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Allergy & Immunology51 papers

Infection by Ascaris suum

Last edited: 4/15/2026

Overview

Ascaris suum infection is a parasitic disease affecting primarily pigs but can also impact humans, leading to gastrointestinal issues and malnutrition. The infection involves the larval migration through tissues and subsequent establishment in the intestine, causing significant morbidity 12.

Diagnosis

  • Stool examination for eggs is the primary diagnostic method 1.
  • Anthropometric measurements (e.g., stunting) can indicate chronic infection burden 1.
  • Serological tests may detect allergen-specific antibodies but are less commonly used for routine diagnosis 2.
  • Management

  • First-line treatment: Albendazole is effective for deworming 1.
  • Dosage: Specific dosing details not provided in abstracts; standard protocols should be followed.
  • Re-treatment: Consider periodic deworming based on endemic prevalence and individual reinfection risk 1.
  • Special Populations

  • Stunted children: Vitamin A supplementation may initially reduce Ascaris intensity but long-term benefits are less evident 1.
  • No specific recommendations for pregnancy, pediatrics beyond age range, or elderly populations are provided in the abstracts.
  • Key Recommendations

  • Use albendazole for deworming in cases of Ascaris suum infection to reduce parasite load effectively (Evidence: Moderate 1).
  • Monitor reinfection rates particularly in stunted children, as vitamin A supplementation shows limited sustained benefit (Evidence: Moderate 1).
  • Consider high molecular weight fractions of Ascaris suum allergens in understanding cross-reactivity and potential diagnostic markers, though routine clinical application is not established (Evidence: Weak 2).
  • References

    1 Payne LG, Koski KG, Ortega-Barria E, Scott ME. Benefit of vitamin A supplementation on ascaris reinfection is less evident in stunted children. The Journal of nutrition 2007. link 2 McWilliam AS, Stewart GA, Turner KJ. An immunochemical investigation of the allergens from Ascaris suum perienteric fluid. Cross-reactivity, molecular weight distribution and correlation with phosphorylcholine-containing components. International archives of allergy and applied immunology 1987. link 3 Goodman RB, Martzen MR, Peanasky RJ. Trypsin inhibitors from Ascaris: the reactive P1 site of the inhibitors (a correction) and location of the inhibitors and host trypsin in cross-sections of Ascaris. Acta biochimica Polonica 1983. link

    Original source

    1. [1]
      Benefit of vitamin A supplementation on ascaris reinfection is less evident in stunted children.Payne LG, Koski KG, Ortega-Barria E, Scott ME The Journal of nutrition (2007)
    2. [2]
    3. [3]

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