Overview
Moderate aortic regurgitation (AR) is a condition characterized by backward flow of blood from the aorta into the left ventricle during diastole, with a moderate degree of severity. This can lead to volume overload of the left ventricle and potential adverse cardiac remodeling.Diagnosis
Aortic regurgitant volume and regurgitant fraction measured by cardiovascular MRI are associated with a higher incidence of adverse events in patients with moderate-to-severe AR 1.
Adverse left ventricular remodeling, indicated by increased end-diastolic or end-systolic volume on cardiovascular MRI, is also associated with adverse events 1.Management
Cardiovascular MRI parameters, such as aortic regurgitant volume and regurgitant fraction, can help prognosticate patients with moderate-to-severe AR 1.
Adverse remodeling on cardiovascular MRI is a prognostic indicator for adverse events in moderate-to-severe AR 1.Key Recommendations
Cardiovascular MRI parameters including aortic regurgitant volume and regurgitant fraction are associated with increased risk of adverse events in patients with moderate-to-severe AR 1. (Evidence: Moderate)
Adverse left ventricular remodeling, as assessed by increased end-diastolic or end-systolic volume on cardiovascular MRI, is associated with increased risk of adverse events in patients with moderate-to-severe AR 1. (Evidence: Moderate)References
1 Figliozzi S, Stankowski K, Di Maio S, Pateras K, Rojanathagoon T, Marchenko O et al.. Prognostic Value of Cardiovascular MRI in Asymptomatic Patients with Moderate-to-Severe Aortic Regurgitation: A Network Meta-Analysis. Radiology. Cardiothoracic imaging 2025. link