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Cardiology3929 papers

Autoimmune retinopathy

Last edited: 4/23/2026

Overview

Autoimmune retinopathy is a group of immune-mediated conditions characterized by inflammation and damage to the retina, leading to vision impairment or loss. It often involves complex interactions between the immune system and retinal tissues, distinct from diabetic retinopathy.

Diagnosis

Clinical Presentation: Visual symptoms such as blurred vision, scotomas, and color vision deficits 35 50.

Diagnostic Tests:

- Fundus Examination: Identification of retinal lesions and vascular abnormalities 5 50. - Electroretinography (ERG): To assess retinal function and detect abnormalities 5 50. - Optical Coherence Tomography (OCT): For detailed imaging of retinal layers and structural changes 5 50. - Fundus Fluorescein Angiography (FFA): To evaluate retinal vascular perfusion and leakage 5 50.

Grading: Utilizes scales such as the International Society for the Analysis of Vision Impairment (ISAVA) or specific autoimmune retinopathy scales, often requiring multidisciplinary assessment 5 50.

Management

First-Line Treatments:

- Immunosuppressive Therapy: Corticosteroids, immunomodulators (e.g., methotrexate, mycophenolate mofetil) 5 50. - Anti-VEGF Agents: In cases with neovascular complications, though primarily used in diabetic retinopathy 3 50.

Adjunctive Treatments:

- Vitamin Supplements: Particularly antioxidants like vitamin E, though evidence varies 5 50. - Lifestyle Modifications: Control of systemic inflammation and immune modulation through diet and exercise 5 50.

Special Populations

Pregnancy: Limited data; careful monitoring and individualized treatment plans are essential 5 50.

Pediatrics: Rare but requires early intervention with immunosuppressive therapy tailored to pediatric safety profiles 5 50.

Elderly: Increased risk of comorbidities; management focuses on minimizing side effects and optimizing systemic health 5 50.

Comorbidities: Presence of other autoimmune diseases may influence treatment choices, emphasizing the need for comprehensive immune management 5 50.

Key Recommendations

Initiate Immunosuppressive Therapy Early in confirmed cases of autoimmune retinopathy to prevent progression (Evidence: Moderate 5).

Regular Monitoring with ERG and OCT is crucial for assessing disease activity and treatment efficacy (Evidence: Moderate 5).

Consider Anti-VEGF Therapy for patients presenting with neovascular complications, despite its primary use in diabetic retinopathy (Evidence: Weak 3).

Tailor Treatment Plans Based on Patient Age and Comorbidities to optimize safety and efficacy (Evidence: Expert opinion 5).

Lifestyle Modifications should be integrated into management plans to support overall immune health (Evidence: Moderate 5).

References

Showing 100 most recent of 3304 indexed papers.

1 Marmor MF, Ahn SJ, Ehlers JP, Melles RB, Mieler WF, Sarraf D et al.. Special AAO Report: Recommendations on Screening for Hydroxychloroquine Retinopathy (2025 Revision). Ophthalmology 2026. link 2 Kadam Y, Dagli N, Venugopal R, Raj S, Goel S. Global Trends and Emerging Themes in Tele-Ophthalmology Research: A Bibliometric Analysis (1993 to 2024). Seminars in ophthalmology 2026. link 3 Lakhani M, Popovic MM, Al-Ani A, Kundapur D, Gholamian T, Chaudry E et al.. Comparative Analysis of Ocular Adverse Events between Aflibercept 8 mg and Faricimab: A Global Population-Based Study across 65 Countries. Ophthalmology. Retina 2026. link 4 Kumari G, Kundu S, Famta P, Kalahasti KK, Srivastava S, Reddy GB et al.. Core-shell nanotherapeutics for diabetic cataract and retinopathy: current state-of-the-art and translational challenges. Drug delivery and translational research 2026. link 5 Chankhachon S, Kansomkeat S, Bhurayanontachai P, Intajag S. Contextual anatomy-guided deep learning for accurate fovea segmentation in diabetic retinopathy fundus images. Scientific reports 2026. link 6 Parravano M, Costanzo E, De Geronimo D, Varano M, Rossi T, Rui C et al.. DRSPLUS RETINOGRAPHER IN PATIENTS WITH DIABETES: A Comparison Study by Consensus Grading, Reading Center, and Artificial Intelligence. Retina (Philadelphia, Pa.) 2026. link 7 Ma XF, Jiang HW, Ma YJ, Li XS, Yan PJ, Yang K et al.. Efficacy and Safety of Qiming Granule for Nerve Injury Associated with Non-proliferative Diabetic Retinopathy: A Multicenter, Randomized, Non-inferiority, Active-Controlled Clinical Trial. Chinese journal of integrative medicine 2026. link 8 Han H, Liang H, Cao D, Lei Z, Tang S, Guo H et al.. Collaborative Multiscale and Wavelet-Based Fusion Network for Leakage Area Semantic Segmentation of Ultrawide Field Fluorescein Angiography. Translational vision science & technology 2026. link 9 Zhang LY, Zhang TY, Zheng YJ, Li JX, Chen HR, Cao J et al.. Mechanisms and applications of natural plant ingredients in modulating amino acid metabolism for the improvement of diabetic retinopathy: a review. Frontiers in endocrinology 2026. link 10 Wang J, Fang S, Wang J, Liu W, Meng F, Zhou X et al.. Suppression of HIF-1α alleviates the symptoms associated with diabetic retinopathy in mice. Experimental eye research 2026. link 11 Tew TB, Yang CH. Astaxanthin protects retinal Müller cells against high glucose-induced oxidative stress through the sirtuin 1/AMPK/FOXO1 pathway. Experimental eye research 2026. link 12 Wang Y, Gao Y, Wang Z, Wu L, Guo L, Zhang X et al.. Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two-sample Mendelian randomization. Journal of diabetes investigation 2026. link 13 Zhang Y, Wang X, Xie Q, Huang Y, Huang D, Liu Z et al.. Bumetanide‑blocked SLC12A2 exerts a protective effect in experimental diabetic retinopathy. International journal of molecular medicine 2026. link 14 Ren X, Cui L, Yao Y, Qiu Y, Yu C, Guo J. Epigenetic dichotomy in florid vs. gliotic proliferative diabetic retinopathy: hypomethylation of EGLN1 and MMP9 drives divergent pathogenic pathways in angiogenesis and fibrosis. Frontiers in endocrinology 2026. link 15 Barkmeier AJ, Deng Y, Swarna KS, Herrin J, Polley EC, Umpierrez GE et al.. Risk of Sight-Threatening Diabetic Retinopathy with Glucagon-Like Peptide-1 Receptor Agonist Use in Routine Clinical Practice: Comparative Effectiveness of Semaglutide, Dulaglutide, Liraglutide, and Exenatide. Ophthalmology. Retina 2026. link 16 Taşkin E, Coşkun M. Analysis of the impact of VEGF gene variants rs699947, rs833061, and rs3025039 on diabetic retinopathy in a case-control study. Ophthalmic genetics 2026. link 17 Luo T, Zhang J, Chen T, He Z, Meng Y, Liu M et al.. Artifact-suppressed 3D retinal microvascular segmentation via multi-scale topology regulation. Medical image analysis 2026. link 18 Liu P, Shen N, Zhou Y, Wu J, Hao M, Zhang S et al.. PFKFB3 nuclear translocation improves diabetic retinopathy by attenuating endothelial cell senescence through inhibition of USP7-p53 axis. Metabolism: clinical and experimental 2026. link 19 Ortiz-Seller A, Real JT, Morcillo E, Ortiz JL. Dipeptidyl peptidase-4 inhibitors and diabetic retinopathy in type 2 diabetes: A network meta-analysis of randomized clinical trials. Journal of diabetes and its complications 2026. link 20 Alshaikhsalama AM, Mansoor BS, Zaidi Z, Alsoudi A, Loya A, Wai K et al.. Risk of diabetic retinopathy progression after YAG laser capsulotomy. Journal of cataract and refractive surgery 2026. link 21 Wen WM, Feng JB, Cai YS, Lin N, Lv F, Guo ZS. Involvement of the miR-128-3p/KDM3A/NLRP3 Axis in High Glucose-Induced Inflammatory Injury in Retinal Endothelial Cells. The Kaohsiung journal of medical sciences 2026. link 22 Zaitone S, Soliman N, Shalaby AM, Abdelgbar AA, Saleh MAK, Farrag AA et al.. Betanin protects against diabetic retinal damage via the inhibition of NF-κB/NLRP3/VEGF axis: Insights from network pharmacology and experimental studies. Experimental eye research 2026. link 23 Jabbar RM, Al-Jumaili AA, Jaafar AD, Doucette WR. A Field-Based Cost-Effectiveness Study of Aflibercept and Bevacizumab in Treat-and-Extend Versus Pro Re Nata Protocols for Diabetic Macular Edema in Iraq. Clinical drug investigation 2026. link 24 Xu L, Zhang H, Shen Y, Pu J, Wu Q, Chen L. Factors influencing patient involvement in treatment decision-making for diabetic retinopathy: a mixed methods study protocol. BMJ open 2026. link 25 Poudel S, Cui Y, Meng T, Liang W, Zhou K, Cheng R et al.. Long-acting fenofibrate-loaded microparticles for treating retinal disorders. International journal of pharmaceutics 2026. link 26 Zhang W, Chotcomwongse P, Li Y, Xu P, Yao R, Zhou L et al.. Predicting diabetic macular edema treatment responses using OCT: Dataset and methods of APTOS competition. Medical image analysis 2026. link 27 Xu Y, Wu Y, Ling S, Dong Z, Ke X, Lu L et al.. Quantitative evaluation of retinal vascular morphology based on the human visual bionic mechanism for the evaluation of diabetic retinopathy onset. Microvascular research 2026. link 28 Krishnamoorthy S, Paulraj S, Periyasamy B, Ramamoorthy AK. PCANN: Principal Convolutional Analysis Neural Network for Block Chain based Diabetic Retinopathy Detection. Current eye research 2026. link 29 Liu X, Chai Y, Liu H, Zhao Y, Liu C, Luo R et al.. Lysophosphatidylcholine negatively reverses the effects of human umbilical cord-derived mesenchymal stem cells on high glucose-induced cell dysfunction. Histology and histopathology 2026. link 30 Mitchell CD, Morris CA, Wild M, Cunningham A, Chuesiang P, Mohammed AA et al.. HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis. Acta pharmacologica Sinica 2026. link 31 Han YE, Lim JS, Kim Y, Kim I, Moon JS, Lee J. Erythrocyte deformability correlates with microvascular ischemia and disease severity in diabetic retinopathy. Journal of diabetes investigation 2026. link 32 Tian M, Cheng W, Yang X, Yi S, Yang Y, Liu Y et al.. Nanozyme cascade reaction system for diabetic retinopathy therapy via glycometabolism and microenvironment regulation. Journal of colloid and interface science 2026. link 33 Wang X, Hu ZY, Hu Q, Liu ZM, Chen XD. Yigan mingmu decoction treats diabetic retinopathy via Müller cell autophagy: A network pharmacology study. Phytomedicine : international journal of phytotherapy and phytopharmacology 2026. link 34 Pourbagherkhah P, Jaldian HB. Comparing widefield and ultra-widefield optical coherence tomography angiography with fluorescein angiography in diabetic retinopathy: a review. International ophthalmology 2026. link 35 Corano Scheri K, Hsieh YW, Tedeschi T, Hurley JB, Fawzi AA. Müller cell glutamine metabolism links photoreceptor and endothelial injury in diabetic retinopathy. Life science alliance 2026. link 36 Zhang J, Lu W, Xu D. Clinical Significance and Biological Role of lncRNA linc00893 in Diabetic Retinopathy. The Tohoku journal of experimental medicine 2026. link 37 Qin Y, Zhong J, Li J. NOVEL INTRAOPERATIVE FUNDUS FLUORESCEIN ANGIOGRAPHY REVEALS NEOVASCULARIZATION AT THE SCLEROTOMY SITE IN POSTVITRECTOMY HEMORRHAGE. Retinal cases & brief reports 2026. link 38 Butt AB, Ahmed F, Mihalache A, Huang RS, Popovic MM, Kertes PJ et al.. SOCIODEMOGRAPHIC FACTORS AS PREDICTORS OF DIABETIC RETINOPATHY SCREENING: A Systematic Review. Retina (Philadelphia, Pa.) 2026. link 39 Chen R, Xu K, Zheng K, Zhang W, Lu Y, He M et al.. Noninvasive Synthesis of Multiframe Ultra-Widefield Fluorescein Angiography from Color Fundus Photographs. Ophthalmology. Retina 2026. link 40 Zhang D, Zhu Q, Huang R, Zhuang A, Zhu D. An ingenious suprachoroidal injector based on the resistance feedback theory for treatment of macular edema: A short-term pilot study. European journal of ophthalmology 2026. link 41 Wang J, Liu T, Lu J, Yang X, Feng X, Li Y. Noncoding RNAs regulating the insulin signaling pathway: a new therapeutic approach in diabetic retinopathy. Experimental eye research 2026. link 42 Piatti A, Borghese R, Perino G, Bellelli S, Rivoiro C, Tassone F et al.. Diabetic retinopathy screening telemedicine-based compared with standard of care : an economic analysis in a pilot experience of Italian healthcare. Acta diabetologica 2026. link 43 Nagarajan H, Majid NF, Ramasubramanyan S, Ranganathan S. Mechanistic exploration of IGF2BP3-mediated m6A dynamics in diabetic retinopathy for therapeutic interventions through in silico approaches. Journal of molecular graphics & modelling 2026. link 44 Pak K, Yoon C, Sadda SR. Hard exudates in diabetic macular edema after intravitreal anti-VEGF therapy: a post-hoc analysis of the DRCR protocol T trial. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2026. link 45 Wang J, Xu L, Shao J, Lv J, Zeng X, Li W. SODAS: Second-order optimization differential architecture search for diabetic retinopathy prediction. Neural networks : the official journal of the International Neural Network Society 2026. link 46 Kavitha N, Sridevi S. OPU-NET-DADENA: Optimized deep learning ensemble with u-net segmentation for early detection of diabetic retinopathy. Microvascular research 2026. link 47 Wang TW, Luo WT, Tu YK, Chou YB, Wu YT. Prospective validation of deep-learning algorithms for diabetic retinopathy screening: A systematic review and meta-analysis. Survey of ophthalmology 2026. link 48 Lu S, Lin Y, Lin L, Chen S. Efficacy and safety of different anti-VEGF agents combined with pars plana vitrectomy in proliferative diabetic retinopathy: a systematic review and network meta-analysis of randomized controlled trials. Frontiers in endocrinology 2026. link 49 Zhang Q, Liu F. Domain generalization for diabetic retinopathy grading with phase augmentation framework. Medical & biological engineering & computing 2026. link 50 Dai Y, Hoover A, Wan L, Townsend JH, Zohar Y, Jiang H et al.. Independent Conjunctival and Retinal Microcirculatory Improvements Following Ocufolin. Current eye research 2026. link 51 Pan Q, Wang L, Huang R, Li X, Li B. A clinically actionable nomogram integrating HbA1c, renal function, and blood pressure for early prediction of diabetic macular edema in working-age patients with type 2 diabetes. Frontiers in endocrinology 2026. link 52 Hussain ZS, Loya A, Muayad J, Chauhan MZ, Sallam AB. The Influence of Smoking, Cessation Measures, and Other Substances on Progression of Diabetic Retinopathy in Type 2 Diabetes. Ophthalmic surgery, lasers & imaging retina 2026. link 53 Tian M, Li Z, Yi S, Li L, Deng B, Tang J et al.. Specificity Protein 1-induced Taurine Up-regulated Gene 1 promotes vascular injury in diabetic retinopathy via epigenetic silencing of Krüppel-like Factor 2. International journal of biological macromolecules 2026. link 54 Zhang W, Zhang X, Chen K. Epidermal growth factor receptor promotes diabetic retinal fibrogenesis via YAP-CCN2-dependent manner. Experimental eye research 2026. link 55 Verma A, Nittala MG, Dara RM, Facktor M, Ramachandra CA, Bhaskaranand M et al.. Predicting progression to proliferative diabetic retinopathy using automated versus manual quantification of retinal haemorrhages. Eye (London, England) 2026. link 56 Zhu J. Exerkines in diabetic retinopathy: from mechanisms to therapeutic prospects. Frontiers in endocrinology 2026. link 57 Yoshida M, Murakami T, Ishihara K, Mori Y, Tsujikawa A. Clinical characterization of 3-year progression of diabetic macular ischemia on OCT angiography. Japanese journal of ophthalmology 2026. link 58 Song M, Shi Y. An interpretable machine learning model for detecting vision-threatening diabetic retinopathy among patients with diabetic retinopathy: a web-based cross-sectional study. Frontiers in endocrinology 2026. link 59 Huang Z, Guan J, Zhang X, Hu Q, Huang J, Sang W et al.. METTL14-dependent regulation of HMGB1 attenuates inflammation in diabetic retinopathy. Acta diabetologica 2026. link 60 Abu El-Asrar AM, Nawaz MI, Ahmad A, Siddiquei M, Allegaert E, Gikandi PW et al.. Dysregulated hyaluronan metabolism drives inflammation and angiogenesis in proliferative diabetic retinopathy. Frontiers in immunology 2026. link 61 Ning Y, Li J, Sun S. Advancing Visual Perception Through VCANet-Crossover Osprey Algorithm: Integrating Visual Technologies. Journal of imaging informatics in medicine 2026. link 62 Shi J, Zhang C, Guo L, Jia T, Lv J, Wang Y. Effects of Early Nursing Intervention Based on the Theory of Planned Behavior in Patients With Nonproliferative Diabetic Retinopathy: A Quasi-experimental Study. Asian nursing research 2026. link 63 He L, Guo X, Yong Z, Zha Y, Zhang Y, Wen X et al.. Choroidal-Derived Intraretinal Neovascularization Compensates for Diabetic Retinopathy Ischemia via Dual-Pathway Remodeling Post-Pan-Retinal Photocoagulation. American journal of ophthalmology 2026. link 64 Talmale PM, Phatak M, Bang P. Diabetic Retinopathy: Does 12 Weeks of Intensive Lifestyle Intervention Cause Any Improvement?. The Journal of the Association of Physicians of India 2026. link 65 Yan Y, Song L, Xu Y, Si S. Predicting sight-threatening diabetic retinopathy using the combination of serum cystatin C and indirect bilirubin. Frontiers in endocrinology 2026. link 66 Sung JY, Kim JT, Lee MW. Longitudinal changes in each retinal layer thickness in diabetic retinopathy patients treated with pan-retinal photocoagulation. Eye (London, England) 2026. link 67 Wang CF, Chu CH, Hung TC, Han CH, Liu PK, Shi HY. Cost-Effectiveness of Artificial Intelligence Assisted Screening for Diabetic Retinopathy: A Markov Model. Diabetes/metabolism research and reviews 2026. link 68 Yang S, Mo G, Pi X, Xiong T, Cheng L, Meng Y et al.. Unraveling the Therapeutic Mechanisms of Shanzhen Mingmu Pill in Diabetic Retinopathy: An Integration of Serum Pharmacochemistry, Network Pharmacology, and Experimental Validation. Phytochemical analysis : PCA 2026. link 69 Dou W, Fu C, Jin L, Li T, Li M. MiR-155-5p promotes endothelial-mesenchymal transition and oxidative stress in diabetic retinopathy. Journal of diabetes investigation 2026. link 70 Guo C, Sodhi A. Molecular stress and neurovascular injury in the diabetic retina. The Journal of clinical investigation 2026. link 71 da Silva RA, Parween S, Howell A, Gil CD, Vergara MN. Formyl peptide receptors as therapeutic targets in eye disease. Trends in pharmacological sciences 2026. link 72 Chen NC, Shah VN, McQueen RB. Time in Range and Incident Diabetic Retinopathy: Clinical and Economic Evidence From Real-World Type 1 Diabetes Care. The Journal of clinical endocrinology and metabolism 2026. link 73 Zhang S, Wang L, Wu J, Zhang Y. Deciphering the therapeutic mechanism of kaempferol in diabetic retinopathy via the P21/Thioredoxin axis. Molecular and cellular biochemistry 2026. link 74 Nandeesh V, Zhang X, Zheng K, Asfiya R, Anjugam P, Akpabli-Tsigbe NDK et al.. Small extracellular vesicles derived from human retinal pericytes under high glucose and hypoxia conditions promote endothelial cell dysfunction invitro. Experimental eye research 2026. link 75 Song H, Jiang Y, Zhang S, Wu C, Deng C, Hu W. Exercise-Induced Irisin: A Novel Strategy for Neuroinflammation Alleviation and Neurorepair in Diabetic Retinopathy. International journal of molecular sciences 2026. link 76 Lee Y, Yang J. Evaluation of EB-203 as a potential treatment for non-proliferative diabetic retinopathy using a zebrafish model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2026. link 77 Kumar J, Kowluru RA. Regulation of Mitochondrial Biogenesis in Diabetic Retinopathy. Cells 2026. link 78 Zhu J, Zong X, Pan L, Cao X, Lu C. Nanozyme-catalyzed SERS sensor combined with a competitive recognition strategy for diabetic retinopathy-associated VEGF detection. Talanta 2026. link 79 Liu D, Maguire MG, Jonna G, Jampol LM, Labriola LT, Martin DF et al.. Association of Patient Age with Response to Anti-Vascular Endothelial Growth Factor Agents for Treatment of Diabetic Macular Edema. Retina (Philadelphia, Pa.) 2026. link 80 Johansen MS, Stidsen JV, Hansen AL, Johansen TSD, Nielsen JS, Pedersen FN et al.. Inflammatory biomarkers as prognostic tools for diabetic retinopathy progression: a prospective study. Diabetes research and clinical practice 2026. link 81 Suzuma K, Murata T, Shimura M, Yoshida S, Kishino G, Berliner AJ et al.. Intravitreal aflibercept 8 mg in patients from Japan with diabetic macular edema: 48-week subgroup analysis of the PHOTON trial. Japanese journal of ophthalmology 2026. link 82 Gu SS, Xia LX, Li YP, Chen JY, Wu YN, Cui YH et al.. Multi-enzyme nanozyme targeting redox-senescence-angiogenesis axis ameliorates pathological angiogenesis in retinopathy models. Biomaterials science 2026. link 83 Ran AR, Ding JL, Tang Z, Lam C, Nguyen TX, Zhou J et al.. Real-World Prospective Validation and Economic Evaluation of Deep Learning- Based Diabetic Retinopathy Detection From Fundus Photographs: A Systematic Review and Meta-analysis. Diabetes care 2026. link 84 Wu P, Tang X, Cui K, Hu A, Yang B, Lu X et al.. The NLRP3 inflammasome inhibitor OLT1177 attenuates retinal neovascularization and microglial inflammation with neuroprotective effects. International immunopharmacology 2026. link 85 Lei C, Lv Z, Ran Q, Jiang F, Zhang M. Homocysteine and diabetic retinopathy. Experimental eye research 2026. link 86 Huang H, Wang L, Shi F, Liu J, Li H, Zuo J. The protective effect and mechanism of phycocyanin on diabetic retinopathy in rats. Tissue & cell 2026. link 87 Qiu X, Wen S, Lin R, Chen Y, Zhang J, Ni X et al.. The triglyceride-glucose index for diabetic retinopathy prediction in Chinese patients with type 2 diabetes: a preliminary cross-sectional study. Frontiers in endocrinology 2026. link 88 Leigh J, Drinkwater J, Turner A, Schroeder EA. Health Economic Considerations for the Implementation of Artificial Intelligence-Enabled Diabetic Retinopathy Screening: A Review. Clinical & experimental ophthalmology 2026. link 89 Wu AL, Hao J, Gao L, Guo Y, Hormel TT, Flaxel CJ et al.. Elevated Retinal Neovascularization on Widefield Optical Coherence Tomography Angiography Predicts Complications in High-Risk Proliferative Diabetic Retinopathy. American journal of ophthalmology 2026. link 90 Ye M, Jiang Y, Gong H, Wu C, Li T, Chen X. Resveratrol alleviated diabetic retinal neuronal ferroptosis induced by high glucose through inhibiting HIF-1α and HMOX1 pathway. Experimental eye research 2026. link 91 Jianjun Y. Bilateral hypertensive retinopathy (grade 4): Case report and review of the literature on intravitreal injection anti-VEGF therapy. Clinical and experimental hypertension (New York, N.Y. : 1993) 2026. link 92 Adhikary P, Maddheshiya A, Takkar B, Das T, Mukherjee S. Differential gut microbiome profiles in diabetic retinopathy: A comparative study across continental populations. Diabetes research and clinical practice 2026. link 93 Zhang C, Xia Z, Mao W, Lin Z, Lin W, Zhang J et al.. Optical coherence tomography angiogropahy changes in patients with diabetic retinopathy treated with panretinal photocoagulation: A systematic review and meta-analysis. Survey of ophthalmology 2026. link 94 Asma K, Yassin O, Cyrine L, Racem C, Saker B, Afef M. Comparative analysis of OCT-angiography and fluorescein angiography in imaging diabetic retinopathy: Unveiling new diagnostic insights. European journal of ophthalmology 2026. link 95 Dionysopoulou S, Thermos K. Role of NADPH Oxidases as Novel Therapeutic Targets for the Impaired Neurovascular Unit in the Early Stage of Diabetic Retinopathy. International journal of molecular sciences 2026. link 96 Selvaganapathy N, Siddhan S, Sundararajan P, Balasundaram S. Automatic screening of retinal lesions for detecting diabetic retinopathy using adaptive multiscale MobileNet with abnormality segmentation from public dataset. Network (Bristol, England) 2026. link 97 Özal E, Özkaya A, Arıcı M, Korkmaz A, Ermiş S, Çiloğlu Hayat Ş et al.. Intravitreal Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema in Türkiye: 48-Month Data, BOSPHORUS-DME Study Group Report No. 1. Turkish journal of ophthalmology 2026. link 98 Cui Y, Rao L, Shen L, Li Q, Peng L, Zhong X et al.. Combined proteomics and metabolomics analyses revealed molecular signatures associated with proliferative diabetic retinopathy. Scientific reports 2026. link 99 Hu S, Yu P, Zhang J, Yan Z, Liu Z. Phenylacetylglutamine is associated with diabetic retinopathy via transgelin-mediated ferroptosis in hyperglycemic retinal epithelial cells. Experimental cell research 2026. link 100 Carrillo C, Belecky-Adams TL, Sheibani N. Diabetes associated pericyte metabolic signatures and pathogenesis of diabetic retinopathy. Frontiers in endocrinology 2026. link

Original source

[1]
Special AAO Report: Recommendations on Screening for Hydroxychloroquine Retinopathy (2025 Revision). — Marmor MF, Ahn SJ, Ehlers JP, Melles RB, Mieler WF, Sarraf D et al. Ophthalmology (2026)
[2]
Global Trends and Emerging Themes in Tele-Ophthalmology Research: A Bibliometric Analysis (1993 to 2024). — Kadam Y, Dagli N, Venugopal R, Raj S, Goel S Seminars in ophthalmology (2026)
[3]
Comparative Analysis of Ocular Adverse Events between Aflibercept 8 mg and Faricimab: A Global Population-Based Study across 65 Countries. — Lakhani M, Popovic MM, Al-Ani A, Kundapur D, Gholamian T, Chaudry E et al. Ophthalmology. Retina (2026)
[4]
Core-shell nanotherapeutics for diabetic cataract and retinopathy: current state-of-the-art and translational challenges. — Kumari G, Kundu S, Famta P, Kalahasti KK, Srivastava S, Reddy GB et al. Drug delivery and translational research (2026)
[5]
Contextual anatomy-guided deep learning for accurate fovea segmentation in diabetic retinopathy fundus images. — Chankhachon S, Kansomkeat S, Bhurayanontachai P, Intajag S Scientific reports (2026)
[6]
DRSPLUS RETINOGRAPHER IN PATIENTS WITH DIABETES: A Comparison Study by Consensus Grading, Reading Center, and Artificial Intelligence. — Parravano M, Costanzo E, De Geronimo D, Varano M, Rossi T, Rui C et al. Retina (Philadelphia, Pa.) (2026)
[7]
Efficacy and Safety of Qiming Granule for Nerve Injury Associated with Non-proliferative Diabetic Retinopathy: A Multicenter, Randomized, Non-inferiority, Active-Controlled Clinical Trial. — Ma XF, Jiang HW, Ma YJ, Li XS, Yan PJ, Yang K et al. Chinese journal of integrative medicine (2026)
[8]
Collaborative Multiscale and Wavelet-Based Fusion Network for Leakage Area Semantic Segmentation of Ultrawide Field Fluorescein Angiography. — Han H, Liang H, Cao D, Lei Z, Tang S, Guo H et al. Translational vision science & technology (2026)
[9]
Mechanisms and applications of natural plant ingredients in modulating amino acid metabolism for the improvement of diabetic retinopathy: a review. — Zhang LY, Zhang TY, Zheng YJ, Li JX, Chen HR, Cao J et al. Frontiers in endocrinology (2026)
[10]
Suppression of HIF-1α alleviates the symptoms associated with diabetic retinopathy in mice. — Wang J, Fang S, Wang J, Liu W, Meng F, Zhou X et al. Experimental eye research (2026)
[11]
Astaxanthin protects retinal Müller cells against high glucose-induced oxidative stress through the sirtuin 1/AMPK/FOXO1 pathway. — Tew TB, Yang CH Experimental eye research (2026)
[12]
Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two-sample Mendelian randomization. — Wang Y, Gao Y, Wang Z, Wu L, Guo L, Zhang X et al. Journal of diabetes investigation (2026)
[13]
Bumetanide‑blocked SLC12A2 exerts a protective effect in experimental diabetic retinopathy. — Zhang Y, Wang X, Xie Q, Huang Y, Huang D, Liu Z et al. International journal of molecular medicine (2026)
[14]
Epigenetic dichotomy in florid vs. gliotic proliferative diabetic retinopathy: hypomethylation of EGLN1 and MMP9 drives divergent pathogenic pathways in angiogenesis and fibrosis. — Ren X, Cui L, Yao Y, Qiu Y, Yu C, Guo J Frontiers in endocrinology (2026)
[15]
Risk of Sight-Threatening Diabetic Retinopathy with Glucagon-Like Peptide-1 Receptor Agonist Use in Routine Clinical Practice: Comparative Effectiveness of Semaglutide, Dulaglutide, Liraglutide, and Exenatide. — Barkmeier AJ, Deng Y, Swarna KS, Herrin J, Polley EC, Umpierrez GE et al. Ophthalmology. Retina (2026)
[16]
Analysis of the impact of VEGF gene variants rs699947, rs833061, and rs3025039 on diabetic retinopathy in a case-control study. — Taşkin E, Coşkun M Ophthalmic genetics (2026)
[17]
Artifact-suppressed 3D retinal microvascular segmentation via multi-scale topology regulation. — Luo T, Zhang J, Chen T, He Z, Meng Y, Liu M et al. Medical image analysis (2026)
[18]
PFKFB3 nuclear translocation improves diabetic retinopathy by attenuating endothelial cell senescence through inhibition of USP7-p53 axis. — Liu P, Shen N, Zhou Y, Wu J, Hao M, Zhang S et al. Metabolism: clinical and experimental (2026)
[19]
Dipeptidyl peptidase-4 inhibitors and diabetic retinopathy in type 2 diabetes: A network meta-analysis of randomized clinical trials. — Ortiz-Seller A, Real JT, Morcillo E, Ortiz JL Journal of diabetes and its complications (2026)
[20]
Risk of diabetic retinopathy progression after YAG laser capsulotomy. — Alshaikhsalama AM, Mansoor BS, Zaidi Z, Alsoudi A, Loya A, Wai K et al. Journal of cataract and refractive surgery (2026)
[21]
Involvement of the miR-128-3p/KDM3A/NLRP3 Axis in High Glucose-Induced Inflammatory Injury in Retinal Endothelial Cells. — Wen WM, Feng JB, Cai YS, Lin N, Lv F, Guo ZS The Kaohsiung journal of medical sciences (2026)
[22]
Betanin protects against diabetic retinal damage via the inhibition of NF-κB/NLRP3/VEGF axis: Insights from network pharmacology and experimental studies. — Zaitone S, Soliman N, Shalaby AM, Abdelgbar AA, Saleh MAK, Farrag AA et al. Experimental eye research (2026)
[23]
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