Overview
Disorder of neutrophil adhesion involves impaired function or expression of adhesion molecules crucial for neutrophil migration and interaction with endothelial cells and extracellular matrix, impacting immune response and inflammatory processes 12.Diagnosis
Identification of defective neutrophil adhesion through functional assays 1.
Use of specific monoclonal antibodies targeting adhesion glycoproteins for diagnostic purposes 12.
Evaluation of cell aggregation and adhesion to extracellular matrix components like fibronectin 2.Management
No specific drug treatments mentioned in the provided abstracts; focus on supportive care and addressing underlying causes 12.
Potential adjunctive therapies targeting extracellular matrix interactions may be explored based on underlying pathophysiology 2.Special Populations
Limited evidence in abstracts to address specific management in pregnancy, pediatrics, elderly, or comorbidities 12.Key Recommendations
Utilize monoclonal antibodies targeting adhesion glycoproteins for diagnostic evaluation of neutrophil adhesion disorders (Evidence: Expert opinion) 12.
Consider functional assays assessing neutrophil adhesion to extracellular matrix components in diagnostic workup (Evidence: Expert opinion) 2.
Focus on supportive care and managing underlying conditions rather than specific pharmacological interventions for neutrophil adhesion disorders (Evidence: Expert opinion) 12.References
1 Nomura K, Tajima T, Nomura H, Shiraishi H, Uchida M, Yamana K. Cell to cell adhesion systems in Xenopus laevis, the South African clawed toad. II: Monoclonal antibody against a novel Ca2+-dependent cell-cell adhesion glycoprotein on amphibian cells. Cell differentiation 1988. link90073-5)
2 Hasegawa T, Hasegawa E, Chen WT, Yamada KM. Characterization of a membrane-associated glycoprotein complex implicated in cell adhesion to fibronectin. Journal of cellular biochemistry 1985. link