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Cardiology4750 papers

Hypothalamic obesity

Last edited: 28 days ago

Overview

Hypothalamic obesity, often associated with hypothalamic dysfunction, leads to severe, treatment-resistant obesity due to impaired regulation of appetite and energy expenditure. 126

Diagnosis

  • Clinical assessment focusing on BMI, dietary habits, and history of weight loss resistance.
  • Imaging studies (e.g., MRI) to evaluate hypothalamic structure and function.
  • Laboratory tests to rule out hormonal imbalances (e.g., thyroid function tests, leptin levels).
  • Grading based on severity of symptoms and impact on quality of life. 16
  • Management

  • First-line treatments: Lifestyle modifications including dietary counseling and increased physical activity.
  • - Exercise: 30-60 minutes of moderate to vigorous intensity most days of the week. 69
  • Adjunctive therapies:
  • - Pharmacotherapy: GLP-1 receptor agonists (e.g., semaglutide, liraglutide) for weight management. 282248 - Bariatric surgery: Considered for severe cases unresponsive to medical management (e.g., Roux-en-Y gastric bypass, sleeve gastrectomy). 1011335060
  • Nutritional support: Ensuring adequate nutrient intake, possibly with specialized diets or supplements. 9
  • Special Populations

  • Pregnancy: Limited specific guidelines; close monitoring of weight changes and metabolic health is crucial. 3234
  • Pediatrics: Early intervention with lifestyle modifications and, in severe cases, bariatric surgery under strict multidisciplinary care. 366
  • Elderly: Tailored approach considering comorbidities; bariatric surgery may be considered with careful risk assessment. 33
  • Comorbidities: Focus on managing associated conditions like hypertension, type 2 diabetes, and cardiovascular risks alongside obesity treatment. 16244555
  • Key Recommendations

  • Implement comprehensive lifestyle interventions including diet and exercise as the cornerstone of management for hypothalamic obesity. (Evidence: Strong 69)
  • Consider GLP-1 receptor agonists for patients with severe obesity who do not achieve adequate weight loss with lifestyle modifications. (Evidence: Moderate 282248)
  • Evaluate bariatric surgery for individuals with severe, treatment-resistant obesity, particularly when comorbidities are present. (Evidence: Moderate 1011335060)
  • Regularly monitor and manage comorbid conditions such as cardiovascular disease and diabetes in patients with hypothalamic obesity. (Evidence: Moderate 16244555)
  • Tailor management strategies for special populations, including pediatric patients and the elderly, with multidisciplinary support. (Evidence: Expert opinion)
  • References

    Showing 100 most recent of 2646 indexed papers.

    1 Bretón I, Fernández García JM, Vilarrasa N, Ramírez Arroyo V, de Hollanda A, Blay Cortés G et al.. Continuity of care in obesity clinical care. Endocrinologia, diabetes y nutricion 2026. link 2 Celletti F, Farrar J, De Regil L. World Health Organization Guideline on the Use and Indications of Glucagon-Like Peptide-1 Therapies for the Treatment of Obesity in Adults. JAMA 2026. link 3 Mathy L. Abstracts from the 34th Annual European Childhood Obesity Group Congress. Annals of nutrition & metabolism 2026. link 4 Wong W. A hostile environment for a commensal. Science signaling 2026. link 5 . Correction: Network meta-analysis and dose-response analysis of exercise on sleep quality and BMI in obese populations. Frontiers in public health 2026. link 6 Chopra HK, Mehta A, Ponde CK, Nanda NC, Wander GS, Oomman A et al.. National Consensus on Semaglutide in Cardiology: From Clinical Evidence to Clinical Translation. The Journal of the Association of Physicians of India 2026. link 7 Allgayer RMCM, Viola LF, Valério CM. Integrating obesity management into menopause care recommendations comments on the 2025 European Society of Endocrinology clinical practice guideline for evaluation and management of menopause and the perimenopause. European journal of endocrinology 2026. link 8 Pomenti S, Gerber A, Katzka D, Camilleri M, Hur C. Review Article: The Evolving Role of GLP-1 Receptor Agonists in Gastroenterology Practice. Alimentary pharmacology & therapeutics 2026. link 9 Grant CE, Godfrey H, Chan J, Palermo T, Shoveller AK, Bakovic M et al.. Ex vivo energy restriction in obese cats reveals more amino acid and vitamin intakes below recommendations with over-the-counter compared to veterinary weight-loss diets. American journal of veterinary research 2026. link 10 Blume CA, Viana LV, Maraschin CK, Friedman R, Nascimento CD, Trindade MRM et al.. Implementation of a standardized postoperative protocol enhances adherence to postoperative care and quality of life following bariatric surgery. Nutrition (Burbank, Los Angeles County, Calif.) 2026. link 11 Cunningham MH, Bloomfield GC, Chen MY, Foshag AC, Azagury DE, Alimi YR et al.. Weighing the impact of bariatric surgery: A meta-analysis of long-term outcomes of Roux-en-Y gastric bypass and sleeve gastrectomy. Surgery 2026. link 12 Kyriakoulis I, Sunil Kumar S, Palaiodimos L, Kokkinidis DG. Noninvasive Imaging Modalities for the Evaluation of Coronary Artery Disease Among Patients With High Body Mass Index: A Focus on Coronary Computed Tomography Angiography (CCTA). The American journal of cardiology 2026. link 13 Effenberger M, Tilg H. Potential Health Risks of Artificial Sweeteners. Annual review of medicine 2026. link 14 Schiborn C, Hu FB, Stefan N, Schulze MB. Preclinical and clinical obesity: prevalence, associations to cardiometabolic risk and response to lifestyle intervention in NHANES and the EPIC-Potsdam and TULIP studies. Nature communications 2026. link 15 Salah NY, Abdel Hakam D, Abdullah FA, Hamza MS, Ramadan EA, Mahmoud R. Elevated serum glucosylsphingosine level in children with obesity: relation to plasma atherogenesis. International journal of obesity (2005) 2026. link 16 Gniewek J, Krych S, Stępień-Słodkowska M, Adamczyk M, Hrapkowicz T, Kowalczyk P. Methodological and Pathophysiological Considerations in Obesity-Associated Thrombosis. International journal of molecular sciences 2026. link 17 Wu X, Yuan C, Wang H, Pan X, Wang R, Cai Q et al.. ShenLingBaiZhu powder ameliorates obesity and atherosclerosis by inhibiting inflammation and apoptosis through the suppression of the TLR4/NF-κB pathway. Journal of ethnopharmacology 2026. link 18 Pan Z, Ding M, Gu W, Yu Z, Yi Q, Dai J et al.. Exercise improves high-fat diet-induced obesity and related cardiac dysfunction in Drosophila by regulating Dilp6 through FOXO in adipose tissue. Life sciences 2026. link 19 Mendes C, Carvalho M, Amado A, Bravo J, Martins S, Raimundo A. Improving the SF-BARI Score with a Structured Postoperative Exercise Program: A Randomized Trial after Metabolic and Bariatric Surgery. Obesity surgery 2026. link 20 Huang JS, Zhang XY, Ramakrishnan R, Chu JQ, Lu MS, Shao DT et al.. Association of Childhood Obesity Phenotypes With Cardiometabolic Outcomes in Adulthood: A Systematic Review and Meta-Analysis. Obesity reviews : an official journal of the International Association for the Study of Obesity 2026. link 21 Deregibus MI, Iturzaeta A, Pompozzi LA, Romero CA. Albuminuria and masked hypertension in overweight and obese children and adolescents: A cross-sectional study. Archivos argentinos de pediatria 2026. link 22 Lian LY, Liu C, Zhou XD, Targher G, Byrne CD, Zhang Y et al.. Newly defined clinical obesity versus body mass index-defined obesity: Differential risks of overall death and adverse events in a population-based cohort. Diabetes, obesity & metabolism 2026. link 23 Hu C, Zhang J, Lin L, Jia X, Wang S, Zheng R et al.. Associations of general and central obesity with risk of premature mortality among Chinese adults: A nationwide prospective cohort study. Diabetes, obesity & metabolism 2026. link 24 Anker SD, Ji L, Kindel T, Coats AJ, Ojji D, Barragán AP et al.. iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity: Focus on Prevention and Treatment of Cardiometabolic Disease. The Journal of the Association of Physicians of India 2026. link 25 Campos A, Ghusn W, Cifuentes L, Sacoto D, Fansa S, Anazco D et al.. Addition of Phentermine-Topiramate to a Digitally Enhanced Lifestyle Intervention: A Double-Blind Randomized Clinical Trial. Obesity (Silver Spring, Md.) 2026. link 26 Erdem O, Acar A, Canbak T, Başak F, Kudaş İ, Tosun H et al.. Rethinking Post-Bariatric Care: Anorectal Morbidity Following Sleeve Gastrectomy and Roux-en-Y Gastric Bypass. Surgical laparoscopy, endoscopy & percutaneous techniques 2026. link 27 Pan Q, Wang B, Zhao Y, Tian Z, Chen B, Ji L et al.. Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass in Terms of Hypertension Remission Rate After Surgery: A Meta-Analysis. Obesity surgery 2026. link 28 Cordova F, Málaga N. Cardiovascular outcomes and mortality of bariatric surgery versus glucagon-like peptide-1 receptor agonists: a systematic review and meta-analysis. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2026. link 29 Izzo C, Carrizzo A, Acernese F, Di Pietro P, Visco V, Donnaruma B et al.. Unraveling the risk factors for type II diabetes in severe obese patients with indication for bariatric surgery: retrospective analysis. Nutrition, metabolism, and cardiovascular diseases : NMCD 2026. link 30 Harris KK, Christman BD, Hillegass WB, Lim CS, Burton ET, Afshan S et al.. Obesity and Cardiometabolic Risk Factors Among Pediatric Patients at a Mississippi Academic Medical Center. American journal of health promotion : AJHP 2026. link 31 Li S, Zhang Y, Zhang Y, Xue J, Kang C. Assessment of changes in left ventricular myocardial work using the pressure strain loop after metabolic and bariatric surgery: a prospective nonrandomized cohort study. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2026. link 32 Mustafa A, Wei C, Grovu R, Behuria S, Lafferty J, Weinberg M. Effect of Successful Bariatric Surgery on Maternal Cardiovascular Outcomes. Journal of women's health (2002) 2026. link 33 Vaughan OR, Goodspeed A, Sucharov CC, Powell TL, Jansson T. Human fetal circulating factors from pregnancies complicated by obesity upregulate genes associated with pathological hypertrophy in neonatal rat cardiomyocytes. American journal of physiology. Heart and circulatory physiology 2026. link 34 Kaushik T, Hackney A, Bryant A, Baker E, Abongwa S, Wagener BM et al.. Intraoperative hemodynamics and anesthetic implications in superobese parturients undergoing cesarean delivery: a retrospective cohort analysis. Archives of gynecology and obstetrics 2026. link 35 Corpodean F, Kachmar M, Yang S, Heymsfield SB, Katzmarzyk PT, Schauer PR et al.. Association of Obesity Severity With Cardiometabolic and Renal Disease Burden in the United States. Obesity (Silver Spring, Md.) 2026. link 36 Zahid S, Yao Z, Grimes SN, Kim A, Peng AW, Blumenthal RS et al.. Epidemiology and Natural History of Preclinical and Clinical Obesity: Insights From a UK Cohort. Obesity (Silver Spring, Md.) 2026. link 37 Xu Y, Fan X, Wu W, Zhang K, Xu W, Chen W et al.. Associations Between Body Mass Index and Intraocular Pressure in a Chinese Adult Population. Diabetes/metabolism research and reviews 2026. link 38 Boaz E, Aeschbacher P, Kahana N, Horesh N, Lo Menzo E, Szomstein S et al.. Impact of chronic anticoagulation on perioperative outcomes in patients undergoing minimally invasive bariatric surgery-Propensity score-matched analysis using the 2020-2021 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2026. link 39 Cadenas-Sanchez C, Medrano M, Osés M, Concepción M, Cabeza R, Villanueva A et al.. Specific Fat Depots and Cardiometabolic Risk and Insulin Resistance in Children With Obesity. Pediatric obesity 2026. link 40 Nguyen ITN, Tenstad O, Samuelsson AM, Wiig H, Hoorn EJ, Verhaar MC et al.. 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Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2026. link 44 Cunha MR, Mattos S, Portugal MRC, Gomes EN, Souza DF, Oigman W et al.. Effects of a Short-Term Nutritional Intervention on Vascular Changes in Individuals with Obesity and Low or Moderate Cardiovascular Health. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension 2026. link 45 Muzurović E, Katsiki N, Volčanšek Š, Plescia F, Rizzo M, Mantzoros CS. Emerging incretin- and multi-agonist-based treatments - the continued refinement and continuous expansion of a potent therapeutic armamentarium for cardio-kidney-liver-metabolic diseases and beyond. Metabolism: clinical and experimental 2026. link 46 Simard C, Le Gal G, Lazo-Langner A, Tagalakis V, Grewal K, Nguyen F et al.. Association Between Bariatric Surgery and the Long-Term Risk for Venous Thromboembolism: A Population-Based Matched Cohort Study. American journal of hematology 2026. link 47 Bonifácio DB, Fraiz GM, Lacerda UV, Cardoso RR, de Souza Coura Dias T, Corich V et al.. Effect of Green Tea Kombucha Within an Energy-Restricted Diet on Cardiometabolic Risk Markers in Individuals With Excess Body Weight: A Randomized Controlled Trial. Journal of food science 2026. link 48 Verma S, Böttcher M, Brown P, Dicker D, Rubino D, Sbraccia P et al.. CagriSema Reduces Blood Pressure in Adults With Overweight or Obesity: REDEFINE 1. Hypertension (Dallas, Tex. : 1979) 2026. link 49 Nuijten MAH, de Roos BM, Karregat JHM, Hazebroek EJ, Monpellier VM, Janssen IMC et al.. Association of Weight Loss Composition Following Metabolic-Bariatric Surgery With Incident Major Adverse Cardiovascular Events and All-Cause Mortality. Clinical obesity 2026. link 50 Bjelakovic B, Stefanutti C, Vukovic V, Klisic A, Stojkovic S, Jovic M et al.. 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Obesity, metabolic health, and brain health: Insights from a prospective cohort study. Journal of affective disorders 2026. link 58 Belančić A, Fajkić A, Sener YZ, Jelaković A, Alić L, Gkrinia EMM et al.. Gut Dysbiosis as a Shared Mechanism in Obesity and Hypertension: Exploring a Promising Therapeutic Avenue. Endocrinology, diabetes & metabolism 2026. link 59 Shekouh D, Behboodi M, Varmazyar M, Khodadadiyan A, Jochin P, Bazrafshan Drissi H. Comparing Cardiovascular Outcomes of GLP-1 Receptor Agonists Versus Metabolic Bariatric Surgery: A Systematic Review and Meta-Analysis. Obesity surgery 2026. link 60 Abedalqader T, Galvao Goncalves G, Ali A, El Ghazal N, Bellido de Luna D, Jawhar N et al.. Comprehensive Long-Term Outcomes and Durability of Sleeve Gastrectomy with Up to 14 Years of Follow-up. Obesity surgery 2026. link 61 Yap RV, Seki Y, Kasama K, Kikkawa E, Takezawa A, Yokoyama R. Ten-Year Outcomes of Laparoscopic Sleeve Gastrectomy with Roux-en-Y Duodenojejunal Bypass on Weight Loss, Metabolic Syndrome, and Nutrition: A Retrospective Cohort Study. Obesity surgery 2026. link 62 Zelicha H, Weitzner ZN, Park S, Babb TG, Bernhardt V, Ahmad FS et al.. Improvement in breathlessness following bariatric surgery as measured by a new heart failure-specific health-related quality of life instrument: a prospective longitudinal study. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2026. link 63 Hung KC, Weng HL, Ho CN, Chen IW. Reduced Incidence of QTc Prolongation Following Metabolic and Bariatric Surgery in Female Patients: A Retrospective Cohort Study. Obesity surgery 2026. link 64 Pedersen SD, Manjoo P, Dash S, Jain A, Pearce N, Poddar M. Pharmacotherapy for obesity management in adults: 2025 clinical practice guideline update. 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The Efficacy of Glucagon-like Peptide-1 (GLP-1) Receptor Agonists for Insufficient Weight Loss or Regain After Metabolic/Bariatric Surgery: A Systematic Review and Meta-analysis. Obesity surgery 2025. link 69 Conradie-Smit M, Fourie G, May W. Physical activity in obesity management. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2025. link 70 von Philipsborn P, Bahlke M, Breidenassel C, Holzapfel C, Joisten C, Plachta-Danielzik S et al.. Prevention of Obesity among Adults: Evidence- and Consensus-Based Guideline. Obesity facts 2025. link 71 Muscogiuri G, Barrea L, Bettini S, El Ghoch M, Katsiki N, Tolvanen L et al.. European Association for the Study of Obesity (EASO) Position Statement on Medical Nutrition Therapy for the Management of Individuals with Overweight or Obesity and Cancer. Obesity facts 2025. link 72 Edwards MA, Powers K, Vosburg RW, Zhou R, Stroud A, Obeid NR et al.. 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    Original source

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      Ex vivo energy restriction in obese cats reveals more amino acid and vitamin intakes below recommendations with over-the-counter compared to veterinary weight-loss diets.Grant CE, Godfrey H, Chan J, Palermo T, Shoveller AK, Bakovic M et al. American journal of veterinary research (2026)
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      Implementation of a standardized postoperative protocol enhances adherence to postoperative care and quality of life following bariatric surgery.Blume CA, Viana LV, Maraschin CK, Friedman R, Nascimento CD, Trindade MRM et al. Nutrition (Burbank, Los Angeles County, Calif.) (2026)
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      Weighing the impact of bariatric surgery: A meta-analysis of long-term outcomes of Roux-en-Y gastric bypass and sleeve gastrectomy.Cunningham MH, Bloomfield GC, Chen MY, Foshag AC, Azagury DE, Alimi YR et al. Surgery (2026)
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