Overview
Sleep-related movement disorders can be caused by medications. Quetiapine, an atypical antipsychotic, is sometimes used off-label to treat insomnia, though its efficacy and safety for this purpose are still being evaluated 1.Diagnosis
Management
Low-dose quetiapine may improve sleep quality compared to placebo 1.
Low-dose quetiapine may increase total sleep time compared to placebo 1.
Dosages of 50 mg, 150 mg, and 300 mg of quetiapine have shown effects on sleep 1.
Adverse events and discontinuation due to adverse events are common with quetiapine use 1.Special Populations
The effects of quetiapine on sleep in the elderly require cautious interpretation due to high heterogeneity in studies 1.Key Recommendations
Quetiapine may be effective for improving sleep quality and increasing total sleep time compared to placebo 1. (Evidence: Strong)
Adverse events and discontinuations due to adverse events are common with quetiapine use, warranting caution 1. (Evidence: Moderate)
The use of quetiapine for sleep in the elderly should be approached with caution due to high heterogeneity observed in studies 1. (Evidence: Moderate)References
1 Lin CY, Chiang CH, Tseng MM, Tam KW, Loh EW. Effects of quetiapine on sleep: A systematic review and meta-analysis of clinical trials. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2023. link