Overview
Aortic stenosis (AS) is a progressive disorder characterized by narrowing of the aortic valve 1. The rate of progression can vary, and factors influencing it are not fully understood 1.Diagnosis
Aortic valve stenosis progression can be assessed using echocardiographic parameters such as mean gradient (MG), peak velocity (PV), peak gradient (PG), or aortic valve area (AVA), or by computed tomography calcium score (AVC) 1.
Pooled annualized progression rates include MG +4.10 mm Hg and AVA -0.08 cm²/year 1.
Increasing baseline severity of AS is associated with faster progression 1.Management
No management strategies are discussed in the provided abstracts.Special Populations
No information on special populations is provided in the abstracts.Key Recommendations
Increasing baseline hemodynamic and anatomic severity is associated with faster AS progression 1. (Evidence: Moderate)
The pooled annualized progression of mean gradient is +4.10 mm Hg 1. (Evidence: Moderate)
The pooled annualized progression of aortic valve area is -0.08 cm²/year 1. (Evidence: Moderate)
More studies are needed to determine if sex differences affect AS progression 1. (Evidence: Weak)References
1 Willner N, Prosperi-Porta G, Lau L, Nam Fu AY, Boczar K, Poulin A et al.. Aortic Stenosis Progression: A Systematic Review and Meta-Analysis. JACC. Cardiovascular imaging 2023. link