Channel Fluorescent Probe for Investigating the Roles of NLRP3 Inflammasome and Ferroptosis during Hepatic Ischemia-Reperfusion Injury. Analytical chemistry 2026. link 17 Jin S, Wang K, Shen Z, Hu B, Dou Q, Xu D et al.. Fructus Gardenia Extract Improves Cerebral Ischemia-Reperfusion Injury via RIPK1-RIPK3-MLKL Axis. The Tohoku journal of experimental medicine 2026. link 18 Lu S, Tong J, Jiang J, Zhang Q, Huang Y. Dynamic regulation and targeted intervention of neutrophils in hepatic ischemia‑reperfusion injury (Review). International journal of molecular medicine 2026. link 19 Johnson CF, Schafer CM, Burge KY, Coon BG, Chaaban H, Griffin CT. RIPK3 Protects Against Endothelial Activation and Vascular Permeability in a Mouse Model of Ischemia-Reperfusion Injury. Arteriosclerosis, thrombosis, and vascular biology 2026. link 20 Hu Y, Cao Y, Chen Q, Tan W, Wang Y, Wu Y et al.. Novel 2,4-thiazolidinedione derivatives as selective AMPKα1 activators for renal ischemia-reperfusion injury therapeutics. European journal of medicinal chemistry 2026. link 21 Xu L, Wang M, Feng Y, Wang S, Qian Y, Jiang W et al.. Mitophagy Activation via the YAP/Parkin Pathway Underlies the Neuroprotective Action of Tetramethylpyrazine in Cerebral Ischemia/Reperfusion Injury. Biomolecules 2026. link 22 Dong X, Zhang J, Xu G, Zhu J, Wan H, He Y. Dopamine receptors: Potential therapeutic targets for ischemia-reperfusion injury: A review. International journal of biological macromolecules 2026. link 23 Wang K, Wang YR, Zhao J, Zhou RM, Xu XF, Wang T et al.. A sulfur-substituted hemicyanine-based activatable probe for photoacoustic visualization of neutrophil elastase in liver I/R injury. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2026. link 24 Khalaf HM, Ahmed SM, Abdelmonaem AA, Saleh RK, Mohamed AA, Ali ASA et al.. Repurposing rupatadine to attenuate ovarian ischemia reperfusion in rats through modulation of PAF/NF-κB/TNF-α/IL-1β; HIF-1α/VEGF/Caspase 3 signaling pathways. Naunyn-Schmiedeberg's archives of pharmacology 2026. link 25 Su Y, Huang B, Liu D, Yu L, Chen Y. Cell-Membrane-Camouflaged Biomimetic Nanomedicines for Cerebral Ischemia-Reperfusion Injury Treatment. Advanced healthcare materials 2026. link 26 Lian H, Sun Y, Zhang M, Gao X, Wang J, Dai Q. Miro1 Mediates the Neuroprotective Effects of Electroacupuncture Against Cerebral Ischemia-Reperfusion Injury in Mice. Journal of integrative neuroscience 2026. link 27 Wang Y, Shi X, Wu L, Tian H. L-3n-butylphthalide maintains BBB permeability and attenuates cerebral ischemia-reperfusion injury in rats by increasing PGC-1. The International journal of neuroscience 2026. link 28 Guo Y, Dong X, Liu M, Wang J, Guo S. Forsythoside A Alleviates Neuroinflammatory Damage via Inhibiting TLR4/NF-κB/NLRP3 Activation-Induced Astrocyte Pyroptosis in Cerebral Ischemia-Reperfusion. CNS neuroscience & therapeutics 2026. link 29 Wang L, Hou C, Li S, Yang L, Lin Y, Wang S et al.. Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia-Reperfusion Injury. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026. link 30 Zhang SC, Jiang HX, Yu X, Kong XW, Chai JH, Liang J et al.. Clarification of the Yin-Jing medicinal property characteristic of Ligusticum chuanxiong Hort. via potentiating therapeutic effect, guidance and targetability. Journal of ethnopharmacology 2026. link 31 Wu Y, Zhang Y, Zhang S, Yang H, Ci X. Aging-associated GSK3β overexpression exacerbates hepatic ischemia-reperfusion injury through Nrf2 deficiency-induced hepatocyte ferroptosis. Life sciences 2026. link 32 Lin Z, Deng H, Yang G, Huang K. Biosponge-armored polydopamine-modified conducting polypyrrole restores redox-iron homeostasis for enhanced neuroprotection in retinal ischemia-reperfusion injury. Biomaterials 2026. link 33 Zhou T, Jiang Z, Hu Q, Qiu S, Gao J, Zhang J et al.. ROS-responsive diselenide exosomes restore mitophagy to resolve sterile inflammation in liver IRI. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2026. link 34 Yang M, Wang J, Li C, Yang Z, Dong W, Zhang C et al.. Serine Glycine Restriction Aggravates Hepatic Ischemia-reperfusion Injury. Transplantation 2026. link 35 Yildizdal S, Atalay Ö, Önal D, Pehlivanoğlu B, Talim B, Gököz Ö et al.. Can Prolonged Ischemia Time in Extremity Transfer Be Resolved Using an Extracorporeal Circulation Model? An Experimental Study. Annals of plastic surgery 2026. link 36 Wen SH, Zhang YN, Shen JT, Guo Y, Chang ZN, Zhang HF et al.. PD-1 blockade promotes mucosal CD4+ T cell IL-10 production through altering microbiota to reduce intestinal ischemia reperfusion injury. Gut microbes 2026. link 37 Gültekin Ç, Sayiner S, Çetinel Ş, Şehirli AÖ. The Influence of Bromelain Administration on Pro-Inflammatory Cytokines and Lipid Peroxidation in a Rat Model of Intestinal Ischemia/Reperfusion Injury. Veterinary medicine and science 2026. link 38 Li XY, Xie JY, Yin YT, Weng XG, Huang ZY, Wang LS et al.. Obacunone inhibits RIPK1/RIPK3/MLKL-mediated necroptosis by suppressing mitochondrial ROS and MIF signaling in intestinal ischemia-reperfusion injury. International immunopharmacology 2026. link 39 Li W, Wu T, Li H, Guan Z, Ding M, Guo W. Ubiquitination of Rhomboid 5 Homolog 2 by Constitutive Photomorphogenic 1 Alleviates Hepatic Ischemia-reperfusion Injury by Regulating the Transforming Growth Factor-β Activating Kinase 1-C-Jun N-terminal Kinase/p38 Signaling Pathway. Cellular and molecular gastroenterology and hepatology 2026. link 40 Healy CR, Redmond MC, Gethin G, Pandit A, Finn DP. Sex differences in pain-related behaviour and the endocannabinoid system following hind limb ischemia-reperfusion injury. The journal of pain 2026. link 41 Wang Z, Zhang R, Dai D, Zhang M, Gao D, Zhang J et al.. Remimazolam mitigates cerebral ischemia/reperfusion injury by concurrently alleviating damage to the blood-brain barrier and RIP3/MLKL-driven necroptosis. International immunopharmacology 2026. link 42 Tang B, Xu X, Zhao W, Zhou Q, Du G, Wang H. Electroacupuncture regulates neuronal ferroptosis and ferritinophagy through lysosomal-mediated TFEB activation in cerebral ischemia-reperfusion. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026. link 43 Luo X, Hu Q, Ye Q, Zhong Z. Receptor for advanced glycation end-product in ischemia-reperfusion injury. International immunopharmacology 2026. link 44 Sarcon AK, Wan R, Reisdorf RL, Jacobs JF, Selim OA, Boynton FDD et al.. Ischemia-Reperfusion Injury in a Composite Tissue Microsurgical Model. Plastic and reconstructive surgery 2026. link 45 Wang H, Li X, Liu Z, Lu R, Li X, Zhang X. ANXA1 regulates microglia polarization and autophagy via PI3K/Akt/mTOR pathway to reduce inflammatory injury after cerebral ischemia-reperfusion. Cellular signalling 2026. link 46 Aamer H, Nour EM, Refaie A, Youssef M, Ramzy EA, Khater S et al.. The impact of medical ozone on renal ischemic/reperfusion injury: A prospective randomized controlled study in dogs. Veterinary journal (London, England : 1997) 2026. link 47 Mammadov A, Demiryürek AT, Saracaloğlu A, Demirkiran C, Değim İT, Eronat Ö et al.. Contribution of adenosine A. Turkish journal of medical sciences 2026. link 48 Sebin SO, Gulakar B, Tanyeli A, Guler MC, Erbas E, Baser S et al.. Alpha-pinene mitigates renal ischemia-reperfusion injury via anti-oxidant, anti-inflammatory, anti-apoptotic effects and favorable eNOS/iNOS shifts in rats. Toxicon : official journal of the International Society on Toxinology 2026. link 49 Chen X, Wang B, Li W, Jin N, Lu G, Wang J. The role of gasdermin D-mediated pyroptosis in hepatic ischemia-reperfusion injury and prediction of the therapeutic natural products. Biochemical pharmacology 2026. link 50 Stein CS, Zhang X, Witmer NH, Pennington ER, Hahn S, Straub AC et al.. Mitoregulin supports mitochondrial membrane integrity and protects against cardiac ischaemia-reperfusion injury. Cardiovascular research 2026. link 51 Alalawy AI, Hamad RS, Alasmari A, Al-Massabi R, Alanazi YF, Obidan A et al.. STING inhibition and BD1-selective BET blockade limit ischemia-reperfusion-induced hepatic tissue remodeling by suppressing pro-inflammasome signaling. Tissue & cell 2026. link 52 Li W, Meng C, Yang S, Xie Y, Huang Z, Wang T. ELABELA: A Potential Therapeutic Target for Ischemia-Reperfusion Injury. Biomolecules 2026. link 53 Li Z, Wang X, Cui Y, Liu Y, Wei R, Wang Y et al.. Silencing OGFOD1 ameliorates hepatic ischemia-reperfusion injury through abrogating oxidative stress and apoptosis via downregulating SPARC. Biochemical pharmacology 2026. link 54 Wang H, Chang M, Tang L, Xu J, Tang S, Meng F et al.. Spleen-derived immune cells potentiate cerebral ischemia-reperfusion injury through brain-spleen communication. European journal of pharmacology 2026. link 55 Korkmaz E, Beytur A, Taşlıdere A, Tekin Ç, Tekin S. Protective effect of dapagliflozin against hepatic ischemia-reperfusion injury in rats. Molecular biology reports 2026. link 56 Li R, Wang A, Cao J, Li K, Zhang H, Wang Y et al.. Single-cell RNA sequencing reveals the role of neutrophils in intestinal ischemia-reperfusion injury in mice. Life sciences 2026. link 57 Bai Y, Feng J, Wu XY, Yao ZS, Liu YT, Li YH et al.. Aspartame exacerbates cerebral ischemia-reperfusion injury via mitochondrial dysfunction and ERK/CREB1 pathway suppression. Ecotoxicology and environmental safety 2026. link 58 Wang J, Zhang T, Zhang X, Yang Q, Cui W. Histone lactylation exacerbates cerebral ischemia-reperfusion injury via NSUN2-mediated epigenetic activation of astrocytic neuroinflammation. Neurological research 2026. link 59 Guven C, Türk A, Koçak S, Zencirci B, Yalcin A, Aydın H et al.. Cortexin modulates OPG/RANK/RANKL and TRPC1 expression in cerebral ischemia-reperfusion injury. Neurological research 2026. link 60 Song Y, Lu X, Ren X, Li M, Meng F, Miao Y et al.. TRIM25 triggers pyroptosis through mitochondrial DNA release in intestinal ischemia-reperfusion injury. Free radical biology & medicine 2026. link 61 Nie R, Duan Y, Cao X, Pang M, Wang Z, Fan H. Pathological mechanisms of hepatic ischemia-reperfusion injury and stem cell-based therapeutic strategies: Mechanistic insights and translational perspectives. Pathology, research and practice 2026. link 62 Xie C, Feng YA, Xu LZ, Ma Y, Zhang L, Tan R et al.. An activatable NIR-I superoxide anion fluorescent probe selective for tracking cerebral ischemia-reperfusion injury. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2026. link 63 Ye W, Chen Y, Guo J, Zheng H, Zhou Y, Liu B. Microvascular Perfusion Monitored by Laser Speckle Contrast Imaging during Renal Ischemia-Reperfusion Injury in Mice. Journal of visualized experiments : JoVE 2026. link 64 Feng Y, Zheng H, Wang F, Luo R, Xu C, Yang T. Site-1 protease-derived sPRR contributes to renal ischemia-reperfusion injury in mice by promoting macrophage classical activation. Clinical science (London, England : 1979) 2026. link 65 Hu D, Sun L, Su M, Xing X. The Mechanism of G Protein-Coupled Receptor Regulation of Ferroptosis in Hepatic Ischemia-Reperfusion Injury. International journal of molecular sciences 2026. link 66 Min M, Wang J, Fang X, Chen Y, Wang Y. Exposure to ischemia-related neoepitopes exacerbates secondary ischemia-reperfusion injury in mice. Transplant immunology 2026. link 67 Chen L, Yao F, Cheng H, Guo M, Gao Y, Cai S et al.. Cold-inducible RNA binding protein ameliorates oxygen-glucose deprivation-induced hippocampal neuron injury through anti-apoptotic and anti-oxidative pathways. PeerJ 2026. link 68 Zhang J, Luo Y, Xie C, Zhang M, Qin H, Zhou Y et al.. PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury. Redox biology 2026. link 69 Liao W, Wu X, Gong J, Li S. Oridonin Ameliorates Macrophage Oxidative Stress and Pyroptosis In Liver Ischemia-Reperfusion Injury by Inhibiting Mitochondrial ROS/TXNIP/NLRP3. Shock (Augusta, Ga.) 2026. link 70 Sun S, Ren K, He B, Zhao Y, Jiang R, Zhu X et al.. Inhalation metal-phenolic nanozyme as a novel therapeutic strategy for lung ischemia-reperfusion injury. Biomaterials advances 2026. link 71 Zeng H, Yu X, Zheng Z, Wang Z, Dong W, Gan J. Ciprofol attenuates cerebral Ischemia‒reperfusion injury in rats by inhibiting ferroptosis through upregulating AMPK. Scientific reports 2026. link 72 Ai L, Ren H, Wang Y, Liu M, Qiu Y, Feng J et al.. The Neuroprotective Role of Ginsenoside Rg1 Against Cerebral Ischemia-Reperfusion Damage Through Inhibition of Mitophagy via Blocking Mitophagosome-Lysosome Fusion. Cell proliferation 2026. link 73 Pan H, Lu J, Han T, Liang H, Zhang W, Hou W et al.. TPPU alleviates hepatic ischemia-reperfusion injury by regulating macrophage polarization. Biochemical pharmacology 2026. link 74 Gu Y, Liu X, Zhang X, Zhang N. BACH1 drives ferroptosis in lung ischemia-reperfusion injury through epigenetic suppression of STAT3-Mediated antioxidant defense. Archives of biochemistry and biophysics 2026. link 75 Li Z, Ming Q, Yang T, Liu M, Fu L, Yang J et al.. Pyroptosis in cerebral ischemia‑reperfusion injury: Molecular mechanisms and therapeutic implications (Review). Molecular medicine reports 2026. link 76 Wu T, Yu Q, Wang Y, Tang H, Guo W. Trillin attenuates liver ischemia-reperfusion injury by inhibiting autophagy through regulation of the cGAS-STING pathway. International immunopharmacology 2026. link 77 Lu P, Shen R, Yang J, Wu L, Wang R. Dynamic regulation and targeted interventions of macrophages in ischemia-reperfusion injury. Journal of advanced research 2026. link 78 Pi Y, Wang Y, Guo Q, Zheng W, Zhou H, Deng L et al.. Oleanolic acid alleviates intestinal injury after hepatic ischemia-reperfusion under steatosis via PPARG-dependent M2 macrophage polarization. International immunopharmacology 2026. link 79 Chen Y, Deng Y, Tang R, Li S, Mei Z, Ge J. Unlocking the gasotransmitter: hydrogen sulfide as a multitarget regulator in ischemia-reperfusion injury. Medical gas research 2026. link 80 Li S, Hu X, Yan X, Peng F, Qin X, Liu X et al.. Daidzein attenuates hepatic ischemia/reperfusion injury via HMGB1-TLR4 signaling pathway. Toxicon : official journal of the International Society on Toxinology 2026. link 81 Chen X, Zhou Y, Zhang Z, Yuan G, He S, Xiao F. Identification of mitochondrial dysfunction-related biomarkers and immune infiltration in liver ischemia-reperfusion injury via integrated bioinformatics and machine learning. Biochemical and biophysical research communications 2026. link 82 Wang K, Xu C, Wang H, Zhang Y, Zhang Z, Yan R et al.. Puerarin protects against renal ischemia-reperfusion injury by restoring mitochondrial function and modulating the PI3K/AKT/NF-k B pathway and suppressing inflammatory responses. Cellular signalling 2026. link 83 Yang Q, Huang T, Chen H, Cao X, Zhu W, Peng Y et al.. Natural glycosides from Cistanche deserticola alleviate hepatic ischemia-reperfusion injury via a cAMP-mediated signaling pathway. Journal of ethnopharmacology 2026. link 84 Sun F, She R, Yang T, Chen B, Liao Z, Liao J et al.. Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology 2026. link 85 Borjigin P, Deng C, Su R, Li J, Ying Y, Chen Y et al.. Pearl Powder Fluorescent Carbon Dots Alleviate Neuroinflammation in Cerebral Ischemia/Reperfusion Through Suppression of Anxa2/NF-κB Signaling Pathway. International journal of nanomedicine 2026. link 86 Li L, Shen Y, Li J, Wang X. Ubiquitin-specific protease 15 reverses the protective effects of sevoflurane on cerebral ischemia-reperfusion injury in mice by deubiquitinating transforming growth factor-βR1. International journal of biological macromolecules 2026. link 87 Han L, Zhai W. ALDH2 Mediated Ferroptosis Regulation in Ischemia-Reperfusion Injury. Journal of cellular and molecular medicine 2026. link 88 Fan W, Guan Q, Xu Z, Lin L, Du J, Yu B et al.. Constructing Mg-Based Hydrogen Container for Mitochondrial Dysfunction and Neuronal Ferroptosis in TCAR-Induced Cerebral Ischemia/Reperfusion Injury. Advanced healthcare materials 2026. link 89 Mohamed RA, Ghoneim ME, Tawfiq RA, El Sayed NF. Amygdalin synergizes with the TNF-α monoclonal antibody infliximab to modulate HSP90 and related necro-inflammatory/oxidative stress pathways in a rat model of hepatic I/R. Naunyn-Schmiedeberg's archives of pharmacology 2026. link 90 Wang Q, Li S, Li M, Zhou W, Zhang J, Wu Z et al.. TRIM56 Aggravates Cerebral Ischemia-Reperfusion Injury via Inhibiting KLF4-Activated Ferroptosis Signaling. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026. link 91 Zhang Y, Jing Y, Liao H, Ding K, Zhang L, Liao S et al.. STING deficiency alleviates ischemia-reperfusion injury via JAK2/STAT3-mediated macrophage polarization and autophagy. International immunopharmacology 2026. link 92 Chen Y, Shi WQ, Zhang P, Wang R, Ye WB, Lin GQ et al.. Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis. Acta pharmacologica Sinica 2026. link 93 Ruan Z, Li Y, Chen Y. Astragaloside IV alleviates neuroinflammation in cerebral ischemia-reperfusion injury by inhibiting HTR2B-mediated microglial M1 polarization. Neurological research 2026. link 94 Du P, Deng M, Ge X, Wang W, Zhang M, Wang P. ZFP36L1-mediated PRDM1 mRNA degradation inhibits inflammatory activation of Kupffer cells and ameliorates DCD liver ischemic-reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease 2026. link 95 Lin M, Wu X, Zhang S. Sufentanil attenuates renal ischemia-reperfusion injury via the lncRNA KCNQ1OT1/miR-211-5p/HMGB1 axis. Pathology, research and practice 2025. link 96 Zhang Y, Lv J, Bai J, Zhang X, Wu G, Lei X et al.. TXNIP knockdown ameliorates hepatic ischemia/reperfusion injury by inhibiting apoptosis and improving mitochondrial dysfunction via HIF-1α. Molecular and cellular biochemistry 2025. link 97 Li M, Nie H, He Q, Zhang Z, Yu S, Wang T et al.. Astrocytic Gap Junctions protein Cx43/Cx30 modulate EAAT1 and glutamate to mediate cerebral ischemia-reperfusion injury. Brain research 2025. link 98 Sheng M, Liu W, Cao Y, Wang S, Lin Y, Yu W. TARGETING S100A9-TLR2 AXIS CONTROLS MACROPHAGE NLRP3 INFLAMMASOME ACTIVATION IN FATTY LIVER ISCHEMIA REPERFUSION INJURY. Shock (Augusta, Ga.) 2025. link 99 Walsh D, Kostyunina DS, Blake A, Boylan J, McLoughlin P. Shear stress-induced restoration of pulmonary microvascular endothelial barrier function following ischemia reperfusion injury requires VEGFR2 signaling. American journal of physiology. Lung cellular and molecular physiology 2025. link 100 Ding Y, Jie K, Xin L, Shao B. Astragaloside IV plays a neuroprotective role by promoting PPARγ in cerebral ischemia-reperfusion rats. Behavioural brain research 2025. link

Original source

[1]
Electroacupuncture at Zusanli (ST36) Alleviate Intestinal Ischemia-Reperfusion Injury by Regulating the Cholinergic-miRNA 124 Pathway. — Geng Y, Lv H, Liu Y, Guo D, Zheng J, Li Y et al. Neurogastroenterology and motility (2026)
[2]
A novel Notch1-DLL4 inhibitor attenuates intestinal ischemia-reperfusion injuries. — Tenet M, Jin H, Holland S, Hollis R, Aziz M, Wang P Surgery (2026)
[3]
Overexpression of Soluble Fibrinogen-like Protein 2 in MSCs Ameliorates Renal Ischemia-Reperfusion Injury in Mice by Modulating Neutrophils. — Chen GS, Xiong WH, Li DZ, Zhang PH, Wang YT, Zhang YC et al. Balkan medical journal (2026)
[4]
M2 macrophage-derived exosome nanoplatform for targeted H — Zuo T, Shi C, Li J, Li D, Luo X, Xu M et al. Acta biomaterialia (2026)
[5]
Molecular Mechanisms, Dynamic Lesions, and Therapeutic Targets in Intestinal Ischemia-Reperfusion Injury: A Systematic Review. — Marton J, Ciocan RA, Bâldea I, Gherman ML, Gheban D, Filip A et al. International journal of molecular sciences (2026)
[6]
Panax Notoginseng Saponins Inhibit Apoptosis and Alleviate Renal Ischemia-Reperfusion Injury Through the ROCK2/NF-κB Pathway. — Xin L, Kanghao N, Jiacheng L, Xiaodong Y, Juhan Y, Xinyang Z et al. Molecular biotechnology (2026)
[7]
Unveiling a novel function of Aconitase-2: attenuating lung ischemia-reperfusion injury via inhibition of pulmonary endothelial apoptosis. — Sun J, Xu B, Chen Y, Sui M, Wang M, Ma R et al. Redox biology (2026)
[8]
EMP1-driven ferroptosis in liver sinusoidal endothelial cells exacerbates hepatic ischemia-reperfusion injury via P38 MAPK. — Yang Z, Wang Z, Huang J, Luo M, Luo X, Zeng W et al. Free radical biology & medicine (2026)
[9]
Rutin and skeletal muscle ischemia-reperfusion injury: Effects of acute treatment. — Ergün Y, Baykişi Y, Kılınç M, Toksözlü F, Aykan DA, Mavigök AN et al. Tissue & cell (2026)
[10]
HPCAL1-BNIP3 axis promotes mitophagy-ferroptosis feedback loop that exacerbates intestinal ischemia-reperfusion injury. — Ren X, Lu X, Song Y, Li M, Shao T, Guo M et al. Free radical biology & medicine (2026)
[11]
Role of Histamine in Liver Ischemia-Reperfusion Injury-Implication for H1 Receptor Antagonist in the Clinical Application. — Kawamoto H, Uchida Y, Hirao H, Saga K, Kawasoe J, Kadono K et al. Transplantation (2026)
[12]
Sfrp2 in Microglia Inhibited S100a8-Mediated Neuroinflammation and Protected Neural Damage Following Retinal Ischemia-Reperfusion. — Tao S, Hu W, Hu Y, Cheng Q, Lin Z, Xu H et al. Investigative ophthalmology & visual science (2026)
[13]
Shenkangling alleviates renal fibrosis induced by renal ischemia-reperfusion injury by mitigating mitochondrial damage through modulation of the STING signaling pathway. — Mao Y, Lin S, Wu M, Ma H, Ji J, Zhou H Phytomedicine : international journal of phytotherapy and phytopharmacology (2026)
[14]
Licochalcone A promotes SP1/DNA-PKcs-dependent NHEJ repair to prevent ferroptosis and attenuate hepatic ischemia-reperfusion injury. — Li M, Mao Z, Lu L, Xu H, Guo Y, Song C et al. Phytomedicine : international journal of phytotherapy and phytopharmacology (2026)
[15]
Propionate intervenes mast cell function to alleviate intestinal ischemia-reperfusion injury by regulating AhR/Notch1 pathway. — Liang Y, Sheng R, Hu Y, Huang D, Li X, Deng H et al. Microbial pathogenesis (2026)
[16]
A Visible/NIR-II Dual-Channel Fluorescent Probe for Investigating the Roles of NLRP3 Inflammasome and Ferroptosis during Hepatic Ischemia-Reperfusion Injury. — Chao JJ, Chen LY, Chen J, Ding YX, Mao GJ, Hu L et al. Analytical chemistry (2026)
[17]
Fructus Gardenia Extract Improves Cerebral Ischemia-Reperfusion Injury via RIPK1-RIPK3-MLKL Axis. — Jin S, Wang K, Shen Z, Hu B, Dou Q, Xu D et al. The Tohoku journal of experimental medicine (2026)
[18]
Dynamic regulation and targeted intervention of neutrophils in hepatic ischemia‑reperfusion injury (Review). — Lu S, Tong J, Jiang J, Zhang Q, Huang Y International journal of molecular medicine (2026)
[19]
RIPK3 Protects Against Endothelial Activation and Vascular Permeability in a Mouse Model of Ischemia-Reperfusion Injury. — Johnson CF, Schafer CM, Burge KY, Coon BG, Chaaban H, Griffin CT Arteriosclerosis, thrombosis, and vascular biology (2026)
[20]
Novel 2,4-thiazolidinedione derivatives as selective AMPKα1 activators for renal ischemia-reperfusion injury therapeutics. — Hu Y, Cao Y, Chen Q, Tan W, Wang Y, Wu Y et al. European journal of medicinal chemistry (2026)
[21]
Mitophagy Activation via the YAP/Parkin Pathway Underlies the Neuroprotective Action of Tetramethylpyrazine in Cerebral Ischemia/Reperfusion Injury. — Xu L, Wang M, Feng Y, Wang S, Qian Y, Jiang W et al. Biomolecules (2026)
[22]
Dopamine receptors: Potential therapeutic targets for ischemia-reperfusion injury: A review. — Dong X, Zhang J, Xu G, Zhu J, Wan H, He Y International journal of biological macromolecules (2026)
[23]
A sulfur-substituted hemicyanine-based activatable probe for photoacoustic visualization of neutrophil elastase in liver I/R injury. — Wang K, Wang YR, Zhao J, Zhou RM, Xu XF, Wang T et al. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2026)
[24]
Repurposing rupatadine to attenuate ovarian ischemia reperfusion in rats through modulation of PAF/NF-κB/TNF-α/IL-1β; HIF-1α/VEGF/Caspase 3 signaling pathways. — Khalaf HM, Ahmed SM, Abdelmonaem AA, Saleh RK, Mohamed AA, Ali ASA et al. Naunyn-Schmiedeberg's archives of pharmacology (2026)
[25]
Cell-Membrane-Camouflaged Biomimetic Nanomedicines for Cerebral Ischemia-Reperfusion Injury Treatment. — Su Y, Huang B, Liu D, Yu L, Chen Y Advanced healthcare materials (2026)
[26]
Miro1 Mediates the Neuroprotective Effects of Electroacupuncture Against Cerebral Ischemia-Reperfusion Injury in Mice. — Lian H, Sun Y, Zhang M, Gao X, Wang J, Dai Q Journal of integrative neuroscience (2026)
[27]
L-3n-butylphthalide maintains BBB permeability and attenuates cerebral ischemia-reperfusion injury in rats by increasing PGC-1 — Wang Y, Shi X, Wu L, Tian H The International journal of neuroscience (2026)
[28]
Forsythoside A Alleviates Neuroinflammatory Damage via Inhibiting TLR4/NF-κB/NLRP3 Activation-Induced Astrocyte Pyroptosis in Cerebral Ischemia-Reperfusion. — Guo Y, Dong X, Liu M, Wang J, Guo S CNS neuroscience & therapeutics (2026)
[29]
Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia-Reperfusion Injury. — Wang L, Hou C, Li S, Yang L, Lin Y, Wang S et al. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2026)
[30]
Clarification of the Yin-Jing medicinal property characteristic of Ligusticum chuanxiong Hort. via potentiating therapeutic effect, guidance and targetability. — Zhang SC, Jiang HX, Yu X, Kong XW, Chai JH, Liang J et al. Journal of ethnopharmacology (2026)
[31]
Aging-associated GSK3β overexpression exacerbates hepatic ischemia-reperfusion injury through Nrf2 deficiency-induced hepatocyte ferroptosis. — Wu Y, Zhang Y, Zhang S, Yang H, Ci X Life sciences (2026)
[32]
Biosponge-armored polydopamine-modified conducting polypyrrole restores redox-iron homeostasis for enhanced neuroprotection in retinal ischemia-reperfusion injury. — Lin Z, Deng H, Yang G, Huang K Biomaterials (2026)
[33]
ROS-responsive diselenide exosomes restore mitophagy to resolve sterile inflammation in liver IRI. — Zhou T, Jiang Z, Hu Q, Qiu S, Gao J, Zhang J et al. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2026)
[34]
Serine Glycine Restriction Aggravates Hepatic Ischemia-reperfusion Injury. — Yang M, Wang J, Li C, Yang Z, Dong W, Zhang C et al. Transplantation (2026)
[35]
Can Prolonged Ischemia Time in Extremity Transfer Be Resolved Using an Extracorporeal Circulation Model? An Experimental Study. — Yildizdal S, Atalay Ö, Önal D, Pehlivanoğlu B, Talim B, Gököz Ö et al. Annals of plastic surgery (2026)
[36]
PD-1 blockade promotes mucosal CD4+ T cell IL-10 production through altering microbiota to reduce intestinal ischemia reperfusion injury. — Wen SH, Zhang YN, Shen JT, Guo Y, Chang ZN, Zhang HF et al. Gut microbes (2026)
[37]
The Influence of Bromelain Administration on Pro-Inflammatory Cytokines and Lipid Peroxidation in a Rat Model of Intestinal Ischemia/Reperfusion Injury. — Gültekin Ç, Sayiner S, Çetinel Ş, Şehirli AÖ Veterinary medicine and science (2026)
[38]
Obacunone inhibits RIPK1/RIPK3/MLKL-mediated necroptosis by suppressing mitochondrial ROS and MIF signaling in intestinal ischemia-reperfusion injury. — Li XY, Xie JY, Yin YT, Weng XG, Huang ZY, Wang LS et al. International immunopharmacology (2026)
[39]
Ubiquitination of Rhomboid 5 Homolog 2 by Constitutive Photomorphogenic 1 Alleviates Hepatic Ischemia-reperfusion Injury by Regulating the Transforming Growth Factor-β Activating Kinase 1-C-Jun N-terminal Kinase/p38 Signaling Pathway. — Li W, Wu T, Li H, Guan Z, Ding M, Guo W Cellular and molecular gastroenterology and hepatology (2026)
[40]
Sex differences in pain-related behaviour and the endocannabinoid system following hind limb ischemia-reperfusion injury. — Healy CR, Redmond MC, Gethin G, Pandit A, Finn DP The journal of pain (2026)
[41]
Remimazolam mitigates cerebral ischemia/reperfusion injury by concurrently alleviating damage to the blood-brain barrier and RIP3/MLKL-driven necroptosis. — Wang Z, Zhang R, Dai D, Zhang M, Gao D, Zhang J et al. International immunopharmacology (2026)
[42]
Electroacupuncture regulates neuronal ferroptosis and ferritinophagy through lysosomal-mediated TFEB activation in cerebral ischemia-reperfusion. — Tang B, Xu X, Zhao W, Zhou Q, Du G, Wang H Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2026)
[43]
Receptor for advanced glycation end-product in ischemia-reperfusion injury. — Luo X, Hu Q, Ye Q, Zhong Z International immunopharmacology (2026)
[44]
Ischemia-Reperfusion Injury in a Composite Tissue Microsurgical Model. — Sarcon AK, Wan R, Reisdorf RL, Jacobs JF, Selim OA, Boynton FDD et al. Plastic and reconstructive surgery (2026)
[45]
ANXA1 regulates microglia polarization and autophagy via PI3K/Akt/mTOR pathway to reduce inflammatory injury after cerebral ischemia-reperfusion. — Wang H, Li X, Liu Z, Lu R, Li X, Zhang X Cellular signalling (2026)
[46]
The impact of medical ozone on renal ischemic/reperfusion injury: A prospective randomized controlled study in dogs. — Aamer H, Nour EM, Refaie A, Youssef M, Ramzy EA, Khater S et al. Veterinary journal (London, England : 1997) (2026)
[47]
Contribution of adenosine A — Mammadov A, Demiryürek AT, Saracaloğlu A, Demirkiran C, Değim İT, Eronat Ö et al. Turkish journal of medical sciences (2026)
[48]
Alpha-pinene mitigates renal ischemia-reperfusion injury via anti-oxidant, anti-inflammatory, anti-apoptotic effects and favorable eNOS/iNOS shifts in rats. — Sebin SO, Gulakar B, Tanyeli A, Guler MC, Erbas E, Baser S et al. Toxicon : official journal of the International Society on Toxinology (2026)
[49]
The role of gasdermin D-mediated pyroptosis in hepatic ischemia-reperfusion injury and prediction of the therapeutic natural products. — Chen X, Wang B, Li W, Jin N, Lu G, Wang J Biochemical pharmacology (2026)
[50]
Mitoregulin supports mitochondrial membrane integrity and protects against cardiac ischaemia-reperfusion injury. — Stein CS, Zhang X, Witmer NH, Pennington ER, Hahn S, Straub AC et al. Cardiovascular research (2026)
[51]
STING inhibition and BD1-selective BET blockade limit ischemia-reperfusion-induced hepatic tissue remodeling by suppressing pro-inflammasome signaling. — Alalawy AI, Hamad RS, Alasmari A, Al-Massabi R, Alanazi YF, Obidan A et al. Tissue & cell (2026)
[52]
ELABELA: A Potential Therapeutic Target for Ischemia-Reperfusion Injury. — Li W, Meng C, Yang S, Xie Y, Huang Z, Wang T Biomolecules (2026)
[53]
Silencing OGFOD1 ameliorates hepatic ischemia-reperfusion injury through abrogating oxidative stress and apoptosis via downregulating SPARC. — Li Z, Wang X, Cui Y, Liu Y, Wei R, Wang Y et al. Biochemical pharmacology (2026)
[54]
Spleen-derived immune cells potentiate cerebral ischemia-reperfusion injury through brain-spleen communication. — Wang H, Chang M, Tang L, Xu J, Tang S, Meng F et al. European journal of pharmacology (2026)
[55]
Protective effect of dapagliflozin against hepatic ischemia-reperfusion injury in rats. — Korkmaz E, Beytur A, Taşlıdere A, Tekin Ç, Tekin S Molecular biology reports (2026)
[56]
Single-cell RNA sequencing reveals the role of neutrophils in intestinal ischemia-reperfusion injury in mice. — Li R, Wang A, Cao J, Li K, Zhang H, Wang Y et al. Life sciences (2026)
[57]
Aspartame exacerbates cerebral ischemia-reperfusion injury via mitochondrial dysfunction and ERK/CREB1 pathway suppression. — Bai Y, Feng J, Wu XY, Yao ZS, Liu YT, Li YH et al. Ecotoxicology and environmental safety (2026)
[58]
Histone lactylation exacerbates cerebral ischemia-reperfusion injury via NSUN2-mediated epigenetic activation of astrocytic neuroinflammation. — Wang J, Zhang T, Zhang X, Yang Q, Cui W Neurological research (2026)
[59]
Cortexin modulates OPG/RANK/RANKL and TRPC1 expression in cerebral ischemia-reperfusion injury. — Guven C, Türk A, Koçak S, Zencirci B, Yalcin A, Aydın H et al. Neurological research (2026)
[60]
TRIM25 triggers pyroptosis through mitochondrial DNA release in intestinal ischemia-reperfusion injury. — Song Y, Lu X, Ren X, Li M, Meng F, Miao Y et al. Free radical biology & medicine (2026)
[61]
Pathological mechanisms of hepatic ischemia-reperfusion injury and stem cell-based therapeutic strategies: Mechanistic insights and translational perspectives. — Nie R, Duan Y, Cao X, Pang M, Wang Z, Fan H Pathology, research and practice (2026)
[62]
An activatable NIR-I superoxide anion fluorescent probe selective for tracking cerebral ischemia-reperfusion injury. — Xie C, Feng YA, Xu LZ, Ma Y, Zhang L, Tan R et al. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2026)
[63]
Microvascular Perfusion Monitored by Laser Speckle Contrast Imaging during Renal Ischemia-Reperfusion Injury in Mice. — Ye W, Chen Y, Guo J, Zheng H, Zhou Y, Liu B Journal of visualized experiments : JoVE (2026)
[64]
Site-1 protease-derived sPRR contributes to renal ischemia-reperfusion injury in mice by promoting macrophage classical activation. — Feng Y, Zheng H, Wang F, Luo R, Xu C, Yang T Clinical science (London, England : 1979) (2026)
[65]
The Mechanism of G Protein-Coupled Receptor Regulation of Ferroptosis in Hepatic Ischemia-Reperfusion Injury. — Hu D, Sun L, Su M, Xing X International journal of molecular sciences (2026)
[66]
Exposure to ischemia-related neoepitopes exacerbates secondary ischemia-reperfusion injury in mice. — Min M, Wang J, Fang X, Chen Y, Wang Y Transplant immunology (2026)
[67]
Cold-inducible RNA binding protein ameliorates oxygen-glucose deprivation-induced hippocampal neuron injury through anti-apoptotic and anti-oxidative pathways. — Chen L, Yao F, Cheng H, Guo M, Gao Y, Cai S et al. PeerJ (2026)
[68]
PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury. — Zhang J, Luo Y, Xie C, Zhang M, Qin H, Zhou Y et al. Redox biology (2026)
[69]
Oridonin Ameliorates Macrophage Oxidative Stress and Pyroptosis In Liver Ischemia-Reperfusion Injury by Inhibiting Mitochondrial ROS/TXNIP/NLRP3. — Liao W, Wu X, Gong J, Li S Shock (Augusta, Ga.) (2026)
[70]
Inhalation metal-phenolic nanozyme as a novel therapeutic strategy for lung ischemia-reperfusion injury. — Sun S, Ren K, He B, Zhao Y, Jiang R, Zhu X et al. Biomaterials advances (2026)
[71]
Ciprofol attenuates cerebral Ischemia‒reperfusion injury in rats by inhibiting ferroptosis through upregulating AMPK. — Zeng H, Yu X, Zheng Z, Wang Z, Dong W, Gan J Scientific reports (2026)
[72]
The Neuroprotective Role of Ginsenoside Rg1 Against Cerebral Ischemia-Reperfusion Damage Through Inhibition of Mitophagy via Blocking Mitophagosome-Lysosome Fusion. — Ai L, Ren H, Wang Y, Liu M, Qiu Y, Feng J et al. Cell proliferation (2026)
[73]
TPPU alleviates hepatic ischemia-reperfusion injury by regulating macrophage polarization. — Pan H, Lu J, Han T, Liang H, Zhang W, Hou W et al. Biochemical pharmacology (2026)
[74]
BACH1 drives ferroptosis in lung ischemia-reperfusion injury through epigenetic suppression of STAT3-Mediated antioxidant defense. — Gu Y, Liu X, Zhang X, Zhang N Archives of biochemistry and biophysics (2026)
[75]
Pyroptosis in cerebral ischemia‑reperfusion injury: Molecular mechanisms and therapeutic implications (Review). — Li Z, Ming Q, Yang T, Liu M, Fu L, Yang J et al. Molecular medicine reports (2026)
[76]
Trillin attenuates liver ischemia-reperfusion injury by inhibiting autophagy through regulation of the cGAS-STING pathway. — Wu T, Yu Q, Wang Y, Tang H, Guo W International immunopharmacology (2026)
[77]
Dynamic regulation and targeted interventions of macrophages in ischemia-reperfusion injury. — Lu P, Shen R, Yang J, Wu L, Wang R Journal of advanced research (2026)
[78]
Oleanolic acid alleviates intestinal injury after hepatic ischemia-reperfusion under steatosis via PPARG-dependent M2 macrophage polarization. — Pi Y, Wang Y, Guo Q, Zheng W, Zhou H, Deng L et al. International immunopharmacology (2026)
[79]
Unlocking the gasotransmitter: hydrogen sulfide as a multitarget regulator in ischemia-reperfusion injury. — Chen Y, Deng Y, Tang R, Li S, Mei Z, Ge J Medical gas research (2026)
[80]
Daidzein attenuates hepatic ischemia/reperfusion injury via HMGB1-TLR4 signaling pathway. — Li S, Hu X, Yan X, Peng F, Qin X, Liu X et al. Toxicon : official journal of the International Society on Toxinology (2026)
[81]
Identification of mitochondrial dysfunction-related biomarkers and immune infiltration in liver ischemia-reperfusion injury via integrated bioinformatics and machine learning. — Chen X, Zhou Y, Zhang Z, Yuan G, He S, Xiao F Biochemical and biophysical research communications (2026)
[82]
Puerarin protects against renal ischemia-reperfusion injury by restoring mitochondrial function and modulating the PI3K/AKT/NF-k B pathway and suppressing inflammatory responses. — Wang K, Xu C, Wang H, Zhang Y, Zhang Z, Yan R et al. Cellular signalling (2026)
[83]
Natural glycosides from Cistanche deserticola alleviate hepatic ischemia-reperfusion injury via a cAMP-mediated signaling pathway. — Yang Q, Huang T, Chen H, Cao X, Zhu W, Peng Y et al. Journal of ethnopharmacology (2026)
[84]
Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway. — Sun F, She R, Yang T, Chen B, Liao Z, Liao J et al. Phytomedicine : international journal of phytotherapy and phytopharmacology (2026)
[85]
Pearl Powder Fluorescent Carbon Dots Alleviate Neuroinflammation in Cerebral Ischemia/Reperfusion Through Suppression of Anxa2/NF-κB Signaling Pathway. — Borjigin P, Deng C, Su R, Li J, Ying Y, Chen Y et al. International journal of nanomedicine (2026)
[86]
Ubiquitin-specific protease 15 reverses the protective effects of sevoflurane on cerebral ischemia-reperfusion injury in mice by deubiquitinating transforming growth factor-βR1. — Li L, Shen Y, Li J, Wang X International journal of biological macromolecules (2026)
[87]
ALDH2 Mediated Ferroptosis Regulation in Ischemia-Reperfusion Injury. — Han L, Zhai W Journal of cellular and molecular medicine (2026)
[88]
Constructing Mg-Based Hydrogen Container for Mitochondrial Dysfunction and Neuronal Ferroptosis in TCAR-Induced Cerebral Ischemia/Reperfusion Injury. — Fan W, Guan Q, Xu Z, Lin L, Du J, Yu B et al. Advanced healthcare materials (2026)
[89]
Amygdalin synergizes with the TNF-α monoclonal antibody infliximab to modulate HSP90 and related necro-inflammatory/oxidative stress pathways in a rat model of hepatic I/R. — Mohamed RA, Ghoneim ME, Tawfiq RA, El Sayed NF Naunyn-Schmiedeberg's archives of pharmacology (2026)
[90]
TRIM56 Aggravates Cerebral Ischemia-Reperfusion Injury via Inhibiting KLF4-Activated Ferroptosis Signaling. — Wang Q, Li S, Li M, Zhou W, Zhang J, Wu Z et al. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2026)
[91]
STING deficiency alleviates ischemia-reperfusion injury via JAK2/STAT3-mediated macrophage polarization and autophagy. — Zhang Y, Jing Y, Liao H, Ding K, Zhang L, Liao S et al. International immunopharmacology (2026)
[92]
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis. — Chen Y, Shi WQ, Zhang P, Wang R, Ye WB, Lin GQ et al. Acta pharmacologica Sinica (2026)
[93]
Astragaloside IV alleviates neuroinflammation in cerebral ischemia-reperfusion injury by inhibiting HTR2B-mediated microglial M1 polarization. — Ruan Z, Li Y, Chen Y Neurological research (2026)
[94]
ZFP36L1-mediated PRDM1 mRNA degradation inhibits inflammatory activation of Kupffer cells and ameliorates DCD liver ischemic-reperfusion injury. — Du P, Deng M, Ge X, Wang W, Zhang M, Wang P Biochimica et biophysica acta. Molecular basis of disease (2026)
[95]
Sufentanil attenuates renal ischemia-reperfusion injury via the lncRNA KCNQ1OT1/miR-211-5p/HMGB1 axis. — Lin M, Wu X, Zhang S Pathology, research and practice (2025)
[96]
TXNIP knockdown ameliorates hepatic ischemia/reperfusion injury by inhibiting apoptosis and improving mitochondrial dysfunction via HIF-1α. — Zhang Y, Lv J, Bai J, Zhang X, Wu G, Lei X et al. Molecular and cellular biochemistry (2025)
[97]
Astrocytic Gap Junctions protein Cx43/Cx30 modulate EAAT1 and glutamate to mediate cerebral ischemia-reperfusion injury. — Li M, Nie H, He Q, Zhang Z, Yu S, Wang T et al. Brain research (2025)
[98]
TARGETING S100A9-TLR2 AXIS CONTROLS MACROPHAGE NLRP3 INFLAMMASOME ACTIVATION IN FATTY LIVER ISCHEMIA REPERFUSION INJURY. — Sheng M, Liu W, Cao Y, Wang S, Lin Y, Yu W Shock (Augusta, Ga.) (2025)
[99]
Shear stress-induced restoration of pulmonary microvascular endothelial barrier function following ischemia reperfusion injury requires VEGFR2 signaling. — Walsh D, Kostyunina DS, Blake A, Boylan J, McLoughlin P American journal of physiology. Lung cellular and molecular physiology (2025)
[100]
Astragaloside IV plays a neuroprotective role by promoting PPARγ in cerebral ischemia-reperfusion rats. — Ding Y, Jie K, Xin L, Shao B Behavioural brain research (2025)

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