Epidemiology
Among 392 Malassezia isolates from patients with Malassezia folliculitis (MF), pityriasis versicolor (PV), and healthy subjects, Malassezia furfur (67.86%) and Malassezia globosa (18.88%) were predominantly found [PMID:32068525].
Diagnosis
Molecular analysis revealed that M. furfur strains were more susceptible to itraconazole, terbinafine, and bifonazole than M. globosa strains, with minimum inhibitory concentrations (MICs) for itraconazole, posaconazole, voriconazole, and ketoconazole being <1 μg/ml [PMID:32068525].
All isolates of Malassezia pachydermatis were inhibited when cultured on Sabouraud Dextrose Agar plates with high concentrations of gentamycin, potentially causing false-negative cultures [PMID:20149702].
Management
The study demonstrated synergistic effects between terbinafine and itraconazole, suggesting potential benefits of combined antifungal therapy for managing Malassezia infections [PMID:32068525].
The study suggests that topical gentamycin could serve as an effective treatment for external otitis in dogs due to its inhibitory effect on Malassezia pachydermatis growth [PMID:20149702].
There is a hypothesis that gentamycin could be used as a therapeutic approach, particularly as an 'antibiotic-lock' technique, for managing catheter-associated infections caused by Malassezia species in humans [PMID:20149702].
References
1 Li W, Zhang ZW, Luo Y, Liang N, Pi XX, Fan YM. Molecular epidemiology, in vitro susceptibility and exoenzyme screening of Malassezia clinical isolates. Journal of medical microbiology 2020. link 2 Aspíroz C, Gilaberte Y, Rezusta A, Boekhout T, Rubio MA. Gentamycin inhibits the growth of Malassezia pachydermatis in culture. Revista iberoamericana de micologia 2010. link
2 papers cited of 4 indexed.