Insulin resistance

Overview

Diagnosis

Management

Special Populations

Key Recommendations

References

Showing 100 most recent of 281 indexed papers.

1 Torfs T, Veltrop RJA, Lezzoche G, Heymans SRB, Verdonschot JAJ, Nabben M. Metabolic Dysregulation in Laminopathies: Implications for Heart Failure and Cardiac Health. Current heart failure reports 2026. link 2 Lin E, Yan YT, Chen MH, Yang AC, Kuo PH, Tsai SJ. Gene clusters linked to insulin resistance identified in a genome-wide study of the Taiwan Biobank population. Nature communications 2025. link 3 Lonardo A, Weiskirchen R. Insulin Resistance at the Crossroads of Metabolic Inflammation, Cardiovascular Disease, Organ Failure and Cancer. Biomolecules 2025. link 4 Sun Y, Ji H, Sun W, An X, Lian F. Triglyceride glucose (TyG) index: A promising biomarker for diagnosis and treatment of different diseases. European journal of internal medicine 2025. link 5 Brown N, Elston MS. Systematic Review-Type B Insulin Resistance With Isolated Hypoglycemia and Suppressed Insulin. The Journal of clinical endocrinology and metabolism 2024. link 6 Singh A, Singh N. Vitamin D intervention as a curative measure for glucose intolerance in obese children and adolescents: a systematic review on randomized control trials. European journal of pediatrics 2024. link 7 Kataoka N, Imamura T, Nakamura M, Kinugawa K. A Clinical Diagnosis of Laminopathy without Systolic Dysfunction: When Does Nuclei Malformation Start?. Internal medicine (Tokyo, Japan) 2024. link 8 Kalmpourtzidou A, Di Napoli I, Vincenti A, De Giuseppe R, Casali PM, Tomasinelli CE et al.. Epicardial fat and insulin resistance in healthy older adults: a cross-sectional analysis. GeroScience 2024. link 9 Koda S, Wada K, Yamakawa M, Nakashima Y, Hayashi M, Takeda N et al.. Associations of Plasma 25-Hydroxy Vitamin D and Dietary Vitamin D Intake with Insulin Resistance in Healthy Japanese Women. Journal of nutritional science and vitaminology 2023. link 10 Rootwelt-Norberg C, Christensen AH, Skjølsvik ET, Chivulescu M, Vissing CR, Bundgaard H et al.. Timing of cardioverter-defibrillator implantation in patients with cardiac laminopathies-External validation of the LMNA-risk ventricular tachyarrhythmia calculator. Heart rhythm 2023. link 11 Rojek A, Wikiera B, Noczynska A, Niedziela M. Syndrome of Congenital Insulin Resistance Caused by a Novel . Journal of clinical research in pediatric endocrinology 2023. link 12 Zhou M, Huang R. Associations of Serum Total 25OHD, 25OHD3, and epi-25OHD3 with Insulin Resistance: Cross-Sectional Analysis of the National Health and Nutrition Examination Survey, 2011-2016. Nutrients 2022. link 13 Tucker LA. Serum, Dietary, and Supplemental Vitamin D Levels and Insulin Resistance in 6294 Randomly Selected, Non-Diabetic U.S. Adults. Nutrients 2022. link 14 Polymeris A, Papapetrou PD. Anthropometric indicators of insulin resistance. Hormones (Athens, Greece) 2022. link 15 Iaccarino G, Franco D, Sorriento D, Strisciuglio T, Barbato E, Morisco C. Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention. Journal of cardiovascular translational research 2021. link 16 Whytock KL, Shepherd SO, Cocks M, Wagenmakers AJM, Strauss JA. Young, healthy males and females present cardiometabolic protection against the detrimental effects of a 7-day high-fat high-calorie diet. European journal of nutrition 2021. link 17 Sorriento D, Rusciano MR, Visco V, Fiordelisi A, Cerasuolo FA, Poggio P et al.. The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions. Cells 2021. link 18 Weissenbach M, Haiduven D, Qutaishat SS. Exploring the role of infection preventionists in antimicrobial stewardship programs through several lenses: A brief report. American journal of infection control 2020. link 19 Aoki S, Nakase K, Nakaminami H, Wajima T, Hayashi N, Noguchi N. Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, . Antimicrobial agents and chemotherapy 2020. link 20 Nakagomi A, Sunami Y, Kawasaki Y, Fujisawa T, Kobayashi Y. Sex difference in the association between surrogate markers of insulin resistance and arterial stiffness. Journal of diabetes and its complications 2020. link 21 . Mirfin Mpundu: accessing medicines, fighting resistance. Bulletin of the World Health Organization 2019. link 22 Kitano H, Teishima J, Shigemura K, Ohge H, Fujisawa M, Matsubara A. Current status of countermeasures for infectious diseases and resistant microbes in the field of urology. International journal of urology : official journal of the Japanese Urological Association 2019. link 23 Wei J, Luo X, Zhou S, He X, Zheng J, Sun X et al.. Associations between iron status and insulin resistance in Chinese children and adolescents: findings from the China Health and Nutrition Survey. Asia Pacific journal of clinical nutrition 2019. link.0019) 24 Vargas-Alarcón G, Pérez-Hernández N, Rodríguez-Pérez JM, Fragoso JM, Posadas-Romero C, López-Bautista F et al.. Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study. Cytokine 2019. link 25 Dallak M, Bin-Jaliah I, Sakr HF, Al-Ani B, Haidara MA. Swim exercise inhibits hemostatic abnormalities in a rat model of obesity and insulin resistance. Archives of physiology and biochemistry 2019. link 26 Kwapich M, Lacroix D, Espiard S, Ninni S, Brigadeau F, Kouakam C et al.. Cardiometabolic assessment of lamin A/C gene mutation carriers: a phenotype-genotype correlation. Diabetes & metabolism 2019. link 27 Choi YS, Klaric JS, Beltran TH. Prediction of Insulin Resistance with Anthropometric and Clinical Laboratory Measures in Nondiabetic Teenagers. Metabolic syndrome and related disorders 2019. link 28 Peretto G, Di Resta C, Perversi J, Forleo C, Maggi L, Politano L et al.. Cardiac and Neuromuscular Features of Patients With LMNA-Related Cardiomyopathy. Annals of internal medicine 2019. link 29 Laitinen TT, Nuotio J, Juonala M, Niinikoski H, Rovio S, Viikari JSA et al.. Success in Achieving the Targets of the 20-Year Infancy-Onset Dietary Intervention: Association With Insulin Sensitivity and Serum Lipids. Diabetes care 2018. link 30 Radin Umar RZ, Sommerich CM, Lavender SA, Sanders E, Evans KD. Conceptual frameworks for the workplace change adoption process: elements integration from decision making and learning cycle process. Ergonomics 2018. link 31 Michael OS, Olatunji LA. Ameliorative effect of nicotine exposure on insulin resistance is accompanied by decreased cardiac glycogen synthase kinase-3 and plasminogen activator inhibitor-1 during oral oestrogen-progestin therapy. Archives of physiology and biochemistry 2018. link 32 Araújo J, Severo M, Santos S, Ramos E. Life course path analysis of total and central adiposity throughout adolescence on adult blood pressure and insulin resistance. Nutrition, metabolism, and cardiovascular diseases : NMCD 2017. link 33 Madej-Pilarczyk A, Niezgoda A, Janus M, Wojnicz R, Marchel M, Fidziańska A et al.. Limb-girdle muscular dystrophy with severe heart failure overlapping with lipodystrophy in a patient with LMNA mutation p.Ser334del. Journal of applied genetics 2017. link 34 Rannelli LA, MacRae JM, Mann MC, Ramesh S, Hemmelgarn BR, Rabi D et al.. Sex differences in associations between insulin resistance, heart rate variability, and arterial stiffness in healthy women and men: a physiology study. Canadian journal of physiology and pharmacology 2017. link 35 Matone A, Derlindati E, Marchetti L, Spigoni V, Dei Cas A, Montanini B et al.. Identification of an early transcriptomic signature of insulin resistance and related diseases in lymphomonocytes of healthy subjects. PloS one 2017. link 36 El-Hajj Fuleihan G, Baddoura R, Habib RH, Halaby G, Arabi A, Rahme M et al.. Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial. The American journal of clinical nutrition 2016. link 37 Akter S, Eguchi M, Kuwahara K, Kochi T, Ito R, Kurotani K et al.. High dietary acid load is associated with insulin resistance: The Furukawa Nutrition and Health Study. Clinical nutrition (Edinburgh, Scotland) 2016. link 38 Jujić A, Nilsson PM, Persson M, Holst JJ, Torekov SS, Lyssenko V et al.. Atrial Natriuretic Peptide in the High Normal Range Is Associated With Lower Prevalence of Insulin Resistance. The Journal of clinical endocrinology and metabolism 2016. link 39 Marlais M, Coward RJ. Paediatrics, insulin resistance and the kidney. Pediatric nephrology (Berlin, Germany) 2015. link 40 Li F, Xia K, Sheikh SA, Cheng J, Li C, Yang T. Involvement of RBP4 in hyperinsulinism-induced vascular smooth muscle cell proliferation. Endocrine 2015. link 41 Alegría-Torres JA, García-Domínguez ML, Cruz M, Aradillas-García C. Q192R polymorphism of paraoxonase 1 gene associated with insulin resistance in Mexican children. Archives of medical research 2015. link 42 Ochoa JE, Gallo JA, Correa MM, Zapata N, McEwen JG, Bilo G et al.. Insulin resistance and beat-to-beat cardiovascular dynamics: a constant relationship across different body mass index and blood pressure categories. The Journal of clinical endocrinology and metabolism 2015. link 43 Moore A, Hochner H, Sitlani CM, Williams MA, Hoofnagle AN, de Boer IH et al.. Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study. Public health nutrition 2015. link 44 Palmer ND, Stevens RD, Antinozzi PA, Anderson A, Bergman RN, Wagenknecht LE et al.. Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study. The Journal of clinical endocrinology and metabolism 2015. link 45 Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L et al.. Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell 2015. link 46 Petillo R, D'Ambrosio P, Torella A, Taglia A, Picillo E, Testori A et al.. Novel mutations in LMNA A/C gene and associated phenotypes. Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 2015. link 47 Kranenburg LC, Westermann CM, de Sain-van der Velden MG, de Graaf-Roelfsema E, Buyse J, Janssens GP et al.. The effect of long-term oral L-carnitine administration on insulin sensitivity, glucose disposal, plasma concentrations of leptin and acylcarnitines, and urinary acylcarnitine excretion in warmblood horses. The veterinary quarterly 2014. link 48 Oldenburg J, Müller CR, Rost S, Watzka M, Bevans CG. Comparative genetics of warfarin resistance. Hamostaseologie 2014. link 49 Takatori S, Fujiwara H, Zamami Y, Hashikawa-Hobara N, Kawasaki H. Decreased perivascular CGRP-containing nerves in Otsuka Long-Evans Tokushima Fatty rats with insulin resistance and hypertension. Hypertension research : official journal of the Japanese Society of Hypertension 2014. link 50 Supakul L, Pintana H, Apaijai N, Chattipakorn S, Shinlapawittayatorn K, Chattipakorn N. Protective effects of garlic extract on cardiac function, heart rate variability, and cardiac mitochondria in obese insulin-resistant rats. European journal of nutrition 2014. link 51 Matsha TE, Macharia M, Yako YY, Erasmus RT, Hassan MS, Kengne AP. Gamma-glutamyltransferase, insulin resistance and cardiometabolic risk profile in a middle-aged African population. European journal of preventive cardiology 2014. link 52 Okamura T, Tawa M, Geddawy A, Shimosato T, Iwasaki H, Shintaku H et al.. Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats. Journal of pharmacological sciences 2014. link 53 Baron S, Bedarida T, Cottart CH, Vibert F, Vessieres E, Ayer A et al.. Dual effects of resveratrol on arterial damage induced by insulin resistance in aged mice. The journals of gerontology. Series A, Biological sciences and medical sciences 2014. link 54 Parker VE, Semple RK. Genetics in endocrinology: genetic forms of severe insulin resistance: what endocrinologists should know. European journal of endocrinology 2013. link 55 Dali-Youcef N, Mecili M, Ricci R, Andrès E. Metabolic inflammation: connecting obesity and insulin resistance. Annals of medicine 2013. link 56 Sullivan TR, Duque G, Keech AC, Herrmann M. An old friend in a new light: the role of osteocalcin in energy metabolism. Cardiovascular therapeutics 2013. link 57 Veena SR, Krishnaveni GV, Karat SC, Osmond C, Fall CH. Testing the fetal overnutrition hypothesis; the relationship of maternal and paternal adiposity to adiposity, insulin resistance and cardiovascular risk factors in Indian children. Public health nutrition 2013. link 58 Sossa C, Delisle H, Agueh V, Makoutodé M, Fayomi B. Insulin resistance status and four-year changes in other cardiometabolic risk factors in West-African adults: the Benin study. European journal of preventive cardiology 2013. link 59 Fullerton MD, Steinberg GR, Schertzer JD. Immunometabolism of AMPK in insulin resistance and atherosclerosis. Molecular and cellular endocrinology 2013. link 60 Chen SC, Kennedy BK, Lampe PD. Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects. Experimental cell research 2013. link 61 Vella CA, Burgos X, Ellis CJ, Zubia RY, Ontiveros D, Reyes H et al.. Associations of insulin resistance with cardiovascular risk factors and inflammatory cytokines in normal-weight Hispanic women. Diabetes care 2013. link 62 Lee C, Liese A, Wagenknecht L, Lorenzo C, Haffner S, Hanley A. Fish consumption, insulin sensitivity and beta-cell function in the Insulin Resistance Atherosclerosis Study (IRAS). Nutrition, metabolism, and cardiovascular diseases : NMCD 2013. link 63 Zhou YB, Gao Q, Li P, Han Y, Zhang F, Qi YF et al.. Adrenomedullin attenuates vascular calcification in fructose-induced insulin resistance rats. Acta physiologica (Oxford, England) 2013. link 64 Kaviani M, Abdollahian M, Almasi V, Amini M, Yamini AA. Effects of vitamin D on insulin resistance in nursing home residents: an interventional study. Endokrynologia Polska 2012. link 65 Handberg A, Højlund K, Gastaldelli A, Flyvbjerg A, Dekker JM, Petrie J et al.. Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population. Journal of internal medicine 2012. link 66 Urbina EM, Gao Z, Khoury PR, Martin LJ, Dolan LM. Insulin resistance and arterial stiffness in healthy adolescents and young adults. Diabetologia 2012. link 67 Martinez-Hervas S, Argente C, Garcia-Jodar J, Priego A, Real JT, Carratala A et al.. Misclassification of subjects with insulin resistance and associated cardiovascular risk factors by homeostasis model assessment index. Utility of a postprandial method based on oral glucose tolerance test. Metabolism: clinical and experimental 2011. link 68 Kidambi S, Kotchen JM, Krishnaswami S, Grim CE, Kotchen TA. Cardiovascular correlates of insulin resistance in normotensive and hypertensive African Americans. Metabolism: clinical and experimental 2011. link 69 Huisamen B, Pêrel SJ, Friedrich SO, Salie R, Strijdom H, Lochner A. ANG II type I receptor antagonism improved nitric oxide production and enhanced eNOS and PKB/Akt expression in hearts from a rat model of insulin resistance. Molecular and cellular biochemistry 2011. link 70 Semple RK, Williams RM, Dunger DB. What is the best management strategy for patients with severe insulin resistance?. Clinical endocrinology 2010. link 71 von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. The British journal of nutrition 2010. link 72 Lee K. Usefulness of the metabolic syndrome criteria as predictors of insulin resistance among obese Korean women. Public health nutrition 2010. link 73 Rodríguez-Colón SM, Li X, Shaffer ML, He F, Bixler EO, Vgontzas AN et al.. Insulin resistance and circadian rhythm of cardiac autonomic modulation. Cardiovascular diabetology 2010. link 74 Burut DF, Borai A, Livingstone C, Ferns G. Serum heat shock protein 27 antigen and antibody levels appear to be related to the macrovascular complications associated with insulin resistance: a pilot study. Cell stress & chaperones 2010. link 75 Draznin B. Mitogenic action of insulin: friend, foe or 'frenemy'?. Diabetologia 2010. link 76 Imrie H, Abbas A, Kearney M. Insulin resistance, lipotoxicity and endothelial dysfunction. Biochimica et biophysica acta 2010. link 77 Aigner E, Hinz C, Steiner K, Rossmann B, Pfleger J, Hohla F et al.. Iron stores, liver transaminase levels and metabolic risk in healthy teenagers. European journal of clinical investigation 2010. link 78 Fiorentini A, Perciaccante A, Valente R, Paris A, Serra P, Tubani L. The correlation among QTc interval, hyperglycaemia and the impaired autonomic activity. Autonomic neuroscience : basic & clinical 2010. link 79 Miao Z, Yan S, Wang J, Wang B, Li Y, Xing X et al.. Insulin resistance acts as an independent risk factor exacerbating high-purine diet induced renal injury and knee joint gouty lesions. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2009. link 80 Renard D, Fourcade G, Milhaud D, Bessis D, Esteves-Vieira V, Boyer A et al.. Novel LMNA mutation in atypical Werner syndrome presenting with ischemic disease. Stroke 2009. link 81 Misra A, Khurana L, Isharwal S, Bhardwaj S. South Asian diets and insulin resistance. The British journal of nutrition 2009. link 82 Lastra-Lastra G, Sowers JR, Restrepo-Erazo K, Manrique-Acevedo C, Lastra-González G. Role of aldosterone and angiotensin II in insulin resistance: an update. Clinical endocrinology 2009. link 83 Sharma AK, Srinivasan BP. Triple verses glimepiride plus metformin therapy on cardiovascular risk biomarkers and diabetic cardiomyopathy in insulin resistance type 2 diabetes mellitus rats. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009. link 84 Olofsson SO, Boström P, Andersson L, Rutberg M, Perman J, Borén J. Lipid droplets as dynamic organelles connecting storage and efflux of lipids. Biochimica et biophysica acta 2009. link 85 Torigoe Y, Takahashi N, Hara M, Yoshimatsu H, Saikawa T. Adrenomedullin improves cardiac expression of heat-shock protein 72 and tolerance against ischemia/reperfusion injury in insulin-resistant rats. Endocrinology 2009. link 86 Yajnik CS, Joglekar CV, Lubree HG, Rege SS, Naik SS, Bhat DS et al.. Adiposity, inflammation and hyperglycaemia in rural and urban Indian men: Coronary Risk of Insulin Sensitivity in Indian Subjects (CRISIS) Study. Diabetologia 2008. link 87 Raher MJ, Thibault HB, Buys ES, Kuruppu D, Shimizu N, Brownell AL et al.. A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload. American journal of physiology. Heart and circulatory physiology 2008. link 88 Sumner AE, Cowie CC. Ethnic differences in the ability of triglyceride levels to identify insulin resistance. Atherosclerosis 2008. link 89 Ortega FB, Ruiz JR, Castillo MJ, Sjöström M. Physical fitness in childhood and adolescence: a powerful marker of health. International journal of obesity (2005) 2008. link 90 Rittig K, Holder K, Stock J, Tschritter O, Peter A, Stefan N et al.. Endothelial NO-synthase intron 4 polymorphism is associated with disturbed in vivo nitric oxide production in individuals prone to type 2 diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2008. link 91 Liese AD, Gilliard T, Schulz M, D'Agostino RB, Wolever TM. Carbohydrate nutrition, glycaemic load, and plasma lipids: the Insulin Resistance Atherosclerosis Study. European heart journal 2007. link 92 Cardellini M, Marini MA, Frontoni S, Hribal ML, Andreozzi F, Perticone F et al.. Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients. American journal of physiology. Endocrinology and metabolism 2007. link 93 Gonsolin D, Couturier K, Garait B, Rondel S, Novel-Chaté V, Peltier S et al.. High dietary sucrose triggers hyperinsulinemia, increases myocardial beta-oxidation, reduces glycolytic flux and delays post-ischemic contractile recovery. Molecular and cellular biochemistry 2007. link 94 Vine DF, Takechi R, Russell JC, Proctor SD. Impaired postprandial apolipoprotein-B48 metabolism in the obese, insulin-resistant JCR:LA-cp rat: increased atherogenicity for the metabolic syndrome. Atherosclerosis 2007. link 95 Samaha FF, Foster GD, Makris AP. Low-carbohydrate diets, obesity, and metabolic risk factors for cardiovascular disease. Current atherosclerosis reports 2007. link 96 Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E et al.. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arteriosclerosis, thrombosis, and vascular biology 2007. link 97 Valtueña S, Del Rio D, Pellegrini N, Ardigò D, Franzini L, Salvatore S et al.. The total antioxidant capacity of the diet is an independent predictor of plasma beta-carotene. European journal of clinical nutrition 2007. link 98 Liu J, Wade TJ, Tan H. Cardiovascular risk factors and anthropometric measurements of adolescent body composition: a cross-sectional analysis of the Third National Health and Nutrition Examination Survey. International journal of obesity (2005) 2007. link 99 Anfossi G, Russo I, Doronzo G, Trovati M. Relevance of the vascular effects of insulin in the rationale of its therapeutical use. Cardiovascular & hematological disorders drug targets 2007. link 100 Maioli MA, Marrosu G, Mateddu A, Solla E, Carboni N, Tacconi P et al.. A novel mutation in the central rod domain of lamin A/C producing a phenotype resembling the Emery-Dreifuss muscular dystrophy phenotype. Muscle & nerve 2007. link