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Cardiology3 papers

Perforation of atrium following procedure

Last edited: 4/10/2026

Overview

Atrial perforation is a rare but serious complication that can occur during cardiac procedures, particularly those involving transseptal access. It can lead to cardiac tamponade and hemodynamic instability.

Diagnosis

  • No specific diagnostic criteria or grading systems are mentioned in the provided abstracts.
  • Management

  • Protamine administration after catheter ablation of atrial fibrillation was associated with a reduction in time to hemostasis and time to ambulation 1.
  • Protamine administration did not appear to increase the risk of vascular complications (excluding minor hematoma) or cerebrovascular accidents 1.
  • Special Populations

  • No information is available in the provided abstracts.
  • Key Recommendations

  • Protamine administration may be considered post-procedure to expedite hemostasis and ambulation following catheter ablation of atrial fibrillation 1. (Evidence: Moderate)
  • References

    1 Kewcharoen J, Shah K, Bhardwaj R, Contractor T, Turagam MK, Mandapati R et al.. Periprocedural outcomes of protamine administration after catheter ablation of atrial fibrillation. Reviews in cardiovascular medicine 2022. link

    Original source

    1. [1]
      Periprocedural outcomes of protamine administration after catheter ablation of atrial fibrillation.Kewcharoen J, Shah K, Bhardwaj R, Contractor T, Turagam MK, Mandapati R et al. Reviews in cardiovascular medicine (2022)

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