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Dermatology67 papers

Complex regional pain syndrome of foot

Last edited: 4/15/2026

Overview

Complex regional pain syndrome (CRPS) of the foot involves chronic pain, swelling, and functional impairment following an injury or trauma, often disproportionate to the inciting event. 1

Diagnosis

  • Clinical Presentation: Pain disproportionate to injury, sensory abnormalities, and motor dysfunction 1.
  • Physical Examination: Focus on plantar foot assessment and gait cycle evaluation 1.
  • Imaging: Weight-bearing radiographs to rule out anatomic abnormalities 1.
  • Management

  • First-Line Treatments:
  • - Physical Therapy: To improve mobility and strength 1. - Orthotics: Custom or prefabricated to address biomechanical issues 2. - Shoe Wear Modification: To reduce pressure and improve comfort 1. - Injections: Such as corticosteroids for localized pain relief 1.
  • Adjunctive Treatments:
  • - Pharmacologic Management: - Acetaminophen: For mild pain relief 3. - Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): For inflammation and pain 3. - Topical Medications: Including NSAIDs or capsaicin for localized pain 3. - Gabapentin: For neuropathic pain components 3. - Tricyclic Antidepressants: For chronic pain management 3. - Opioids: Reserved for severe pain when other treatments fail, with caution due to risks in older patients 3.

    Special Populations

  • Elderly Patients: Foot pain management is crucial to prevent disability; consider pharmacologic options carefully due to polypharmacy and comorbidities 3.
  • Key Recommendations

  • Thorough Physical Examination and Weight-Bearing Radiographs for Diagnosis: Essential for identifying CRPS in the foot 1 (Evidence: Strong).
  • Initial Treatment with Nonoperative Measures: Including physical therapy, orthotics, and shoe modifications 1 (Evidence: Strong).
  • Consider Pharmacologic Interventions Based on Pain Severity: Utilize NSAIDs, gabapentin, and tricyclic antidepressants for persistent pain, with opioids as a last resort 3 (Evidence: Moderate).
  • References

    1 Charen DA, Markowitz JS, Cheung ZB, Matijakovich DJ, Chan JJ, Vulcano E. Overview of Metatarsalgia. Orthopedics 2019. link 2 Kripke C. Custom vs. prefabricated orthoses for foot pain. American family physician 2009. link 3 Martin EW. Pharmacologic management of foot pain in the older patient. Journal of the American Podiatric Medical Association 2004. link

    Original source

    1. [1]
      Overview of Metatarsalgia.Charen DA, Markowitz JS, Cheung ZB, Matijakovich DJ, Chan JJ, Vulcano E Orthopedics (2019)
    2. [2]
      Custom vs. prefabricated orthoses for foot pain.Kripke C American family physician (2009)
    3. [3]
      Pharmacologic management of foot pain in the older patient.Martin EW Journal of the American Podiatric Medical Association (2004)

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