Overview
3-M syndrome is a rare, autosomal recessive disorder characterized by prenatal growth restriction, distinctive facial features, and absence of microcephaly and intellectual disability 1.Diagnosis
Clinical history and examination identifying growth restriction and facial dysmorphism
Radiographic findings to confirm diagnosis
Additional features may include small nails and abnormal dermatoglyphics 1Management
No specific pharmacological treatments mentioned; management is supportive 1
Regular monitoring for associated complications and developmental milestones 1Special Populations
No specific information provided regarding pregnancy, pediatrics, elderly, or comorbidities 1Key Recommendations
Establish diagnosis through clinical evaluation, radiographic assessment, and identification of characteristic features (Evidence: Expert opinion) 1
Implement supportive care focusing on growth monitoring and developmental support (Evidence: Expert opinion) 1References
1 Marik I, Marikova O, Kuklik M, Zemkova D, Kozlowski K. 3-M syndrome in two sisters. Journal of paediatrics and child health 2002. link