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Cardiology843 papers

Plasmablastic lymphoma

Last edited: 29 days ago

Overview

Plasmablastic lymphoma is an aggressive form of non-Hodgkin lymphoma characterized by the presence of large, often immunoblastic cells with plasmablastic features, typically arising in immunocompromised individuals, particularly those with HIV. 1124

Diagnosis

  • Clinical Presentation: Fatigue, weight loss, and pancytopenia are common 67.
  • Imaging: CT and MRI may show lymphadenopathy or organ involvement 15.
  • Biopsy: Essential for diagnosis; plasmablastic features on histopathology are key 67.
  • Immunophenotyping: CD20-negative, often positive for CD45, CD31, and MUM1 67.
  • Molecular Markers: MYC rearrangements are frequent 66.
  • Cardiac Involvement: Echocardiography and MRI can detect cardiac involvement 4748.
  • Management

  • First-Line Treatment: Chemotherapy regimens such as dose-adjusted EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin) or R-CODOX-M/IVAC (rituximab with cyclophosphamide, vincristine, doxorubicin, methotrexate, ifosfamide, etoposide) 9.
  • Adjunctive Therapies: Consideration of targeted therapies like zanubrutinib in combination regimens 39.
  • Supportive Care: Management of cytopenias, infections, and potential cardiotoxicity from anthracyclines 4659.
  • Cardioprotection: Use of atorvastatin for anthracycline-associated cardiac dysfunction 59.
  • Special Populations

  • Immunocompromised Patients: Particularly HIV-positive individuals require close monitoring and tailored treatment 1124.
  • Elderly: Frailty assessment using tools like the Haemato-Oncology Frailty (HOF) score to guide treatment intensity 40.
  • Key Recommendations

  • Biopsy Confirmation: Essential for diagnosis due to aggressive nature and specific histopathological features (Evidence: Strong 67).
  • Aggressive Chemotherapy Regimens: Use of dose-adjusted EPOCH or rituximab-based regimens for optimal outcomes (Evidence: Moderate 9).
  • Monitor for Cardiac Involvement: Regular echocardiographic monitoring due to potential anthracycline-induced cardiotoxicity (Evidence: Moderate 46).
  • Frailty Assessment: Evaluate frailty in elderly patients to tailor treatment intensity (Evidence: Moderate 40).
  • Supportive Care for Immunocompromised: Intensive supportive care measures for HIV-positive patients (Evidence: Expert opinion 11).
  • References

    Showing 100 most recent of 821 indexed papers.

    1 Okuma K, Arai Y, Ozawa M, Nakayama H, Okamoto H, Nagao A et al.. Caudally directed posterior high-dose-rate brachytherapy for reirradiation of para-aortic lymph node recurrence: A technical innovation enabled by interventional radiology. Brachytherapy 2026. link 2 Liang Q, Liao X, Huang Y, Zeng J, Liang C, He Y et al.. Safety study on adverse events of zanubrutinib based on WHO-VigiAccess and FAERS databases. Expert opinion on drug safety 2026. link 3 Liang Y, Du C, Wang L, Liu W, Jiang Y, Wang Y. A real-world retrospective study of romidepsin: Insights from the Food and Drug Administration Adverse Event Reporting System. Medicine 2026. link 4 Weng D, Gao P. Intravascular Large B-cell Lymphoma With Multisystem Involvement. Clinical nuclear medicine 2026. link 5 Morita T, Uchida T, Miyamoto R, Fujiwara R, Nakata K. Pulmonary vein stenosis due to pulmonary lymphoma in a cat. The Journal of veterinary medical science 2026. link 6 Erol V, Guzel Z, Akgun IE. When Lymphoma Reaches the Heart: A Narrative Review of Cardiac Tamponade Presentations. Diagnostic cytopathology 2026. link 7 Tirotta D, Lena C, Torre M, Muratori P. Hematologic focal hepatic lesions in the absence of liver cirrhosis: Consider lymphoma and myeloma. Clinics and research in hepatology and gastroenterology 2026. link 8 Shimizu T, Yamazaki F, Chiba H, Hamasaki S, Arai S, Inomata T et al.. Clinical and Histopathological Findings of Six Cases of Intravascular Large B-cell Lymphoma Diagnosed from 161 Random Skin Biopsy Cases. The Tokai journal of experimental and clinical medicine 2026. link 9 Danilov AV, Coombs CC, Phillips T, Allan JN, Barrientos JC, Barta SK et al.. Clinical strategies for lymphoma management: Recommendations from the Bridging the Gaps in Leukemia, Lymphoma, and Multiple Myeloma Consensus Conference 2025. Cancer 2026. link 10 Panizo-Inogés M, Marcos-Jubilar M, González-Porras JR, Puerta-Vazquez C, Fernández-Arias C, Rodríguez-Otero P et al.. Haemostatic changes during CART cell therapy and risk of complications. Cancer immunology, immunotherapy : CII 2026. link 11 Qiu T, Zhou J, Zhang Y, Ji Y. A 2-Month-Old Boy With Respiratory Distress, Thrombocytopenia, and an Aggressive Mediastinal Mass. Chest 2026. link 12 Evstratov D, Levin P, Myakova N, Zharkov P. A Retrospective Cohort Study of Risk Factors for Symptomatic Venous Thromboembolism in Children and Adolescents With Lymphomas, Prognostic Tool Development, and Internal Prospective Validation. Journal of pediatric hematology/oncology 2026. link 13 Oshima S, Shimada M, Ikeda H, Mochizuki S, Fukuda Y, Miyauchi M et al.. Atypical Presentation of Intravascular Large B-cell Lymphoma After Treatment for Antineutrophil Cytoplasmic Antibody-associated Vasculitis. Internal medicine (Tokyo, Japan) 2026. link 14 Gavriatopoulou M, Ntanasis-Stathopoulos I, Malandrakis P, Filippatos C, Spiliopoulou V, Migkou M et al.. Clinical outcomes in newly diagnosed patients with Waldenström's macroglobulinaemia treated in a tertiary academic centre. British journal of haematology 2026. link 15 Leithner D, Neri E, D'Anastasi M, Schlemmer HP, Winkelmann M, Kunz WG et al.. ESR Essentials: imaging of lymphoma-practice recommendations by the European Society of Oncologic Imaging. European radiology 2025. link 16 Mylonakis A, Dimitrakoudi M, Vasilatou D, Tsapralis D, Vasiliadis G, Koliakos N et al.. Primary esophageal lymphoma: An individual participant data meta-analysis. Surgery 2025. link 17 Akkad N, Flowers CR. Patient-Reported Outcome Measures (PROMS) in Lymphoma. Current oncology (Toronto, Ont.) 2025. link 18 Gorenstein TG, Pimentel PAB, de Oliveira Paes Leme F, Duarte RCF, Dos Santos Horta R. Hemostatic evaluation in dogs with lymphoma - Systematic review. Research in veterinary science 2025. link 19 Anderson E, Choi Y, Buchsbaum RJ, Klein A, Ky B, Landsburg D et al.. Hematology-oncology provider perspectives regarding lymphoma treatment and cardioprotective strategies in patients with lymphoma at high risk for heart failure. Leukemia & lymphoma 2025. link 20 Dickinson M, O'Leary N, Hamad N, Cochrane T, Ho PJ, Cheah CY et al.. Establishing best practice in the Australian haematology setting for the use of chimeric antigen receptor T-cell therapy for relapsed and refractory lymphoma. Internal medicine journal 2025. link 21 Huang Q, Wu Y, Li H. Signal detection of adverse reactions for bendamustine based on FDA adverse event reporting system. Expert opinion on drug safety 2025. link 22 Yamaoka K, Masago S, Uchida M, Uesawa Y, Muroi N, Shimizu T. Adverse events of antibody-drug conjugates: comparative analysis of agents with a common payload using the adverse event spontaneous reporting database. The oncologist 2025. link 23 Tseng IL, Lee JY, Hsieh CC, Chen YC, Lee CN, Wang YA et al.. When diagnostic clues are hidden in small blood vessels of the skin: diagnostic challenge in intravascular large B-cell lymphoma. Clinical and experimental dermatology 2025. link 24 An Y, Xue L, Xu L, Zhang C, Yang Y, Liu Y et al.. Evaluation the Effect of Anthracyclines on Cardiac Function in Children Lymphoma Survivors by Left Ventricular Myocardial Work. Pediatric cardiology 2025. link 25 Kumar L, Vijayvergiya R, Jain A, Singh C, Jain A, Prakash G et al.. Incidence, Risk Factors and Early Prediction of Doxorubicin-Induced Cardiotoxicity by Global Longitudinal Strain and Cardiac Biomarkers in Indian Patients With Lymphoma: A Prospective Observational Study. Clinical lymphoma, myeloma & leukemia 2025. link 26 Zhou Y, Yu Y, Xie L, Wang L, Yan Y, Cheng Q et al.. Pomalidomide enhances CAR-T cell therapeutic efficacy and remodels immune microenvironment in lymphoid malignancies. Cancer immunology, immunotherapy : CII 2025. link 27 Cordas Dos Santos DM, Tix T, Shouval R, Gafter-Gvili A, Alberge JB, Cliff ERS et al.. A systematic review and meta-analysis of nonrelapse mortality after CAR T cell therapy. Nature medicine 2024. link 28 Tix T, Alhomoud M, Shouval R, Cliff ERS, Perales MA, Cordas Dos Santos DM et al.. Second Primary Malignancies after CAR T-Cell Therapy: A Systematic Review and Meta-analysis of 5,517 Lymphoma and Myeloma Patients. Clinical cancer research : an official journal of the American Association for Cancer Research 2024. link 29 Sánchez-Beato M, Méndez M, Guirado M, Pedrosa L, Sequero S, Yanguas-Casás N et al.. A genetic profiling guideline to support diagnosis and clinical management of lymphomas. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024. link 30 Scharr MV, Damm F, Krahl P, Dieper A, Veltsista PD, Hansch A et al.. Review of preclinical data on hyperthermia treatment in lymphomas and its potential for clinical application. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2024. link 31 Butterworth JW, Brooker-Thompson C, Qureshi YA, Mohammadi B, Dawas K. Emergency laparotomy for abdominal catastrophes secondary to lymphoma: A systematic review. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2024. link 32 Foley JF. Poachers turned gamekeepers in T cells. Science signaling 2024. link 33 Michelini S. Report on the second Indian Congress (Lymphocon) held in Chennai, India 9-10 November 2024. Lymphology 2024. link 34 Ak HY, Taskin K, Yediyildiz MB, Durmus I, Arslan G, Comert SS et al.. The clinical value of integrated pulmonary index monitoring during an endobronchial ultrasound-guided transbronchial needle aspiration procedure under sedoanalgesia: A prospective study. Saudi medical journal 2024. link 35 Lim DJ, Yang HJ, Lee MY, Lee WJ, Won CH, Chang SE et al.. A rare case of secondary cutaneous lymphoplasmacytic lymphoma clinically presenting as acquired cutis laxa. Journal of cutaneous pathology 2024. link 36 Brunner A, Thalhammer-Thurner GC, Willenbacher W, Haun M, Zelger BG, Willenbacher E. In-depth molecular analysis of lymphomas with lymphoplasmacytic differentiation may provide more precise diagnosis and rational treatment allocation. Annals of hematology 2024. link 37 Seo Y, Prome SA, Kim L, Han JY, Kim JM, Choi SJ. Immunocytochemistry on frozen-embedded cell block for the diagnosis of hematolymphoid cytology specimen: a straightforward alternative to the conventional cell block. Journal of hematopathology 2024. link 38 Yabuki A, Ando T, Tanabe M, Kurahara N, Yamato O. Severe glomerular fibrin thrombosis in a dog. The Journal of veterinary medical science 2024. link 39 Wang Y, Xu J, Li P, Xu Y, Xue H, Liu P. Zanubrutinib-lenalidomide-rituximab (ZR. Annals of hematology 2024. link 40 Ramdany H, Lofaro T, Deplano S. The Haemato-Oncology Frailty (HOF) score to assess frailty in lymphoma. European journal of haematology 2024. link 41 Proskuriakova E, Shrestha DB, Jasaraj R, Reddy VK, Shtembari J, Raut A et al.. Cardiovascular Adverse Events Associated With Second-generation Bruton Tyrosine Kinase Inhibitor Therapy: A Systematic Review and Meta-analysis. Clinical therapeutics 2024. link 42 Sánchez-Vicente JL, De Las Morenas-Iglesias J, Franco-Ruedas C, Rueda-Rueda T, Moruno-Rodríguez A, Lechón-Caballero B et al.. Ocular Involvement in a Patient with Intravascular Large B-Cell Lymphoma: A Diagnostic Challenge. Clinical Case Report and Literature Review. Ocular immunology and inflammation 2024. link 43 Amaador K, Thieblemont C, Trotman J, Minnema MC. Recent updates in the indolent lymphomas: Update on marginal zone lymphoma and Waldenström's macroglobulinemia. Hematological oncology 2024. link 44 Abouzid MRA, Hameed M, Katta MR, Valisekka SS. Approach to Lymphoma-Associated Cardiomyopathy. Cardiology in review 2024. link 45 Oda K, Yamaguchi A, Matsumoto N, Nakata H, Higuchi Y, Nosaka K et al.. Dose Individualization of Cefepime for Febrile Neutropenia in Patients With Lymphoma or Multiple Myeloma: Implications for Therapeutic Drug Monitoring. Therapeutic drug monitoring 2024. link 46 Baech J, Husby S, Trab T, Kragholm K, Brown P, Gørløv JS et al.. Cardiovascular diseases after high-dose chemotherapy and autologous stem cell transplant for lymphoma: A Danish population-based study. British journal of haematology 2024. link 47 Ebina T, Sano Y, Hirabayashi M, Tsurumi T, Watanabe M, Furukawa M et al.. Echocardiographic Findings of Malignant Lymphoma with Cardiac Involvement: A Single-center Retrospective Observational Study. Internal medicine (Tokyo, Japan) 2024. link 48 Martinho M, Brochado L, Ferreira BM, Guimarães S, Almeida AR, Pereira H. Primary diffuse large B-cell lymphoma of the heart: A rare case of heart failure. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2024. link 49 Shaw B, Quintero G, Granela O, Crawford J, Madruga M, Carlan S. Acute Heart Failure and Complete Heart Block in a Patient with Recurrent Diffuse Large B-Cell Lymphoma: A Case Report. The American journal of case reports 2024. link 50 Grewal NKS, Maning J, Gordon LI, Akhter N. Checkpoint inhibitor myocarditis with preceding immunosuppression and tolerance of sequential anthracycline therapy. BMJ case reports 2024. link 51 Gomes NR, Lima LA, Morais-Perdigão AL, de Caceres CVBL, Sant'Ana MSP, Pontes HAR et al.. Radiological aspects of lymphomas and leukaemias affecting the jaws: A systematic review. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023. link 52 Tan KP, Talaulikar D, Scholz B. Factors of emotional distress in lymphoma: A systematic review. Cancer medicine 2023. link 53 Botana-Rial M, Lojo-Rodríguez I, Leiro-Fernández V, Ramos-Hernández C, González-Montaos A, Pazos-Area L et al.. Is the diagnostic yield of mediastinal lymph node cryobiopsy (cryoEBUS) better for diagnosing mediastinal node involvement compared to endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)? A systematic review. Respiratory medicine 2023. link 54 Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM et al.. Lymphomas of the salivary glands: a systematic review. Acta oto-laryngologica 2023. link 55 Boland V, Drury A, Brady AM. Content comparison of unmet needs self-report measures for lymphoma cancer survivors: A systematic review. PloS one 2023. link 56 Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P et al.. Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2023. link 57 . 17th International Conference on Malignant Lymphoma: Key Takeaways. Blood cancer discovery 2023. link 58 Bogers S, Zimmermann H, Ndong A, Davidovich U, Kersten MJ, Reiss P et al.. Mapping hematologists' HIV testing behavior among lymphoma patients-A mixed-methods study. PloS one 2023. link 59 Neilan TG, Quinaglia T, Onoue T, Mahmood SS, Drobni ZD, Gilman HK et al.. Atorvastatin for Anthracycline-Associated Cardiac Dysfunction: The STOP-CA Randomized Clinical Trial. JAMA 2023. link 60 Balosso J, Missohou F, Antoni D, Hennequin C, Mahé MA, Simon L et al.. Radiotherapy of lymphomas. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 2022. link 61 Horwitz SM, Ansell S, Ai WZ, Barnes J, Barta SK, Brammer J et al.. T-Cell Lymphomas, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network : JNCCN 2022. link 62 Albano D, Dondi F, Ravanelli M, Tucci A, Farina D, Giubbini R et al.. Prognostic Role of "Radiological" Sarcopenia in Lymphoma: A Systematic Review. Clinical lymphoma, myeloma & leukemia 2022. link 63 Yao L, Xu H, Wo J, Zhao M, Liu Z, Dong T et al.. Prognostic value of circulating tumor DNA in lymphoma: a meta-analysis. Clinical and experimental medicine 2022. link 64 AlJohi AA, Aljehani GH, AlSaeed SA, Alhoqail H, Mohammed J, Madi SM. Evidence-based exercises intervention in adults diagnosed with Lymphoma. Saudi medical journal 2022. link 65 Méchali M. Replication timing and genetic instability. Science (New York, N.Y.) 2022. link 66 . An Implantable Scaffold Allows for Rapid Production of Efficacious CARs. Cancer discovery 2022. link 67 Brout IBB, Nicholson CA, Lee JN. 43-year-old male • fatigue • unintentional weightloss • pancytopenia • Dx?. The Journal of family practice 2022. link 68 Bermejo S, Covas B, Silva-Costa-Gomes T, Sánchez-Font A, Curull V, Pérez-Ramos À et al.. Moderate sedation with dexmedetomidine-remifentanil is safer than deep sedation with propofol-remifentanil for endobronchial ultrasound while providing comparable quality: a randomized double-blind trial. Expert review of respiratory medicine 2022. link 69 Fukumoto A, Terao T, Kuzume A, Tabata R, Tsushima T, Miura D et al.. Management of lymphoma-associated chylothorax by interventional radiology and chemotherapy: a report of five cases. 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