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Musculoskeletal399 papers

Nonunion following arthrodesis

Last edited: 4/15/2026

Overview

Nonunion following arthrodesis refers to the failure of bone healing after surgical fusion procedures, leading to persistent pain, instability, and functional impairment 3.

Diagnosis

  • Persistent pain and lack of radiographic evidence of bone union beyond the expected healing period 3.
  • Clinical examination revealing abnormal mobility or signs of mechanical irritation 3.
  • Radiographic imaging (X-rays, CT, MRI) to confirm absence of union and assess for hardware issues 3.
  • Management

  • First-line treatments: Revision surgery, including the use of double plates bolted together for tibial nonunions, has shown higher success rates compared to single plates 3.
  • Adjunctive therapies: Low-intensity pulsed ultrasound (LIPUS) may be considered for scaphoid nonunions post-surgery, though evidence is limited and primarily observational 1.
  • Specific interventions: Proximal hamate graft for proximal scaphoid reconstruction can restore native wrist kinematics, improving functional outcomes 2.
  • Special Populations

  • Pediatrics: Not addressed in provided abstracts.
  • Elderly: Not specifically discussed; however, functional outcomes noted as "fair" in healed cases of tibial osteotomy 3.
  • Comorbidities: No specific guidance provided for patients with comorbidities in the given abstracts.
  • Key Recommendations

  • For tibial nonunion following osteotomy, consider using double plates bolted together to enhance union rates (Evidence: Moderate 3).
  • In scaphoid nonunions, postoperative application of LIPUS may be beneficial, though further high-quality evidence is needed (Evidence: Weak 1).
  • Proximal hamate graft reconstruction can effectively restore wrist kinematics post-scaphoid nonunion surgery, improving functional outcomes (Evidence: Moderate 2).
  • References

    1 White NJ, Patterson ED, Dhaliwal GS, Hildebrand KA. Low-Intensity Pulsed Ultrasound Versus Sham in the Treatment of Operatively Managed Scaphoid Nonunions: The SNAPU Randomized Controlled Trial. The Journal of bone and joint surgery. American volume 2024. link 2 Burnier M, Gil JA, Hooke A, Elhassan B, Kakar S. Does Proximal Hamate Graft for Proximal Scaphoid Reconstruction Restore Native Wrist Kinematics?. Hand (New York, N.Y.) 2023. link 3 Cameron HU, Welsh RP, Jung YB, Noftall F. Repair of nonunion of tibial osteotomy. Clinical orthopaedics and related research 1993. link

    Original source

    1. [1]
      Low-Intensity Pulsed Ultrasound Versus Sham in the Treatment of Operatively Managed Scaphoid Nonunions: The SNAPU Randomized Controlled Trial.White NJ, Patterson ED, Dhaliwal GS, Hildebrand KA The Journal of bone and joint surgery. American volume (2024)
    2. [2]
      Does Proximal Hamate Graft for Proximal Scaphoid Reconstruction Restore Native Wrist Kinematics?Burnier M, Gil JA, Hooke A, Elhassan B, Kakar S Hand (New York, N.Y.) (2023)
    3. [3]
      Repair of nonunion of tibial osteotomy.Cameron HU, Welsh RP, Jung YB, Noftall F Clinical orthopaedics and related research (1993)

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