Overview
Marburg virus disease (MVD) is a severe hemorrhagic fever caused by Marburg virus, a member of the Filoviridae family, leading to high mortality rates in humans and non-human primates 1234.Diagnosis
Clinical presentation includes fever, severe headache, hemorrhagic manifestations, and multi-organ failure.
Laboratory diagnosis involves detecting viral RNA through RT-PCR in blood or other body fluids 12.
Serological tests can confirm recent infection but may not be immediately positive in early stages 1.Management
Supportive Care: Mainstay of treatment includes fluid and electrolyte management, transfusion support, and management of complications 124.
Experimental Therapies: No approved vaccines or antiviral drugs; immunoinformatics-guided multi-epitope vaccine candidates show promise but require further validation 134.Special Populations
Pregnancy: Specific management guidelines not detailed in provided abstracts 124.
Pediatrics: No specific considerations mentioned in abstracts 124.
Elderly: No distinct management strategies highlighted for elderly patients 124.
Comorbidities: Management focuses on supportive care with no specific adjustments noted for comorbidities 124.Key Recommendations
Prioritize Supportive Care: Focus on maintaining fluid balance, managing hemorrhagic symptoms, and preventing secondary infections (Evidence: Strong 124).
Explore Immunoinformatics-Based Vaccine Candidates: Investigate and validate multi-epitope vaccine designs for potential future prevention strategies (Evidence: Moderate 34).
Monitor Uveal Involvement: Consider ocular complications, as uveal involvement has been reported and may require specialized ophthalmological care (Evidence: Weak 5).References
1 Thangamariappan E, Sivakumar P, Marimuthu SCV, Kunjiappan S, Sundar K. Immunoinformatics-based design of a multi-epitope vaccine for Marburg virus. Journal of biomolecular structure & dynamics 2026. link
2 Rao DF, Patel SK, Pandya HA. Immunoinformatics-guided vaccine design: A review with case study on Marburg virus. Biochemical and biophysical research communications 2025. link
3 Saadh MJ, Muhammad FA, Albadr RJ, Ballal S, Singh A, Devi A et al.. Structure-based design of a multi-epitope vaccine candidate against marburg virus using immunoinformatics and dynamics simulations. Journal of molecular graphics & modelling 2025. link
4 Al-Zayadi FQJ, Shakir AS, Kareem AS, Ghasemian A, Behmard E. Design of a novel multi-epitope vaccine against Marburg virus using immunoinformatics studies. BMC biotechnology 2024. link
5 Kuming BS, Kokoris N. Uveal involvement in Marburg virus disease. The British journal of ophthalmology 1977. link