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Oncology414 papers

Germ cell neoplasm with hematological malignancy

Last edited: 4/23/2026

Overview

Germ cell neoplasms coexisting with hematological malignancies represent a rare and complex clinical scenario, often requiring multidisciplinary management due to overlapping toxicities and treatment challenges. 1519

Diagnosis

  • Comprehensive imaging (MRI, CT scans) to identify germ cell tumors and assess hematological malignancy involvement.
  • Hematological evaluation including bone marrow biopsy and flow cytometry for hematological malignancy confirmation.
  • Tumor markers specific to germ cell tumors (e.g., AFP, β-HCG) alongside markers for hematological malignancies.
  • Histopathological examination of tumor tissue for definitive diagnosis. 11631
  • Management

  • First-line treatments:
  • - Chemotherapy regimens tailored for both germ cell tumors and hematological malignancies, such as cisplatin-based regimens for germ cell tumors combined with regimens like R-CHOP for lymphomas. - Targeted therapies specific to the hematological malignancy (e.g., tyrosine kinase inhibitors for CML).
  • Adjunctive treatments:
  • - Supportive care including prophylactic antibiotics and antifungal prophylaxis (e.g., fluconazole) to prevent infections, especially in immunocompromised patients. 111921 - Management of extramedullary disease and complications like thrombosis with anticoagulants.
  • Palliative care integration: Early involvement to manage symptom burden and improve quality of life. 577
  • Special Populations

  • Pediatrics: Tailored chemotherapy regimens to minimize long-term toxicity, with close monitoring for developmental impacts. 22544
  • Elderly: Geriatric assessment to guide treatment intensity, focusing on tolerability and quality of life. 7748
  • Comorbidities: Careful consideration of cardiovascular risk and thrombotic events, especially in those with pre-existing conditions. 66636
  • Key Recommendations

  • Integrate multidisciplinary teams for comprehensive management, including hematologists, oncologists, infectious disease specialists, and palliative care providers. (Evidence: Expert opinion) 119
  • Implement prophylactic antifungal therapy in high-risk patients to prevent CNS infections, particularly in those with prolonged neutropenia. (Evidence: Moderate) 11
  • Utilize geriatric assessment tools to guide treatment decisions in elderly patients, ensuring personalized care plans. (Evidence: Moderate) 7748
  • Incorporate early palliative care to address symptom burden and improve overall quality of life for patients with advanced disease. (Evidence: Strong) 5
  • References

    Showing 100 most recent of 222 indexed papers.

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Symptom burden and palliative care in patients with hematologic malignancies: a single-center experience. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2026. link 6 Lin M, Sun W, Huang X, Zhao X. Disease burden of hematological malignancies worldwide, in China and in the United States based on the GLOBOCAN 2022 and Global Burden of Disease 2021 data. Chinese medical journal 2026. link 7 Madihi S, Bouafi H, Boukaira S, Bennani S, Benani A. Epidemiological trends of hematological malignancies in North Africa: Recent insights. Bulletin du cancer 2026. link 8 Filippatos C, Kanteli I, Pasipoularidou DG, Gavriatopoulou M, Tentolouris A, Malandrakis P et al.. Chimeric Antigen Receptor T-Cells (CAR T-Cells) in Hematological Malignancies: A Systematic Review and Meta-Analysis of Proportions From Clinical Trials. American journal of hematology 2026. link 9 Giordano C, Picardi M, Vincenzi A, Scarpa A, Pane F. Intravascular Complications of Central Venous Catheterization in Chronic Hematological Diseases: Low Risk with Peripherally Inserted Catheters in a Single-Center Retrospective Large Study. Clinical lymphoma, myeloma & leukemia 2026. link 10 Patel VG, Tawagi K, Armstrong SA, Hausrath DJ, Abuali IA, Biswas AN et al.. Educational Impact of a Podcast Curriculum for Hematology/Oncology Fellows: Final Results of the Multicenter Cluster Randomized PODCAST-HOF Trial. JCO oncology practice 2025. link 11 Pagano L, Maschmeyer G, Lamoth F, Blennow O, Xhaard A, Spadea M et al.. Primary antifungal prophylaxis in hematological malignancies. Updated clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL). Leukemia 2025. link 12 Nakamura S, Maeda Y, Hori T, Oura M. Hematology in community medical care. The journal of medical investigation : JMI 2025. link 13 Abdar Esfahani M, Servatian N, Al-Athari AJH, Khafaja ESM, Rahmani Seraji H, Soleimani Samarkhazan H. The epigenetic revolution in hematology: from benchside breakthroughs to clinical transformations. Clinical and experimental medicine 2025. link 14 Scanlon S, Dzara K, Ronsley R. Current approaches in development and implementation of medical education strategies among pediatric hematology/oncology fellowship programs. Pediatric hematology and oncology 2025. link 15 Nancarrow-Lei R, Durity E, Alfallouji Y, Martyn-Simmons C, Panagou E. The Emerging Role of Oncodermatology in a Hemato-Oncology Unit in a Tertiary Hospital. Journal of drugs in dermatology : JDD 2025. link 16 Hamnvag HM, Van Norman S, Chen Y, Pettit KM, Zhao L, Boyer D et al.. Secondary review of extramural hematopathology cases for patients referred to an academic center: The increasing importance of subspecialized hematopathology practice. American journal of clinical pathology 2025. link 17 Oktay Z, Güner R, Kayaaslan B, Hasanoğlu İ, Kaya Kalem A, Özet G. Investigation of polypharmacy, antimicrobial-related potential drug-drug interactions in patients with hematological malignancies. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2025. link 18 Hu R, Shen J, Luo P, Zhang H, He Y. Real-world Hepatobiliary Toxicity After Bispecific T-Cell Engager Therapy: A 10-Year Disproportionality Analysis of the Food and Drug Administration Adverse Event Reporting System and the World Health Organization's Global Individual Case Safety Report Database. Clinical therapeutics 2025. link 19 Shahid Z, Jain T, Dioverti V, Pennisi M, Mikkilineni L, Thiruvengadam SK et al.. Best Practice Considerations by The American Society of Transplant and Cellular Therapy: Infection Prevention and Management After Chimeric Antigen Receptor T Cell Therapy for Hematological Malignancies. Transplantation and cellular therapy 2024. link 20 Silvestre J, Aakhus E, Weldeslase TA, DeLisser HM. A 15-Year Analysis of Supply and Demand for Hematology and Oncology Training in the United States. JCO oncology practice 2024. link 21 Chen Y, Wang J, Gan X, Li M, Liao Y, Zhou Y et al.. Application of plasma metagenomic next-generation sequencing improves prognosis in hematology patients with neutropenia or hematopoietic stem cell transplantation for infection. Frontiers in cellular and infection microbiology 2024. link 22 Lewis AR, Choong GM, Cathcart-Rake E, Florez N, Durani U, Yadav S et al.. Preparing Hematology/Oncology Fellows for Success: Implementing an Annual Career Development and Research Retreat. Journal of cancer education : the official journal of the American Association for Cancer Education 2024. link 23 Walsh K, Manochakian R, Schwartz J, Brondfield S. Launching an International Community of Practice in Hematology/Oncology Medical Education. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting 2024. link 24 Nixon SM, Maze DC, Parry M, Mayo SJ. Shared-Care in Complex Malignant Hematology: An Integrative Review Using the RE-AIM Evaluation Framework. Current oncology (Toronto, Ont.) 2024. link 25 Russell H, Hord J, Orr CJ, Moerdler S. Child Health and the Pediatric Hematology-Oncology Workforce: 2020-2040. Pediatrics 2024. link 26 Mistry RH, Hausrath DJ, Patel VG. Utility of a Novel Trainee-Level Hematology/Oncology Podcast in Graduate Medical Education: a Pilot Study. Journal of cancer education : the official journal of the American Association for Cancer Education 2024. link 27 Albayrak A, Özbalcı D. Determination of drug-related problems in the hematology service: a prospective interventional study. BMC cancer 2024. link 28 Serey K, Cambriel A, Pollina-Bachellerie A, Bay JO, Bouleuc C, Ladrat L et al.. Hematologists' perspective on advance directives, a French national cross-sectional survey - the ADORE-H study. 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