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Cardiology1 paper

Pleomorphic adenoma

Last edited: 6 h ago

Overview

Pleomorphic adenoma is the most common benign neoplasm of the salivary glands, characterized by its biphasic pattern of epithelial and myoepithelial cells 1.

Diagnosis

  • Histopathological Examination: Essential for diagnosis, showing dual epithelial and myoepithelial cell populations 1.
  • Immunohistochemistry: Utilize S100 and smooth muscle actin (SMA) stains to confirm myoepithelial cell presence 1.
  • Intravascular Tumor Identification: Rarely, intravascular tumor infiltration by plasmacytoid myoepithelial cells may be observed; requires thorough serial section analysis 1.

    • Management

  • Surgical Excision: Wide local excision with clear margins is the standard treatment 1.
  • Further Analysis for Intravascular Components: In cases where intravascular tumor is identified, consider additional histopathological scrutiny to rule out malignancy 1.

    • Special Populations

  • No Specific Guidelines Provided: The abstract does not cover special populations such as pregnancy, pediatrics, elderly, or comorbidities 1.

    • Key Recommendations

  • Perform wide local excision with clear margins for pleomorphic adenomas to ensure complete removal 1 (Evidence: Strong).
  • Conduct thorough histopathological examination including serial sections and immunohistochemistry (S100, SMA) to identify intravascular tumor components 1 (Evidence: Moderate).
  • Monitor for intravascular tumor infiltration by plasmacytoid myoepithelial cells, though currently no specific adjunctive treatments are indicated beyond thorough surgical and pathological assessment 1 (Evidence: Weak).

    • References

    1 Coleman H, Altini M. Intravascular tumour in intra-oral pleomorphic adenomas: a diagnostic and therapeutic dilemma. Histopathology 1999. link

    Original source

    1. [1]
      Intravascular tumour in intra-oral pleomorphic adenomas: a diagnostic and therapeutic dilemma. — Coleman H, Altini M Histopathology (1999)

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